logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB0268 : peroxiredoxin 2 [Bos taurus]

[ CaMP Format ]

This entry is computationally expanded from SB0091

* Basic Information

OrganismBos taurus (cattle)
Protein NamesPeroxiredoxin-2; 1.11.1.15; peroxiredoxin 2
Gene NamesPRDX2; peroxiredoxin 2
Gene Locus7; chromosome 7
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_777188 NM_174763 286793 Q9BGI3 N/A N/A N/A bta:286793

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 199 aa

Average Mass: 21.946 kDa

Monoisotopic Mass: 21.932 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
AhpC-TSA 1. 9142215.91.1e-61
1-cysPrx_C 1. 15219585.71.7e-22
--- cleavage 183 (inside 1-cysPrx_C 152..195) ---
--- cleavage 195 (inside 1-cysPrx_C 152..195) ---
--- cleavage 194 (inside 1-cysPrx_C 152..195) ---
--- cleavage 184 (inside 1-cysPrx_C 152..195) ---
--- cleavage 182 (inside 1-cysPrx_C 152..195) ---

3. Sequence Information

Fasta Sequence: XSB0268.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

5 [sites]

Cleavage sites (±10aa)

[Site 1] PAGWTPGSDT183-IKPNVDDSKE

Thr183 Ile

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Pro174Ala175Gly176Trp177Thr178Pro179Gly180Ser181Asp182Thr183
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ile184Lys185Pro186Asn187Val188Asp189Asp190Ser191Lys192Glu193

Sequence conservation (by blast)

[Site 2] PNVDDSKEYF195-SKHN

Phe195 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Pro186Asn187Val188Asp189Asp190Ser191Lys192Glu193Tyr194Phe195
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser196Lys197His198Asn199------

Sequence conservation (by blast)

[Site 3] KPNVDDSKEY194-FSKHN

Tyr194 Phe

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys185Pro186Asn187Val188Asp189Asp190Ser191Lys192Glu193Tyr194
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Phe195Ser196Lys197His198Asn199-----

Sequence conservation (by blast)

[Site 4] AGWTPGSDTI184-KPNVDDSKEY

Ile184 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ala175Gly176Trp177Thr178Pro179Gly180Ser181Asp182Thr183Ile184
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys185Pro186Asn187Val188Asp189Asp190Ser191Lys192Glu193Tyr194

Sequence conservation (by blast)

[Site 5] CPAGWTPGSD182-TIKPNVDDSK

Asp182 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Cys173Pro174Ala175Gly176Trp177Thr178Pro179Gly180Ser181Asp182
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Thr183Ile184Lys185Pro186Asn187Val188Asp189Asp190Ser191Lys192

Sequence conservation (by blast)

* References

[PubMed ID: 14662316] Leyens G, Donnay I, Knoops B, Cloning of bovine peroxiredoxins-gene expression in bovine tissues and amino acid sequence comparison with rat, mouse and primate peroxiredoxins. Comp Biochem Physiol B Biochem Mol Biol. 2003 Dec;136(4):943-55.