XSB0267 : protein kinase C, beta [Bos taurus]
[ CaMP Format ]
This entry is computationally expanded from SB0039
* Basic Information
| Organism | Bos taurus (cattle) |
| Protein Names | Protein kinase C beta type; PKC-beta; PKC-B; 2.7.11.13; protein kinase C; beta; beta 1 polypeptide |
| Gene Names | PRKCB; PRKCB1; protein kinase C, beta |
| Gene Locus | 25; chromosome 25 |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_777012 | NM_174587 | 282325 | P05126 | N/A | N/A | N/A | bta:282325 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 673 aa
Average Mass: 76.915 kDa
Monoisotopic Mass: 76.865 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| C1_1 1. | 37 | 89 | 80.1 | 8.2e-21 |
| C1_1 2. | 102 | 154 | 97.3 | 5.4e-26 |
| C2 1. | 173 | 260 | 128.3 | 2.5e-35 |
| --- cleavage 311 --- | ||||
| --- cleavage 320 --- | ||||
| Pkinase 1. | 342 | 600 | 265.0 | 1.8e-76 |
| Pkinase_C 1. | 620 | 665 | 55.6 | 1.9e-13 |
3. Sequence Information
Fasta Sequence: XSB0267.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
2 [sites]
Cleavage sites (±10aa)
[Site 1] RQKFERAKIG311-PGPKTPEEKT
Gly311 
Pro
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Arg302 | Gln303 | Lys304 | Phe305 | Glu306 | Arg307 | Ala308 | Lys309 | Ile310 | Gly311 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Pro312 | Gly313 | Pro314 | Lys315 | Thr316 | Pro317 | Glu318 | Glu319 | Lys320 | Thr321 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| EGEYFNVPVPPEGSEGNEELRQKFERAKIGPGPKTPEEKTTNTISKFDNNGNRDRMKLTD |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Bos taurus | 129.00 | 3 | protein kinase C, beta |
| 2 | Oryctolagus cuniculus | 122.00 | 3 | unnamed protein product |
| 3 | N/A | 119.00 | 10 | - |
| 4 | Rattus norvegicus | 119.00 | 4 | protein kinase C, beta |
| 5 | Mus musculus | 119.00 | 4 | protein kinase C, beta 1 |
| 6 | Macaca mulatta | 118.00 | 7 | PREDICTED: protein kinase C, beta 1 isoform 5 |
| 7 | Canis familiaris | 116.00 | 3 | PREDICTED: similar to Protein kinase C, beta type |
| 8 | Homo sapiens | 115.00 | 9 | protein kinase C, beta isoform 2 |
| 9 | Monodelphis domestica | 110.00 | 3 | PREDICTED: similar to Protein kinase C beta type ( |
| 10 | Gallus gallus | 109.00 | 3 | PREDICTED: similar to protein kinase C beta-1 |
| 11 | Latimeria chalumnae | 102.00 | 2 | protein kinase C beta 1 |
| 12 | Protopterus dolloi | 100.00 | 2 | protein kinase C beta 1 |
| 13 | Tetraodon nigroviridis | 97.40 | 3 | unnamed protein product |
| 14 | Danio rerio | 96.30 | 7 | protein kinase C, beta 1 |
| 15 | Scyliorhinus canicula | 90.10 | 2 | protein kinase C |
| 16 | Petromyzon marinus | 65.10 | 1 | protein kinase C |
| 17 | synthetic construct | 58.20 | 1 | protein kinase C alpha |
| 18 | Xenopus tropicalis | 56.20 | 1 | hypothetical protein LOC780209 |
| 19 | Takifugu rubripes | 53.10 | 1 | protein kinase C, alpha type |
| 20 | Xenopus laevis | 52.80 | 1 | protein kinase C, alpha |
| 21 | Myxine glutinosa | 46.20 | 1 | protein kinase C |
| 22 | Caenorhabditis briggsae | 36.20 | 1 | Hypothetical protein CBG16150 |
| 23 | Aplysia californica | 35.40 | 1 | KPC1_APLCA Calcium-dependent protein kinase C (APL |
| 24 | Apis mellifera | 33.50 | 1 | PREDICTED: similar to Protein C kinase 53E CG6622- |
Top-ranked sequences
| organism | matching |
|---|---|
| Bos taurus | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLTD 341 |
