XSB0306 : precursor [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0054
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Glucagon; Glicentin; Glicentin-related polypeptide; GRPP; Oxyntomodulin; OXY; OXM; Glucagon-like peptide 1; GLP-1; Glucagon-like peptide 1(7-37); GLP-1(7-37); Glucagon-like peptide 1(7-36); GLP-1(7-36); Glucagon-like peptide 2; GLP-2; precursor; RecName: Full=Glucagon; Contains:RecName: Full=Glicentin; Contains:RecName: Full=Glicentin-related polypeptide; Short=GRPP; Contains:RecName: Full=Oxyntomodulin; Short=OXY; Short=OXM; Contains:RecName: Full=Glucagon; Contains:RecName: Full=Glucagon-like peptide 1; Short=GLP-1; 7-37; 7-36 |
| Gene Names | GCG |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 179 aa
Average Mass: 20.781 kDa
Monoisotopic Mass: 20.768 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Hormone_2 1. | 53 | 80 | 66.4 | 1.1e-16 |
| --- cleavage 67 (inside Hormone_2 53..80) --- | ||||
| --- cleavage 69 (inside Hormone_2 53..80) --- | ||||
| --- cleavage 77 (inside Hormone_2 53..80) --- | ||||
| --- cleavage 79 (inside Hormone_2 53..80) --- | ||||
| --- cleavage 74 (inside Hormone_2 53..80) --- | ||||
| Hormone_2 2. | 98 | 125 | 52.6 | 1.5e-12 |
| Hormone_2 3. | 146 | 173 | 45.7 | 1.9e-10 |
3. Sequence Information
Fasta Sequence: XSB0306.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
* Cleavage Information
5 [sites]
Cleavage sites (±10aa)
[Site 1] FTSDYSKYLD67-SRRAQDFVQW
Asp67 
Ser
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Phe58 | Thr59 | Ser60 | Asp61 | Tyr62 | Ser63 | Lys64 | Tyr65 | Leu66 | Asp67 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ser68 | Arg69 | Arg70 | Ala71 | Gln72 | Asp73 | Phe74 | Val75 | Gln76 | Trp77 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| ADPLSDPDQMNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFER |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 129.00 | 9 | glucagon, isoform CRA_b |
| 2 | Pan troglodytes | 106.00 | 2 | PREDICTED: fibroblast activation protein, alpha su |
| 3 | N/A | 79.70 | 43 | 0 |
| 4 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | 64.70 | 1 | AAB31092.1 |
| 5 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | 61.60 | 1 | glucagon=proglucagon-derived 3.5 kda peptide |
| 6 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | 60.80 | 1 | glucagon II |
| 7 | Contains: Glucagon; Glucagon-like peptide | 60.10 | 4 | GLUC_AMICA Glucagon precursor |
| 8 | Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | 60.10 | 1 | glucagon |
| 9 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | 58.50 | 1 | glucagon G-29 |
| 10 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | 57.80 | 1 | GLUC1_ORENI Glucagon-1 (Glucagon I) gb |
| 11 | Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | 56.20 | 1 | GLUC_LAMFL Glucagon gb |
| 12 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | 53.50 | 1 | glucagon |
| 13 | deshis1, Desphe6, Glu9 | 53.50 | 1 | A Chain A, Nmr Solution Structure Of The Glucagon |
| 14 | Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | 47.00 | 1 | GLUC1_PETMA Glucagon-1 precursor |
| 15 | Gallus gallus | 44.30 | 4 | glucagon isoform 1 |
| 16 | Meleagris gallopavo | 44.30 | 2 | preproglucagon B |
| 17 | Agkistrodon piscivorus | 44.30 | 1 | proglucagon |
| 18 | Capra hircus | 43.90 | 1 | glucagon |
| 19 | Oncorhynchus tshawytscha | 43.50 | 1 | S78474_1 proglucagon |
| 20 | Monodelphis domestica | 42.70 | 3 | PREDICTED: similar to Gastric inhibitory polypepti |
| 21 | Xenopus laevis | 42.40 | 5 | proglucagon I |
| 22 | Rattus norvegicus | 42.40 | 3 | Glucose-dependent insulinotropic peptide |
| 23 | Xenopus tropicalis | 42.40 | 2 | glucagon |
| 24 | Canis familiaris | 42.40 | 2 | PREDICTED: similar to Gastric inhibitory polypepti |
| 25 | Danio rerio | 42.00 | 4 | hypothetical protein LOC494052 |
| 26 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | 42.00 | 1 | GLUC_HELSU Glucagon precursor |
| 27 | Heloderma suspectum | 41.60 | 2 | proglucagon |
| 28 | Hoplobatrachus rugulosus | 41.60 | 1 | AF324209_1 proglucagon |
| 29 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | 41.20 | 1 | glucagon-like peptide, GLP |
| 30 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | 41.20 | 1 | GLUC2_LOPAM Glucagon-2 precursor (Glucagon II) |
| 31 | Heloderma horridum | 40.80 | 1 | EXE3_HELHO Exendin-3 precursor emb |
| 32 | Bos taurus | 40.40 | 5 | PREDICTED: similar to Gastric inhibitory polypepti |
| 33 | Ictalurus punctatus | 40.40 | 3 | proglucagon I |
| 34 | Macaca mulatta | 40.40 | 3 | PREDICTED: gastric inhibitory polypeptide |
| 35 | Protopterus dolloi | 40.40 | 1 | proglucagon |
| 36 | Sebastes caurinus | 40.00 | 4 | proglucagon II |
| 37 | Tetraodon nigroviridis | 40.00 | 2 | unnamed protein product |
| 38 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | 40.00 | 2 | GLUC_CARAU Glucagon precursor |
| 39 | Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | 40.00 | 1 | GLUC2_ONCMY Glucagon-2 precursor (Glucagon II) |
| 40 | Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | 40.00 | 1 | GLUC1_ONCMY Glucagon-1 precursor (Glucagon I) |
| 41 | Neoceratodus forsteri | 39.70 | 1 | proglucagon |
| 42 | Mus musculus | 39.30 | 5 | gastric inhibitory polypeptide |
| 43 | Bufo marinus | 38.90 | 1 | proglucagon |
| 44 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | 38.90 | 1 | glucagon-like peptide-2, GLP-2=proglucagon-derived |
| 45 | Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | 38.10 | 1 | GLUC2_PETMA Glucagon-2 precursor |
| 46 | synthetic construct | 37.00 | 1 | Homo sapiens glucagon |
| 47 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | 36.60 | 1 | GLUC1_LOPAM Glucagon-1 precursor (Glucagon I) |
| 48 | Phodopus sungorus | 36.60 | 1 | glucagon precursor |
| 49 | Sus scrofa | 36.20 | 1 | glucagon |
| 50 | Canis lupus familiaris | 35.80 | 1 | glucagon |
| 51 | Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | 35.80 | 1 | GLUC_LEPSP Glucagon precursor |
| 52 | Heloderma suspectum, venom, Peptide, 39 aa | 35.40 | 1 | A Chain A, Solution Structure Of Exendin-4 In 30-V |
| 53 | Hydrolagus colliei | 35.40 | 1 | proglucagon |
| 54 | Squalus acanthias | 35.40 | 1 | proglucagon |
| 55 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | 34.70 | 1 | glucagon-like peptide-1, GLP-1=proglucagon-derived |
| 56 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | 34.70 | 1 | GLUC2_ORENI Glucagon-2 (Glucagon II) gb |
| 57 | Candida glabrata | 32.70 | 1 | unnamed protein product |
| 58 | Ambloplites rupestris | 32.30 | 1 | proglucagon |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 38 ADPLSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 97 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 38 ADPLSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 97 |
| Pan troglodytes | Query 38 ADPLSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDE 94 ||||||||||||||||||||||||||||||#||||||||||||||||| +++| || | Sbjct 960 ADPLSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRN-SSVAYRHAE 1015 |
| N/A | Query 53 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIA 89 |||||||||||||||#|||||||||||||||||+|||| Sbjct 1 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNKNNIA 37 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | Query 53 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRN 84 ||+||||||||||+|#+|||+|||||||+|||| Sbjct 1 HSEGTFTSDYSKYMD#NRRAKDFVQWLMSTKRN 32 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNT 81 |||||||||||||||#+||||||+||||+| Sbjct 1 HSQGTFTSDYSKYLD#NRRAQDFIQWLMST 29 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | Query 53 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRN 84 ||+|||++||||||+#+|||||||||| |+||| Sbjct 1 HSEGTFSNDYSKYLE#TRRAQDFVQWLKNSKRN 32 |
| Contains: Glucagon; Glucagon-like peptide | Query 53 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNT 81 |||||||+|||||+|#+|||||||||||+| Sbjct 1 HSQGTFTNDYSKYMD#TRRAQDFVQWLMST 29 |
| Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNT 81 |||||||+|||||+|#+|||||||||||+| Sbjct 1 HSQGTFTNDYSKYMD#TRRAQDFVQWLMST 29 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNT 81 ||+||||||||||+|#+|||+|||||||+| Sbjct 1 HSEGTFTSDYSKYMD#NRRAKDFVQWLMST 29 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | Query 53 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRN 84 ||+|||++||||||+# |+|||||+|||| ||+ Sbjct 1 HSEGTFSNDYSKYLE#DRKAQDFVRWLMNNKRS 32 |
| Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNT 81 ||||+||||||||||#|++|+||| ||||| Sbjct 1 HSQGSFTSDYSKYLD#SKQAKDFVIWLMNT 29 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLD#SRRAQDFVQWLMN 80 ||+|||||||||||+#+++|+|||+|||| Sbjct 1 HSEGTFTSDYSKYLE#NKQAKDFVRWLMN 28 |
| deshis1, Desphe6, Glu9 | Query 54 SQGTFTSDYSKYLD#SRRAQDFVQWLMNT 81 |||| ||+||||||#|||||||||||||| Sbjct 1 SQGT-TSEYSKYLD#SRRAQDFVQWLMNT 27 |
| Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 92 ||||+|||||||||||+#+++|+|||+|||| || + + +|| Sbjct 41 KRHSEGTFTSDYSKYLE#NKQAKDFVRWLMNAKRGGSELQRRH 82 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNR---------NNIAKRHDE 94 +||+ ||||+| + |||#++ |+||| || + ++| |+ ||| | Sbjct 80 RRHADGTFTNDMTSYLD#AKAARDFVSWLARSDKSRRDGGDHLAENSEDKRHAE 132 |
| Gallus gallus | Query 38 ADPLSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRN------------- 84 ++|| + |+|| |||||||||||||||||#||||||||||||+|||| Sbjct 40 SEPLDESRQLNEVKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMSTKRNGQQGQEDKENDKF 99 Query 85 -----RNNIAKRHDEFER 97 | |+||| |||| Sbjct 100 PDQLSSNAISKRHSEFER 117 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNI 88 +||+ |||||| +| ||# |++|++||+||| + ++ Sbjct 164 RRHADGTFTSDINKILD#DMAAKEFLKWLINTKVTQRDL 201 Query 48 NEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 86 +| +||++||+||| + ||+# + |++|+ ||+| + |+ Sbjct 113 SEFERHAEGTYTSDITSYLE#GQAAKEFIAWLVNGRGRRD 151 |
| Meleagris gallopavo | Query 38 ADPLSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRN------------- 84 ++|| + |+|| |||||||||||||||||#||||||||||||+|||| Sbjct 40 SEPLDESRQLNEVKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMSTKRNGQQGQEDKENDEF 99 Query 85 -----RNNIAKRHDEFER 97 | |+||| |||| Sbjct 100 PDQLSSNAISKRHSEFER 117 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNI 88 +||+ |||||| +| ||# |++|++||+||| + ++ Sbjct 164 RRHADGTFTSDINKILD#DMAAKEFLKWLINTKVTQRDL 201 Query 48 NEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 86 +| +||++||+||| + ||+# + |++|+ ||+| + |+ Sbjct 113 SEFERHAEGTYTSDITSYLE#GQAAKEFIAWLVNGRGRRD 151 |
| Agkistrodon piscivorus | Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNI 88 +||+ |||||||+| ||# |+|++||+| | + ++ Sbjct 82 RRHADGTFTSDYNKLLD#DIATQEFLKWLINQKVTQRDL 119 Query 49 EDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 86 | +||+ ||+||| | ||+# + |++|+ ||+| + |+ Sbjct 32 EYERHADGTYTSDISSYLE#GQAAKEFIAWLVNGRGRRD 69 |
| Capra hircus | Query 48 NEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNR 85 +| +||++|||||| | ||+# + |++|+ ||+ + | Sbjct 8 DEFERHAEGTFTSDVSSYLE#GQAAKEFIAWLVKGRGRR 45 |
| Oncorhynchus tshawytscha | Query 54 SQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 92 | |||++||||| +# | ||||||||||+||+ +||| Sbjct 2 SXGTFSNDYSKYQE#ERMAQDFVQWLMNSKRS-GAPSKRH 39 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNR 85 |||+ ||+||| | || # + |+||| || + + | Sbjct 37 KRHADGTYTSDVSTYLQ#DQAAKDFVSWLKSGRARR 71 |
| Monodelphis domestica | Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 97 +|+++||| |||| +|# |||| ||++ | +| + ||+ || Sbjct 51 QRYAEGTFISDYSITMD#KIMQQDFVNWLLSQKGKKN--SWRHNITER 95 |
| Xenopus laevis | Query 39 DPLSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 97 + + | +|+ | |||||||||||||||||#||||||||||||||||+ +++|+ ++|| Sbjct 39 EAVDDSEQLKEVKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRS-GELSRRNADYER 96 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 97 +||++|||||| ++ ||# + |++|+ ||+| ++ |++|+ |||| Sbjct 95 ERHAEGTFTSDVTQQLD#EKAAKEFIDWLINGGPSKEIISRRNAEFER 141 Query 50 DKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNI 88 |+||+ |+||+| +| ||# ||+|+ |++||+ ++ Sbjct 224 DRRHADGSFTNDINKVLD#IIAAQEFLDWVINTQETERDL 262 Query 52 RHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 86 ||++||||+| + ||+# + |++|| ||+ + || Sbjct 179 RHAEGTFTNDMTNYLE#EKAAKEFVGWLIKGRPKRN 213 Query 49 EDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDE 94 | +||++||+|+| ++||+# + |++|++||+ | + + || | Sbjct 138 EFERHAEGTYTNDVTEYLE#EKAAKEFIEWLIKGKPKKIRYS-RHAE 182 |
| Rattus norvegicus | Query 52 RHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNN 87 |+++||| |||| +|# | |||| ||+ | +|+ Sbjct 43 RYAEGTFISDYSIAMD#KIRQQDFVNWLLAQKGKKND 78 |
| Xenopus tropicalis | Query 39 DPLSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 97 + + | |+ | |||||||||||||||||#|||||||+||||||||+ +++|+ ++|| Sbjct 39 EAVDDSQQLKEVKRHSQGTFTSDYSKYLD#SRRAQDFIQWLMNTKRS-GGLSRRNADYER 96 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 97 +||++|||||| +++||# + |++|+ ||+| ++ |++|+ + || Sbjct 95 ERHAEGTFTSDVTQHLD#EKAAKEFIDWLINGGPSKEIISRRNADVER 141 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDE 94 +||++||+|+| ++||+# + |++|++||+| | + + || | Sbjct 140 ERHAEGTYTNDVTEYLE#EKAAKEFIEWLINGKPKKIRYS-RHAE 182 Query 52 RHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 86 ||++||||+| + ||+# + |++|| ||+ + || Sbjct 179 RHAEGTFTNDMTNYLE#EKAAKEFVGWLIKGRPKRN 213 Query 50 DKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTK 82 |+||+ |+||+| +| ||# ||+|+ |++||+ Sbjct 224 DRRHADGSFTNDINKVLD#IIAAQEFLDWVINTQ 256 |
| Canis familiaris | Query 52 RHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNN 87 |+++||| |||| +|# | |||| ||+ | +|+ Sbjct 43 RYAEGTFISDYSIAMD#KIRQQDFVNWLLAQKGKKND 78 |
| Danio rerio | Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDE 94 ||||+|||++||||||+#+|||||||||||| ||| ++ ||| | Sbjct 48 KRHSEGTFSNDYSKYLE#TRRAQDFVQWLMNAKRNGGSV-KRHAE 90 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWL 78 |||++||+||| | || # + || || || Sbjct 86 KRHAEGTYTSDVSSYLQ#DQAAQSFVAWL 113 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | Query 38 ADPLSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKR-------------- 83 |+|| | |+|| |||||||||||||||||#+||||||||||||||| Sbjct 38 AEPLDDSRQLNEVKRHSQGTFTSDYSKYLD#TRRAQDFVQWLMNTKRSGQQGVEEREKENL 97 Query 84 ----NRNNIAKRHDEFER 97 + | +|+ | |+|| Sbjct 98 LDQLSSNGLARHHAEYER 115 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNI 88 +||+ |||||||++ ||# |+|++||+| | + ++ Sbjct 162 RRHADGTFTSDYNQLLD#DIATQEFLKWLINQKVTQRDL 199 Query 49 EDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 86 | +||+ | +||| | ||+# + |++|+ ||+| + |+ Sbjct 112 EYERHADGRYTSDISSYLE#GQAAKEFIAWLVNGRGRRD 149 |
| Heloderma suspectum | Query 38 ADPLSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKR-------------- 83 |+|| | |+|| |||||||||||||||||#+||||||||||||||| Sbjct 38 AEPLDDSRQLNEVKRHSQGTFTSDYSKYLD#TRRAQDFVQWLMNTKRSGQQGVEEREKENL 97 Query 84 ----NRNNIAKRHDEFER 97 + | +|+ | |+|| Sbjct 98 LDQLSSNGLARHHAEYER 115 Query 49 EDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNR 85 | +||+ | +||| | ||+# + |++|+ ||+| + | Sbjct 112 EYERHADGRYTSDISSYLE#GQAAKEFIAWLVNGRGRR 148 |
| Hoplobatrachus rugulosus | Query 39 DPLSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 97 + | | | || |||||||||||||||||#|||||||||||||+||+ |+||+ +||| Sbjct 39 EALDDSDHHNEVKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNSKRS-GGISKRNVQFER 96 Query 50 DKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNT 81 |+||+ |+||||++| ||# + ||+|+ |++|| Sbjct 178 DRRHADGSFTSDFNKALD#IKAAQEFLDWIINT 209 Query 52 RHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 86 ||++|||||| + ||+# + |++|| ||+ + || Sbjct 134 RHAEGTFTSDMTSYLE#EKAAKEFVDWLIKGRPKRN 168 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDE 94 +||++||+|+| +++|+# + |++|+ ||+ | + ++ || | Sbjct 95 ERHAEGTYTNDVTQFLE#EKAAKEFIDWLIKGKPKKQRLS-RHAE 137 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | Query 53 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRN 84 |+ ||||+| + |||#++ |+||| || + ++ Sbjct 1 HADGTFTNDMTSYLD#AKAARDFVSWLARSDKS 32 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | Query 41 LSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 92 |++| + ||||+|||++||||||+#+|||||||||| |+| || + +|| Sbjct 40 LTEPIEPLNMKRHSEGTFSNDYSKYLE#TRRAQDFVQWLKNSK--RNGLFRRH 89 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWL 78 +||+ ||+||| | || # + |+||| || Sbjct 87 RRHADGTYTSDVSSYLQ#DQAAKDFVSWL 114 |
| Heloderma horridum | Query 39 DPLSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMN 80 | | ++ |||| |||||| || ++# + |++|| | Sbjct 34 DSASSESFASKIKRHSDGTFTSDLSKQME#EEAVRLFIEWLKN 75 |
