XSB0389 : Calcium/calmodulin-dependent protein kinase type IV
[ CaMP Format ]
This entry is computationally expanded from SB0006
* Basic Information
| Organism | Rattus sp. |
| Protein Names | CaMK IV; 2.7.11.17; CAM kinase-GR; Calspermin; CaM kinase IV beta [Rattus sp.]; CaM kinase IV beta |
| Gene Names | Ca2+/calmodulin-dependent protein kinase IV beta polypeptide, CaM kinase IV beta; Camk4 |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein |
Entrez Nucleotide |
Entrez Gene |
UniProt |
OMIM |
HGNC |
HPRD |
KEGG |
| AAB28372 |
N/A |
N/A |
P13234 |
N/A |
N/A |
N/A |
rno:25050 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 502 aa
Average Mass: 55.706 kDa
Monoisotopic Mass: 55.671 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| --- cleavage 51 --- |
| Pkinase 1. | 70 | 324 | 402.5 | 7.2e-118 |
| RNA_pol_delta 1. | 334 | 468 | -81.8 | 3.7 |
3. Sequence Information
Fasta Sequence: XSB0389.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] CSSVTSSTEN51-LVPDYWIDGS
Asn51 
Leu
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Cys42 | Ser43 | Ser44 | Val45 | Thr46 | Ser47 | Ser48 | Thr49 | Glu50 | Asn51 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Leu52 | Val53 | Pro54 | Asp55 | Tyr56 | Trp57 | Ile58 | Asp59 | Gly60 | Ser61 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
FRSPAAKMLKVTVPSCPSSPCSSVTSSTENLVPDYWIDGSKRDPLSDFFEVESELGRGAT
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
N/A |
82.80 |
3 |
1 |
| 2 |
Rattus sp. |
82.80 |
1 |
Ca2+/calmodulin-dependent protein kinase IV beta p |
| 3 |
Rattus norvegicus |
77.00 |
2 |
calmodulin-dependent protein kinase IV |
| 4 |
Homo sapiens |
67.80 |
2 |
CAMK4 protein |
| 5 |
Pan troglodytes |
67.80 |
1 |
PREDICTED: calcium/calmodulin-dependent protein ki |
| 6 |
Macaca mulatta |
67.80 |
1 |
PREDICTED: calcium/calmodulin-dependent protein ki |
| 7 |
Mus musculus |
67.40 |
2 |
calcium/calmodulin-dependent protein kinase IV |
| 8 |
Bos taurus |
63.50 |
1 |
PREDICTED: similar to calcium/calmodulin-dependent |
| 9 |
Macaca fascicularis |
62.00 |
2 |
unnamed protein product |
| 10 |
synthetic construct |
62.00 |
1 |
calcium/calmodulin-dependent protein kinase IV |
| 11 |
Danio rerio |
52.80 |
1 |
calcium/calmodulin-dependent protein kinase IV |
| 12 |
Monodelphis domestica |
52.40 |
1 |
PREDICTED: similar to calcium/calmodulin-dependent |
| 13 |
Xenopus laevis |
50.10 |
1 |
calcium/calmodulin-dependent protein kinase IV |
| 14 |
Gallus gallus |
50.10 |
1 |
calcium/calmodulin-dependent protein kinase IV |
Top-ranked sequences
| organism | matching |
|---|
| N/A |
Query 22 FRSPAAKMLKXXXXXXXXXXXXXXXXXXEN#LVPDYWIDGSKRDPLSDFFEVESELGRGAT 81
|||||||||| ||#||||||||||||||||||||||||||||||
