XSB0349 : epidermal growth factor receptor [Danio rerio]
[ CaMP Format ]
This entry is computationally expanded from SB0050
* Basic Information
| Organism | Danio rerio (zebrafish) |
| Protein Names | epidermal growth factor receptor |
| Gene Names | egfr |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 1191 aa
Average Mass: 132.660 kDa
Monoisotopic Mass: 132.573 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Recep_L_domain 1. | 54 | 166 | 115.0 | 2.4e-31 |
| Furin-like 1. | 182 | 336 | 281.5 | 1.9e-81 |
| Recep_L_domain 2. | 359 | 479 | 139.4 | 1.1e-38 |
| SapA 1. | 573 | 599 | -10.7 | 3.1 |
| SKG6 1. | 638 | 671 | -3.2 | 1.7 |
| Pkinase_Tyr 1. | 711 | 967 | 459.4 | 5.2e-135 |
| --- cleavage 732 (inside Pkinase_Tyr 711..967) --- | ||||
3. Sequence Information
Fasta Sequence: XSB0349.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] GTVHKGLWVP732-EGENVKIPVA
Pro732 
Glu
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gly723 | Thr724 | Val725 | His726 | Lys727 | Gly728 | Leu729 | Trp730 | Val731 | Pro732 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Glu733 | Gly734 | Glu735 | Asn736 | Val737 | Lys738 | Ile739 | Pro740 | Val741 | Ala742 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| LRILKETEFKKIKVLGSGAFGTVHKGLWVPEGENVKIPVAIKVLREATSPKANKEIMDEA |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Danio rerio | 120.00 | 5 | epidermal growth factor receptor |
| 2 | N/A | 112.00 | 23 | - |
| 3 | Homo sapiens | 112.00 | 18 | epidermal growth factor receptor isoform a |
| 4 | Mus musculus | 112.00 | 10 | AF275367_1 epidermal growth factor receptor |
| 5 | Pan troglodytes | 112.00 | 8 | PREDICTED: epidermal growth factor receptor isofor |
| 6 | Rattus norvegicus | 112.00 | 8 | epidermal growth factor receptor |
| 7 | Macaca mulatta | 112.00 | 6 | PREDICTED: epidermal growth factor receptor, parti |
| 8 | Monodelphis domestica | 112.00 | 4 | PREDICTED: similar to Epidermal growth factor rece |
| 9 | synthetic construct | 112.00 | 4 | epidermal growth factor receptor |
| 10 | Canis familiaris | 112.00 | 4 | PREDICTED: similar to Epidermal growth factor rece |
| 11 | Tetraodon nigroviridis | 112.00 | 3 | unnamed protein product |
| 12 | Rous-associated virus type 1 | 112.00 | 2 | polyprotein |
| 13 | Sus scrofa | 112.00 | 2 | epidermal growth factor receptor |
| 14 | Bos taurus | 112.00 | 1 | PREDICTED: similar to epidermal growth factor rece |
| 15 | Xiphophorus xiphidium | 111.00 | 2 | epidermal growth factor receptor |
| 16 | Xenopus laevis | 110.00 | 3 | epidermal growth factor receptor |
| 17 | Felis catus | 108.00 | 2 | v-erb-b2 erythroblastic leukemia viral oncogene ho |
| 18 | Mesocricetus auratus | 108.00 | 1 | ERBB2_MESAU Receptor tyrosine-protein kinase erbB- |
| 19 | Canis lupus familiaris | 108.00 | 1 | erbB-2 |
| 20 | Gallus gallus | 107.00 | 5 | erbB-2 |
| 21 | Avian erythroblastosis virus | 107.00 | 2 | gag,v-erb-A,v-erb-B |
| 22 | Xiphophorus sp. | 104.00 | 1 | XMRK_XIPMA Melanoma receptor tyrosine-protein kina |
| 23 | Ovis aries | 96.30 | 1 | erythroblastic leukemia viral oncogene-like 2 |
| 24 | Pongo pygmaeus | 79.30 | 1 | ERBB3_PONPY Receptor tyrosine-protein kinase erbB- |
| 25 | Ciona intestinalis | 77.80 | 1 | epidermal growth factor receptor |
| 26 | Drosophila melanogaster | 77.40 | 127 | mutant epidermal growth factor receptor |
| 27 | Anopheles gambiae | 76.60 | 1 | putative epidermal growth factor receptor |
| 28 | Anopheles gambiae str. PEST | 76.60 | 1 | ENSANGP00000018805 |
| 29 | Strongylocentrotus purpuratus | 76.30 | 1 | PREDICTED: similar to v-erb-a erythroblastic leuke |
| 30 | Drosophila simulans | 75.50 | 1 | epidermal growth factor receptor |
Top-ranked sequences
| organism | matching |
|---|---|
| Danio rerio | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |
| N/A | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||||||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |
| Homo sapiens | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||||||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 704 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 763 |
| Mus musculus | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||||||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |
| Pan troglodytes | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||||||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 704 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 763 |
| Rattus norvegicus | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||||||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 705 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 764 |
| Macaca mulatta | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||||||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 704 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 763 |
