logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB0297 : Chain B, Crystal Structure Of Rhoa.Gdp.Mgf3-In Complex With Rhogap

[ CaMP Format ]

This entry is computationally expanded from SB0038

* Basic Information

OrganismHomo sapiens (human)
Protein NamesTransforming protein RhoA; H12
Gene NamesARH12, ARHA, RHO12; ARH12; ARHA; RHO12
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
1OW3_B N/A N/A P61586 N/A N/A N/A hsa:387

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 193 aa

Average Mass: 21.735 kDa

Monoisotopic Mass: 21.721 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Ras 1. 7180326.94.1e-95
--- cleavage 180 (inside Ras 7..180) ---

3. Sequence Information

Fasta Sequence: XSB0297.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1A2B (X-ray; 240 A; A=1-181), 1CC0 (X-ray; 500 A; A/C=1-190), 1CXZ (X-ray; 220 A; A=1-181), 1DPF (X-ray; 200 A; A=1-180), 1FTN (X-ray; 210 A; A=1-193), 1KMQ (X-ray; 155 A; A=4-181), 1LB1 (X-ray; 281 A; B/D/F/H=1-189), 1OW3 (X-ray; 180 A; B=1-193), 1S1C (X-ray; 260 A; A/B=1-181), 1TX4 (X-ray; 165 A; B=3-179), 1X86 (X-ray; 322 A; B/D/F/H=1-193), 1XCG (X-ray; 250 A; B/F=3-180), 2RGN (X-ray; 350 A; C/F=1-193)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] FEMATRAALQ180-ARRGKKKSGC

Gln180 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Phe171Glu172Met173Ala174Thr175Arg176Ala177Ala178Leu179Gln180
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala181Arg182Arg183Gly184Lys185Lys186Lys187Ser188Gly189Cys190

Sequence conservation (by blast)

* References

[PubMed ID: 11927263] Graham DL, Lowe PN, Grime GW, Marsh M, Rittinger K, Smerdon SJ, Gamblin SJ, Eccleston JF, MgF(3)(-) as a transition state analog of phosphoryl transfer. Chem Biol. 2002 Mar;9(3):375-81.