XSB0165 : insulin-like growth factor-binding protein 4 [Bos taurus]
[ CaMP Format ]
This entry is computationally expanded from SB0070
* Basic Information
| Organism | Bos taurus (cattle) |
| Protein Names | insulin-like growth factor-binding protein 4 |
| Gene Names | IGFBP-4 |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 141 aa
Average Mass: 15.701 kDa
Monoisotopic Mass: 15.691 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| --- cleavage 42 --- | ||||
| --- cleavage 26 --- | ||||
| Thyroglobulin_1 1. | 57 | 132 | 144.0 | 4.7e-40 |
3. Sequence Information
Fasta Sequence: XSB0165.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
2 [sites]
Cleavage sites (±10aa)
[Site 1] STSGGKMKVI42-GAPREEARPV
Ile42 
Gly
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ser33 | Thr34 | Ser35 | Gly36 | Gly37 | Lys38 | Met39 | Lys40 | Val41 | Ile42 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Gly43 | Ala44 | Pro45 | Arg46 | Glu47 | Glu48 | Ala49 | Arg50 | Pro51 | Val52 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| PCSAHDRKCLQKHLAKIRDRSTSGGKMKVIGAPREEARPVPQGSCQSELHRALERLAASQ |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Bos taurus | 125.00 | 2 | insulin-like growth factor-binding protein 4 |
| 2 | Ovis aries | 123.00 | 1 | IBP4_SHEEP Insulin-like growth factor-binding prot |
| 3 | Equus caballus | 120.00 | 1 | insulin-like growth factor binding protein-4 |
| 4 | Canis familiaris | 120.00 | 1 | PREDICTED: similar to Insulin-like growth factor b |
| 5 | Sus scrofa | 119.00 | 1 | IBP4 |
| 6 | N/A | 118.00 | 3 | - |
| 7 | Homo sapiens | 118.00 | 2 | insulin-like growth factor binding protein 4 precu |
| 8 | synthetic construct | 118.00 | 2 | insulin-like growth factor binding protein 4 |
| 9 | Pan troglodytes | 118.00 | 1 | PREDICTED: similar to Insulin-like growth factor-b |
| 10 | Bubalus bubalis | 106.00 | 1 | insulin-like growth factor binding protein-4 |
| 11 | Mus musculus | 103.00 | 3 | insulin-like growth factor binding protein 4 |
| 12 | Rattus norvegicus | 103.00 | 1 | insulin-like growth factor binding protein 4 |
| 13 | Monodelphis domestica | 90.10 | 1 | PREDICTED: similar to SWI/SNF-related matrix-assoc |
| 14 | Gallus gallus | 82.40 | 1 | insulin-like growth factor binding protein 4 |
| 15 | Tetraodon nigroviridis | 40.40 | 1 | unnamed protein product |
| 16 | Oncorhynchus mykiss | 37.40 | 1 | insulin-like growth factor binding protein 4 |
Top-ranked sequences
| organism | matching |
|---|---|
| Bos taurus | Query 13 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEARPVPQGSCQSELHRALERLAASQ 72 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 13 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEARPVPQGSCQSELHRALERLAASQ 72 |
| Ovis aries | Query 13 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEARPVPQGSCQSELHRALERLAASQ 72 ||||||||||||||||||||||||||||||#|||||| ||||||||||||||||||||||| Sbjct 109 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEVRPVPQGSCQSELHRALERLAASQ 168 |
| Equus caballus | Query 13 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEARPVPQGSCQSELHRALERLAASQ 72 |||||||+||||| |||||||||||||||+#| |||||||||||||||||||||||||||| Sbjct 109 PCSAHDRRCLQKHFAKIRDRSTSGGKMKVV#GVPREEARPVPQGSCQSELHRALERLAASQ 168 |
| Canis familiaris | Query 13 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEARPVPQGSCQSELHRALERLAASQ 72 |||||||+||||| ||||||||||||||||#| |||||||||||||||||||||||||||| Sbjct 323 PCSAHDRRCLQKHFAKIRDRSTSGGKMKVI#GVPREEARPVPQGSCQSELHRALERLAASQ 382 |
| Sus scrofa | Query 13 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEARPVPQGSCQSELHRALERLAASQ 72 ||| ||+||||||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 131 PCSPQDRRCLQKHLAKIRDRSTSGGKMKVI#GAPREEARPVPQGSCQSELHRALERLAASQ 190 |
