XSB0380 : unknown [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0050
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Putative uncharacterized protein EGFR; unknown |
| Gene Names | EGFR |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 387 aa
Average Mass: 43.533 kDa
Monoisotopic Mass: 43.505 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Pkinase_Tyr 1. | 1 | 145 | 105.3 | 2.1e-28 |
3. Sequence Information
Fasta Sequence: XSB0380.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
4 [sites]
Cleavage sites (±10aa)
[Site 1] VQPTCVNSTF328-DSPAHWAQKG
Phe328 
Asp
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Val319 | Gln320 | Pro321 | Thr322 | Cys323 | Val324 | Asn325 | Ser326 | Thr327 | Phe328 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Asp329 | Ser330 | Pro331 | Ala332 | His333 | Trp334 | Ala335 | Gln336 | Lys337 | Gly338 |
Sequence conservation (by blast)
[Site 2] FFPKEAKPNG362-IFKGSTAENA
Gly362 Ile
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Phe353 | Phe354 | Pro355 | Lys356 | Glu357 | Ala358 | Lys359 | Pro360 | Asn361 | Gly362 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ile363 | Phe364 | Lys365 | Gly366 | Ser367 | Thr368 | Ala369 | Glu370 | Asn371 | Ala372 |
Sequence conservation (by blast)
[Site 3] IDRNGLQSCP236-IKEDSFLQRY
Pro236 Ile
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ile227 | Asp228 | Arg229 | Asn230 | Gly231 | Leu232 | Gln233 | Ser234 | Cys235 | Pro236 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ile237 | Lys238 | Glu239 | Asp240 | Ser241 | Phe242 | Leu243 | Gln244 | Arg245 | Tyr246 |
Sequence conservation (by blast)
[Site 4] LTEDSIDDTF263-LPVPEYINQS
Phe263 Leu
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Leu254 | Thr255 | Glu256 | Asp257 | Ser258 | Ile259 | Asp260 | Asp261 | Thr262 | Phe263 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Leu264 | Pro265 | Val266 | Pro267 | Glu268 | Tyr269 | Ile270 | Asn271 | Gln272 | Ser273 |
Sequence conservation (by blast)
* References
[PubMed ID: 12853948] Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, Vanbrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam AM, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang SP, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, Wilson RK, The DNA sequence of human chromosome 7. Nature. 2003 Jul 10;424(6945):157-64.