| Oryctolagus cuniculus | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||||||||||||||||||||# | ||||||||||||||||||||||||||| Sbjct 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLTD 341 |
| N/A | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||||||||||||||||||||# | | ||||| ||||||||||||||||||| Sbjct 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 |
| Rattus norvegicus | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||||||||||||||||||||# | | ||||| ||||||||||||||||||| Sbjct 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 |
| Mus musculus | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||||||||||||||||||||# | | ||||| ||||||||||||||||||| Sbjct 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 |
| Macaca mulatta | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||||||||||||||||||| # | | ||||||||+|||||||||||||||| Sbjct 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIS#QGTKVPEEKTTNTVSKFDNNGNRDRMKLTD 341 |
| Canis familiaris | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||||||||||||||||||| # | | ||||||||||| ||||||||||||| Sbjct 274 EGEYFNVPVPPEGSEGNEELRQKFERAKIS#QGTKAPEEKTTNTISKLDNNGNRDRMKLTD 333 |
| Homo sapiens | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||||| ||||||||||||| # | | ||||||||+|||||||||||||||| Sbjct 282 EGEYFNVPVPPEGSEANEELRQKFERAKIS#QGTKVPEEKTTNTVSKFDNNGNRDRMKLTD 341 |
| Monodelphis domestica | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||| ||||||||||||||||# | | |||| | ||| ||||||||||||| Sbjct 279 EGEYFNVPVPPEGEEGNEELRQKFERAKIG#QGTKVTEEKTANAISKIDNNGNRDRMKLTD 338 |
| Gallus gallus | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||| ||||||||||||||||# | | +||||| ||||||||+||||||+| Sbjct 281 EGEYFNVPVPPEGEEGNEELRQKFERAKIG#TGSKAADEKTTNAISKFDNNGSRDRMKLSD 340 |
| Latimeria chalumnae | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||| |||||||+||||||||#|| | |+| |+ ||| |||||||+||+| Sbjct 204 EGEYFNVPVPPEGEEGNEELRKKFERAKIG#PGSKATEDKVKNSSSKFGNNGNRDRIKLSD 263 |
| Protopterus dolloi | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||| ||||||||||||||||#|| + |+| | +||||||||||+||+| Sbjct 213 EGEYFNVPVPPEGEEGNEELRQKFERAKIG#PGAEAAEDKIANA-AKFDNNGNRDRVKLSD 271 |
| Tetraodon nigroviridis | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||| ||||||||||||||||#|| | + |+ | |+||+|||+||||| | Sbjct 218 EGEYFNVPVPPEGEEGNEELRQKFERAKIG#PG-KNTDGKSANAASRFDSNGNQDRMKLAD 276 |
| Danio rerio | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||| ||||||||||||||||#| || + ++| |||||+|||||||||+| Sbjct 281 EGEYFNVPVPPEGEEGNEELRQKFERAKIG#PS-KT-DGSSSNAISKFDSNGNRDRMKLSD 338 |
| Scyliorhinus canicula | Query 282 EGEYFNVPVPPE-GSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLT 340 ||||+||||||| ||||||||||||||+||#|| | ||| +++ || | ||||||||| Sbjct 202 EGEYYNVPVPPEEDSEGNEELRQKFERARIG#PGSKAAEEKRSSSWSKID-NGNRDRMKLA 260 Query 341 D 341 | Query 341 D 341 |
| Petromyzon marinus | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PG--PKTPEEKTTNTISKFDNNGNRDRMKL 339 ||||+|||+ |+ +|+ |+|+|||+|++|#| |+ +|+ |++| || | ||+| Sbjct 212 EGEYYNVPIAPDIEDGDTEMRRKFEKARLG#PSVKPRASDERRANSLSAILNNANVDRVKA 271 Query 340 TD 341 | Sbjct 272 DD 273 |
| synthetic construct | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPK---TPEEKTTNTISKFDNNGNRDRMK 338 ||||+|||+| ||| |||||||+||+|#| +| | + + | ||+| Sbjct 282 EGEYYNVPIPEGDEEGNMELRQKFEKAKLG#PAGNKVISPSE------DRKQPSNNLDRVK 335 Query 339 LTD 341 ||| Query 339 LTD 341 |