| Monodelphis domestica | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||||||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 730 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 789 |
| synthetic construct | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||||||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 704 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 763 |
| Canis familiaris | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||||||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 1092 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 1151 |
| Tetraodon nigroviridis | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||| ||||||||||||||||+||||||#|||+||||||||||||||||||||+|+||| Sbjct 674 LRILKEPEFKKIKVLGSGAFGTVYKGLWVP#EGEDVKIPVAIKVLREATSPKANKDILDEA 733 |
| Rous-associated virus type 1 | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||+|||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 278 LRILKETEFKKVKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 337 |
| Sus scrofa | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||+|||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 699 LRILKETEFKKVKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 758 |
| Bos taurus | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||+|||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 681 LRILKETEFKKVKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 740 |
| Xiphophorus xiphidium | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||| ||||||||||||||||+||||||#|||+|||||||||||||||||||+||+||| Sbjct 714 LRILKEPEFKKIKVLGSGAFGTVYKGLWVP#EGEDVKIPVAIKVLREATSPKANQEILDEA 773 |
| Xenopus laevis | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||||||||||||||++|||+|#||| +||||||| |||||||||||||+||| Sbjct 289 LRILKETEFKKIKVLGSGAFGTVYQGLWIP#EGEGIKIPVAIKELREATSPKANKEILDEA 348 |
| Felis catus | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 +||||||| +|+|||||||||||+||+|+|#+||||||||||||||| |||||||||+||| Sbjct 712 MRILKETELRKVKVLGSGAFGTVYKGIWIP#DGENVKIPVAIKVLRENTSPKANKEILDEA 771 |
| Mesocricetus auratus | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 +||||||| +|+|||||||||||+||+|+|#+||||||||||||||| |||||||||+||| Sbjct 712 MRILKETELRKVKVLGSGAFGTVYKGIWIP#DGENVKIPVAIKVLRENTSPKANKEILDEA 771 |
| Canis lupus familiaris | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 +||||||| +|+|||||||||||+||+|+|#+||||||||||||||| |||||||||+||| Sbjct 711 MRILKETELRKVKVLGSGAFGTVYKGIWIP#DGENVKIPVAIKVLRENTSPKANKEILDEA 770 |
| Gallus gallus | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 +||||||| ||+|||||||||||+||+|+|#+||+|||||||||||| |||||||||+||| Sbjct 701 MRILKETELKKVKVLGSGAFGTVYKGIWIP#DGESVKIPVAIKVLRENTSPKANKEILDEA 760 |
| Avian erythroblastosis virus | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||+|||| ||||||+||||+|#||| | |||||| |||||||||||||+||| Sbjct 546 LRILKETEFKKVKVLGFGAFGTVYKGLWIP#EGEKVTIPVAIKELREATSPKANKEILDEA 605 |
| Xiphophorus sp. | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 ||||||||||| +||||||||||+|||| |#+|||++||||||||||||||| |+|++||| Sbjct 702 LRILKETEFKKDRVLGSGAFGTVYKGLWNP#DGENIRIPVAIKVLREATSPKVNQEVLDEA 761 |
| Ovis aries | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKAN 755 +||||||| +|+|||||||||||+||+|+|#+||||||||||||||| |||||| Sbjct 63 MRILKETELRKVKVLGSGAFGTVYKGIWIP#DGENVKIPVAIKVLRENTSPKAN 115 |
| Pongo pygmaeus | Query 704 RILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMD 760 || |||| ||+|||||| |||||||+|+|#|||++|||| |||+ + + ++ + + | Sbjct 702 RIFKETELKKLKVLGSGVFGTVHKGVWIP#EGESIKIPVCIKVIEDKSGRQSFQAVTD 758 |
| Ciona intestinalis | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#E---GENVKIPVAIKVLREATSPKANKEIM 759 |||+|| | + |+|||||||||||| |+|#+ | ||+||||||||+ +| |+ ||+ Sbjct 115 LRIVKEAELRIGKILGSGAFGTVHKGYWIP#DLAPRERVKVPVAIKVLRDESSQVASNEIL 174 Query 760 DEA 762 ||| Query 760 DEA 762 |
| Drosophila melanogaster | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||+|+|| +| ||| |||| |+||+|||#|||||||||||| | ++| ++++| + || Sbjct 830 LRIVKDTELRKGGVLGMGAFGRVYKGVWVP#EGENVKIPVAIKELLKSTGAESSEEFLREA 889 |
| Anopheles gambiae | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||+|| | ++ ||| |||| | ||+|+|#|||+|||||||||| | + +++|| ++|| Sbjct 826 LRIIKEAEIRRGGVLGMGAFGRVFKGVWMP#EGESVKIPVAIKVLMEMSGSESSKEFLEEA 885 |
| Anopheles gambiae str. PEST | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||+|| | ++ ||| |||| | ||+|+|#|||+|||||||||| | + +++|| ++|| Sbjct 827 LRIIKEAEIRRGGVLGMGAFGRVFKGVWMP#EGESVKIPVAIKVLMEMSGSESSKEFLEEA 886 |
| Strongylocentrotus purpuratus | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMD 760 |+|+|+|| | ||||||||||+||||+|#+|| ++|||||| ||| || | +|+++ Sbjct 1012 LKIIKDTELKLGPVLGSGAFGTVYKGLWIP#DGEKIRIPVAIKALRE-VSPHAAEELLE 1068 |
| Drosophila simulans | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||+|+ | +| ||| |||| |+||+|||#|||||||||||| | ++| ++++| + || Sbjct 829 LRIVKDAELRKGGVLGMGAFGRVYKGVWVP#EGENVKIPVAIKELLKSTGAESSEEFLREA 888 |
* References
None.