| Bos taurus | Query 52 RHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNN 87 |+++||| |||| +|# | |||| ||+ | +++ Sbjct 81 RYAEGTFISDYSIAMD#KIRQQDFVNWLLAQKGKKSD 116 |
| Ictalurus punctatus | Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 92 +|||+|||++||||||+#+||||||||||||+||+ ++ |+|| Sbjct 49 RRHSEGTFSNDYSKYLE#TRRAQDFVQWLMNSKRS-DSPARRH 89 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 92 +|| |+|||| +| ||#| |++++||+||+ + + ||| Sbjct 134 RRHVDGSFTSDVNKVLD#SLAAKEYLQWVMNSPSSAS--GKRH 173 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWL 78 +||+ ||+||| | || # + |+||+ || Sbjct 87 RRHADGTYTSDVSSYLQ#DQAAKDFITWL 114 |
| Macaca mulatta | Query 52 RHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNN 87 |+++||| |||| +|# |||| ||+ | +|+ Sbjct 51 RYAEGTFISDYSIAMD#KIHQQDFVNWLLAQKGKKND 86 |
| Protopterus dolloi | Query 39 DPLSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 97 + + + + | |||||||| |||+| |+#++ | | || ||+||| ++|||+| || Sbjct 18 EAVDESREHTEAKRHSQGTFMSDYAKLLE#AKHALDLVQRLMSTKRT-GAVSKRHNEIER 75 Query 48 NEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 97 || +||++||+||| | ||+# + +|++||| + |+ +| +| Sbjct 71 NEIERHAEGTYTSDISSYLE#GQAVNEFIRWLMKGRGRRDFSETDIEEMDR 120 Query 42 SDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTK 82 |+ | |+||+ || ||| + |+#| ++|+ ||+| | Sbjct 111 SETDIEEMDRRHADGTVTSDINSVLE#SIATREFLNWLINAK 151 |
| Sebastes caurinus | Query 41 LSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 92 |++| ++ ||||+|||++||||||+#+|||||||||| |+||| ++ +|| Sbjct 40 LAEPIELPNMKRHSEGTFSNDYSKYLE#TRRAQDFVQWLKNSKRN-GSLFRRH 90 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNR 85 +||+ ||+||| | || # + |++|| || + | Sbjct 88 RRHADGTYTSDVSSYLQ#DQAAKEFVYWLKTGRGRR 122 |
| Tetraodon nigroviridis | Query 41 LSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 92 |++| ++ ||||+|||++||||||+#+|||||||||| |+||| ++ +|| Sbjct 777 LTEPSDLSNMKRHSEGTFSNDYSKYLE#TRRAQDFVQWLKNSKRN-GSLFRRH 827 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNR 85 +||+ ||+||| | || # + |++|| || + | Sbjct 825 RRHADGTYTSDVSAYLQ#DQAAKEFVSWLKTGRGRR 859 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDE 94 ||||+|||++||||||+#+|||||||+||||+| | + |||| | Sbjct 48 KRHSEGTFSNDYSKYLE#TRRAQDFVEWLMNSKSNGGS-AKRHAE 90 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWL 78 |||++||+||| | +| # + ||+|| || Sbjct 86 KRHAEGTYTSDISSFLR#DQAAQNFVAWL 113 |
| Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 92 || |+|||++ |||| +# | |+||+ ||||+||+ +||| Sbjct 50 KRQSEGTFSNYYSKYQE#ERMARDFLHWLMNSKRS-GAPSKRH 90 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNN 87 |||+ ||+||| | || # + |+||| || + | + Sbjct 88 KRHADGTYTSDVSTYLQ#DQAAKDFVSWLKSGPARRES 124 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHD 93 +|| |+|||| +| ||#| |++++ |+| +| + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLD#SLAAKEYLLWVMTSKTSGKSNKRQED 177 |
| Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | Query 39 DPL-SDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 92 ||| | ++ ||||+|||++||||| +# | ||||||||||+||+ +||| Sbjct 37 DPLLEDLMGVSNVKRHSEGTFSNDYSKYQE#ERMAQDFVQWLMNSKRS-GAPSKRH 90 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNN 87 |||+ ||+||| | || # + |+||| || + + | + Sbjct 88 KRHADGTYTSDVSTYLQ#DQAAKDFVSWLKSGRARRES 124 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHD 93 +|| |+|||| +| ||#| |++++ |+| +| + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLD#SLAAKEYLLWVMTSKTSGKSNKRQED 177 |
| Neoceratodus forsteri | Query 39 DPLSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 97 +|+ + | |||||||| |||+| |+#+| | |||| ||||||| ++||| | || Sbjct 10 EPVDASREHTEAKRHSQGTFMSDYAKLLE#ARHALDFVQRLMNTKRN-GGVSKRHSEIER 67 Query 48 NEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 86 +| +||++||+||| | ||+# + | +||+||+ + |+ Sbjct 63 SEIERHAEGTYTSDISSYLE#GQAANEFVRWLLKGRGRRD 101 Query 42 SDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTK 82 || | +||+ || |+| + |+#| ++|+ ||+|+| Sbjct 103 SDTDAEEMGRRHADGTITNDMNNVLE#SIATREFLNWLINSK 143 |
| Mus musculus | Query 52 RHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNN 87 |+++||| |||| +|# | |||| ||+ + +++ Sbjct 43 RYAEGTFISDYSIAMD#KIRQQDFVNWLLAQRGKKSD 78 |
| Bufo marinus | Query 50 DKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNT 81 |+||+ |+||||++| ||# + ||+|+ |++|| Sbjct 107 DRRHADGSFTSDFNKALD#IKAAQEFLDWIINT 138 Query 52 RHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 86 ||++|||||| + +|+# + |++|| ||+ + || Sbjct 62 RHAEGTFTSDMTSFLE#EKAAKEFVDWLIKGRPKRN 96 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDE 94 +||++||+|+| +++|+# + |++|+ ||+ + ++ || | Sbjct 23 ERHAEGTYTNDVTQFLE#EKAAKEFIDWLLKGIPKKQRLS-RHAE 65 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | Query 53 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTK 82 |+ |+|||| +| ||#+ |++|+ ||++|| Sbjct 1 HADGSFTSDINKVLD#TIAAKEFLNWLISTK 30 |
| Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | Query 52 RHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRN------RNNIAKRHDE 94 |||||+|||||||+||# ++|+||| ||+|||| |+ ||| + Sbjct 43 RHSQGSFTSDYSKHLD#VKQAKDFVTWLLNTKRRGVDAQAGANLEKRHSD 91 Query 48 NEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKR 83 | +|||| |+||+| + ||# |++|++|| | Sbjct 84 NLEKRHSDGSFTNDMNVMLD#RMSAKNFLEWLKQQGR 119 |
| synthetic construct | Query 38 ADPLSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 97 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 38 ADPLSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 97 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTK 82 +||+ |+|+ + + ||#+ |+||+ ||+ || Sbjct 144 RRHADGSFSDEMNTILD#NLAARDFINWLIQTK 175 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | Query 43 DPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 92 +| +++ ||||+|||++||||||+# |+||+||+|||| ||+ ||| Sbjct 43 EPRELSNMKRHSEGTFSNDYSKYLE#DRKAQEFVRWLMNNKRS-GVAEKRH 91 Query 50 DKRHSQGTFTSDYSKYLD#SRRAQDFVQWL 78 +|||+ |||||| | || # + +||| | Sbjct 88 EKRHADGTFTSDVSSYLK#DQAIKDFVDRL 116 |
| Phodopus sungorus | Query 56 GTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 86 |||||| | ||+# + |++|+ ||+ + |+ Sbjct 1 GTFTSDVSSYLE#GQAAKEFIAWLVKGRGRRD 31 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTK 82 +||+ |+|+ + + ||#| +||+ ||+ || Sbjct 44 RRHADGSFSDEMNTILD#SLATRDFINWLIQTK 75 |
| Sus scrofa | Query 39 DPLSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 97 ||| ||||| |||||||||||||||||||#|||||||||||||||||+|||||||||||| Sbjct 39 DPLDDPDQMTEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNKNNIAKRHDEFER 97 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTK 82 +||+ |+|+ + + ||#+ +||+ ||++|| Sbjct 144 RRHADGSFSDEMNTVLD#NLATRDFINWLLHTK 175 |
| Canis lupus familiaris | Query 39 DPLSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 97 +||+| |||||||||||||||||||||||#|||||||||||||||||+|||||||||||| Sbjct 39 EPLNDLDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNKNNIAKRHDEFER 97 Query 51 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTK 82 +||+ |+|+ + + ||#+ +||+ ||+ || Sbjct 144 RRHADGSFSDEMNTVLD#TLATRDFINWLLQTK 175 |
| Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | Query 53 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRN 84 |||||||+|||||||#+|||||||||||+|||+ Sbjct 1 HSQGTFTNDYSKYLD#TRRAQDFVQWLMSTKRS 32 Query 53 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNR 85 |+ ||+||| | || # + |+ || || + | Sbjct 45 HADGTYTSDVSSYLQ#DQAAKKFVTWLKQGQDRR 77 |
| Heloderma suspectum, venom, Peptide, 39 aa | Query 53 HSQGTFTSDYSKYLD#SRRAQDFVQWLMN 80 | +|||||| || ++# + |++|| | Sbjct 1 HGEGTFTSDLSKQME#EEAVRLFIEWLKN 28 |
| Hydrolagus colliei | Query 39 DPLSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNI--AKRH 92 + +|+| + + |||+ | |+||||||||#+|| +||||||++|||| | ||| Sbjct 18 ESVSNPSTVTDVKRHTDGIFSSDYSKYLD#NRRTKDFVQWLLSTKRNGANTDKTKRH 73 Query 48 NEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNN--IAKRHDEFER 97 ++ |||+ | +||| + |# +++ ||+ | | + +|+ ++||| | | Sbjct 68 DKTKRHADGIYTSDVASLTD#YLKSKRFVESLSNYNKRQNDRRMSKRHVEGAR 119 Query 49 EDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFE 96 | | ++ + +|+| ||+#++ |+||+ ||+ + | + |+ | | Sbjct 116 EGARRTEEDYPNDFSSYLE#AKAAKDFIDWLIK-GQGRRDFAEESREIE 162 |
| Squalus acanthias | Query 44 PDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFE 96 |++| |+||+ |||||+ + ||#+ |++|+ |++|+| | | | | Sbjct 118 PEEM--DRRHADGTFTSEINIVLD#TIAAKEFLNWILNSK----TIQSRDSEIE 164 Query 67 D#SRRAQDFVQWLMNTKRNRNNIAKRHDE 94 |#+|||+|||||||+|||| + ||| | Sbjct 1 D#NRRAKDFVQWLMSTKRNGDK-TKRHAE 27 Query 48 NEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWL--MNTKRNRNNIAKRHDEFER 97 ++ |||++||+||| |# +|+ || | | ++| +|+||| | | Sbjct 20 DKTKRHAEGTYTSDVDSLSD#YFKAKRFVDSLTSYNKRQNGRSISKRHVESTR 71 Query 49 EDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNR 85 | ||++|++ | | ||+#++ |+||+ ||+ + | Sbjct 68 ESTRHTEGSYR-DISSYLE#AKAAKDFINWLIKGRGRR 103 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | Query 53 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNR 85 |+ || ||| | +|+# + ++|+ ||++ + | Sbjct 1 HADGTLTSDISSFLE#KQATKEFIAWLVSGRGRR 33 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | Query 56 GTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 86 ||+||| | || # + |++|| || + |+ Sbjct 3 GTYTSDVSSYLQ#DQAAKEFVSWLKTGRGRRD 33 |
| Candida glabrata | Query 41 LSDPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAK 90 |+| | ||+ | | | | + +|#+ || |+ + | +| +| Sbjct 351 LADGDDDEEDEEDSSSTSESSYDEEID#NEEKQDIVEEEEDADENDDNFSK 400 |
| Ambloplites rupestris | Query 53 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 92 |||||||+||+ ||+# |+||||++|||| ||+ ||| Sbjct 1 HSQGTFTNDYTNYLE#DRQAQDFIRWLMNNKRS-GAAEKRH 39 Query 50 DKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMN--------TKRNRNNIAKRHDE 94 +|||+ |||| | | # + +||| | + | | | ++|| | Sbjct 36 EKRHADGTFTDDASSDFY#DQAIKDFVAKLKSGQDRREPETDRRREAFSRRHVE 88 |
[Site 2] SDYSKYLDSR69-RAQDFVQWLM
Arg69 Arg
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ser60 | Asp61 | Tyr62 | Ser63 | Lys64 | Tyr65 | Leu66 | Asp67 | Ser68 | Arg69 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Arg70 | Ala71 | Gln72 | Asp73 | Phe74 | Val75 | Gln76 | Trp77 | Leu78 | Met79 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| PLSDPDQMNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHA |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 130.00 | 10 | glucagon, isoform CRA_b |
| 2 | Pan troglodytes | 102.00 | 2 | PREDICTED: fibroblast activation protein, alpha su |
| 3 | N/A | 79.70 | 44 | 0 |
| 4 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | 64.70 | 1 | AAB31092.1 |
| 5 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | 61.60 | 1 | glucagon=proglucagon-derived 3.5 kda peptide |
| 6 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | 60.80 | 1 | glucagon II |
| 7 | Contains: Glucagon; Glucagon-like peptide | 60.10 | 4 | GLUC_AMICA Glucagon precursor |
| 8 | Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | 60.10 | 1 | glucagon |
| 9 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | 58.50 | 1 | glucagon G-29 |
| 10 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | 57.80 | 1 | GLUC1_ORENI Glucagon-1 (Glucagon I) gb |
| 11 | Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | 56.20 | 1 | GLUC_LAMFL Glucagon gb |
| 12 | deshis1, Desphe6, Glu9 | 53.50 | 1 | A Chain A, Nmr Solution Structure Of The Glucagon |
| 13 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | 53.50 | 1 | glucagon |
| 14 | Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | 47.00 | 1 | GLUC1_PETMA Glucagon-1 precursor |
| 15 | Agkistrodon piscivorus | 45.10 | 1 | proglucagon |
| 16 | Gallus gallus | 44.30 | 4 | glucagon isoform 1 |
| 17 | Meleagris gallopavo | 44.30 | 2 | preproglucagon B |
| 18 | Monodelphis domestica | 43.90 | 3 | PREDICTED: similar to Gastric inhibitory polypepti |
| 19 | Oncorhynchus tshawytscha | 43.50 | 1 | S78474_1 proglucagon |
| 20 | Rattus norvegicus | 42.70 | 5 | Glucose-dependent insulinotropic peptide |
| 21 | Canis familiaris | 42.70 | 2 | PREDICTED: similar to Gastric inhibitory polypepti |
| 22 | Xenopus laevis | 42.40 | 5 | proglucagon I |
| 23 | Xenopus tropicalis | 42.40 | 2 | glucagon |
| 24 | Danio rerio | 42.00 | 5 | hypothetical protein LOC494052 |
| 25 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | 42.00 | 1 | GLUC_HELSU Glucagon precursor |
| 26 | Heloderma suspectum | 41.60 | 2 | proglucagon |
| 27 | Hoplobatrachus rugulosus | 41.60 | 1 | AF324209_1 proglucagon |
| 28 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | 41.20 | 1 | GLUC2_LOPAM Glucagon-2 precursor (Glucagon II) |
| 29 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | 41.20 | 1 | glucagon-like peptide, GLP |
| 30 | Macaca mulatta | 40.80 | 3 | PREDICTED: gastric inhibitory polypeptide |
| 31 | Bos taurus | 40.40 | 5 | PREDICTED: similar to Gastric inhibitory polypepti |
| 32 | Ictalurus punctatus | 40.40 | 3 | proglucagon I |
| 33 | Protopterus dolloi | 40.40 | 1 | proglucagon |
| 34 | Sebastes caurinus | 40.00 | 4 | proglucagon II |
| 35 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | 40.00 | 2 | GLUC_CARAU Glucagon precursor |
| 36 | Tetraodon nigroviridis | 40.00 | 2 | unnamed protein product |
| 37 | Heloderma horridum | 40.00 | 1 | EXE3_HELHO Exendin-3 precursor emb |
| 38 | Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | 40.00 | 1 | GLUC1_ONCMY Glucagon-1 precursor (Glucagon I) |
| 39 | Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | 40.00 | 1 | GLUC2_ONCMY Glucagon-2 precursor (Glucagon II) |
| 40 | Mus musculus | 39.70 | 6 | gastric inhibitory polypeptide |
| 41 | Neoceratodus forsteri | 39.70 | 1 | proglucagon |
| 42 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | 38.90 | 1 | glucagon-like peptide-2, GLP-2=proglucagon-derived |
| 43 | Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | 38.10 | 1 | GLUC2_PETMA Glucagon-2 precursor |
| 44 | synthetic construct | 37.00 | 1 | Homo sapiens glucagon |
| 45 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | 36.60 | 1 | GLUC1_LOPAM Glucagon-1 precursor (Glucagon I) |
| 46 | Phodopus sungorus | 36.60 | 1 | glucagon precursor |
| 47 | Sus scrofa | 36.20 | 1 | glucagon |
| 48 | Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | 35.80 | 1 | GLUC_LEPSP Glucagon precursor |
| 49 | Canis lupus familiaris | 35.80 | 1 | glucagon |
| 50 | Squalus acanthias | 35.40 | 1 | proglucagon |
| 51 | Hydrolagus colliei | 35.40 | 1 | proglucagon |
| 52 | Heloderma suspectum, venom, Peptide, 39 aa | 35.40 | 1 | A Chain A, Solution Structure Of Exendin-4 In 30-V |
| 53 | Bufo marinus | 35.40 | 1 | proglucagon |
| 54 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | 34.70 | 1 | glucagon-like peptide-1, GLP-1=proglucagon-derived |
| 55 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | 34.70 | 1 | GLUC2_ORENI Glucagon-2 (Glucagon II) gb |
| 56 | Capra hircus | 34.30 | 1 | glucagon |
| 57 | Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | 33.50 | 1 | VIP_MOUSE VIP peptides precursor |
| 58 | Arvicanthis ansorgei | 32.70 | 1 | vasoactive intestinal polypeptide |
| 59 | Candida glabrata | 32.70 | 1 | unnamed protein product |
| 60 | Ambloplites rupestris | 32.30 | 1 | proglucagon |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 40 PLSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 40 PLSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 |
| Pan troglodytes | Query 40 PLSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDE 94 ||||||||||||||||||||||||||||||#||||||||||||||| +++| || | Sbjct 962 PLSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRN-SSVAYRHAE 1015 |
| N/A | Query 53 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIA 89 |||||||||||||||||#|||||||||||||||+|||| Sbjct 1 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNKNNIA 37 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | Query 53 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRN 84 ||+||||||||||+|+|#||+|||||||+|||| Sbjct 1 HSEGTFTSDYSKYMDNR#RAKDFVQWLMSTKRN 32 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNT 81 |||||||||||||||+|#|||||+||||+| Sbjct 1 HSQGTFTSDYSKYLDNR#RAQDFIQWLMST 29 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | Query 53 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRN 84 ||+|||++||||||++|#||||||||| |+||| Sbjct 1 HSEGTFSNDYSKYLETR#RAQDFVQWLKNSKRN 32 |
| Contains: Glucagon; Glucagon-like peptide | Query 53 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNT 81 |||||||+|||||+|+|#||||||||||+| Sbjct 1 HSQGTFTNDYSKYMDTR#RAQDFVQWLMST 29 |
| Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNT 81 |||||||+|||||+|+|#||||||||||+| Sbjct 1 HSQGTFTNDYSKYMDTR#RAQDFVQWLMST 29 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNT 81 ||+||||||||||+|+|#||+|||||||+| Sbjct 1 HSEGTFTSDYSKYMDNR#RAKDFVQWLMST 29 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | Query 53 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRN 84 ||+|||++||||||+ |#+|||||+|||| ||+ Sbjct 1 HSEGTFSNDYSKYLEDR#KAQDFVRWLMNNKRS 32 |
| Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNT 81 ||||+|||||||||||+#+|+||| ||||| Sbjct 1 HSQGSFTSDYSKYLDSK#QAKDFVIWLMNT 29 |
| deshis1, Desphe6, Glu9 | Query 54 SQGTFTSDYSKYLDSR#RAQDFVQWLMNT 81 |||| ||+||||||||#|||||||||||| Sbjct 1 SQGT-TSEYSKYLDSR#RAQDFVQWLMNT 27 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSR#RAQDFVQWLMN 80 ||+|||||||||||+++#+|+|||+|||| Sbjct 1 HSEGTFTSDYSKYLENK#QAKDFVRWLMN 28 |
| Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 92 ||||+|||||||||||+++#+|+|||+|||| || + + +|| Sbjct 41 KRHSEGTFTSDYSKYLENK#QAKDFVRWLMNAKRGGSELQRRH 82 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNR---------NNIAKRHDE 94 +||+ ||||+| + |||++# |+||| || + ++| |+ ||| | Sbjct 80 RRHADGTFTNDMTSYLDAK#AARDFVSWLARSDKSRRDGGDHLAENSEDKRHAE 132 |
| Agkistrodon piscivorus | Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNI 88 +||+ |||||||+| || # |+|++||+| | + ++ Sbjct 82 RRHADGTFTSDYNKLLDDI#ATQEFLKWLINQKVTQRDL 119 Query 49 EDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH---DEFERHA 99 | +||+ ||+||| | ||+ +# |++|+ ||+| + |+ | | ||| Sbjct 32 EYERHADGTYTSDISSYLEGQ#AAKEFIAWLVNGRGRRDFSEGAHTGEDLGRRHA 85 |
| Gallus gallus | Query 40 PLSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRN--------------- 84 || + |+|| |||||||||||||||||||#||||||||||+|||| Sbjct 42 PLDESRQLNEVKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMSTKRNGQQGQEDKENDKFPD 101 Query 85 ---RNNIAKRHDEFERHA 99 | |+||| |||||| Sbjct 102 QLSSNAISKRHSEFERHA 119 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNI 88 +||+ |||||| +| || # |++|++||+||| + ++ Sbjct 164 RRHADGTFTSDINKILDDM#AAKEFLKWLINTKVTQRDL 201 Query 48 NEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRN 86 +| +||++||+||| + ||+ +# |++|+ ||+| + |+ Sbjct 113 SEFERHAEGTYTSDITSYLEGQ#AAKEFIAWLVNGRGRRD 151 |
| Meleagris gallopavo | Query 40 PLSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRN--------------- 84 || + |+|| |||||||||||||||||||#||||||||||+|||| Sbjct 42 PLDESRQLNEVKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMSTKRNGQQGQEDKENDEFPD 101 Query 85 ---RNNIAKRHDEFERHA 99 | |+||| |||||| Sbjct 102 QLSSNAISKRHSEFERHA 119 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNI 88 +||+ |||||| +| || # |++|++||+||| + ++ Sbjct 164 RRHADGTFTSDINKILDDM#AAKEFLKWLINTKVTQRDL 201 Query 48 NEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRN 86 +| +||++||+||| + ||+ +# |++|+ ||+| + |+ Sbjct 113 SEFERHAEGTYTSDITSYLEGQ#AAKEFIAWLVNGRGRRD 151 |
| Monodelphis domestica | Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 +|+++||| |||| +| # |||| ||++ | +| + ||+ || | Sbjct 51 QRYAEGTFISDYSITMDKI#MQQDFVNWLLSQKGKKN--SWRHNITERKA 97 |
| Oncorhynchus tshawytscha | Query 54 SQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 92 | |||++||||| + |# ||||||||||+||+ +||| Sbjct 2 SXGTFSNDYSKYQEER#MAQDFVQWLMNSKRS-GAPSKRH 39 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNR 85 |||+ ||+||| | || +# |+||| || + + | Sbjct 37 KRHADGTYTSDVSTYLQDQ#AAKDFVSWLKSGRARR 71 |
| Rattus norvegicus | Query 52 RHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 |+++||| |||| +| #| |||| ||+ | +|+ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKI#RQQDFVNWLLAQKGKKND--WKHNLTQREA 88 |
| Canis familiaris | Query 52 RHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 |+++||| |||| +| #| |||| ||+ | +|+ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKI#RQQDFVNWLLAQKGKKND--WKHNITQREA 88 |
| Xenopus laevis | Query 41 LSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 + | +|+ | |||||||||||||||||||#||||||||||||||+ +++|+ ++|||| Sbjct 41 VDDSEQLKEVKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRS-GELSRRNADYERHA 98 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 +||++|||||| ++ || +# |++|+ ||+| ++ |++|+ |||||| Sbjct 95 ERHAEGTFTSDVTQQLDEK#AAKEFIDWLINGGPSKEIISRRNAEFERHA 143 Query 52 RHSQGTFTSDYSKYLDSR#RAQDFVQWLM--NTKRNRNNIAKRHDEFERHA 99 ||++||||+| + ||+ +# |++|| ||+ ||| + + + ||| Sbjct 179 RHAEGTFTNDMTNYLEEK#AAKEFVGWLIKGRPKRNFSEVHSVEEMDRRHA 228 Query 50 DKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNI 88 |+||+ |+||+| +| || # ||+|+ |++||+ ++ Sbjct 224 DRRHADGSFTNDINKVLDII#AAQEFLDWVINTQETERDL 262 Query 49 EDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDE 94 | +||++||+|+| ++||+ +# |++|++||+ | + + || | Sbjct 138 EFERHAEGTYTNDVTEYLEEK#AAKEFIEWLIKGKPKKIRYS-RHAE 182 |
| Xenopus tropicalis | Query 41 LSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 + | |+ | |||||||||||||||||||#|||||+||||||||+ +++|+ ++|||| Sbjct 41 VDDSQQLKEVKRHSQGTFTSDYSKYLDSR#RAQDFIQWLMNTKRS-GGLSRRNADYERHA 98 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 +||++|||||| +++|| +# |++|+ ||+| ++ |++|+ + |||| Sbjct 95 ERHAEGTFTSDVTQHLDEK#AAKEFIDWLINGGPSKEIISRRNADVERHA 143 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDE 94 +||++||+|+| ++||+ +# |++|++||+| | + + || | Sbjct 140 ERHAEGTYTNDVTEYLEEK#AAKEFIEWLINGKPKKIRYS-RHAE 182 Query 52 RHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRN 86 ||++||||+| + ||+ +# |++|| ||+ + || Sbjct 179 RHAEGTFTNDMTNYLEEK#AAKEFVGWLIKGRPKRN 213 Query 50 DKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTK 82 |+||+ |+||+| +| || # ||+|+ |++||+ Sbjct 224 DRRHADGSFTNDINKVLDII#AAQEFLDWVINTQ 256 |
| Danio rerio | Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDE 94 ||||+|||++||||||++|#||||||||||| ||| ++ ||| | Sbjct 48 KRHSEGTFSNDYSKYLETR#RAQDFVQWLMNAKRNGGSV-KRHAE 90 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWL 78 |||++||+||| | || +# || || || Sbjct 86 KRHAEGTYTSDVSSYLQDQ#AAQSFVAWL 113 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | Query 40 PLSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKR---------------- 83 || | |+|| |||||||||||||||||+|#|||||||||||||| Sbjct 40 PLDDSRQLNEVKRHSQGTFTSDYSKYLDTR#RAQDFVQWLMNTKRSGQQGVEEREKENLLD 99 Query 84 --NRNNIAKRHDEFERHA 99 + | +|+ | |+|||| Sbjct 100 QLSSNGLARHHAEYERHA 117 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNI 88 +||+ |||||||++ || # |+|++||+| | + ++ Sbjct 162 RRHADGTFTSDYNQLLDDI#ATQEFLKWLINQKVTQRDL 199 Query 49 EDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRN 86 | +||+ | +||| | ||+ +# |++|+ ||+| + |+ Sbjct 112 EYERHADGRYTSDISSYLEGQ#AAKEFIAWLVNGRGRRD 149 |
| Heloderma suspectum | Query 40 PLSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKR---------------- 83 || | |+|| |||||||||||||||||+|#|||||||||||||| Sbjct 40 PLDDSRQLNEVKRHSQGTFTSDYSKYLDTR#RAQDFVQWLMNTKRSGQQGVEEREKENLLD 99 Query 84 --NRNNIAKRHDEFERHA 99 + | +|+ | |+|||| Sbjct 100 QLSSNGLARHHAEYERHA 117 Query 49 EDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNR 85 | +||+ | +||| | ||+ +# |++|+ ||+| + | Sbjct 112 EYERHADGRYTSDISSYLEGQ#AAKEFIAWLVNGRGRR 148 |
| Hoplobatrachus rugulosus | Query 41 LSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 | | | || |||||||||||||||||||#|||||||||||+||+ |+||+ +||||| Sbjct 41 LDDSDHHNEVKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNSKRS-GGISKRNVQFERHA 98 Query 50 DKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNT 81 |+||+ |+||||++| || +# ||+|+ |++|| Sbjct 178 DRRHADGSFTSDFNKALDIK#AAQEFLDWIINT 209 Query 52 RHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRN 86 ||++|||||| + ||+ +# |++|| ||+ + || Sbjct 134 RHAEGTFTSDMTSYLEEK#AAKEFVDWLIKGRPKRN 168 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDE 94 +||++||+|+| +++|+ +# |++|+ ||+ | + ++ || | Sbjct 95 ERHAEGTYTNDVTQFLEEK#AAKEFIDWLIKGKPKKQRLS-RHAE 137 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | Query 41 LSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 92 |++| + ||||+|||++||||||++|#||||||||| |+| || + +|| Sbjct 40 LTEPIEPLNMKRHSEGTFSNDYSKYLETR#RAQDFVQWLKNSK--RNGLFRRH 89 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWL 78 +||+ ||+||| | || +# |+||| || Sbjct 87 RRHADGTYTSDVSSYLQDQ#AAKDFVSWL 114 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | Query 53 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRN 84 |+ ||||+| + |||++# |+||| || + ++ Sbjct 1 HADGTFTNDMTSYLDAK#AARDFVSWLARSDKS 32 |
| Macaca mulatta | Query 52 RHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 |+++||| |||| +| # |||| ||+ | +|+ +|+ +| | Sbjct 51 RYAEGTFISDYSIAMDKI#HQQDFVNWLLAQKGKKND--WKHNITQREA 96 |
| Bos taurus | Query 52 RHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNN 87 |+++||| |||| +| #| |||| ||+ | +++ Sbjct 81 RYAEGTFISDYSIAMDKI#RQQDFVNWLLAQKGKKSD 116 |
| Ictalurus punctatus | Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 92 +|||+|||++||||||++|#|||||||||||+||+ ++ |+|| Sbjct 49 RRHSEGTFSNDYSKYLETR#RAQDFVQWLMNSKRS-DSPARRH 89 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 92 +|| |+|||| +| ||| # |++++||+||+ + + ||| Sbjct 134 RRHVDGSFTSDVNKVLDSL#AAKEYLQWVMNSPSSAS--GKRH 173 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWL 78 +||+ ||+||| | || +# |+||+ || Sbjct 87 RRHADGTYTSDVSSYLQDQ#AAKDFITWL 114 |
| Protopterus dolloi | Query 49 EDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 | |||||||| |||+| |+++# | | || ||+||| ++|||+| |||| Sbjct 28 EAKRHSQGTFMSDYAKLLEAK#HALDLVQRLMSTKRT-GAVSKRHNEIERHA 77 Query 48 NEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFER 97 || +||++||+||| | ||+ +# +|++||| + |+ +| +| Sbjct 71 NEIERHAEGTYTSDISSYLEGQ#AVNEFIRWLMKGRGRRDFSETDIEEMDR 120 Query 42 SDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTK 82 |+ | |+||+ || ||| + |+| # ++|+ ||+| | Sbjct 111 SETDIEEMDRRHADGTVTSDINSVLESI#ATREFLNWLINAK 151 |
| Sebastes caurinus | Query 41 LSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 92 |++| ++ ||||+|||++||||||++|#||||||||| |+||| ++ +|| Sbjct 40 LAEPIELPNMKRHSEGTFSNDYSKYLETR#RAQDFVQWLKNSKRN-GSLFRRH 90 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNR 85 +||+ ||+||| | || +# |++|| || + | Sbjct 88 RRHADGTYTSDVSSYLQDQ#AAKEFVYWLKTGRGRR 122 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDE 94 ||||+|||++||||||++|#||||||+||||+| | + |||| | Sbjct 48 KRHSEGTFSNDYSKYLETR#RAQDFVEWLMNSKSNGGS-AKRHAE 90 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWL 78 |||++||+||| | +| +# ||+|| || Sbjct 86 KRHAEGTYTSDISSFLRDQ#AAQNFVAWL 113 |
| Tetraodon nigroviridis | Query 41 LSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 92 |++| ++ ||||+|||++||||||++|#||||||||| |+||| ++ +|| Sbjct 777 LTEPSDLSNMKRHSEGTFSNDYSKYLETR#RAQDFVQWLKNSKRN-GSLFRRH 827 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNR 85 +||+ ||+||| | || +# |++|| || + | Sbjct 825 RRHADGTYTSDVSAYLQDQ#AAKEFVSWLKTGRGRR 859 |
| Heloderma horridum | Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMN 80 |||| |||||| || ++ # + |++|| | Sbjct 46 KRHSDGTFTSDLSKQMEEE#AVRLFIEWLKN 75 |
| Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | Query 41 LSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 92 | | ++ ||||+|||++||||| + |# ||||||||||+||+ +||| Sbjct 40 LEDLMGVSNVKRHSEGTFSNDYSKYQEER#MAQDFVQWLMNSKRS-GAPSKRH 90 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNN 87 |||+ ||+||| | || +# |+||| || + + | + Sbjct 88 KRHADGTYTSDVSTYLQDQ#AAKDFVSWLKSGRARRES 124 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHD 93 +|| |+|||| +| ||| # |++++ |+| +| + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLDSL#AAKEYLLWVMTSKTSGKSNKRQED 177 |
| Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 92 || |+|||++ |||| + |# |+||+ ||||+||+ +||| Sbjct 50 KRQSEGTFSNYYSKYQEER#MARDFLHWLMNSKRS-GAPSKRH 90 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNN 87 |||+ ||+||| | || +# |+||| || + | + Sbjct 88 KRHADGTYTSDVSTYLQDQ#AAKDFVSWLKSGPARRES 124 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHD 93 +|| |+|||| +| ||| # |++++ |+| +| + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLDSL#AAKEYLLWVMTSKTSGKSNKRQED 177 |
| Mus musculus | Query 52 RHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 |+++||| |||| +| #| |||| ||+ + +++ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKI#RQQDFVNWLLAQRGKKSD--WKHNITQREA 88 |
| Neoceratodus forsteri | Query 40 PLSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 |+ + | |||||||| |||+| |++|# | |||| ||||||| ++||| | |||| Sbjct 11 PVDASREHTEAKRHSQGTFMSDYAKLLEAR#HALDFVQRLMNTKRN-GGVSKRHSEIERHA 69 Query 48 NEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRN 86 +| +||++||+||| | ||+ +# | +||+||+ + |+ Sbjct 63 SEIERHAEGTYTSDISSYLEGQ#AANEFVRWLLKGRGRRD 101 Query 42 SDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTK 82 || | +||+ || |+| + |+| # ++|+ ||+|+| Sbjct 103 SDTDAEEMGRRHADGTITNDMNNVLESI#ATREFLNWLINSK 143 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | Query 53 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTK 82 |+ |+|||| +| ||+ # |++|+ ||++|| Sbjct 1 HADGSFTSDINKVLDTI#AAKEFLNWLISTK 30 |
| Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | Query 52 RHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRN------RNNIAKRHDE 94 |||||+|||||||+|| +#+|+||| ||+|||| |+ ||| + Sbjct 43 RHSQGSFTSDYSKHLDVK#QAKDFVTWLLNTKRRGVDAQAGANLEKRHSD 91 Query 48 NEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKR 83 | +|||| |+||+| + || # |++|++|| | Sbjct 84 NLEKRHSDGSFTNDMNVMLDRM#SAKNFLEWLKQQGR 119 |
| synthetic construct | Query 40 PLSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 40 PLSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTK 82 +||+ |+|+ + + ||+ # |+||+ ||+ || Sbjct 144 RRHADGSFSDEMNTILDNL#AARDFINWLIQTK 175 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | Query 43 DPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 92 +| +++ ||||+|||++||||||+ |#+||+||+|||| ||+ ||| Sbjct 43 EPRELSNMKRHSEGTFSNDYSKYLEDR#KAQEFVRWLMNNKRS-GVAEKRH 91 Query 50 DKRHSQGTFTSDYSKYLDSR#RAQDFVQWL 78 +|||+ |||||| | || +# +||| | Sbjct 88 EKRHADGTFTSDVSSYLKDQ#AIKDFVDRL 116 |
| Phodopus sungorus | Query 56 GTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRN 86 |||||| | ||+ +# |++|+ ||+ + |+ Sbjct 1 GTFTSDVSSYLEGQ#AAKEFIAWLVKGRGRRD 31 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTK 82 +||+ |+|+ + + ||| # +||+ ||+ || Sbjct 44 RRHADGSFSDEMNTILDSL#ATRDFINWLIQTK 75 |
| Sus scrofa | Query 40 PLSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 || ||||| |||||||||||||||||||||#|||||||||||||||+|||||||||||||| Sbjct 40 PLDDPDQMTEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNKNNIAKRHDEFERHA 99 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTK 82 +||+ |+|+ + + ||+ # +||+ ||++|| Sbjct 144 RRHADGSFSDEMNTVLDNL#ATRDFINWLLHTK 175 |
| Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | Query 53 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRN 84 |||||||+|||||||+|#||||||||||+|||+ Sbjct 1 HSQGTFTNDYSKYLDTR#RAQDFVQWLMSTKRS 32 Query 53 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNR 85 |+ ||+||| | || +# |+ || || + | Sbjct 45 HADGTYTSDVSSYLQDQ#AAKKFVTWLKQGQDRR 77 |
| Canis lupus familiaris | Query 40 PLSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 ||+| |||||||||||||||||||||||||#|||||||||||||||+|||||||||||||| Sbjct 40 PLNDLDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNKNNIAKRHDEFERHA 99 Query 48 NEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRN 86 +| +||++|||||| | ||+ +# |++|+ ||+ + |+ Sbjct 93 DEFERHAEGTFTSDVSSYLEGQ#AAKEFIAWLVKGRGRRD 131 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTK 82 +||+ |+|+ + + ||+ # +||+ ||+ || Sbjct 144 RRHADGSFSDEMNTVLDTL#ATRDFINWLLQTK 175 |
| Squalus acanthias | Query 44 PDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFE 96 |++| |+||+ |||||+ + ||+ # |++|+ |++|+| | | | | Sbjct 118 PEEM--DRRHADGTFTSEINIVLDTI#AAKEFLNWILNSK----TIQSRDSEIE 164 Query 48 NEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWL--MNTKRNRNNIAKRHDEFERH 98 ++ |||++||+||| | #+|+ || | | ++| +|+||| | || Sbjct 20 DKTKRHAEGTYTSDVDSLSDYF#KAKRFVDSLTSYNKRQNGRSISKRHVESTRH 72 Query 67 DSR#RAQDFVQWLMNTKRNRNNIAKRHDE 94 |+|#||+|||||||+|||| + ||| | Sbjct 1 DNR#RAKDFVQWLMSTKRNGDK-TKRHAE 27 Query 49 EDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNR 85 | ||++|++ | | ||+++# |+||+ ||+ + | Sbjct 68 ESTRHTEGSYR-DISSYLEAK#AAKDFINWLIKGRGRR 103 |