| Xenopus tropicalis | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||+|||+| | +|| |||||||+||+|#| | +| | | ++||| Sbjct 286 EGEYYNVPIPEEEDDGNIELRQKFEKAKLG#PAGNKVISPTDERRPYVPSN-NIDSVRLTD 344 |
| Takifugu rubripes | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPK--TPEEKTTNTISKFDNNGNRDRMKL 339 ||||+|||+| | + | |||||||+||+|# | | || + ++ +|| ||++| Sbjct 280 EGEYYNVPIP-EVDDVNLELRQKFEKAKLG#QGKKVITPSDHRRFSLP----SGNMDRVRL 334 Query 340 TD 341 | Sbjct 335 ND 336 |
| Xenopus laevis | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||+|||+| | +|| |||||||+||+|#| | +| | | ++||| Sbjct 286 EGEYYNVPIP-EADDGNLELRQKFEKAKLG#PAGNKVINPTGERRPYIPSN-NIDSIRLTD 343 |
| Myxine glutinosa | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||+|||| ||| || ||||+ +|++| # | + + | + ||+ | | Sbjct 203 EGEYYNVPVAPEGEEG-LELRQRLQRSQIA#RSDKNKQSPAKDQPSDSASLSGLDRVNLED 261 |
| Caenorhabditis briggsae | Query 282 EGEYFNVPVPPEGSEGNEELRQKF-ERAKIG#PGPKT--PEEKTTNTISKFDNNGNRDRMK 338 |||++|+ + || | |++|+| + || # | | | | | ||| +| Sbjct 352 EGEFYNINITPEYDEDMEKVRKKMNDNFKIS#RDSSAGKPRESTPRATSTSLTNTNRDVIK 411 Query 339 LTD 341 +| Sbjct 412 ASD 414 |
| Aplysia californica | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFD 329 |||++ ||| + +| +|++ | |+ | # + || +|| | Sbjct 266 EGEFYGVPVTDDITESIQEIKSKMHRSSIS#SEKRYPEPDKVQNMSKQD 313 |
| Apis mellifera | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKF--DNNGNRDRMKL 339 ||||+||||| || + | + | #| + +||| | | | | | ++ Sbjct 299 EGEYYNVPVPEEGVDLAE------LKMKPS#PQKTSVTKKTTTTQDKEVPHNMGKSDLIRA 352 Query 340 TD 341 +| Sbjct 353 SD 354 |
[Site 2] GPGPKTPEEK320-TTNTISKFDN
Lys320 Thr
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gly311 | Pro312 | Gly313 | Pro314 | Lys315 | Thr316 | Pro317 | Glu318 | Glu319 | Lys320 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Thr321 | Thr322 | Asn323 | Thr324 | Ile325 | Ser326 | Lys327 | Phe328 | Asp329 | Asn330 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| PPEGSEGNEELRQKFERAKIGPGPKTPEEKTTNTISKFDNNGNRDRMKLTDFNFLMVLGK |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Bos taurus | 127.00 | 3 | protein kinase C, beta |
| 2 | Oryctolagus cuniculus | 121.00 | 3 | unnamed protein product |
| 3 | N/A | 117.00 | 11 | - |
| 4 | Rattus norvegicus | 117.00 | 4 | protein kinase C, beta |
| 5 | Mus musculus | 117.00 | 4 | protein kinase C, beta 1 |
| 6 | Macaca mulatta | 116.00 | 7 | PREDICTED: protein kinase C, beta 1 isoform 5 |
| 7 | Homo sapiens | 114.00 | 8 | protein kinase C, beta isoform 2 |
| 8 | Canis familiaris | 114.00 | 3 | PREDICTED: similar to Protein kinase C, beta type |
| 9 | Gallus gallus | 108.00 | 3 | PREDICTED: similar to protein kinase C beta-1 |
| 10 | Monodelphis domestica | 108.00 | 3 | PREDICTED: similar to Protein kinase C beta type ( |
| 11 | Latimeria chalumnae | 101.00 | 2 | protein kinase C beta 1 |
| 12 | Protopterus dolloi | 98.60 | 2 | protein kinase C beta 1 |
| 13 | Tetraodon nigroviridis | 95.90 | 2 | unnamed protein product |
| 14 | Danio rerio | 94.70 | 6 | protein kinase C, beta 1 |
| 15 | Scyliorhinus canicula | 91.30 | 2 | protein kinase C |
| 16 | Petromyzon marinus | 65.50 | 1 | protein kinase C |
| 17 | synthetic construct | 59.30 | 1 | protein kinase C alpha |
| 18 | Xenopus tropicalis | 54.30 | 1 | hypothetical protein LOC780209 |
| 19 | Takifugu rubripes | 54.30 | 1 | protein kinase C, alpha type |
| 20 | Xenopus laevis | 53.90 | 1 | protein kinase C, alpha |
| 21 | Myxine glutinosa | 40.40 | 1 | protein kinase C |
| 22 | Caenorhabditis briggsae | 39.70 | 1 | Hypothetical protein CBG16150 |
