XSB0360 : 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
[ CaMP Format ]
This entry is computationally expanded from SB0008
* Basic Information
| Organism | Mus musculus (house mouse) |
| Protein Names | Phosphoinositide phospholipase C; Phospholipase C-beta-1; PLC-beta-1; PLC-I; PLC-154; 3.1.4.11 |
| Gene Names | Plcb |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 1216 aa
Average Mass: 138.325 kDa
Monoisotopic Mass: 138.238 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Chitin_synth_1 1. | 92 | 181 | -114.0 | 0.99 |
| efhand_like 1. | 224 | 315 | 164.0 | 4.4e-46 |
| PI-PLC-X 1. | 318 | 468 | 327.6 | 2.6e-95 |
| PI-PLC-Y 1. | 539 | 656 | 292.0 | 1.3e-84 |
| C2 1. | 678 | 761 | 55.9 | 1.5e-13 |
| --- cleavage 880 --- | ||||
| DUF1154 1. | 903 | 946 | 7.0 | 0.0029 |
| PLC-beta_C 1. | 997 | 1189 | 426.1 | 5.4e-125 |
3. Sequence Information
Fasta Sequence: XSB0360.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] APKPPSQAPH880-SQPAPGSVKA
His880 
Ser
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ala871 | Pro872 | Lys873 | Pro874 | Pro875 | Ser876 | Gln877 | Ala878 | Pro879 | His880 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ser881 | Gln882 | Pro883 | Ala884 | Pro885 | Gly886 | Ser887 | Val888 | Lys889 | Ala890 |
Sequence conservation (by blast)
* References
[PubMed ID: 11471062] Ehringer MA, Thompson J, Conroy O, Xu Y, Yang F, Canniff J, Beeson M, Gordon L, Bennett B, Johnson TE, Sikela JM, High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Mamm Genome. 2001 Aug;12(8):657-63.