| N/A | Query 13 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEARPVPQGSCQSELHRALERLAASQ 72 |||||||+||||| ||||||||||||||| #|||||+|||||||||||||||||||||||| Sbjct 130 PCSAHDRRCLQKHFAKIRDRSTSGGKMKVN#GAPREDARPVPQGSCQSELHRALERLAASQ 189 |
| Homo sapiens | Query 13 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEARPVPQGSCQSELHRALERLAASQ 72 |||||||+||||| ||||||||||||||| #|||||+|||||||||||||||||||||||| Sbjct 130 PCSAHDRRCLQKHFAKIRDRSTSGGKMKVN#GAPREDARPVPQGSCQSELHRALERLAASQ 189 |
| synthetic construct | Query 13 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEARPVPQGSCQSELHRALERLAASQ 72 |||||||+||||| ||||||||||||||| #|||||+|||||||||||||||||||||||| Sbjct 130 PCSAHDRRCLQKHFAKIRDRSTSGGKMKVN#GAPREDARPVPQGSCQSELHRALERLAASQ 189 |
| Pan troglodytes | Query 13 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEARPVPQGSCQSELHRALERLAASQ 72 |||||||+||||| ||||||||||||||| #|||||+|||||||||||||||||||||||| Sbjct 130 PCSAHDRRCLQKHFAKIRDRSTSGGKMKVN#GAPREDARPVPQGSCQSELHRALERLAASQ 189 |
| Bubalus bubalis | Query 21 CLQKHLAKIRDRSTSGGKMKVI#GAPREEARPVPQGSCQSELHRALERLAASQ 72 ||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 21 CLQKHLAKIRDRSTSGGKMKVI#GAPREEARPVPQGSCQSELHRALERLAASQ 72 |
| Mus musculus | Query 13 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEARPVPQGSCQSELHRALERLAASQ 72 |||||| +|||||+||||||| |||++#| |||| ||||||||||||||||||||||| Sbjct 130 PCSAHDHRCLQKHMAKIRDRS----KMKIV#GTPREEPRPVPQGSCQSELHRALERLAASQ 185 |
| Rattus norvegicus | Query 13 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEARPVPQGSCQSELHRALERLAASQ 72 |||||| +|||||+||+|||| ||||+#| |||| ||||||||||||||||||||||| Sbjct 130 PCSAHDHRCLQKHMAKVRDRS----KMKVV#GTPREEPRPVPQGSCQSELHRALERLAASQ 185 |
| Monodelphis domestica | Query 13 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#G--APREEARPVPQGSCQSELHRALERLAA 70 |||+|||||+||| |||| |++ |||| |#| | ||+ ||+ ||||||||||||||| | Sbjct 130 PCSSHDRKCMQKHSAKIRVVSSNSGKMKSI#GSSAHREDTRPMAQGSCQSELHRALERLGA 189 Query 71 SQ 72 || Query 71 SQ 72 |
| Gallus gallus | Query 13 PCSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAP--REEARPVPQGSCQSELHRALERLAA 70 ||| |||||||| || | +| ||+ #|+| |||+||+ ||||||||||||||||| Sbjct 135 PCSIHDRKCLQKQQAK---RINNGNKMRSS#GSPHHREESRPIAQGSCQSELHRALERLAA 191 Query 71 SQ 72 || Query 71 SQ 72 |
| Tetraodon nigroviridis | Query 14 CSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEARPVPQGSCQSELHRALERLAAS 71 || |++|+|| ||+ +||+ + # + ||| + | |++|| |||+|||++ Sbjct 139 CSQQDKRCIQKTLARHLSKSTN----QRS#NSGREETKAV-LAPCRAELQRALDRLASN 191 |
| Oncorhynchus mykiss | Query 14 CSAHDRKCLQKHLAKIRDRSTSGGKMKVI#GAPREEARPVPQGSCQSELHRALERLAAS 71 || |++|+|| ||+ +||+ # |+ | |++|| |||+|| ++ Sbjct 19 CSPQDKRCIQKTLARHPAKSTNQRSNNAR#EDPKAALAP-----CRAELQRALDRLVSN 71 |
[Site 2] HDRKCLQKHL26-AKIRDRSTSG
Leu26 Ala
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| His17 | Asp18 | Arg19 | Lys20 | Cys21 | Leu22 | Gln23 | Lys24 | His25 | Leu26 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ala27 | Lys28 | Ile29 | Arg30 | Asp31 | Arg32 | Ser33 | Thr34 | Ser35 | Gly36 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| KDEGDHPNNSFSPCSAHDRKCLQKHLAKIRDRSTSGGKMKVIGAPREEARPVPQGS |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Bos taurus | 121.00 | 2 | insulin-like growth factor-binding protein 4 |
| 2 | Ovis aries | 119.00 | 1 | IBP4_SHEEP Insulin-like growth factor-binding prot |
| 3 | Canis familiaris | 117.00 | 1 | PREDICTED: similar to Insulin-like growth factor b |
| 4 | Equus caballus | 116.00 | 1 | insulin-like growth factor binding protein-4 |
| 5 | Sus scrofa | 115.00 | 1 | IBP4 |
| 6 | Homo sapiens | 114.00 | 2 | insulin-like growth factor binding protein 4 precu |
| 7 | N/A | 114.00 | 2 | - |
| 8 | synthetic construct | 114.00 | 2 | insulin-like growth factor binding protein 4 |
| 9 | Pan troglodytes | 114.00 | 1 | PREDICTED: similar to Insulin-like growth factor-b |