| 23 | Aplysia californica | 35.40 | 1 | KPC1_APLCA Calcium-dependent protein kinase C (APL |
| 24 | Apis mellifera | 34.70 | 1 | PREDICTED: similar to Protein C kinase 53E CG6622- |
| 25 | Branchiostoma lanceolatum | 34.30 | 1 | protein kinase C |
| 26 | Aedes aegypti | 33.50 | 1 | protein kinase c |
| 27 | Caenorhabditis elegans | 33.10 | 4 | protein kinase C2 A isoform |
Top-ranked sequences
| organism | matching |
|---|---|
| Bos taurus | Query 291 PPEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 291 PPEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |
| Oryctolagus cuniculus | Query 291 PPEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 ||||||||||||||||||||| | ||||||#|||||||||||||||||||||||||||||| Sbjct 291 PPEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |
| N/A | Query 291 PPEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 ||||||||||||||||||||| | | ||||#| |||||||||||||||||||||||||||| Sbjct 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |
| Rattus norvegicus | Query 291 PPEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 ||||||||||||||||||||| | | ||||#| |||||||||||||||||||||||||||| Sbjct 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |
| Mus musculus | Query 291 PPEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 ||||||||||||||||||||| | | ||||#| |||||||||||||||||||||||||||| Sbjct 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |
| Macaca mulatta | Query 291 PPEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||||||||||||||||||| | | ||||#||||+||||||||||||||||||||||||| Sbjct 291 PPEGSEGNEELRQKFERAKISQGTKVPEEK#TTNTVSKFDNNGNRDRMKLTDFNFLMVLGK 350 |
| Homo sapiens | Query 291 PPEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||||| ||||||||||||| | | ||||#||||+||||||||||||||||||||||||| Sbjct 291 PPEGSEANEELRQKFERAKISQGTKVPEEK#TTNTVSKFDNNGNRDRMKLTDFNFLMVLGK 350 |
| Canis familiaris | Query 291 PPEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||||||||||||||||||| | | ||||#||||||| |||||||||||||||||||||| Sbjct 283 PPEGSEGNEELRQKFERAKISQGTKAPEEK#TTNTISKLDNNGNRDRMKLTDFNFLMVLGK 342 |
| Gallus gallus | Query 291 PPEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||| |||||||||||||||| | | +||#||| ||||||||+||||||+|||||||||| Sbjct 290 PPEGEEGNEELRQKFERAKIGTGSKAADEK#TTNAISKFDNNGSRDRMKLSDFNFLMVLGK 349 |
| Monodelphis domestica | Query 291 PPEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||| |||||||||||||||| | | |||#| | ||| |||||||||||||||||||||| Sbjct 288 PPEGEEGNEELRQKFERAKIGQGTKVTEEK#TANAISKIDNNGNRDRMKLTDFNFLMVLGK 347 |
| Latimeria chalumnae | Query 291 PPEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||| |||||||+|||||||||| | |+|# |+ ||| |||||||+||+|||||||||| Sbjct 213 PPEGEEGNEELRKKFERAKIGPGSKATEDK#VKNSSSKFGNNGNRDRIKLSDFNFLMVLGK 272 |
| Protopterus dolloi | Query 291 PPEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||| |||||||||||||||||| + |+|# | +||||||||||+||+|||||||||| Sbjct 222 PPEGEEGNEELRQKFERAKIGPGAEAAEDK#IANA-AKFDNNGNRDRVKLSDFNFLMVLGK 280 |
| Tetraodon nigroviridis | Query 291 PPEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||| |||||||||||||||||| | + |#+ | |+||+|||+||||| |||||||||| Sbjct 227 PPEGEEGNEELRQKFERAKIGPGKNT-DGK#SANAASRFDSNGNQDRMKLADFNFLMVLGK 285 |
| Danio rerio | Query 291 PPEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||| ||||||||||||||||| || + #++| |||||+|||||||||+|||||||||| Sbjct 290 PPEGEEGNEELRQKFERAKIGPS-KT-DGS#SSNAISKFDSNGNRDRMKLSDFNFLMVLGK 347 |
