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XSB0428 : PTPRN protein [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0024

* Basic Information

OrganismHomo sapiens (human)
Protein NamesPTPRN protein; Protein tyrosine phosphatase, receptor type, N, isoform CRA_a
Gene NamesPTPRN; hCG_15565
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
AAH70053 N/A 5798 Q6NSL1 601773 N/A N/A hsa:5798

* Information From OMIM

Text: For general information about protein-tyrosine phosphatases (PTPases), see PTPRA (OMIM:176884). Lan et al. (1994) sought to identify genes uniquely and differentially expressed in human beta islet cells of the pancreas. They isolated a gene with homology to receptor type PTPases and obtained a full-length cDNA sequence, termed IA2 by them, from several cDNA clones obtained from a human insulinoma cDNA library. IA2 encodes a 979-amino acid protein with an approximate mass of 105 kD. In contrast to most other receptor PTPases which have 2 tandem PTPase domains, the authors observed that IA2 has a single transmembrane domain and only 1 PTPase domain. Lan et al. (1994) showed by Northern blotting that IA2 is expressed as a 3.8-kb transcript in human brain, pituitary, pancreas, and 5 of 5 insulinoma cell lines studied.

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* Structure Information

1. Primary Information

Length: 950 aa

Average Mass: 102.817 kDa

Monoisotopic Mass: 102.753 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Toxin_19 1. 3971-7.64.4
Prim-Pol 1. 270445-40.24.9
Gram_pos_anchor 1. 5275672.41.8
--- cleavage 579 ---
Y_phosphatase 1. 705939384.71.6e-112

3. Sequence Information

Fasta Sequence: XSB0428.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] CVRQHARQQD579-KERLAALGPE

Asp579 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Cys570Val571Arg572Gln573His574Ala575Arg576Gln577Gln578Asp579
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys580Glu581Arg582Leu583Ala584Ala585Leu586Gly587Pro588Glu589

Sequence conservation (by blast)

* References

[PubMed ID: 12477932] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.