| Hydrolagus colliei | Query 41 LSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 +|+| + + |||+ | |+||||||||+|#| +||||||++|||| | |+ +||| Sbjct 20 VSNPSTVTDVKRHTDGIFSSDYSKYLDNR#RTKDFVQWLLSTKRNGANT----DKTKRHA 74 Query 48 NEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNN--IAKRHDEFER 97 ++ |||+ | +||| + | #+++ ||+ | | + +|+ ++||| | | Sbjct 68 DKTKRHADGIYTSDVASLTDYL#KSKRFVESLSNYNKRQNDRRMSKRHVEGAR 119 Query 49 EDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFE 96 | | ++ + +|+| ||+++# |+||+ ||+ + | + |+ | | Sbjct 116 EGARRTEEDYPNDFSSYLEAK#AAKDFIDWLIK-GQGRRDFAEESREIE 162 |
| Heloderma suspectum, venom, Peptide, 39 aa | Query 53 HSQGTFTSDYSKYLDSR#RAQDFVQWLMN 80 | +|||||| || ++ # + |++|| | Sbjct 1 HGEGTFTSDLSKQMEEE#AVRLFIEWLKN 28 |
| Bufo marinus | Query 52 RHSQGTFTSDYSKYLDSR#RAQDFVQWLM--NTKRNRNNIAKRHDEFERHA 99 ||++|||||| + +|+ +# |++|| ||+ ||| ++++ | ||| Sbjct 62 RHAEGTFTSDMTSFLEEK#AAKEFVDWLIKGRPKRNFSDVSAADDMDRRHA 111 Query 50 DKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNT 81 |+||+ |+||||++| || +# ||+|+ |++|| Sbjct 107 DRRHADGSFTSDFNKALDIK#AAQEFLDWIINT 138 Query 51 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDE 94 +||++||+|+| +++|+ +# |++|+ ||+ + ++ || | Sbjct 23 ERHAEGTYTNDVTQFLEEK#AAKEFIDWLLKGIPKKQRLS-RHAE 65 Query 73 DFVQWLMNTKRNRNNIAKRHDEFERHA 99 || |||||+||+ +++|+ +||||| Sbjct 1 DFAQWLMNSKRS-GGMSRRNVQFERHA 26 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | Query 53 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNR 85 |+ || ||| | +|+ +# ++|+ ||++ + | Sbjct 1 HADGTLTSDISSFLEKQ#ATKEFIAWLVSGRGRR 33 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | Query 56 GTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRN 86 ||+||| | || +# |++|| || + |+ Sbjct 3 GTYTSDVSSYLQDQ#AAKEFVSWLKTGRGRRD 33 |
| Capra hircus | Query 48 NEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNR 85 +| +||++|||||| | ||+ +# |++|+ ||+ + | Sbjct 8 DEFERHAEGTFTSDVSSYLEGQ#AAKEFIAWLVKGRGRR 45 Query 86 NNIAKRHDEFERHA 99 |||||||||||||| Query 86 NNIAKRHDEFERHA 99 |
| Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | Query 47 MNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 ++ + ||+ | ||||||+ | # |+ +++ |+ || ++|++ +||+ Sbjct 75 VSRNARHADGVFTSDYSRLLGQI#SAKKYLESLIG-KRISSSISEDPVPIKRHS 126 |
| Arvicanthis ansorgei | Query 47 MNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 ++ + ||+ | ||||||+ | # |+ +++ |+ || ++| + +||+ Sbjct 58 VSRNARHADGVFTSDYSRLLGQI#SAKKYLESLIG-KRISSSILEDPVPIKRHS 109 |
| Candida glabrata | Query 41 LSDPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAK 90 |+| | ||+ | | | | + +|+ # || |+ + | +| +| Sbjct 351 LADGDDDEEDEEDSSSTSESSYDEEIDNE#EKQDIVEEEEDADENDDNFSK 400 |
| Ambloplites rupestris | Query 53 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 92 |||||||+||+ ||+ |#+||||++|||| ||+ ||| Sbjct 1 HSQGTFTNDYTNYLEDR#QAQDFIRWLMNNKRS-GAAEKRH 39 Query 50 DKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMN--------TKRNRNNIAKRHDE 94 +|||+ |||| | | +# +||| | + | | | ++|| | Sbjct 36 EKRHADGTFTDDASSDFYDQ#AIKDFVAKLKSGQDRREPETDRRREAFSRRHVE 88 |
[Site 3] SRRAQDFVQW77-LMNTKRNRNN
Trp77 Leu
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ser68 | Arg69 | Arg70 | Ala71 | Gln72 | Asp73 | Phe74 | Val75 | Gln76 | Trp77 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Leu78 | Met79 | Asn80 | Thr81 | Lys82 | Arg83 | Asn84 | Arg85 | Asn86 | Asn87 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| NEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDV |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 127.00 | 10 | glucagon, isoform CRA_b |
| 2 | N/A | 79.70 | 45 | 0 |
| 3 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | 64.70 | 1 | AAB31092.1 |
| 4 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | 61.60 | 1 | glucagon=proglucagon-derived 3.5 kda peptide |
| 5 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | 60.80 | 1 | glucagon II |
| 6 | Contains: Glucagon; Glucagon-like peptide | 60.10 | 4 | GLUC_AMICA Glucagon precursor |
| 7 | Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | 60.10 | 1 | glucagon |
| 8 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | 58.50 | 1 | glucagon G-29 |
| 9 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | 57.80 | 1 | GLUC1_ORENI Glucagon-1 (Glucagon I) gb |
| 10 | Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | 56.20 | 1 | GLUC_LAMFL Glucagon gb |
| 11 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | 53.50 | 1 | glucagon |
| 12 | deshis1, Desphe6, Glu9 | 53.50 | 1 | A Chain A, Nmr Solution Structure Of The Glucagon |
| 13 | Monodelphis domestica | 48.90 | 3 | PREDICTED: similar to Gastric inhibitory polypepti |
| 14 | Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | 48.90 | 1 | GLUC1_PETMA Glucagon-1 precursor |
| 15 | Xenopus laevis | 47.00 | 5 | proglucagon II |
| 16 | Hoplobatrachus rugulosus | 46.60 | 1 | AF324209_1 proglucagon |
| 17 | Bufo marinus | 46.60 | 1 | proglucagon |
| 18 | Gallus gallus | 46.20 | 4 | glucagon isoform 1 |
| 19 | Meleagris gallopavo | 46.20 | 2 | preproglucagon B |
| 20 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | 44.70 | 1 | GLUC_HELSU Glucagon precursor |
| 21 | Capra hircus | 43.90 | 1 | glucagon |
| 22 | Oncorhynchus tshawytscha | 43.50 | 1 | S78474_1 proglucagon |
| 23 | Ictalurus punctatus | 43.10 | 3 | proglucagon I |
| 24 | Rattus norvegicus | 42.70 | 6 | Glucose-dependent insulinotropic peptide |
| 25 | Canis familiaris | 42.70 | 2 | PREDICTED: similar to Gastric inhibitory polypepti |
| 26 | Ambloplites rupestris | 42.70 | 1 | proglucagon |
| 27 | Pan troglodytes | 42.40 | 2 | PREDICTED: fibroblast activation protein, alpha su |
| 28 | Xenopus tropicalis | 42.40 | 2 | glucagon |
| 29 | Danio rerio | 42.00 | 6 | hypothetical protein LOC494052 |
| 30 | Bos taurus | 42.00 | 5 | vasoactive intestinal peptide |
| 31 | Macaca mulatta | 41.60 | 3 | PREDICTED: vasoactive intestinal peptide |
| 32 | Heloderma suspectum | 41.60 | 2 | proglucagon |
| 33 | Squalus acanthias | 41.60 | 1 | proglucagon |
| 34 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | 41.20 | 1 | glucagon-like peptide, GLP |
| 35 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | 41.20 | 1 | GLUC2_LOPAM Glucagon-2 precursor (Glucagon II) |
| 36 | Sebastes caurinus | 40.80 | 4 | proglucagon I |
| 37 | Tetraodon nigroviridis | 40.00 | 3 | unnamed protein product |
| 38 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | 40.00 | 2 | GLUC_CARAU Glucagon precursor |
| 39 | Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | 40.00 | 1 | GLUC2_ONCMY Glucagon-2 precursor (Glucagon II) |
| 40 | Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | 40.00 | 1 | GLUC1_ONCMY Glucagon-1 precursor (Glucagon I) |
| 41 | Heloderma horridum | 40.00 | 1 | EXE3_HELHO Exendin-3 precursor emb |
| 42 | Mus musculus | 39.70 | 6 | Gastric inhibitory polypeptide |
| 43 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | 38.90 | 1 | glucagon-like peptide-2, GLP-2=proglucagon-derived |
| 44 | Protopterus dolloi | 38.90 | 1 | proglucagon |
| 45 | Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | 38.50 | 1 | VIP_MOUSE VIP peptides precursor |
| 46 | Agkistrodon piscivorus | 38.50 | 1 | proglucagon |
| 47 | Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | 38.10 | 1 | GLUC2_PETMA Glucagon-2 precursor |
| 48 | Arvicanthis ansorgei | 37.70 | 1 | vasoactive intestinal polypeptide |
| 49 | synthetic construct | 37.00 | 1 | Homo sapiens glucagon |
| 50 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | 36.60 | 1 | GLUC1_LOPAM Glucagon-1 precursor (Glucagon I) |
| 51 | Phodopus sungorus | 36.60 | 1 | glucagon precursor |
| 52 | Neoceratodus forsteri | 36.20 | 1 | proglucagon |
| 53 | Sus scrofa | 36.20 | 1 | glucagon |
| 54 | Canis lupus familiaris | 35.80 | 1 | glucagon |
| 55 | Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | 35.80 | 1 | GLUC_LEPSP Glucagon precursor |
| 56 | Hydrolagus colliei | 35.40 | 1 | proglucagon |
| 57 | Heloderma suspectum, venom, Peptide, 39 aa | 35.40 | 1 | A Chain A, Solution Structure Of Exendin-4 In 30-V |
| 58 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | 34.70 | 1 | GLUC2_ORENI Glucagon-2 (Glucagon II) gb |
| 59 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | 34.70 | 1 | glucagon-like peptide-1, GLP-1=proglucagon-derived |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSD 106 ||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||| Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSD 106 |
| N/A | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIA 89 |||||||||||||||||||||||||#|||||||+|||| Sbjct 1 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNKNNIA 37 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRN 84 ||+||||||||||+|+|||+|||||#||+|||| Sbjct 1 HSEGTFTSDYSKYMDNRRAKDFVQW#LMSTKRN 32 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNT 81 |||||||||||||||+||||||+||#||+| Sbjct 1 HSQGTFTSDYSKYLDNRRAQDFIQW#LMST 29 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRN 84 ||+|||++||||||++|||||||||#| |+||| Sbjct 1 HSEGTFSNDYSKYLETRRAQDFVQW#LKNSKRN 32 |
| Contains: Glucagon; Glucagon-like peptide | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNT 81 |||||||+|||||+|+|||||||||#||+| Sbjct 1 HSQGTFTNDYSKYMDTRRAQDFVQW#LMST 29 |
| Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNT 81 |||||||+|||||+|+|||||||||#||+| Sbjct 1 HSQGTFTNDYSKYMDTRRAQDFVQW#LMST 29 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNT 81 ||+||||||||||+|+|||+|||||#||+| Sbjct 1 HSEGTFTSDYSKYMDNRRAKDFVQW#LMST 29 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRN 84 ||+|||++||||||+ |+|||||+|#||| ||+ Sbjct 1 HSEGTFSNDYSKYLEDRKAQDFVRW#LMNNKRS 32 |
| Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNT 81 ||||+|||||||||||++|+||| |#|||| Sbjct 1 HSQGSFTSDYSKYLDSKQAKDFVIW#LMNT 29 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQW#LMN 80 ||+|||||||||||++++|+|||+|#||| Sbjct 1 HSEGTFTSDYSKYLENKQAKDFVRW#LMN 28 |
| deshis1, Desphe6, Glu9 | Query 54 SQGTFTSDYSKYLDSRRAQDFVQW#LMNT 81 |||| ||+||||||||||||||||#|||| Sbjct 1 SQGT-TSEYSKYLDSRRAQDFVQW#LMNT 27 |
| Monodelphis domestica | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGT 102 +|+++||| |||| +| |||| |#|++ | +| + ||+ || |+|| Sbjct 51 QRYAEGTFISDYSITMDKIMQQDFVNW#LLSQKGKKN--SWRHNITERKADGT 100 |
| Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||+|||||||||||++++|+|||+|#||| || + + + |||+||||+|+ Sbjct 41 KRHSEGTFTSDYSKYLENKQAKDFVRW#LMNAKRGGSELQR------RHADGTFTNDM 91 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNR---NNIAKRHDEFERHAE 100 +||+ ||||+| + |||++ |+||| |#| + ++| + + | +|||| Sbjct 80 RRHADGTFTNDMTSYLDAKAARDFVSW#LARSDKSRRDGGDHLAENSEDKRHAE 132 |
| Xenopus laevis | Query 49 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 | |||||||||||||||||||||||||||#||||||+ +++|+ ++|||||||||||| Sbjct 49 EVKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRS-GGLSRRNADYERHAEGTFTSDV 106 Query 49 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 | +||++||+|+| ++||+ + + |++|#|+ | + + ||||||||+|+ Sbjct 138 EIERHAEGTYTNDVTEYLEEKATKAFIEW#LIKGK-------PKKIRYSRHAEGTFTNDM 189 Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRH 92 ||++||||+| + ||+ + |++|| |#|+| + | ++ + | Sbjct 179 RHAEGTFTNDMTNYLEEKAAKEFVGW#LINGRPKRKDLLEEH 219 |
| Hoplobatrachus rugulosus | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 || |||||||||||||||||||||||||||#|||+||+ |+||+ +||||||||+|+|| Sbjct 48 NEVKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNSKRS-GGISKRNVQFERHAEGTYTNDV 106 Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFE-RHAEGTFTSD 106 ||++|||||| + ||+ + |++|| |#|+ + || +| + |||+|+|||| Sbjct 134 RHAEGTFTSDMTSYLEEKAAKEFVDW#LIKGRPKRNFPDISAEEMDRRHADGSFTSD 189 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 +||++||+|+| +++|+ + |++|+ |#|+ | + ++ ||||||||||+ Sbjct 95 ERHAEGTYTNDVTQFLEEKAAKEFIDW#LIKGKPKKQRLS-------RHAEGTFTSDM 144 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNT 81 |+||+ |+||||++| || + ||+|+ |#++|| Sbjct 178 DRRHADGSFTSDFNKALDIKAAQEFLDW#IINT 209 |
| Bufo marinus | Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQW#LM--NTKRNRNNIAKRHDEFERHAEGTFTSD 106 ||++|||||| + +|+ + |++|| |#|+ ||| ++++ | |||+|+|||| Sbjct 62 RHAEGTFTSDMTSFLEEKAAKEFVDW#LIKGRPKRNFSDVSAADDMDRRHADGSFTSD 118 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 +||++||+|+| +++|+ + |++|+ |#|+ | |+ ||||||||||+ Sbjct 23 ERHAEGTYTNDVTQFLEEKAAKEFIDW#LL------KGIPKK-QRLSRHAEGTFTSDM 72 Query 73 DFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 || ||#|||+||+ +++|+ +||||||||+|+|| Sbjct 1 DFAQW#LMNSKRS-GGMSRRNVQFERHAEGTYTNDV 34 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNT 81 |+||+ |+||||++| || + ||+|+ |#++|| Sbjct 107 DRRHADGSFTSDFNKALDIKAAQEFLDW#IINT 138 |
| Gallus gallus | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRN------------------RNNIA 89 || |||||||||||||||||||||||||||#||+|||| | |+ Sbjct 50 NEVKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMSTKRNGQQGQEDKENDKFPDQLSSNAIS 109 Query 90 KRHDEFERHAEGTFTSDV 107 ||| |||||||||+|||+ Sbjct 110 KRHSEFERHAEGTYTSDI 127 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAK---RHDEFERHAEGTFT 104 +| +||++||+||| + ||+ + |++|+ |#|+| + |+ | + |||+|||| Sbjct 113 SEFERHAEGTYTSDITSYLEGQAAKEFIAW#LVNGRGRRDFPEKALMAEEMGRRHADGTFT 172 Query 105 SDV 107 ||+ Sbjct 173 SDI 175 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNI 88 +||+ |||||| +| || |++|++|#|+||| + ++ Sbjct 164 RRHADGTFTSDINKILDDMAAKEFLKW#LINTKVTQRDL 201 |
| Meleagris gallopavo | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRN------------------RNNIA 89 || |||||||||||||||||||||||||||#||+|||| | |+ Sbjct 50 NEVKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMSTKRNGQQGQEDKENDEFPDQLSSNAIS 109 Query 90 KRHDEFERHAEGTFTSDV 107 ||| |||||||||+|||+ Sbjct 110 KRHSEFERHAEGTYTSDI 127 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAK---RHDEFERHAEGTFT 104 +| +||++||+||| + ||+ + |++|+ |#|+| + |+ | + |||+|||| Sbjct 113 SEFERHAEGTYTSDITSYLEGQAAKEFIAW#LVNGRGRRDFPEKALMAEEMGRRHADGTFT 172 Query 105 SDV 107 ||+ Sbjct 173 SDI 175 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNI 88 +||+ |||||| +| || |++|++|#|+||| + ++ Sbjct 164 RRHADGTFTSDINKILDDMAAKEFLKW#LINTKVTQRDL 201 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKR------------------NRNNIA 89 || |||||||||||||||||+|||||||||#|||||| + | +| Sbjct 48 NEVKRHSQGTFTSDYSKYLDTRRAQDFVQW#LMNTKRSGQQGVEEREKENLLDQLSSNGLA 107 Query 90 KRHDEFERHAEGTFTSDV 107 + | |+||||+| +|||+ Sbjct 108 RHHAEYERHADGRYTSDI 125 Query 49 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAK---RHDEFERHAEGTFTS 105 | +||+ | +||| | ||+ + |++|+ |#|+| + |+ + + | |||+||||| Sbjct 112 EYERHADGRYTSDISSYLEGQAAKEFIAW#LVNGRGRRDFLEEAGTADDIGRRHADGTFTS 171 Query 106 D 106 | Query 106 D 106 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNI 88 +||+ |||||||++ || |+|++|#|+| | + ++ Sbjct 162 RRHADGTFTSDYNQLLDDIATQEFLKW#LINQKVTQRDL 199 |
| Capra hircus | Query 86 NNIAKRHDEFERHAEGTFTSDV 107 |||||||||||||||||||||| Query 86 NNIAKRHDEFERHAEGTFTSDV 107 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNR 85 +| +||++|||||| | ||+ + |++|+ |#|+ + | Sbjct 8 DEFERHAEGTFTSDVSSYLEGQAAKEFIAW#LVKGRGRR 45 |
| Oncorhynchus tshawytscha | Query 54 SQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 | |||++||||| + | |||||||#|||+||+ +|||+||+|||| Sbjct 2 SXGTFSNDYSKYQEERMAQDFVQW#LMNSKRS-------GAPSKRHADGTYTSDV 48 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNR 85 |||+ ||+||| | || + |+||| |#| + + | Sbjct 37 KRHADGTYTSDVSTYLQDQAAKDFVSW#LKSGRARR 71 |
| Ictalurus punctatus | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 +|||+|||++||||||++|||||||||#|||+||+ |||+||+|||| Sbjct 49 RRHSEGTFSNDYSKYLETRRAQDFVQW#LMNSKRS-------DSPARRHADGTYTSDV 98 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEF--ERHAEGTFTSDV 107 +||+ ||+||| | || + |+||+ |#| + + + + | + || +|+||||| Sbjct 87 RRHADGTYTSDVSSYLQDQAAKDFITW#LKSGQPKPDAVETRSVDTLRRRHVDGSFTSDV 145 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRH 92 +|| |+|||| +| ||| |++++||#+||+ + + ||| Sbjct 134 RRHVDGSFTSDVNKVLDSLAAKEYLQW#VMNSPSSAS--GKRH 173 |
| Rattus norvegicus | Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHA 99 |+++||| |||| +| | |||| |#|+ | +|+ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKIRQQDFVNW#LLAQKGKKND--WKHNLTQREA 88 |
| Canis familiaris | Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHA 99 |+++||| |||| +| | |||| |#|+ | +|+ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKIRQQDFVNW#LLAQKGKKND--WKHNITQREA 88 |
| Ambloplites rupestris | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSD 106 |||||||+||+ ||+ |+||||++|#||| | |+ |++ |||+|||| | Sbjct 1 HSQGTFTNDYTNYLEDRQAQDFIRW#LMNNK--RSGAAEK-----RHADGTFTDD 47 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDE--FERHAEGTFTSDV 107 +|||+ |||| | | + +||| #| + + | | | || ||+||||+ Sbjct 36 EKRHADGTFTDDASSDFYDQAIKDFVAK#LKSGQDRREPETDRRREAFSRRHVEGSFTSDI 95 |
