XSB0419 : epidermal growth factor receptor isoform 1 [Mus musculus]
[ CaMP Format ]
This entry is computationally expanded from SB0050
* Basic Information
| Organism | Mus musculus (house mouse) |
| Protein Names | Epidermal growth factor receptor; 2.7.10.1; epidermal growth factor receptor isoform 1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; waved 2 |
| Gene Names | Egfr; epidermal growth factor receptor |
| Gene Locus | 11 9.0 cM; chromosome 11 |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 1210 aa
Average Mass: 134.853 kDa
Monoisotopic Mass: 134.766 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Recep_L_domain 1. | 57 | 168 | 146.5 | 8.3e-41 |
| Furin-like 1. | 184 | 338 | 265.1 | 1.6e-76 |
| Recep_L_domain 2. | 361 | 481 | 140.8 | 4.4e-39 |
| Toxin_16 1. | 490 | 529 | -1.6 | 6.6 |
| NinF 1. | 549 | 614 | -0.5 | 2.9 |
| Gram_pos_anchor 1. | 637 | 674 | -1.4 | 4.2 |
| Pkinase_Tyr 1. | 714 | 970 | 442.5 | 6.5e-130 |
| --- cleavage 735 (inside Pkinase_Tyr 714..970) --- | ||||
3. Sequence Information
Fasta Sequence: XSB0419.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] GTVYKGLWIP735-EGEKVKIPVA
Pro735 
Glu
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gly726 | Thr727 | Val728 | Tyr729 | Lys730 | Gly731 | Leu732 | Trp733 | Ile734 | Pro735 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Glu736 | Gly737 | Glu738 | Lys739 | Val740 | Lys741 | Ile742 | Pro743 | Val744 | Ala745 |
Sequence conservation (by blast)
* References
[PubMed ID: 19305428] Chung BM, Dimri M, George M, Reddi AL, Chen G, Band V, Band H, The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutants. Oncogene. 2009 Apr 23;28(16):1821-32. Epub 2009 Mar 23.