logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB0281 : beta-spectrin [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0052

* Basic Information

OrganismHomo sapiens (human)
Protein NamesSpectrin beta chain, erythrocyte; Beta-I spectrin; beta-spectrin
Gene NamesSPTB1
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
CAA42098 N/A N/A P11277 N/A 11274 N/A hsa:6710

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 229 aa

Average Mass: 26.467 kDa

Monoisotopic Mass: 26.450 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Spectrin 1. 19984.15e-22
Spectrin 2. 10118717.60.0011
--- cleavage 153 (inside Spectrin 101..187) ---

3. Sequence Information

Fasta Sequence: XSB0281.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1S35 (X-ray; 240 A; A=1064-1275), 3EDU (X-ray; 210 A; A=1692-1907), 3F57 (X-ray; 290 A; A/B=1686-1907)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] EAFEKSTASW153-AERFAALEKP

Trp153 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu144Ala145Phe146Glu147Lys148Ser149Thr150Ala151Ser152Trp153
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala154Glu155Arg156Phe157Ala158Ala159Leu160Glu161Lys162Pro163

Sequence conservation (by blast)

* References

[PubMed ID: 3390609] Winkelmann JC, Leto TL, Watkins PC, Eddy R, Shows TB, Linnenbach AJ, Sahr KE, Kathuria N, Marchesi VT, Forget BG, Molecular cloning of the cDNA for human erythrocyte beta-spectrin. Blood. 1988 Jul;72(1):328-34.