| Scyliorhinus canicula | Query 291 PPEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 | | ||||||||||||||+|||| | |||# +++ || | ||||||||| |||||||||| Sbjct 212 PEEDSEGNEELRQKFERARIGPGSKAAEEK#RSSSWSKID-NGNRDRMKLADFNFLMVLGK 270 |
| Petromyzon marinus | Query 292 PEGSEGNEELRQKFERAKIGPG--PKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLG 349 |+ +|+ |+|+|||+|++|| |+ +|+# |++| || | ||+| ||||||||| Sbjct 222 PDIEDGDTEMRRKFEKARLGPSVKPRASDER#RANSLSAILNNANVDRVKADDFNFLMVLG 281 Query 350 K 350 | Query 350 K 350 |
| synthetic construct | Query 292 PEGSE-GNEELRQKFERAKIGPGPK---TPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMV 347 ||| | || |||||||+||+|| +| | # + + | ||+|||||||||| Sbjct 291 PEGDEEGNMELRQKFEKAKLGPAGNKVISPSE-#-----DRKQPSNNLDRVKLTDFNFLMV 344 Query 348 LGK 350 ||| Query 348 LGK 350 |
| Xenopus tropicalis | Query 291 PPEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 | | +|| |||||||+||+|| #| +| | | ++||||+||||||| Sbjct 295 PEEEDDGNIELRQKFEKAKLGPAGNKVISP#TDERRPYVPSN-NIDSVRLTDFSFLMVLGK 353 |
| Takifugu rubripes | Query 292 PEGSEGNEELRQKFERAKIGPGPK--TPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLG 349 || + | |||||||+||+| | | || + # ++ +|| ||++| ||||| +|| Sbjct 289 PEVDDVNLELRQKFEKAKLGQGKKVITPSDH#RRFSLP----SGNMDRVRLNDFNFLALLG 344 Query 350 K 350 | Query 350 K 350 |
| Xenopus laevis | Query 292 PEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 || +|| |||||||+||+|| #| +| | | ++|||| ||||||| Sbjct 295 PEADDGNLELRQKFEKAKLGPAGNKVINP#TGERRPYIPSN-NIDSIRLTDFCFLMVLGK 352 |
| Myxine glutinosa | Query 292 PEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 ||| || | |||+ +|++| | + # + | + ||+ | || || |||| Sbjct 213 PEGEEGLE-LRQRLQRSQIARSDKNKQSP#AKDQPSDSASLSGLDRVNLEDFVFLTVLGK 270 |
| Caenorhabditis briggsae | Query 292 PEGSEGNEELRQKF-ERAKIGPGPKT--PEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVL 348 || | |++|+| + || | | #| | | ||| +| +||||| || Sbjct 362 PEYDEDMEKVRKKMNDNFKISRDSSAGKPRES#TPRATSTSLTNTNRDVIKASDFNFLTVL 421 Query 349 GK 350 || Query 349 GK 350 |
| Aplysia californica | Query 295 SEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 +| +|++ | |+ | + || # +|| +| ++ +||||| |||| Sbjct 279 TESIQEIKSKMHRSSISSEKRYPEPD#KVQNMSK------QDIVRASDFNFLTVLGK 328 |
| Apis mellifera | Query 309 KIGPGPKTPE--EK#TTNTISKF--DNNGNRDRMKLTDFNFLMVLGK 350 |+ | |+ +|#|| | | | | | ++ +|||||||||| Sbjct 318 KMKPSPQKTSVTKK#TTTTQDKEVPHNMGKSDLIRASDFNFLMVLGK 363 |
| Branchiostoma lanceolatum | Query 296 EGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 | +|++ ++ |+ | ++#+ | |+ | || |||||||||| Sbjct 226 ENVAKLKEHLQKQKLDEQRKQKSKR#SEEC-----NIGSLDHMKAADFNFLMVLGK 275 |
| Aedes aegypti | Query 292 PEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 | || + ++ | + | | | # + | | +| ++ ||||||||||| Sbjct 237 PVPEEGTDLVQLKSQMRKTSISKKAPVLC#DKDVPH---NMGKKDVIRATDFNFLMVLGK 292 |
| Caenorhabditis elegans | Query 292 PEGSEGNEELRQKFE-----RAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLM 346 || | |++|+| | || | # +|+ +| | +| +||||| Sbjct 295 PEYDEDMEKVRKKMNENFITRDNSSSKPKDPAAP#RASTLPLGSSNHNV--IKASDFNFLT 352 Query 347 VLGK 350 |||| Query 347 VLGK 350 |
* References
[PubMed ID: 3045562] Nishizuka Y, The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature. 1988 Aug 25;334(6184):661-5.
[PubMed ID: 3755548] ... Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A, Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. Science. 1986 Aug 22;233(4766):859-66.