| Pan troglodytes | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||||||||||||||||||||||||||||#||||||| +++| ||||||||||| Sbjct 970 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRN-SSVA------YRHAEGTFTSDV 1022 Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNR 85 ||++|||||| | ||+ + |++|+ |#|+ + | Sbjct 1012 RHAEGTFTSDVSSYLEGQAAKEFIAW#LVKGRGRR 1045 |
| Xenopus tropicalis | Query 49 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 | ||||||||||||||||||||||||+||#||||||+ +++|+ ++|||||||||||| Sbjct 49 EVKRHSQGTFTSDYSKYLDSRRAQDFIQW#LMNTKRS-GGLSRRNADYERHAEGTFTSDV 106 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 +||++||+|+| ++||+ + |++|++|#|+| | + + ||||||||+|+ Sbjct 140 ERHAEGTYTNDVTEYLEEKAAKEFIEW#LINGK-------PKKIRYSRHAEGTFTNDM 189 Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFE---RHAEGTFTSDV 107 ||++||||+| + ||+ + |++|| |#|+ | + | ++ | | |||+|+||+|+ Sbjct 179 RHAEGTFTNDMTNYLEEKAAKEFVGW#LIK-GRPKRNFSEAHSVEEMDRRHADGSFTNDI 236 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTK 82 |+||+ |+||+| +| || ||+|+ |#++||+ Sbjct 224 DRRHADGSFTNDINKVLDIIAAQEFLDW#VINTQ 256 |
| Danio rerio | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||+|||++||||||++|||||||||#||| ||| ++ +||||||+|||| Sbjct 48 KRHSEGTFSNDYSKYLETRRAQDFVQW#LMNAKRNGGSV-------KRHAEGTYTSDV 97 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#L 78 |||++||+||| | || + || || |#| Sbjct 86 KRHAEGTYTSDVSSYLQDQAAQSFVAW#L 113 |
| Bos taurus | Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSD 106 ||+ | ||||||+ | |+ +++ #|+ || |+|++ +||++ || + Sbjct 80 RHADGVFTSDYSRLLGQLSAKKYLES#LIG-KRVSNSISEDQGPIKRHSDAVFTDN 133 |
| Macaca mulatta | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSD 106 + + ||+ | ||||+|| | |+ +++ #|| || +||++ +||++ || + Sbjct 76 SRNARHADGVFTSDFSKLLGQLSAKKYLES#LMG-KRVSSNISEDPVPVKRHSDAVFTDN 133 |
| Heloderma suspectum | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKR------------------NRNNIA 89 || |||||||||||||||||+|||||||||#|||||| + | +| Sbjct 48 NEVKRHSQGTFTSDYSKYLDTRRAQDFVQW#LMNTKRSGQQGVEEREKENLLDQLSSNGLA 107 Query 90 KRHDEFERHAEGTFTSDV 107 + | |+||||+| +|||+ Sbjct 108 RHHAEYERHADGRYTSDI 125 Query 49 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNR 85 | +||+ | +||| | ||+ + |++|+ |#|+| + | Sbjct 112 EYERHADGRYTSDISSYLEGQAAKEFIAW#LVNGRGRR 148 |
| Squalus acanthias | Query 67 DSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 |+|||+|||||#||+|||| |+ +||||||+|||| Sbjct 1 DNRRAKDFVQW#LMSTKRN-------GDKTKRHAEGTYTSDV 34 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#L--MNTKRNRNNIAKRHDEFERHAEGTF 103 ++ |||++||+||| | +|+ || #| | ++| +|+||| | || ||++ Sbjct 20 DKTKRHAEGTYTSDVDSLSDYFKAKRFVDS#LTSYNKRQNGRSISKRHVESTRHTEGSY 77 Query 49 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRN---------NIAKRHDEFERHA 99 | ||++|++ | | ||+++ |+||+ |#|+ + | | + ||| Sbjct 68 ESTRHTEGSYR-DISSYLEAKAAKDFINW#LIKGRGRREFPEESKEIVNEVIPEEMDRRHA 126 Query 100 EGTFTSDV 107 +|||||++ Sbjct 127 DGTFTSEI 134 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFE 96 |+||+ |||||+ + ||+ |++|+ |#++|+| | | | | Sbjct 122 DRRHADGTFTSEINIVLDTIAAKEFLNW#ILNSK----TIQSRDSEIE 164 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRN 84 |+ ||||+| + |||++ |+||| |#| + ++ Sbjct 1 HADGTFTNDMTSYLDAKAARDFVSW#LARSDKS 32 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||+|||++||||||++|||||||||#| |+||| | |||+||+|||| Sbjct 50 KRHSEGTFSNDYSKYLETRRAQDFVQW#LKNSKRN--------GLFRRHADGTYTSDV 98 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#L 78 +||+ ||+||| | || + |+||| |#| Sbjct 87 RRHADGTYTSDVSSYLQDQAAKDFVSW#L 114 |
| Sebastes caurinus | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||+|||++|||+||+ |+|||||+|#||| ||+ || +|||+||||||| Sbjct 48 KRHSEGTFSNDYSRYLEERKAQDFVRW#LMNNKRS------GADE-KRHADGTFTSDV 97 Query 49 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDE--FERHAEGTFTSD 106 ++|||+ |||||| | || + +||| #| + + | + + | || +|+|||| Sbjct 84 DEKRHADGTFTSDVSSYLKDQAIKDFVNR#LKSGQVRRESETEWRGEAFSRRHVDGSFTSD 143 Query 107 V 107 | Query 107 V 107 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDE 94 +|| |+|||| +| ||| |++++ |#+| +| + + ++ |+ Sbjct 133 RRHVDGSFTSDVNKVLDSMAAKEYLLW#VMTSKPSGESKKRQEDQ 176 |
| Tetraodon nigroviridis | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||+|||++||||||++|||||||||#| |+||| + | |||+||+|||| Sbjct 787 KRHSEGTFSNDYSKYLETRRAQDFVQW#LKNSKRNGS-------LFRRHADGTYTSDV 836 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNR 85 +||+ ||+||| | || + |++|| |#| + | Sbjct 825 RRHADGTYTSDVSAYLQDQAAKEFVSW#LKTGRGRR 859 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||+|||++||||||++|||||||+|#|||+| | + +||||||+|||+ Sbjct 48 KRHSEGTFSNDYSKYLETRRAQDFVEW#LMNSKSNGGSA-------KRHAEGTYTSDI 97 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#L 78 |||++||+||| | +| + ||+|| |#| Sbjct 86 KRHAEGTYTSDISSFLRDQAAQNFVAW#L 113 |
| Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 || |+|||++ |||| + | |+||+ |#|||+||+ +|||+||+|||| Sbjct 50 KRQSEGTFSNYYSKYQEERMARDFLHW#LMNSKRS-------GAPSKRHADGTYTSDV 99 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHD--EFERHAEGTFTSDV 107 |||+ ||+||| | || + |+||| |#| + | + + + || +|+||||| Sbjct 88 KRHADGTYTSDVSTYLQDQAAKDFVSW#LKSGPARRESAEESMNGPMSRRHVDGSFTSDV 146 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHD 93 +|| |+|||| +| ||| |++++ |#+| +| + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLDSLAAKEYLLW#VMTSKTSGKSNKRQED 177 |
| Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||+|||++||||| + | |||||||#|||+||+ +|||+||+|||| Sbjct 50 KRHSEGTFSNDYSKYQEERMAQDFVQW#LMNSKRS-------GAPSKRHADGTYTSDV 99 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNI--AKRHDEFERHAEGTFTSDV 107 |||+ ||+||| | || + |+||| |#| + + | + ++ || +|+||||| Sbjct 88 KRHADGTYTSDVSTYLQDQAAKDFVSW#LKSGRARRESAEESRNGPMSRRHVDGSFTSDV 146 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHD 93 +|| |+|||| +| ||| |++++ |#+| +| + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLDSLAAKEYLLW#VMTSKTSGKSNKRQED 177 |
| Heloderma horridum | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMN 80 |||| |||||| || ++ + |++|#| | Sbjct 46 KRHSDGTFTSDLSKQMEEEAVRLFIEW#LKN 75 |
| Mus musculus | Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHA 99 |+++||| |||| +| | |||| |#|+ + +++ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKIRQQDFVNW#LLAQRGKKSD--WKHNITQREA 88 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTK 82 |+ |+|||| +| ||+ |++|+ |#|++|| Sbjct 1 HADGSFTSDINKVLDTIAAKEFLNW#LISTK 30 |
| Protopterus dolloi | Query 49 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 | |||||||| |||+| |+++ | | || #||+||| ++|||+| |||||||+|||+ Sbjct 28 EAKRHSQGTFMSDYAKLLEAKHALDLVQR#LMSTKRT-GAVSKRHNEIERHAEGTYTSDI 85 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFE-RHAEGTFTSD 106 || +||++||+||| | ||+ + +|++|#|| + |+ +| + |||+|| ||| Sbjct 71 NEIERHAEGTYTSDISSYLEGQAVNEFIRW#LMKGRGRRDFSETDIEEMDRRHADGTVTSD 130 Query 107 V 107 + Sbjct 131 I 131 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTK 82 |+||+ || ||| + |+| ++|+ |#|+| | Sbjct 119 DRRHADGTVTSDINSVLESIATREFLNW#LINAK 151 |
| Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSD 106 + + ||+ | ||||||+ | |+ +++ #|+ || ++|++ +||++ || + Sbjct 76 SRNARHADGVFTSDYSRLLGQISAKKYLES#LIG-KRISSSISEDPVPIKRHSDAVFTDN 133 |
| Agkistrodon piscivorus | Query 49 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRH---DEFERHAEGTFTS 105 | +||+ ||+||| | ||+ + |++|+ |#|+| + |+ | | |||+||||| Sbjct 32 EYERHADGTYTSDISSYLEGQAAKEFIAW#LVNGRGRRDFSEGAHTGEDLGRRHADGTFTS 91 Query 106 D 106 | Query 106 D 106 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNI 88 +||+ |||||||+| || |+|++|#|+| | + ++ Sbjct 82 RRHADGTFTSDYNKLLDDIATQEFLKW#LINQKVTQRDL 119 Query 66 LDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 |+ | ++|+ #| + | +|+ | |+||||+||+|||+ Sbjct 9 LEDREKENFLDQ#LAS-----NGLARPHAEYERHADGTYTSDI 45 |
| Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 |||||+|||||||+|| ++|+||| |#|+|||| + + +||++|+||+|+ Sbjct 43 RHSQGSFTSDYSKHLDVKQAKDFVTW#LLNTKRRGVDAQAGANLEKRHSDGSFTNDM 98 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKR 83 | +|||| |+||+| + || |++|++|#| | Sbjct 84 NLEKRHSDGSFTNDMNVMLDRMSAKNFLEW#LKQQGR 119 |
| Arvicanthis ansorgei | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSD 106 + + ||+ | ||||||+ | |+ +++ #|+ || ++| + +||++ || + Sbjct 59 SRNARHADGVFTSDYSRLLGQISAKKYLES#LIG-KRISSSILEDPVPIKRHSDAVFTDN 116 |
| synthetic construct | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRN---NIAKRHDEFERHAEGTFT 104 +| +||++|||||| | ||+ + |++|+ |#|+ + |+ +| + |||+|+|+ Sbjct 93 DEFERHAEGTFTSDVSSYLEGQAAKEFIAW#LVKGRGRRDFPEEVAIVEELGRRHADGSFS 152 Query 105 SDV 107 ++ Sbjct 153 DEM 155 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTK 82 +||+ |+|+ + + ||+ |+||+ |#|+ || Sbjct 144 RRHADGSFSDEMNTILDNLAARDFINW#LIQTK 175 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||+|||++||||||+ |+||+||+|#||| | |+ +|++ |||+||||||| Sbjct 51 KRHSEGTFSNDYSKYLEDRKAQEFVRW#LMNNK--RSGVAEK-----RHADGTFTSDV 100 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQW#L 78 +|||+ |||||| | || + +||| #| Sbjct 88 EKRHADGTFTSDVSSYLKDQAIKDFVDR#L 116 |
| Phodopus sungorus | Query 56 GTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRN---NIAKRHDEFERHAEGTFTSDV 107 |||||| | ||+ + |++|+ |#|+ + |+ + + |||+|+|+ ++ Sbjct 1 GTFTSDVSSYLEGQAAKEFIAW#LVKGRGRRDFPEEVTIVEELGRRHADGSFSDEM 55 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTK 82 +||+ |+|+ + + ||| +||+ |#|+ || Sbjct 44 RRHADGSFSDEMNTILDSLATRDFINW#LIQTK 75 |
| Neoceratodus forsteri | Query 49 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 | |||||||| |||+| |++| | |||| #||||||| ++||| | |||||||+|||+ Sbjct 20 EAKRHSQGTFMSDYAKLLEARHALDFVQR#LMNTKRN-GGVSKRHSEIERHAEGTYTSDI 77 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEF-ERHAEGTFTSD 106 +| +||++||+||| | ||+ + | +||+|#|+ + |+ +| |||+|| |+| Sbjct 63 SEIERHAEGTYTSDISSYLEGQAANEFVRW#LLKGRGRRDFSDTDAEEMGRRHADGTITND 122 Query 107 V 107 + Sbjct 123 M 123 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTK 82 +||+ || |+| + |+| ++|+ |#|+|+| Sbjct 112 RRHADGTITNDMNNVLESIATREFLNW#LINSK 143 |
| Sus scrofa | Query 49 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 |||||||||||||||||||||||||||||#|||||||+|||||||||||||||||||||| Sbjct 49 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNKNNIAKRHDEFERHAEGTFTSDV 107 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRN---NIAKRHDEFERHAEGTFT 104 +| +||++|||||| | ||+ + |++|+ |#|+ + |+ + + |||+|+|+ Sbjct 93 DEFERHAEGTFTSDVSSYLEGQAAKEFIAW#LVKGRGRRDFPEEVTIVEELRRRHADGSFS 152 Query 105 SDV 107 ++ Sbjct 153 DEM 155 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTK 82 +||+ |+|+ + + ||+ +||+ |#|++|| Sbjct 144 RRHADGSFSDEMNTVLDNLATRDFINW#LLHTK 175 |
| Canis lupus familiaris | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 ||||||||||||||||||||||||||||||#|||||||+|||||||||||||||||||||| Sbjct 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNKNNIAKRHDEFERHAEGTFTSDV 107 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRN---NIAKRHDEFERHAEGTFT 104 +| +||++|||||| | ||+ + |++|+ |#|+ + |+ +| + |||+|+|+ Sbjct 93 DEFERHAEGTFTSDVSSYLEGQAAKEFIAW#LVKGRGRRDFPEEVAIVEEFRRRHADGSFS 152 Query 105 SDV 107 ++ Sbjct 153 DEM 155 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTK 82 +||+ |+|+ + + ||+ +||+ |#|+ || Sbjct 144 RRHADGSFSDEMNTVLDTLATRDFINW#LLQTK 175 |
| Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 |||||||+|||||||+|||||||||#||+|||+ | ||+||+|||| Sbjct 1 HSQGTFTNDYSKYLDTRRAQDFVQW#LMSTKRS-GGITXXXXXXXXHADGTYTSDV 54 Query 53 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNR 85 |+ ||+||| | || + |+ || |#| + | Sbjct 45 HADGTYTSDVSSYLQDQAAKKFVTW#LKQGQDRR 77 |
| Hydrolagus colliei | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 107 |||+ | |+||||||||+|| +|||||#|++|||| | |+ +|||+| +|||| Sbjct 30 KRHTDGIFSSDYSKYLDNRRTKDFVQW#LLSTKRNGANT----DKTKRHADGIYTSDV 82 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNN--IAKRHDEFERHAEGTFTS 105 ++ |||+ | +||| + | +++ ||+ #| | + +|+ ++||| | | | + + Sbjct 68 DKTKRHADGIYTSDVASLTDYLKSKRFVES#LSNYNKRQNDRRMSKRHVEGARRTEEDYPN 127 Query 106 D 106 | Query 106 D 106 Query 49 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFE 96 | | ++ + +|+| ||+++ |+||+ |#|+ + | + |+ | | Sbjct 116 EGARRTEEDYPNDFSSYLEAKAAKDFIDW#LIK-GQGRRDFAEESREIE 162 |
| Heloderma suspectum, venom, Peptide, 39 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQW#LMN 80 | +|||||| || ++ + |++|#| | Sbjct 1 HGEGTFTSDLSKQMEEEAVRLFIEW#LKN 28 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | Query 56 GTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRN 86 ||+||| | || + |++|| |#| + |+ Sbjct 3 GTYTSDVSSYLQDQAAKEFVSW#LKTGRGRRD 33 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNR 85 |+ || ||| | +|+ + ++|+ |#|++ + | Sbjct 1 HADGTLTSDISSFLEKQATKEFIAW#LVSGRGRR 33 |
[Site 4] RAQDFVQWLM79-NTKRNRNNIA
Met79 Asn
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Arg70 | Ala71 | Gln72 | Asp73 | Phe74 | Val75 | Gln76 | Trp77 | Leu78 | Met79 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Asn80 | Thr81 | Lys82 | Arg83 | Asn84 | Arg85 | Asn86 | Asn87 | Ile88 | Ala89 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| DKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSS |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 123.00 | 10 | glucagon, isoform CRA_b |
| 2 | N/A | 79.70 | 45 | 0 |
| 3 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | 64.70 | 1 | AAB31092.1 |
| 4 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | 61.60 | 1 | glucagon=proglucagon-derived 3.5 kda peptide |
| 5 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | 60.80 | 1 | glucagon II |
| 6 | Contains: Glucagon; Glucagon-like peptide | 60.10 | 4 | GLUC_AMICA Glucagon precursor |
| 7 | Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | 60.10 | 1 | glucagon |
| 8 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | 58.50 | 1 | glucagon G-29 |
| 9 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | 57.80 | 1 | GLUC1_ORENI Glucagon-1 (Glucagon I) gb |
| 10 | Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | 56.20 | 1 | GLUC_LAMFL Glucagon gb |
| 11 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | 53.50 | 1 | glucagon |
| 12 | deshis1, Desphe6, Glu9 | 53.50 | 1 | A Chain A, Nmr Solution Structure Of The Glucagon |
| 13 | Monodelphis domestica | 48.90 | 3 | PREDICTED: similar to Gastric inhibitory polypepti |
| 14 | Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | 48.90 | 1 | GLUC1_PETMA Glucagon-1 precursor |
| 15 | Xenopus laevis | 47.00 | 5 | proglucagon II |
| 16 | Hoplobatrachus rugulosus | 46.60 | 1 | AF324209_1 proglucagon |
| 17 | Bufo marinus | 46.60 | 1 | proglucagon |
| 18 | Gallus gallus | 46.20 | 4 | glucagon isoform 1 |
| 19 | Meleagris gallopavo | 46.20 | 2 | preproglucagon B |
| 20 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | 44.70 | 1 | GLUC_HELSU Glucagon precursor |
| 21 | Oncorhynchus tshawytscha | 43.50 | 1 | S78474_1 proglucagon |
| 22 | Ictalurus punctatus | 43.10 | 3 | proglucagon I |
| 23 | Ambloplites rupestris | 43.10 | 1 | proglucagon |
| 24 | Rattus norvegicus | 42.70 | 6 | Glucose-dependent insulinotropic peptide |
| 25 | Canis familiaris | 42.70 | 2 | PREDICTED: similar to Gastric inhibitory polypepti |
| 26 | Capra hircus | 42.70 | 1 | glucagon |
| 27 | Pan troglodytes | 42.40 | 2 | PREDICTED: fibroblast activation protein, alpha su |
| 28 | Xenopus tropicalis | 42.40 | 2 | glucagon |
| 29 | Danio rerio | 42.00 | 6 | hypothetical protein LOC494052 |
| 30 | Bos taurus | 42.00 | 5 | vasoactive intestinal peptide |
| 31 | Squalus acanthias | 41.60 | 1 | proglucagon |
| 32 | Agkistrodon piscivorus | 41.60 | 1 | proglucagon |
| 33 | Macaca mulatta | 41.20 | 3 | PREDICTED: vasoactive intestinal peptide |
| 34 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | 41.20 | 1 | glucagon-like peptide, GLP |
| 35 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | 41.20 | 1 | GLUC2_LOPAM Glucagon-2 precursor (Glucagon II) |
| 36 | Sebastes caurinus | 40.80 | 4 | proglucagon I |
| 37 | Heloderma suspectum | 40.80 | 2 | proglucagon |
| 38 | Tetraodon nigroviridis | 40.00 | 3 | unnamed protein product |
| 39 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | 40.00 | 2 | GLUC_CARAU Glucagon precursor |
| 40 | Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | 40.00 | 1 | GLUC2_ONCMY Glucagon-2 precursor (Glucagon II) |
| 41 | Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | 40.00 | 1 | GLUC1_ONCMY Glucagon-1 precursor (Glucagon I) |
| 42 | Heloderma horridum | 40.00 | 1 | EXE3_HELHO Exendin-3 precursor emb |