Sbjct 22 FRSPAAKMLKVTVPSCPSSPCSSVTSSTEN#LVPDYWIDGSKRDPLSDFFEVESELGRGAT 81
|
| Rattus sp. |
Query 22 FRSPAAKMLKXXXXXXXXXXXXXXXXXXEN#LVPDYWIDGSKRDPLSDFFEVESELGRGAT 81
|||||||||| ||#||||||||||||||||||||||||||||||
Sbjct 22 FRSPAAKMLKVTVPSCPSSPCSSVTSSTEN#LVPDYWIDGSKRDPLSDFFEVESELGRGAT 81
|
| Rattus norvegicus |
Query 22 FRSPAAKMLKXXXXXXXXXXXXXXXXXXEN#LVPDYWIDGSKRDPLSDFFEVESELGR 78
|||||||||| ||#|||||||||||||||||||||||||||
Sbjct 22 FRSPAAKMLKVTVPSCPSSPCSSVTSSTEN#LVPDYWIDGSKRDPLSDFFEVESELGR 78
|
| Homo sapiens |
Query 22 FRSPAAKMLKXXXXXXXXXXXXXXXXXXE----N#LVPDYWIDGSKRDPLSDFFEVESELG 77
|||||||||| +#|||||||||| || ||||||||||||
Sbjct 24 FRSPAAKMLKVTVPSCSASSCSSVTASAAPGTAS#LVPDYWIDGSNRDALSDFFEVESELG 83
Query 78 RGAT 81
||||
Query 78 RGAT 81
|
| Pan troglodytes |
Query 22 FRSPAAKMLKXXXXXXXXXXXXXXXXXXE----N#LVPDYWIDGSKRDPLSDFFEVESELG 77
|||||||||| +#|||||||||| || ||||||||||||
Sbjct 124 FRSPAAKMLKVTVPSCSASSCSSVTASAAPGTAS#LVPDYWIDGSNRDALSDFFEVESELG 183
Query 78 RGAT 81
||||
Query 78 RGAT 81
|
| Macaca mulatta |
Query 22 FRSPAAKMLKXXXXXXXXXXXXXXXXXXE----N#LVPDYWIDGSKRDPLSDFFEVESELG 77
|||||||||| +#|||||||||| || ||||||||||||
Sbjct 134 FRSPAAKMLKVTVPSCSASSCSSVTASAAPGTAS#LVPDYWIDGSNRDALSDFFEVESELG 193
Query 78 RGAT 81
||||
Query 78 RGAT 81
|
| Mus musculus |
Query 50 EN#LVPDYWIDGSKRDPLSDFFEVESELGRGAT 81
||#|||||||||| |||| ||||||||||||||
Sbjct 22 EN#LVPDYWIDGSNRDPLGDFFEVESELGRGAT 53
|
| Bos taurus |
Query 23 RSPAAKMLKXXXXXXXXXXXXXXXXXXE----N#LVPDYWIDGSKRDPLSDFFEVESELGR 78
||||||||| +#||||||+||| || | |||||||||||
Sbjct 258 RSPAAKMLKVTTPSCSASSCSSVTATVAPGPGS#LVPDYWVDGSNRDALGDFFEVESELGR 317
Query 79 GAT 81
|||
Query 79 GAT 81
|
| Macaca fascicularis |
Query 51 N#LVPDYWIDGSKRDPLSDFFEVESELGRGAT 81
+#|||||||||| || ||||||||||||||||
Sbjct 27 S#LVPDYWIDGSNRDALSDFFEVESELGRGAT 57
|
| synthetic construct |
Query 51 N#LVPDYWIDGSKRDPLSDFFEVESELGRGAT 81
+#|||||||||| || ||||||||||||||||
Sbjct 27 S#LVPDYWIDGSNRDALSDFFEVESELGRGAT 57
|
| Danio rerio |
Query 54 PDYWIDGSKRDPLSDFFEVESELGRGAT 81
|+|||||||++ |+||+|+|||||||||
Sbjct 13 PEYWIDGSKKETLADFYELESELGRGAT 40
|
| Monodelphis domestica |
Query 55 DYWIDGSKRDPLSDFFEVESELGRGAT 81
||||||| +| |+||||||+|||||||
Sbjct 96 DYWIDGSNKDSLNDFFEVETELGRGAT 122
|
| Xenopus laevis |
Query 54 PDYWIDGSKRDPLSDFFEVESELGRGAT 81
|||||||| +| |+ ++|+|||||||||
Sbjct 35 PDYWIDGSNKDTLAHYYELESELGRGAT 62
|
| Gallus gallus |
Query 54 PDYWIDGSKRDPLSDFFEVESELGRGAT 81
|||||||| +| |+ +|++|||||||||
Sbjct 15 PDYWIDGSNKDTLTHYFDLESELGRGAT 42
|
* References
[PubMed ID: 8412563] Sakagami H, Kondo H, Cloning and sequencing of a gene encoding the beta polypeptide of Ca2+/calmodulin-dependent protein kinase IV and its expression confined to the mature cerebellar granule cells. Brain Res Mol Brain Res. 1993 Aug;19(3):215-8.
