XSB0369 : PTPRN protein [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0024
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | PTPRN protein |
| Gene Names | PTPRN |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Text: For general information about protein-tyrosine phosphatases (PTPases), see PTPRA (OMIM:176884). Lan et al. (1994) sought to identify genes uniquely and differentially expressed in human beta islet cells of the pancreas. They isolated a gene with homology to receptor type PTPases and obtained a full-length cDNA sequence, termed IA2 by them, from several cDNA clones obtained from a human insulinoma cDNA library. IA2 encodes a 979-amino acid protein with an approximate mass of 105 kD. In contrast to most other receptor PTPases which have 2 tandem PTPase domains, the authors observed that IA2 has a single transmembrane domain and only 1 PTPase domain. Lan et al. (1994) showed by Northern blotting that IA2 is expressed as a 3.8-kb transcript in human brain, pituitary, pancreas, and 5 of 5 insulinoma cell lines studied.
* Structure Information
1. Primary Information
Length: 811 aa
Average Mass: 87.841 kDa
Monoisotopic Mass: 87.786 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Prim-Pol 1. | 102 | 277 | -40.2 | 4.9 |
| FDX-ACB 1. | 306 | 382 | -50.9 | 1.5 |
| Gram_pos_anchor 1. | 388 | 428 | 2.4 | 1.8 |
| --- cleavage 440 --- | ||||
| Y_phosphatase 1. | 566 | 800 | 384.7 | 1.6e-112 |
3. Sequence Information
Fasta Sequence: XSB0369.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] CVRQHARQQD440-KERLAALGPE
Asp440 
Lys
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Cys431 | Val432 | Arg433 | Gln434 | His435 | Ala436 | Arg437 | Gln438 | Gln439 | Asp440 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Lys441 | Glu442 | Arg443 | Leu444 | Ala445 | Ala446 | Leu447 | Gly448 | Pro449 | Glu450 |
Sequence conservation (by blast)
* References
[PubMed ID: 12477932] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.