| 43 | Mus musculus | 39.70 | 6 | Gastric inhibitory polypeptide |
| 44 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | 38.90 | 1 | glucagon-like peptide-2, GLP-2=proglucagon-derived |
| 45 | Protopterus dolloi | 38.90 | 1 | proglucagon |
| 46 | Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | 38.10 | 1 | VIP_MOUSE VIP peptides precursor |
| 47 | Arvicanthis ansorgei | 37.40 | 1 | vasoactive intestinal polypeptide |
| 48 | synthetic construct | 37.00 | 1 | Homo sapiens glucagon |
| 49 | Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | 37.00 | 1 | GLUC2_PETMA Glucagon-2 precursor |
| 50 | Phodopus sungorus | 36.60 | 1 | glucagon precursor |
| 51 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | 36.60 | 1 | GLUC1_LOPAM Glucagon-1 precursor (Glucagon I) |
| 52 | Sus scrofa | 36.20 | 1 | glucagon |
| 53 | Neoceratodus forsteri | 36.20 | 1 | proglucagon |
| 54 | Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | 35.80 | 1 | GLUC_LEPSP Glucagon precursor |
| 55 | Canis lupus familiaris | 35.80 | 1 | glucagon |
| 56 | Heloderma suspectum, venom, Peptide, 39 aa | 35.40 | 1 | A Chain A, Solution Structure Of Exendin-4 In 30-V |
| 57 | Hydrolagus colliei | 35.00 | 1 | proglucagon |
| 58 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | 34.70 | 1 | GLUC2_ORENI Glucagon-2 (Glucagon II) gb |
| 59 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | 34.70 | 1 | glucagon-like peptide-1, GLP-1=proglucagon-derived |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSD 106 ||||||||||||||||||||||||||||||#||||||||||||||||||||||||||| Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSD 106 |
| N/A | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIA 89 |||||||||||||||||||||||||||#|||||+|||| Sbjct 1 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNKNNIA 37 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRN 84 ||+||||||||||+|+|||+|||||||#+|||| Sbjct 1 HSEGTFTSDYSKYMDNRRAKDFVQWLM#STKRN 32 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NT 81 |||||||||||||||+||||||+||||#+| Sbjct 1 HSQGTFTSDYSKYLDNRRAQDFIQWLM#ST 29 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRN 84 ||+|||++||||||++|||||||||| #|+||| Sbjct 1 HSEGTFSNDYSKYLETRRAQDFVQWLK#NSKRN 32 |
| Contains: Glucagon; Glucagon-like peptide | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NT 81 |||||||+|||||+|+|||||||||||#+| Sbjct 1 HSQGTFTNDYSKYMDTRRAQDFVQWLM#ST 29 |
| Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NT 81 |||||||+|||||+|+|||||||||||#+| Sbjct 1 HSQGTFTNDYSKYMDTRRAQDFVQWLM#ST 29 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NT 81 ||+||||||||||+|+|||+|||||||#+| Sbjct 1 HSEGTFTSDYSKYMDNRRAKDFVQWLM#ST 29 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRN 84 ||+|||++||||||+ |+|||||+|||#| ||+ Sbjct 1 HSEGTFSNDYSKYLEDRKAQDFVRWLM#NNKRS 32 |
| Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NT 81 ||||+|||||||||||++|+||| |||#|| Sbjct 1 HSQGSFTSDYSKYLDSKQAKDFVIWLM#NT 29 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQWLM#N 80 ||+|||||||||||++++|+|||+|||#| Sbjct 1 HSEGTFTSDYSKYLENKQAKDFVRWLM#N 28 |
| deshis1, Desphe6, Glu9 | Query 54 SQGTFTSDYSKYLDSRRAQDFVQWLM#NT 81 |||| ||+||||||||||||||||||#|| Sbjct 1 SQGT-TSEYSKYLDSRRAQDFVQWLM#NT 27 |
| Monodelphis domestica | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGT 102 +|+++||| |||| +| |||| ||+#+ | +| + ||+ || |+|| Sbjct 51 QRYAEGTFISDYSITMDKIMQQDFVNWLL#SQKGKKN--SWRHNITERKADGT 100 |
| Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||+|||||||||||++++|+|||+|||#| || + + + |||+||||+|++| Sbjct 41 KRHSEGTFTSDYSKYLENKQAKDFVRWLM#NAKRGGSELQR------RHADGTFTNDMTS 93 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNR---NNIAKRHDEFERHAE 100 +||+ ||||+| + |||++ |+||| || # + ++| + + | +|||| Sbjct 80 RRHADGTFTNDMTSYLDAKAARDFVSWLA#RSDKSRRDGGDHLAENSEDKRHAE 132 |
| Xenopus laevis | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVS 108 |||||||||||||||||||||||||||||#||||+ +++|+ ++||||||||||||+ Sbjct 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRS-GGLSRRNADYERHAEGTFTSDVT 107 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 +||++||+|+| ++||+ + + |++||+# | + + ||||||||+|+++ Sbjct 140 ERHAEGTYTNDVTEYLEEKATKAFIEWLI#KGK-------PKKIRYSRHAEGTFTNDMTN 191 Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRH 92 ||++||||+| + ||+ + |++|| ||+#| + | ++ + | Sbjct 179 RHAEGTFTNDMTNYLEEKAAKEFVGWLI#NGRPKRKDLLEEH 219 |
| Hoplobatrachus rugulosus | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVS 108 |||||||||||||||||||||||||||||#|+||+ |+||+ +||||||||+|+||+ Sbjct 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NSKRS-GGISKRNVQFERHAEGTYTNDVT 107 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 +||++||+|+| +++|+ + |++|+ ||+# | + ++ ||||||||||++| Sbjct 95 ERHAEGTYTNDVTQFLEEKAAKEFIDWLI#KGKPKKQRLS-------RHAEGTFTSDMTS 146 Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFE-RHAEGTFTSD 106 ||++|||||| + ||+ + |++|| ||+# + || +| + |||+|+|||| Sbjct 134 RHAEGTFTSDMTSYLEEKAAKEFVDWLI#KGRPKRNFPDISAEEMDRRHADGSFTSD 189 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NT 81 |+||+ |+||||++| || + ||+|+ |++#|| Sbjct 178 DRRHADGSFTSDFNKALDIKAAQEFLDWII#NT 209 |
| Bufo marinus | Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQWLM--#NTKRNRNNIAKRHDEFERHAEGTFTSD 106 ||++|||||| + +|+ + |++|| ||+ # ||| ++++ | |||+|+|||| Sbjct 62 RHAEGTFTSDMTSFLEEKAAKEFVDWLIKG#RPKRNFSDVSAADDMDRRHADGSFTSD 118 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 +||++||+|+| +++|+ + |++|+ ||+# | |+ ||||||||||++| Sbjct 23 ERHAEGTYTNDVTQFLEEKAAKEFIDWLL#------KGIPKK-QRLSRHAEGTFTSDMTS 74 Query 73 DFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVS 108 || ||||#|+||+ +++|+ +||||||||+|+||+ Sbjct 1 DFAQWLM#NSKRS-GGMSRRNVQFERHAEGTYTNDVT 35 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NT 81 |+||+ |+||||++| || + ||+|+ |++#|| Sbjct 107 DRRHADGSFTSDFNKALDIKAAQEFLDWII#NT 138 |
| Gallus gallus | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRN------------------RNNIAKRH 92 |||||||||||||||||||||||||||||#+|||| | |+||| Sbjct 53 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#STKRNGQQGQEDKENDKFPDQLSSNAISKRH 112 Query 93 DEFERHAEGTFTSDVSS 109 |||||||||+|||++| Sbjct 113 SEFERHAEGTYTSDITS 129 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAK---RHDEFERHAEGTFTSDV 107 +||++||+||| + ||+ + |++|+ ||+#| + |+ | + |||+||||||+ Sbjct 116 ERHAEGTYTSDITSYLEGQAAKEFIAWLV#NGRGRRDFPEKALMAEEMGRRHADGTFTSDI 175 Query 108 S 108 + Sbjct 176 N 176 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNI 88 +||+ |||||| +| || |++|++||+#||| + ++ Sbjct 164 RRHADGTFTSDINKILDDMAAKEFLKWLI#NTKVTQRDL 201 |
| Meleagris gallopavo | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRN------------------RNNIAKRH 92 |||||||||||||||||||||||||||||#+|||| | |+||| Sbjct 53 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#STKRNGQQGQEDKENDEFPDQLSSNAISKRH 112 Query 93 DEFERHAEGTFTSDVSS 109 |||||||||+|||++| Sbjct 113 SEFERHAEGTYTSDITS 129 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAK---RHDEFERHAEGTFTSDV 107 +||++||+||| + ||+ + |++|+ ||+#| + |+ | + |||+||||||+ Sbjct 116 ERHAEGTYTSDITSYLEGQAAKEFIAWLV#NGRGRRDFPEKALMAEEMGRRHADGTFTSDI 175 Query 108 S 108 + Sbjct 176 N 176 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNI 88 +||+ |||||| +| || |++|++||+#||| + ++ Sbjct 164 RRHADGTFTSDINKILDDMAAKEFLKWLI#NTKVTQRDL 201 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKR------------------NRNNIAKRH 92 |||||||||||||||||+|||||||||||#|||| + | +|+ | Sbjct 51 KRHSQGTFTSDYSKYLDTRRAQDFVQWLM#NTKRSGQQGVEEREKENLLDQLSSNGLARHH 110 Query 93 DEFERHAEGTFTSDVSS 109 |+||||+| +|||+|| Sbjct 111 AEYERHADGRYTSDISS 127 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAK---RHDEFERHAEGTFTSD 106 +||+ | +||| | ||+ + |++|+ ||+#| + |+ + + | |||+|||||| Sbjct 114 ERHADGRYTSDISSYLEGQAAKEFIAWLV#NGRGRRDFLEEAGTADDIGRRHADGTFTSD 172 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNI 88 +||+ |||||||++ || |+|++||+#| | + ++ Sbjct 162 RRHADGTFTSDYNQLLDDIATQEFLKWLI#NQKVTQRDL 199 |
| Oncorhynchus tshawytscha | Query 54 SQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 | |||++||||| + | |||||||||#|+||+ +|||+||+|||||+ Sbjct 2 SXGTFSNDYSKYQEERMAQDFVQWLM#NSKRS-------GAPSKRHADGTYTSDVST 50 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNR 85 |||+ ||+||| | || + |+||| || #+ + | Sbjct 37 KRHADGTYTSDVSTYLQDQAAKDFVSWLK#SGRARR 71 |
| Ictalurus punctatus | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 +|||+|||++||||||++|||||||||||#|+||+ |||+||+|||||| Sbjct 49 RRHSEGTFSNDYSKYLETRRAQDFVQWLM#NSKRS-------DSPARRHADGTYTSDVSS 100 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEF--ERHAEGTFTSDVS 108 +||+ ||+||| | || + |+||+ || #+ + + + | + || +|+|||||+ Sbjct 87 RRHADGTYTSDVSSYLQDQAAKDFITWLK#SGQPKPDAVETRSVDTLRRRHVDGSFTSDVN 146 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRH 92 +|| |+|||| +| ||| |++++||+|#|+ + + ||| Sbjct 134 RRHVDGSFTSDVNKVLDSLAAKEYLQWVM#NSPSSAS--GKRH 173 |
| Ambloplites rupestris | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 |||||||+||+ ||+ |+||||++|||#| | |+ |++ |||+|||| | || Sbjct 1 HSQGTFTNDYTNYLEDRQAQDFIRWLM#NNK--RSGAAEK-----RHADGTFTDDASS 50 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDE--FERHAEGTFTSDV 107 +|||+ |||| | | + +||| | #+ + | | | || ||+||||+ Sbjct 36 EKRHADGTFTDDASSDFYDQAIKDFVAKLK#SGQDRREPETDRRREAFSRRHVEGSFTSDI 95 Query 108 S 108 + Sbjct 96 N 96 |
| Rattus norvegicus | Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHA 99 |+++||| |||| +| | |||| ||+# | +|+ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKIRQQDFVNWLL#AQKGKKND--WKHNLTQREA 88 |
| Canis familiaris | Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHA 99 |+++||| |||| +| | |||| ||+# | +|+ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKIRQQDFVNWLL#AQKGKKND--WKHNITQREA 88 |
| Capra hircus | Query 86 NNIAKRHDEFERHAEGTFTSDVSS 109 |||||||||||||||||||||||| Query 86 NNIAKRHDEFERHAEGTFTSDVSS 109 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNR 85 +||++|||||| | ||+ + |++|+ ||+# + | Sbjct 11 ERHAEGTFTSDVSSYLEGQAAKEFIAWLV#KGRGRR 45 |
| Pan troglodytes | Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||||||||||||||||||||||||||||#||||| +++| ||||||||||||| Sbjct 972 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRN-SSVA------YRHAEGTFTSDVSS 1024 Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNR 85 ||++|||||| | ||+ + |++|+ ||+# + | Sbjct 1012 RHAEGTFTSDVSSYLEGQAAKEFIAWLV#KGRGRR 1045 |
| Xenopus tropicalis | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVS 108 ||||||||||||||||||||||||+||||#||||+ +++|+ ++||||||||||||+ Sbjct 51 KRHSQGTFTSDYSKYLDSRRAQDFIQWLM#NTKRS-GGLSRRNADYERHAEGTFTSDVT 107 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 +||++||+|+| ++||+ + |++|++||+#| | + + ||||||||+|+++ Sbjct 140 ERHAEGTYTNDVTEYLEEKAAKEFIEWLI#NGK-------PKKIRYSRHAEGTFTNDMTN 191 Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFE---RHAEGTFTSDVS 108 ||++||||+| + ||+ + |++|| ||+# | + | ++ | | |||+|+||+|++ Sbjct 179 RHAEGTFTNDMTNYLEEKAAKEFVGWLI#K-GRPKRNFSEAHSVEEMDRRHADGSFTNDIN 237 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTK 82 |+||+ |+||+| +| || ||+|+ |++#||+ Sbjct 224 DRRHADGSFTNDINKVLDIIAAQEFLDWVI#NTQ 256 |
| Danio rerio | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||+|||++||||||++|||||||||||#| ||| ++ +||||||+|||||| Sbjct 48 KRHSEGTFSNDYSKYLETRRAQDFVQWLM#NAKRNGGSV-------KRHAEGTYTSDVSS 99 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWL 78 |||++||+||| | || + || || || Sbjct 86 KRHAEGTYTSDVSSYLQDQAAQSFVAWL 113 |
| Bos taurus | Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSD 106 ||+ | ||||||+ | |+ +++ |+# || |+|++ +||++ || + Sbjct 80 RHADGVFTSDYSRLLGQLSAKKYLESLI#G-KRVSNSISEDQGPIKRHSDAVFTDN 133 |
| Squalus acanthias | Query 67 DSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 |+|||+|||||||#+|||| |+ +||||||+|||| | Sbjct 1 DNRRAKDFVQWLM#STKRN-------GDKTKRHAEGTYTSDVDS 36 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWL--M#NTKRNRNNIAKRHDEFERHAEGTFTSDVS 108 |||++||+||| | +|+ || | #| ++| +|+||| | || ||++ |+| Sbjct 23 KRHAEGTYTSDVDSLSDYFKAKRFVDSLTSY#NKRQNGRSISKRHVESTRHTEGSY-RDIS 81 Query 109 S 109 | Query 109 S 109 Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRN---------NIAKRHDEFERHAEGT 102 ||++|++ | | ||+++ |+||+ ||+# + | | + |||+|| Sbjct 71 RHTEGSYR-DISSYLEAKAAKDFINWLI#KGRGRREFPEESKEIVNEVIPEEMDRRHADGT 129 Query 103 FTSDVS 108 |||+++ Sbjct 130 FTSEIN 135 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFE 96 |+||+ |||||+ + ||+ |++|+ |++#|+| | | | | Sbjct 122 DRRHADGTFTSEINIVLDTIAAKEFLNWIL#NSK----TIQSRDSEIE 164 |
| Agkistrodon piscivorus | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRH---DEFERHAEGTFTSD 106 +||+ ||+||| | ||+ + |++|+ ||+#| + |+ | | |||+|||||| Sbjct 34 ERHADGTYTSDISSYLEGQAAKEFIAWLV#NGRGRRDFSEGAHTGEDLGRRHADGTFTSD 92 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNI 88 +||+ |||||||+| || |+|++||+#| | + ++ Sbjct 82 RRHADGTFTSDYNKLLDDIATQEFLKWLI#NQKVTQRDL 119 Query 66 LDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 |+ | ++|+ | #+ | +|+ | |+||||+||+|||+|| Sbjct 9 LEDREKENFLDQLA#S-----NGLARPHAEYERHADGTYTSDISS 47 |
| Macaca mulatta | Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSD 106 ||+ | ||||+|| | |+ +++ ||# || +||++ +||++ || + Sbjct 80 RHADGVFTSDFSKLLGQLSAKKYLESLM#G-KRVSSNISEDPVPVKRHSDAVFTDN 133 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRN 84 |+ ||||+| + |||++ |+||| || # + ++ Sbjct 1 HADGTFTNDMTSYLDAKAARDFVSWLA#RSDKS 32 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||+|||++||||||++|||||||||| #|+||| | |||+||+|||||| Sbjct 50 KRHSEGTFSNDYSKYLETRRAQDFVQWLK#NSKRN--------GLFRRHADGTYTSDVSS 100 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWL 78 +||+ ||+||| | || + |+||| || Sbjct 87 RRHADGTYTSDVSSYLQDQAAKDFVSWL 114 |
| Sebastes caurinus | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||+|||++|||+||+ |+|||||+|||#| ||+ || +|||+||||||||| Sbjct 48 KRHSEGTFSNDYSRYLEERKAQDFVRWLM#NNKRS------GADE-KRHADGTFTSDVSS 99 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDE--FERHAEGTFTSDV 107 +|||+ |||||| | || + +||| | #+ + | + + | || +|+||||| Sbjct 85 EKRHADGTFTSDVSSYLKDQAIKDFVNRLK#SGQVRRESETEWRGEAFSRRHVDGSFTSDV 144 Query 108 S 108 + Sbjct 145 N 145 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDE 94 +|| |+|||| +| ||| |++++ |+|# +| + + ++ |+ Sbjct 133 RRHVDGSFTSDVNKVLDSMAAKEYLLWVM#TSKPSGESKKRQEDQ 176 |
| Heloderma suspectum | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKR------------------NRNNIAKRH 92 |||||||||||||||||+|||||||||||#|||| + | +|+ | Sbjct 51 KRHSQGTFTSDYSKYLDTRRAQDFVQWLM#NTKRSGQQGVEEREKENLLDQLSSNGLARHH 110 Query 93 DEFERHAEGTFTSDVSS 109 |+||||+| +|||+|| Sbjct 111 AEYERHADGRYTSDISS 127 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNR 85 +||+ | +||| | ||+ + |++|+ ||+#| + | Sbjct 114 ERHADGRYTSDISSYLEGQAAKEFIAWLV#NGRGRR 148 |
| Tetraodon nigroviridis | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||+|||++||||||++|||||||||| #|+||| + | |||+||+|||||+ Sbjct 787 KRHSEGTFSNDYSKYLETRRAQDFVQWLK#NSKRNGS-------LFRRHADGTYTSDVSA 838 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNR 85 +||+ ||+||| | || + |++|| || # + | Sbjct 825 RRHADGTYTSDVSAYLQDQAAKEFVSWLK#TGRGRR 859 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||+|||++||||||++|||||||+|||#|+| | + +||||||+|||+|| Sbjct 48 KRHSEGTFSNDYSKYLETRRAQDFVEWLM#NSKSNGGSA-------KRHAEGTYTSDISS 99 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWL 78 |||++||+||| | +| + ||+|| || Sbjct 86 KRHAEGTYTSDISSFLRDQAAQNFVAWL 113 |
| Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 || |+|||++ |||| + | |+||+ |||#|+||+ +|||+||+|||||+ Sbjct 50 KRQSEGTFSNYYSKYQEERMARDFLHWLM#NSKRS-------GAPSKRHADGTYTSDVST 101 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHD--EFERHAEGTFTSDVS 108 |||+ ||+||| | || + |+||| || #+ | + + + || +|+|||||+ Sbjct 88 KRHADGTYTSDVSTYLQDQAAKDFVSWLK#SGPARRESAEESMNGPMSRRHVDGSFTSDVN 147 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHD 93 +|| |+|||| +| ||| |++++ |+|# +| + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLDSLAAKEYLLWVM#TSKTSGKSNKRQED 177 |
| Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||+|||++||||| + | |||||||||#|+||+ +|||+||+|||||+ Sbjct 50 KRHSEGTFSNDYSKYQEERMAQDFVQWLM#NSKRS-------GAPSKRHADGTYTSDVST 101 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNI--AKRHDEFERHAEGTFTSDVS 108 |||+ ||+||| | || + |+||| || #+ + | + ++ || +|+|||||+ Sbjct 88 KRHADGTYTSDVSTYLQDQAAKDFVSWLK#SGRARRESAEESRNGPMSRRHVDGSFTSDVN 147 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHD 93 +|| |+|||| +| ||| |++++ |+|# +| + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLDSLAAKEYLLWVM#TSKTSGKSNKRQED 177 |