| 10 | Mus musculus | 94.40 | 3 | insulin-like growth factor binding protein 4 |
| 11 | Rattus norvegicus | 94.40 | 2 | insulin-like growth factor binding protein 4 |
| 12 | Monodelphis domestica | 82.40 | 1 | PREDICTED: similar to SWI/SNF-related matrix-assoc |
| 13 | Bubalus bubalis | 76.30 | 1 | insulin-like growth factor binding protein-4 |
| 14 | Gallus gallus | 71.60 | 1 | insulin-like growth factor binding protein 4 |
| 15 | Tetraodon nigroviridis | 37.00 | 1 | unnamed protein product |
Top-ranked sequences
| organism | matching |
|---|---|
| Bos taurus | Query 1 KDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEARPVPQGS 56 ||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 KDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEARPVPQGS 56 |
| Ovis aries | Query 1 KDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEARPVPQGS 56 ||||||||||||||||||||||||||#|||||||||||||||||||||| ||||||| Sbjct 97 KDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEVRPVPQGS 152 |
| Canis familiaris | Query 1 KDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEARPVPQGS 56 |||||||||||||||||||+||||| #||||||||||||||||| |||||||||||| Sbjct 311 KDEGDHPNNSFSPCSAHDRRCLQKHF#AKIRDRSTSGGKMKVIGVPREEARPVPQGS 366 |
| Equus caballus | Query 1 KDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEARPVPQGS 56 |||||||||||||||||||+||||| #|||||||||||||||+| |||||||||||| Sbjct 97 KDEGDHPNNSFSPCSAHDRRCLQKHF#AKIRDRSTSGGKMKVVGVPREEARPVPQGS 152 |
| Sus scrofa | Query 1 KDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEARPVPQGS 56 ||||||||||||||| ||+||||||#|||||||||||||||||||||||||||||| Sbjct 119 KDEGDHPNNSFSPCSPQDRRCLQKHL#AKIRDRSTSGGKMKVIGAPREEARPVPQGS 174 |
| Homo sapiens | Query 1 KDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEARPVPQGS 56 |||||||||||||||||||+||||| #||||||||||||||| |||||+|||||||| Sbjct 118 KDEGDHPNNSFSPCSAHDRRCLQKHF#AKIRDRSTSGGKMKVNGAPREDARPVPQGS 173 |
| N/A | Query 1 KDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEARPVPQGS 56 |||||||||||||||||||+||||| #||||||||||||||| |||||+|||||||| Sbjct 118 KDEGDHPNNSFSPCSAHDRRCLQKHF#AKIRDRSTSGGKMKVNGAPREDARPVPQGS 173 |
| synthetic construct | Query 1 KDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEARPVPQGS 56 |||||||||||||||||||+||||| #||||||||||||||| |||||+|||||||| Sbjct 118 KDEGDHPNNSFSPCSAHDRRCLQKHF#AKIRDRSTSGGKMKVNGAPREDARPVPQGS 173 |
| Pan troglodytes | Query 1 KDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEARPVPQGS 56 |||||||||||||||||||+||||| #||||||||||||||| |||||+|||||||| Sbjct 118 KDEGDHPNNSFSPCSAHDRRCLQKHF#AKIRDRSTSGGKMKVNGAPREDARPVPQGS 173 |
| Mus musculus | Query 1 KDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEARPVPQGS 56 ||| +||||||+|||||| +|||||+#||||||| |||++| |||| ||||||| Sbjct 118 KDESEHPNNSFNPCSAHDHRCLQKHM#AKIRDRS----KMKIVGTPREEPRPVPQGS 169 |
| Rattus norvegicus | Query 1 KDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAPREEARPVPQGS 56 ||| +||||||+|||||| +|||||+#||+|||| ||||+| |||| ||||||| Sbjct 118 KDESEHPNNSFNPCSAHDHRCLQKHM#AKVRDRS----KMKVVGTPREEPRPVPQGS 169 |
| Monodelphis domestica | Query 1 KDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIG--APREEARPVPQGS 56 |+| +||||||||||+|||||+||| #|||| |++ |||| || | ||+ ||+ ||| Sbjct 118 KEESEHPNNSFSPCSSHDRKCMQKHS#AKIRVVSSNSGKMKSIGSSAHREDTRPMAQGS 175 |
| Bubalus bubalis | Query 21 CLQKHL#AKIRDRSTSGGKMKVIGAPREEARPVPQGS 56 ||||||#|||||||||||||||||||||||||||||| Query 21 CLQKHL#AKIRDRSTSGGKMKVIGAPREEARPVPQGS 56 |
| Gallus gallus | Query 1 KDEGDHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTSGGKMKVIGAP--REEARPVPQGS 56 |+| +|||||||||| |||||||| #|| | +| ||+ |+| |||+||+ ||| Sbjct 123 KEEIEHPNNSFSPCSIHDRKCLQKQQ#AK---RINNGNKMRSSGSPHHREESRPIAQGS 177 |
| Tetraodon nigroviridis | Query 5 DHPNNSFSPCSAHDRKCLQKHL#AKIRDRSTS 35 +||||| || |++|+|| |#|+ +||+ Sbjct 130 EHPNNSNIRCSQQDKRCIQKTL#ARHLSKSTN 160 |
* References
None.