logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB0245 : beta 7 integrin [Mus sp.]

[ CaMP Format ]

This entry is computationally expanded from SB0062

* Basic Information

OrganismMus sp.
Protein NamesIntegrin beta-7; Integrin beta-P; M290 IEL antigen; beta 7 integrin
Gene Namesbeta 7 integrin; Itgb7
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
AAB23193 N/A N/A P26011 N/A N/A N/A mmu:16421

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 806 aa

Average Mass: 87.413 kDa

Monoisotopic Mass: 87.357 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Integrin_beta 1. 504761062.50
EGF_2 1. 47851116.20.039
EGF_2 2. 5275598.50.32
EGF_2 3. 56659621.30.0039
EGF_2 4. 60563532.61.6e-06
Integrin_B_tail 1. 64572171.82.5e-18
Integrin_b_cyt 1. 74679187.93.7e-23
--- cleavage 765 (inside Integrin_b_cyt 746..791) ---

3. Sequence Information

Fasta Sequence: XSB0245.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] EYRRFEKEQQ765-QLNWKQDNNP

Gln765 Gln

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu756Tyr757Arg758Arg759Phe760Glu761Lys762Glu763Gln764Gln765
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gln766Leu767Asn768Trp769Lys770Gln771Asp772Asn773Asn774Pro775

Sequence conservation (by blast)

* References

[PubMed ID: 1381390] Gurish MF, Bell AF, Smith TJ, Ducharme LA, Wang RK, Weis JH, Expression of murine beta 7, alpha 4, and beta 1 integrin genes by rodent mast cells. J Immunol. 1992 Sep 15;149(6):1964-72.