| Heloderma horridum | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#N 80 |||| |||||| || ++ + |++|| #| Sbjct 46 KRHSDGTFTSDLSKQMEEEAVRLFIEWLK#N 75 |
| Mus musculus | Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHA 99 |+++||| |||| +| | |||| ||+# + +++ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKIRQQDFVNWLL#AQRGKKSD--WKHNITQREA 88 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTK 82 |+ |+|||| +| ||+ |++|+ ||+#+|| Sbjct 1 HADGSFTSDINKVLDTIAAKEFLNWLI#STK 30 |
| Protopterus dolloi | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 |||||||| |||+| |+++ | | || ||#+||| ++|||+| |||||||+|||+|| Sbjct 30 KRHSQGTFMSDYAKLLEAKHALDLVQRLM#STKRT-GAVSKRHNEIERHAEGTYTSDISS 87 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFE-RHAEGTFTSDVSS 109 +||++||+||| | ||+ + +|++|||# + |+ +| + |||+|| |||++| Sbjct 74 ERHAEGTYTSDISSYLEGQAVNEFIRWLM#KGRGRRDFSETDIEEMDRRHADGTVTSDINS 133 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTK 82 |+||+ || ||| + |+| ++|+ ||+#| | Sbjct 119 DRRHADGTVTSDINSVLESIATREFLNWLI#NAK 151 |
| Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSD 106 ||+ | ||||||+ | |+ +++ |+# || ++|++ +||++ || + Sbjct 80 RHADGVFTSDYSRLLGQISAKKYLESLI#G-KRISSSISEDPVPIKRHSDAVFTDN 133 |
| Arvicanthis ansorgei | Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSD 106 ||+ | ||||||+ | |+ +++ |+# || ++| + +||++ || + Sbjct 63 RHADGVFTSDYSRLLGQISAKKYLESLI#G-KRISSSILEDPVPIKRHSDAVFTDN 116 |
| synthetic construct | Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRN---NIAKRHDEFERHAEGTFTSDV 107 +||++|||||| | ||+ + |++|+ ||+# + |+ +| + |||+|+|+ ++ Sbjct 96 ERHAEGTFTSDVSSYLEGQAAKEFIAWLV#KGRGRRDFPEEVAIVEELGRRHADGSFSDEM 155 Query 108 SS 109 ++ Sbjct 156 NT 157 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTK 82 +||+ |+|+ + + ||+ |+||+ ||+# || Sbjct 144 RRHADGSFSDEMNTILDNLAARDFINWLI#QTK 175 |
| Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | Query 52 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVS 108 |||||+|||||||+|| ++|+||| ||+#|||| + + +||++|+||+|++ Sbjct 43 RHSQGSFTSDYSKHLDVKQAKDFVTWLL#NTKRRGVDAQAGANLEKRHSDGSFTNDMN 99 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKR 83 +|||| |+||+| + || |++|++|| # | Sbjct 86 EKRHSDGSFTNDMNVMLDRMSAKNFLEWLK#QQGR 119 |
| Phodopus sungorus | Query 56 GTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRN---NIAKRHDEFERHAEGTFTSDVSS 109 |||||| | ||+ + |++|+ ||+# + |+ + + |||+|+|+ ++++ Sbjct 1 GTFTSDVSSYLEGQAAKEFIAWLV#KGRGRRDFPEEVTIVEELGRRHADGSFSDEMNT 57 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTK 82 +||+ |+|+ + + ||| +||+ ||+# || Sbjct 44 RRHADGSFSDEMNTILDSLATRDFINWLI#QTK 75 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||+|||++||||||+ |+||+||+|||#| | |+ +|++ |||+||||||||| Sbjct 51 KRHSEGTFSNDYSKYLEDRKAQEFVRWLM#NNK--RSGVAEK-----RHADGTFTSDVSS 102 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWL 78 +|||+ |||||| | || + +||| | Sbjct 88 EKRHADGTFTSDVSSYLKDQAIKDFVDRL 116 |
| Sus scrofa | Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||||||||||||||||||||||||||||#|||||+|||||||||||||||||||||||| Sbjct 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNKNNIAKRHDEFERHAEGTFTSDVSS 109 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRN---NIAKRHDEFERHAEGTFTSDV 107 +||++|||||| | ||+ + |++|+ ||+# + |+ + + |||+|+|+ ++ Sbjct 96 ERHAEGTFTSDVSSYLEGQAAKEFIAWLV#KGRGRRDFPEEVTIVEELRRRHADGSFSDEM 155 Query 108 SS 109 ++ Sbjct 156 NT 157 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTK 82 +||+ |+|+ + + ||+ +||+ ||+#+|| Sbjct 144 RRHADGSFSDEMNTVLDNLATRDFINWLL#HTK 175 |
| Neoceratodus forsteri | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 |||||||| |||+| |++| | |||| ||#||||| ++||| | |||||||+|||+|| Sbjct 22 KRHSQGTFMSDYAKLLEARHALDFVQRLM#NTKRN-GGVSKRHSEIERHAEGTYTSDISS 79 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEF-ERHAEGTFTSDVSS 109 +||++||+||| | ||+ + | +||+||+# + |+ +| |||+|| |+|+++ Sbjct 66 ERHAEGTYTSDISSYLEGQAANEFVRWLL#KGRGRRDFSDTDAEEMGRRHADGTITNDMNN 125 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTK 82 +||+ || |+| + |+| ++|+ ||+#|+| Sbjct 112 RRHADGTITNDMNNVLESIATREFLNWLI#NSK 143 |
| Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 |||||||+|||||||+|||||||||||#+|||+ | ||+||+|||||| Sbjct 1 HSQGTFTNDYSKYLDTRRAQDFVQWLM#STKRS-GGITXXXXXXXXHADGTYTSDVSS 56 Query 53 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNR 85 |+ ||+||| | || + |+ || || # + | Sbjct 45 HADGTYTSDVSSYLQDQAAKKFVTWLK#QGQDRR 77 |
| Canis lupus familiaris | Query 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 ||||||||||||||||||||||||||||||#|||||+|||||||||||||||||||||||| Sbjct 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNKNNIAKRHDEFERHAEGTFTSDVSS 109 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRN---NIAKRHDEFERHAEGTFTSDV 107 +||++|||||| | ||+ + |++|+ ||+# + |+ +| + |||+|+|+ ++ Sbjct 96 ERHAEGTFTSDVSSYLEGQAAKEFIAWLV#KGRGRRDFPEEVAIVEEFRRRHADGSFSDEM 155 Query 108 SS 109 ++ Sbjct 156 NT 157 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTK 82 +||+ |+|+ + + ||+ +||+ ||+# || Sbjct 144 RRHADGSFSDEMNTVLDTLATRDFINWLL#QTK 175 |
| Heloderma suspectum, venom, Peptide, 39 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQWLM#N 80 | +|||||| || ++ + |++|| #| Sbjct 1 HGEGTFTSDLSKQMEEEAVRLFIEWLK#N 28 |
| Hydrolagus colliei | Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 109 |||+ | |+||||||||+|| +||||||+#+|||| | |+ +|||+| +||||+| Sbjct 30 KRHTDGIFSSDYSKYLDNRRTKDFVQWLL#STKRNGANT----DKTKRHADGIYTSDVAS 84 Query 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNN--IAKRHDEFERHAEGTFTSDVS 108 |||+ | +||| + | +++ ||+ | #| + +|+ ++||| | | | + +| | Sbjct 71 KRHADGIYTSDVASLTDYLKSKRFVESLS#NYNKRQNDRRMSKRHVEGARRTEEDYPNDFS 130 Query 109 S 109 | Query 109 S 109 Query 51 KRHSQGT------FTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFE 96 ||| +| + +|+| ||+++ |+||+ ||+# + | + |+ | | Sbjct 112 KRHVEGARRTEEDYPNDFSSYLEAKAAKDFIDWLI#K-GQGRRDFAEESREIE 162 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | Query 56 GTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRN 86 ||+||| | || + |++|| || # + |+ Sbjct 3 GTYTSDVSSYLQDQAAKEFVSWLK#TGRGRRD 33 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNR 85 |+ || ||| | +|+ + ++|+ ||+#+ + | Sbjct 1 HADGTLTSDISSFLEKQATKEFIAWLV#SGRGRR 33 |
[Site 5] YLDSRRAQDF74-VQWLMNTKRN
Phe74 Val
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Tyr65 | Leu66 | Asp67 | Ser68 | Arg69 | Arg70 | Ala71 | Gln72 | Asp73 | Phe74 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Val75 | Gln76 | Trp77 | Leu78 | Met79 | Asn80 | Thr81 | Lys82 | Arg83 | Asn84 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| DQMNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFT |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 129.00 | 10 | glucagon, isoform CRA_b |
| 2 | N/A | 79.70 | 44 | 0 |
| 3 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | 64.70 | 1 | AAB31092.1 |
| 4 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | 61.60 | 1 | glucagon=proglucagon-derived 3.5 kda peptide |
| 5 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | 60.80 | 1 | glucagon II |
| 6 | Contains: Glucagon; Glucagon-like peptide | 60.10 | 4 | GLUC_AMICA Glucagon precursor |
| 7 | Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | 60.10 | 1 | glucagon |
| 8 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | 58.50 | 1 | glucagon G-29 |
| 9 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | 57.80 | 1 | GLUC1_ORENI Glucagon-1 (Glucagon I) gb |
| 10 | Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | 56.20 | 1 | GLUC_LAMFL Glucagon gb |
| 11 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | 53.50 | 1 | glucagon |
| 12 | deshis1, Desphe6, Glu9 | 53.50 | 1 | A Chain A, Nmr Solution Structure Of The Glucagon |
| 13 | Monodelphis domestica | 48.90 | 3 | PREDICTED: similar to Gastric inhibitory polypepti |
| 14 | Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | 48.90 | 1 | GLUC1_PETMA Glucagon-1 precursor |
| 15 | Xenopus laevis | 47.00 | 5 | proglucagon II |
| 16 | Hoplobatrachus rugulosus | 46.60 | 1 | AF324209_1 proglucagon |
| 17 | Gallus gallus | 46.20 | 4 | glucagon isoform 1 |
| 18 | Meleagris gallopavo | 46.20 | 2 | preproglucagon B |
| 19 | Bufo marinus | 44.70 | 1 | proglucagon |
| 20 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | 44.70 | 1 | GLUC_HELSU Glucagon precursor |
| 21 | Capra hircus | 43.90 | 1 | glucagon |
| 22 | Oncorhynchus tshawytscha | 43.50 | 1 | S78474_1 proglucagon |
| 23 | Ictalurus punctatus | 43.10 | 3 | proglucagon I |
| 24 | Rattus norvegicus | 42.70 | 5 | Glucose-dependent insulinotropic peptide |
| 25 | Canis familiaris | 42.70 | 2 | PREDICTED: similar to Gastric inhibitory polypepti |
| 26 | Xenopus tropicalis | 42.40 | 2 | glucagon |
| 27 | Pan troglodytes | 42.40 | 2 | PREDICTED: fibroblast activation protein, alpha su |
| 28 | Danio rerio | 42.00 | 6 | hypothetical protein LOC494052 |
| 29 | Bos taurus | 42.00 | 5 | vasoactive intestinal peptide |
| 30 | Macaca mulatta | 41.60 | 3 | PREDICTED: vasoactive intestinal peptide |
| 31 | Heloderma suspectum | 41.60 | 2 | proglucagon |
| 32 | Squalus acanthias | 41.60 | 1 | proglucagon |
| 33 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | 41.20 | 1 | glucagon-like peptide, GLP |
| 34 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | 41.20 | 1 | GLUC2_LOPAM Glucagon-2 precursor (Glucagon II) |
| 35 | Sebastes caurinus | 40.80 | 4 | proglucagon I |
| 36 | Tetraodon nigroviridis | 40.00 | 3 | unnamed protein product |
| 37 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | 40.00 | 2 | GLUC_CARAU Glucagon precursor |
| 38 | Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | 40.00 | 1 | GLUC1_ONCMY Glucagon-1 precursor (Glucagon I) |
| 39 | Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | 40.00 | 1 | GLUC2_ONCMY Glucagon-2 precursor (Glucagon II) |
| 40 | Heloderma horridum | 40.00 | 1 | EXE3_HELHO Exendin-3 precursor emb |
| 41 | Mus musculus | 39.70 | 6 | Gastric inhibitory polypeptide |
| 42 | Protopterus dolloi | 38.90 | 1 | proglucagon |
| 43 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | 38.90 | 1 | glucagon-like peptide-2, GLP-2=proglucagon-derived |
| 44 | Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | 38.50 | 1 | VIP_MOUSE VIP peptides precursor |
| 45 | Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | 38.10 | 1 | GLUC2_PETMA Glucagon-2 precursor |
| 46 | Ambloplites rupestris | 37.70 | 1 | proglucagon |
| 47 | Arvicanthis ansorgei | 37.70 | 1 | vasoactive intestinal polypeptide |
| 48 | synthetic construct | 37.00 | 1 | Homo sapiens glucagon |
| 49 | Phodopus sungorus | 36.60 | 1 | glucagon precursor |
| 50 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | 36.60 | 1 | GLUC1_LOPAM Glucagon-1 precursor (Glucagon I) |
| 51 | Sus scrofa | 36.20 | 1 | glucagon |
| 52 | Neoceratodus forsteri | 36.20 | 1 | proglucagon |
| 53 | Canis lupus familiaris | 35.80 | 1 | glucagon |
| 54 | Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | 35.80 | 1 | GLUC_LEPSP Glucagon precursor |
| 55 | Hydrolagus colliei | 35.40 | 1 | proglucagon |
| 56 | Heloderma suspectum, venom, Peptide, 39 aa | 35.40 | 1 | A Chain A, Solution Structure Of Exendin-4 In 30-V |
| 57 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | 34.70 | 1 | GLUC2_ORENI Glucagon-2 (Glucagon II) gb |
| 58 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | 34.70 | 1 | glucagon-like peptide-1, GLP-1=proglucagon-derived |
| 59 | Agkistrodon piscivorus | 33.50 | 1 | proglucagon |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 45 DQMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 45 DQMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 |
| N/A | Query 53 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIA 89 ||||||||||||||||||||||#||||||||||+|||| Sbjct 1 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNKNNIA 37 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRN 84 ||+||||||||||+|+|||+||#|||||+|||| Sbjct 1 HSEGTFTSDYSKYMDNRRAKDF#VQWLMSTKRN 32 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNT 81 |||||||||||||||+||||||#+||||+| Sbjct 1 HSQGTFTSDYSKYLDNRRAQDF#IQWLMST 29 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRN 84 ||+|||++||||||++||||||#|||| |+||| Sbjct 1 HSEGTFSNDYSKYLETRRAQDF#VQWLKNSKRN 32 |
| Contains: Glucagon; Glucagon-like peptide | Query 53 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNT 81 |||||||+|||||+|+||||||#|||||+| Sbjct 1 HSQGTFTNDYSKYMDTRRAQDF#VQWLMST 29 |
| Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNT 81 |||||||+|||||+|+||||||#|||||+| Sbjct 1 HSQGTFTNDYSKYMDTRRAQDF#VQWLMST 29 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNT 81 ||+||||||||||+|+|||+||#|||||+| Sbjct 1 HSEGTFTSDYSKYMDNRRAKDF#VQWLMST 29 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRN 84 ||+|||++||||||+ |+||||#|+|||| ||+ Sbjct 1 HSEGTFSNDYSKYLEDRKAQDF#VRWLMNNKRS 32 |
| Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNT 81 ||||+|||||||||||++|+||#| ||||| Sbjct 1 HSQGSFTSDYSKYLDSKQAKDF#VIWLMNT 29 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDF#VQWLMN 80 ||+|||||||||||++++|+||#|+|||| Sbjct 1 HSEGTFTSDYSKYLENKQAKDF#VRWLMN 28 |
| deshis1, Desphe6, Glu9 | Query 54 SQGTFTSDYSKYLDSRRAQDF#VQWLMNT 81 |||| ||+|||||||||||||#||||||| Sbjct 1 SQGT-TSEYSKYLDSRRAQDF#VQWLMNT 27 |
| Monodelphis domestica | Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGT 102 +|+++||| |||| +| |||#| ||++ | +| + ||+ || |+|| Sbjct 51 QRYAEGTFISDYSITMDKIMQQDF#VNWLLSQKGKKN--SWRHNITERKADGT 100 |
| Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 ||||+|||||||||||++++|+||#|+|||| || + + + |||+|||| Sbjct 41 KRHSEGTFTSDYSKYLENKQAKDF#VRWLMNAKRGGSELQR------RHADGTFT 88 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNR---NNIAKRHDEFERHAE 100 +||+ ||||+| + |||++ |+||#| || + ++| + + | +|||| Sbjct 80 RRHADGTFTNDMTSYLDAKAARDF#VSWLARSDKSRRDGGDHLAENSEDKRHAE 132 |
| Xenopus laevis | Query 45 DQMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 +|+ | ||||||||||||||||||||||||#|||||||||+ +++|+ ++||||||||| Sbjct 45 EQLKEVKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRS-GGLSRRNADYERHAEGTFT 103 Query 49 EDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 | +||++||+|+| ++||+ + + |#++||+ | + + |||||||| Sbjct 138 EIERHAEGTYTNDVTEYLEEKATKAF#IEWLIKGK-------PKKIRYSRHAEGTFT 186 Query 52 RHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRH 92 ||++||||+| + ||+ + |++|#| ||+| + | ++ + | Sbjct 179 RHAEGTFTNDMTNYLEEKAAKEF#VGWLINGRPKRKDLLEEH 219 |
| Hoplobatrachus rugulosus | Query 45 DQMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 | || ||||||||||||||||||||||||#||||||+||+ |+||+ +||||||||+| Sbjct 45 DHHNEVKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNSKRS-GGISKRNVQFERHAEGTYT 103 Query 52 RHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFE-RHAEGTFT 104 ||++|||||| + ||+ + |++|#| ||+ + || +| + |||+|+|| Sbjct 134 RHAEGTFTSDMTSYLEEKAAKEF#VDWLIKGRPKRNFPDISAEEMDRRHADGSFT 187 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 +||++||+|+| +++|+ + |++|#+ ||+ | + ++ |||||||| Sbjct 95 ERHAEGTYTNDVTQFLEEKAAKEF#IDWLIKGKPKKQRLS-------RHAEGTFT 141 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNT 81 |+||+ |+||||++| || + ||+|#+ |++|| Sbjct 178 DRRHADGSFTSDFNKALDIKAAQEF#LDWIINT 209 |
| Gallus gallus | Query 46 QMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRN------------------RNN 87 |+|| ||||||||||||||||||||||||#|||||+|||| | Sbjct 48 QLNEVKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMSTKRNGQQGQEDKENDKFPDQLSSNA 107 Query 88 IAKRHDEFERHAEGTFT 104 |+||| |||||||||+| Sbjct 108 ISKRHSEFERHAEGTYT 124 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAK---RHDEFERHAEGTFT 104 +| +||++||+||| + ||+ + |++|#+ ||+| + |+ | + |||+|||| Sbjct 113 SEFERHAEGTYTSDITSYLEGQAAKEF#IAWLVNGRGRRDFPEKALMAEEMGRRHADGTFT 172 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNI 88 +||+ |||||| +| || |++|#++||+||| + ++ Sbjct 164 RRHADGTFTSDINKILDDMAAKEF#LKWLINTKVTQRDL 201 |
| Meleagris gallopavo | Query 46 QMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRN------------------RNN 87 |+|| ||||||||||||||||||||||||#|||||+|||| | Sbjct 48 QLNEVKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMSTKRNGQQGQEDKENDEFPDQLSSNA 107 Query 88 IAKRHDEFERHAEGTFT 104 |+||| |||||||||+| Sbjct 108 ISKRHSEFERHAEGTYT 124 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAK---RHDEFERHAEGTFT 104 +| +||++||+||| + ||+ + |++|#+ ||+| + |+ | + |||+|||| Sbjct 113 SEFERHAEGTYTSDITSYLEGQAAKEF#IAWLVNGRGRRDFPEKALMAEEMGRRHADGTFT 172 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNI 88 +||+ |||||| +| || |++|#++||+||| + ++ Sbjct 164 RRHADGTFTSDINKILDDMAAKEF#LKWLINTKVTQRDL 201 |
| Bufo marinus | Query 52 RHSQGTFTSDYSKYLDSRRAQDF#VQWLM--NTKRNRNNIAKRHDEFERHAEGTFT 104 ||++|||||| + +|+ + |++|#| ||+ ||| ++++ | |||+|+|| Sbjct 62 RHAEGTFTSDMTSFLEEKAAKEF#VDWLIKGRPKRNFSDVSAADDMDRRHADGSFT 116 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 +||++||+|+| +++|+ + |++|#+ ||+ | |+ |||||||| Sbjct 23 ERHAEGTYTNDVTQFLEEKAAKEF#IDWLL------KGIPKK-QRLSRHAEGTFT 69 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNT 81 |+||+ |+||||++| || + ||+|#+ |++|| Sbjct 107 DRRHADGSFTSDFNKALDIKAAQEF#LDWIINT 138 Query 73 DF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 ||# |||||+||+ +++|+ +||||||||+| Sbjct 1 DF#AQWLMNSKRS-GGMSRRNVQFERHAEGTYT 31 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | Query 46 QMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKR------------------NRNN 87 |+|| |||||||||||||||||+||||||#||||||||| + | Sbjct 46 QLNEVKRHSQGTFTSDYSKYLDTRRAQDF#VQWLMNTKRSGQQGVEEREKENLLDQLSSNG 105 Query 88 IAKRHDEFERHAEGTFT 104 +|+ | |+||||+| +| Sbjct 106 LARHHAEYERHADGRYT 122 Query 49 EDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAK---RHDEFERHAEGTFT 104 | +||+ | +||| | ||+ + |++|#+ ||+| + |+ + + | |||+|||| Sbjct 112 EYERHADGRYTSDISSYLEGQAAKEF#IAWLVNGRGRRDFLEEAGTADDIGRRHADGTFT 170 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNI 88 +||+ |||||||++ || |+|#++||+| | + ++ Sbjct 162 RRHADGTFTSDYNQLLDDIATQEF#LKWLINQKVTQRDL 199 |
| Capra hircus | Query 86 NNIAKRHDEFERHAEGTFT 104 ||||||||||||||||||| Query 86 NNIAKRHDEFERHAEGTFT 104 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNR 85 +| +||++|||||| | ||+ + |++|#+ ||+ + | Sbjct 8 DEFERHAEGTFTSDVSSYLEGQAAKEF#IAWLVKGRGRR 45 |
| Oncorhynchus tshawytscha | Query 54 SQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 | |||++||||| + | ||||#||||||+||+ +|||+||+| Sbjct 2 SXGTFSNDYSKYQEERMAQDF#VQWLMNSKRS-------GAPSKRHADGTYT 45 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNR 85 |||+ ||+||| | || + |+||#| || + + | Sbjct 37 KRHADGTYTSDVSTYLQDQAAKDF#VSWLKSGRARR 71 |
| Ictalurus punctatus | Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 +|||+|||++||||||++||||||#||||||+||+ |||+||+| Sbjct 49 RRHSEGTFSNDYSKYLETRRAQDF#VQWLMNSKRS-------DSPARRHADGTYT 95 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEF--ERHAEGTFT 104 +||+ ||+||| | || + |+||#+ || + + + + | + || +|+|| Sbjct 87 RRHADGTYTSDVSSYLQDQAAKDF#ITWLKSGQPKPDAVETRSVDTLRRRHVDGSFT 142 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRH 92 +|| |+|||| +| ||| |+++#+||+||+ + + ||| Sbjct 134 RRHVDGSFTSDVNKVLDSLAAKEY#LQWVMNSPSSAS--GKRH 173 |
| Rattus norvegicus | Query 52 RHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHA 99 |+++||| |||| +| | |||#| ||+ | +|+ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKIRQQDF#VNWLLAQKGKKND--WKHNLTQREA 88 |
| Canis familiaris | Query 52 RHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHA 99 |+++||| |||| +| | |||#| ||+ | +|+ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKIRQQDF#VNWLLAQKGKKND--WKHNITQREA 88 |
| Xenopus tropicalis | Query 46 QMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 |+ | ||||||||||||||||||||||||#+||||||||+ +++|+ ++||||||||| Sbjct 46 QLKEVKRHSQGTFTSDYSKYLDSRRAQDF#IQWLMNTKRS-GGLSRRNADYERHAEGTFT 103 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 +||++|||||| +++|| + |++|#+ ||+| ++ |++|+ + |||||||+| Sbjct 95 ERHAEGTFTSDVTQHLDEKAAKEF#IDWLINGGPSKEIISRRNADVERHAEGTYT 148 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 +||++||+|+| ++||+ + |++|#++||+| | + + |||||||| Sbjct 140 ERHAEGTYTNDVTEYLEEKAAKEF#IEWLINGK-------PKKIRYSRHAEGTFT 186 Query 52 RHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFE---RHAEGTFT 104 ||++||||+| + ||+ + |++|#| ||+ | + | ++ | | |||+|+|| Sbjct 179 RHAEGTFTNDMTNYLEEKAAKEF#VGWLIK-GRPKRNFSEAHSVEEMDRRHADGSFT 233 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTK 82 |+||+ |+||+| +| || ||+|#+ |++||+ Sbjct 224 DRRHADGSFTNDINKVLDIIAAQEF#LDWVINTQ 256 |
| Pan troglodytes | Query 45 DQMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 ||||||||||||||||||||||||||||||#|||||||||| +++| |||||||| Sbjct 967 DQMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRN-SSVA------YRHAEGTFT 1019 Query 52 RHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNR 85 ||++|||||| | ||+ + |++|#+ ||+ + | Sbjct 1012 RHAEGTFTSDVSSYLEGQAAKEF#IAWLVKGRGRR 1045 |
| Danio rerio | Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 ||||+|||++||||||++||||||#|||||| ||| ++ +||||||+| Sbjct 48 KRHSEGTFSNDYSKYLETRRAQDF#VQWLMNAKRNGGSV-------KRHAEGTYT 94 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWL 78 |||++||+||| | || + || |#| || Sbjct 86 KRHAEGTYTSDVSSYLQDQAAQSF#VAWL 113 |
| Bos taurus | Query 47 MNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 ++ + ||+ | ||||||+ | |+ +#++ |+ || |+|++ +||++ || Sbjct 75 VSRNVRHADGVFTSDYSRLLGQLSAKKY#LESLIG-KRVSNSISEDQGPIKRHSDAVFT 131 |
| Macaca mulatta | Query 47 MNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 ++ + ||+ | ||||+|| | |+ +#++ || || +||++ +||++ || Sbjct 75 VSRNARHADGVFTSDFSKLLGQLSAKKY#LESLMG-KRVSSNISEDPVPVKRHSDAVFT 131 |
| Heloderma suspectum | Query 46 QMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKR------------------NRNN 87 |+|| |||||||||||||||||+||||||#||||||||| + | Sbjct 46 QLNEVKRHSQGTFTSDYSKYLDTRRAQDF#VQWLMNTKRSGQQGVEEREKENLLDQLSSNG 105 Query 88 IAKRHDEFERHAEGTFT 104 +|+ | |+||||+| +| Sbjct 106 LARHHAEYERHADGRYT 122 Query 49 EDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNR 85 | +||+ | +||| | ||+ + |++|#+ ||+| + | Sbjct 112 EYERHADGRYTSDISSYLEGQAAKEF#IAWLVNGRGRR 148 |
| Squalus acanthias | Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWL--MNTKRNRNNIAKRHDEFERHAEGTF 103 ++ |||++||+||| | +|+ |#| | | ++| +|+||| | || ||++ Sbjct 20 DKTKRHAEGTYTSDVDSLSDYFKAKRF#VDSLTSYNKRQNGRSISKRHVESTRHTEGSY 77 Query 67 DSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 |+|||+||#|||||+|||| |+ +||||||+| Sbjct 1 DNRRAKDF#VQWLMSTKRN-------GDKTKRHAEGTYT 31 Query 49 EDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRN---------NIAKRHDEFERHA 99 | ||++|++ | | ||+++ |+||#+ ||+ + | | + ||| Sbjct 68 ESTRHTEGSYR-DISSYLEAKAAKDF#INWLIKGRGRREFPEESKEIVNEVIPEEMDRRHA 126 Query 100 EGTFT 104 +|||| Sbjct 127 DGTFT 131 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFE 96 |+||+ |||||+ + ||+ |++|#+ |++|+| | | | | Sbjct 122 DRRHADGTFTSEINIVLDTIAAKEF#LNWILNSK----TIQSRDSEIE 164 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRN 84 |+ ||||+| + |||++ |+||#| || + ++ Sbjct 1 HADGTFTNDMTSYLDAKAARDF#VSWLARSDKS 32 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 ||||+|||++||||||++||||||#|||| |+||| | |||+||+| Sbjct 50 KRHSEGTFSNDYSKYLETRRAQDF#VQWLKNSKRN--------GLFRRHADGTYT 95 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWL 78 +||+ ||+||| | || + |+||#| || Sbjct 87 RRHADGTYTSDVSSYLQDQAAKDF#VSWL 114 |
| Sebastes caurinus | Query 45 DQMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 |+++ ||||+|||++|||+||+ |+||||#|+|||| ||+ || +|||+|||| Sbjct 42 DELSNMKRHSEGTFSNDYSRYLEERKAQDF#VRWLMNNKRS------GADE-KRHADGTFT 94 Query 49 EDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDE--FERHAEGTFT 104 ++|||+ |||||| | || + +||#| | + + | + + | || +|+|| Sbjct 84 DEKRHADGTFTSDVSSYLKDQAIKDF#VNRLKSGQVRRESETEWRGEAFSRRHVDGSFT 141 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDE 94 +|| |+|||| +| ||| |+++#+ |+| +| + + ++ |+ Sbjct 133 RRHVDGSFTSDVNKVLDSMAAKEY#LLWVMTSKPSGESKKRQEDQ 176 |
| Tetraodon nigroviridis | Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 ||||+|||++||||||++||||||#|||| |+||| + | |||+||+| Sbjct 787 KRHSEGTFSNDYSKYLETRRAQDF#VQWLKNSKRNGS-------LFRRHADGTYT 833 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNR 85 +||+ ||+||| | || + |++|#| || + | Sbjct 825 RRHADGTYTSDVSAYLQDQAAKEF#VSWLKTGRGRR 859 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 ||||+|||++||||||++||||||#|+||||+| | + +||||||+| Sbjct 48 KRHSEGTFSNDYSKYLETRRAQDF#VEWLMNSKSNGGSA-------KRHAEGTYT 94 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWL 78 |||++||+||| | +| + ||+|#| || Sbjct 86 KRHAEGTYTSDISSFLRDQAAQNF#VAWL 113 |
| Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 ||||+|||++||||| + | ||||#||||||+||+ +|||+||+| Sbjct 50 KRHSEGTFSNDYSKYQEERMAQDF#VQWLMNSKRS-------GAPSKRHADGTYT 96 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNI--AKRHDEFERHAEGTFT 104 |||+ ||+||| | || + |+||#| || + + | + ++ || +|+|| Sbjct 88 KRHADGTYTSDVSTYLQDQAAKDF#VSWLKSGRARRESAEESRNGPMSRRHVDGSFT 143 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHD 93 +|| |+|||| +| ||| |+++#+ |+| +| + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLDSLAAKEY#LLWVMTSKTSGKSNKRQED 177 |
| Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 || |+|||++ |||| + | |+||#+ ||||+||+ +|||+||+| Sbjct 50 KRQSEGTFSNYYSKYQEERMARDF#LHWLMNSKRS-------GAPSKRHADGTYT 96 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHD--EFERHAEGTFT 104 |||+ ||+||| | || + |+||#| || + | + + + || +|+|| Sbjct 88 KRHADGTYTSDVSTYLQDQAAKDF#VSWLKSGPARRESAEESMNGPMSRRHVDGSFT 143 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHD 93 +|| |+|||| +| ||| |+++#+ |+| +| + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLDSLAAKEY#LLWVMTSKTSGKSNKRQED 177 |
| Heloderma horridum | Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMN 80 |||| |||||| || ++ + |#++|| | Sbjct 46 KRHSDGTFTSDLSKQMEEEAVRLF#IEWLKN 75 |
| Mus musculus | Query 52 RHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHA 99 |+++||| |||| +| | |||#| ||+ + +++ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKIRQQDF#VNWLLAQRGKKSD--WKHNITQREA 88 |
| Protopterus dolloi | Query 49 EDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 | |||||||| |||+| |+++ | | #|| ||+||| ++|||+| |||||||+| Sbjct 28 EAKRHSQGTFMSDYAKLLEAKHALDL#VQRLMSTKRT-GAVSKRHNEIERHAEGTYT 82 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFE-RHAEGTFT 104 || +||++||+||| | ||+ + +|#++||| + |+ +| + |||+|| | Sbjct 71 NEIERHAEGTYTSDISSYLEGQAVNEF#IRWLMKGRGRRDFSETDIEEMDRRHADGTVT 128 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTK 82 |+||+ || ||| + |+| ++|#+ ||+| | Sbjct 119 DRRHADGTVTSDINSVLESIATREF#LNWLINAK 151 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTK 82 |+ |+|||| +| ||+ |++|#+ ||++|| Sbjct 1 HADGSFTSDINKVLDTIAAKEF#LNWLISTK 30 |
| Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | Query 47 MNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 ++ + ||+ | ||||||+ | |+ +#++ |+ || ++|++ +||++ || Sbjct 75 VSRNARHADGVFTSDYSRLLGQISAKKY#LESLIG-KRISSSISEDPVPIKRHSDAVFT 131 |
| Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | Query 52 RHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 |||||+|||||||+|| ++|+||#| ||+|||| + + +||++|+|| Sbjct 43 RHSQGSFTSDYSKHLDVKQAKDF#VTWLLNTKRRGVDAQAGANLEKRHSDGSFT 95 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKR 83 | +|||| |+||+| + || |++|#++|| | Sbjct 84 NLEKRHSDGSFTNDMNVMLDRMSAKNF#LEWLKQQGR 119 |
| Ambloplites rupestris | Query 53 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 |||||||+||+ ||+ |+||||#++|||| | |+ |++ |||+|||| Sbjct 1 HSQGTFTNDYTNYLEDRQAQDF#IRWLMNNK--RSGAAEK-----RHADGTFT 45 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDE--FERHAEGTFT 104 +|||+ |||| | | + +||#| | + + | | | || ||+|| Sbjct 36 EKRHADGTFTDDASSDFYDQAIKDF#VAKLKSGQDRREPETDRRREAFSRRHVEGSFT 92 |
| Arvicanthis ansorgei | Query 47 MNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 ++ + ||+ | ||||||+ | |+ +#++ |+ || ++| + +||++ || Sbjct 58 VSRNARHADGVFTSDYSRLLGQISAKKY#LESLIG-KRISSSILEDPVPIKRHSDAVFT 114 |
| synthetic construct | Query 45 DQMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 45 DQMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRN---NIAKRHDEFERHAEGTFT 104 +| +||++|||||| | ||+ + |++|#+ ||+ + |+ +| + |||+|+|+ Sbjct 93 DEFERHAEGTFTSDVSSYLEGQAAKEF#IAWLVKGRGRRDFPEEVAIVEELGRRHADGSFS 152 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTK 82 +||+ |+|+ + + ||+ |+||#+ ||+ || Sbjct 144 RRHADGSFSDEMNTILDNLAARDF#INWLIQTK 175 |
| Phodopus sungorus | Query 56 GTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRN---NIAKRHDEFERHAEGTFT 104 |||||| | ||+ + |++|#+ ||+ + |+ + + |||+|+|+ Sbjct 1 GTFTSDVSSYLEGQAAKEF#IAWLVKGRGRRDFPEEVTIVEELGRRHADGSFS 52 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTK 82 +||+ |+|+ + + ||| +||#+ ||+ || Sbjct 44 RRHADGSFSDEMNTILDSLATRDF#INWLIQTK 75 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | Query 46 QMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 +++ ||||+|||++||||||+ |+||+|#|+|||| | |+ +|++ |||+|||| Sbjct 46 ELSNMKRHSEGTFSNDYSKYLEDRKAQEF#VRWLMNNK--RSGVAEK-----RHADGTFT 97 Query 50 DKRHSQGTFTSDYSKYLDSRRAQDF#VQWL 78 +|||+ |||||| | || + +||#| | Sbjct 88 EKRHADGTFTSDVSSYLKDQAIKDF#VDRL 116 |
| Sus scrofa | Query 45 DQMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 ||| ||||||||||||||||||||||||||#||||||||||+||||||||||||||||||| Sbjct 45 DQMTEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNKNNIAKRHDEFERHAEGTFT 104 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRN---NIAKRHDEFERHAEGTFT 104 +| +||++|||||| | ||+ + |++|#+ ||+ + |+ + + |||+|+|+ Sbjct 93 DEFERHAEGTFTSDVSSYLEGQAAKEF#IAWLVKGRGRRDFPEEVTIVEELRRRHADGSFS 152 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTK 82 +||+ |+|+ + + ||+ +||#+ ||++|| Sbjct 144 RRHADGSFSDEMNTVLDNLATRDF#INWLLHTK 175 |
| Neoceratodus forsteri | Query 49 EDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 | |||||||| |||+| |++| | ||#|| ||||||| ++||| | |||||||+| Sbjct 20 EAKRHSQGTFMSDYAKLLEARHALDF#VQRLMNTKRN-GGVSKRHSEIERHAEGTYT 74 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEF-ERHAEGTFT 104 +| +||++||+||| | ||+ + | +|#|+||+ + |+ +| |||+|| | Sbjct 63 SEIERHAEGTYTSDISSYLEGQAANEF#VRWLLKGRGRRDFSDTDAEEMGRRHADGTIT 120 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTK 82 +||+ || |+| + |+| ++|#+ ||+|+| Sbjct 112 RRHADGTITNDMNNVLESIATREF#LNWLINSK 143 |
| Canis lupus familiaris | Query 45 DQMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 ||||||||||||||||||||||||||||||#||||||||||+||||||||||||||||||| Sbjct 45 DQMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNKNNIAKRHDEFERHAEGTFT 104 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRN---NIAKRHDEFERHAEGTFT 104 +| +||++|||||| | ||+ + |++|#+ ||+ + |+ +| + |||+|+|+ Sbjct 93 DEFERHAEGTFTSDVSSYLEGQAAKEF#IAWLVKGRGRRDFPEEVAIVEEFRRRHADGSFS 152 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTK 82 +||+ |+|+ + + ||+ +||#+ ||+ || Sbjct 144 RRHADGSFSDEMNTVLDTLATRDF#INWLLQTK 175 |
| Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | Query 53 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 |||||||+|||||||+||||||#|||||+|||+ | ||+||+| Sbjct 1 HSQGTFTNDYSKYLDTRRAQDF#VQWLMSTKRS-GGITXXXXXXXXHADGTYT 51 Query 53 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNR 85 |+ ||+||| | || + |+ |#| || + | Sbjct 45 HADGTYTSDVSSYLQDQAAKKF#VTWLKQGQDRR 77 |
| Hydrolagus colliei | Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 |||+ | |+||||||||+|| +||#||||++|||| | |+ +|||+| +| Sbjct 30 KRHTDGIFSSDYSKYLDNRRTKDF#VQWLLSTKRNGANT----DKTKRHADGIYT 79 Query 48 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNN--IAKRHDEFERHAE 100 ++ |||+ | +||| + | +++ |#|+ | | + +|+ ++||| | | | Sbjct 68 DKTKRHADGIYTSDVASLTDYLKSKRF#VESLSNYNKRQNDRRMSKRHVEGARRTE 122 Query 49 EDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFE 96 | | ++ + +|+| ||+++ |+||#+ ||+ + | + |+ | | Sbjct 116 EGARRTEEDYPNDFSSYLEAKAAKDF#IDWLIK-GQGRRDFAEESREIE 162 |
| Heloderma suspectum, venom, Peptide, 39 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDF#VQWLMN 80 | +|||||| || ++ + |#++|| | Sbjct 1 HGEGTFTSDLSKQMEEEAVRLF#IEWLKN 28 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | Query 56 GTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRN 86 ||+||| | || + |++|#| || + |+ Sbjct 3 GTYTSDVSSYLQDQAAKEF#VSWLKTGRGRRD 33 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | Query 53 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNR 85 |+ || ||| | +|+ + ++|#+ ||++ + | Sbjct 1 HADGTLTSDISSFLEKQATKEF#IAWLVSGRGRR 33 |
| Agkistrodon piscivorus | Query 49 EDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRH---DEFERHAEGTFT 104 | +||+ ||+||| | ||+ + |++|#+ ||+| + |+ | | |||+|||| Sbjct 32 EYERHADGTYTSDISSYLEGQAAKEF#IAWLVNGRGRRDFSEGAHTGEDLGRRHADGTFT 90 Query 51 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNI 88 +||+ |||||||+| || |+|#++||+| | + ++ Sbjct 82 RRHADGTFTSDYNKLLDDIATQEF#LKWLINQKVTQRDL 119 Query 66 LDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 |+ | ++|#+ | + | +|+ | |+||||+||+| Sbjct 9 LEDREKENF#LDQLAS-----NGLARPHAEYERHADGTYT 42 |
* References
[PubMed ID: 6877358] Bell GI, Sanchez-Pescador R, Laybourn PJ, Najarian RC, Exon duplication and divergence in the human preproglucagon gene. Nature. 1983 Jul 28-Aug 3;304(5924):368-71.