XSB0481 : von Willebrand factor [Canis lupus familiaris]
[ CaMP Format ]
This entry is computationally expanded from SB0030
* Basic Information
| Organism | Canis lupus familiaris (dog) |
| Protein Names | von Willebrand factor; vWF |
| Gene Names | VWF; F8VWF; von Willebrand factor |
| Gene Locus | 27; chromosome 27 |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_001002932 | NM_001002932 | 399544 | Q28295 | N/A | N/A | N/A | cfa:399544 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 2813 aa
Average Mass: 309.662 kDa
Monoisotopic Mass: 309.455 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| VWD 1. | 35 | 179 | 141.0 | 3.7e-39 |
| C8 1. | 218 | 292 | 100.3 | 6.7e-27 |
| TIL 1. | 295 | 348 | 45.4 | 2.3e-10 |
| VWD 2. | 388 | 541 | 189.3 | 1.1e-53 |
| C8 2. | 577 | 649 | 124.1 | 4.7e-34 |
| TIL 2. | 652 | 707 | 43.5 | 8.4e-10 |
| --- cleavage 763 --- | ||||
| TIL 3. | 776 | 827 | 25.1 | 0.00016 |
| VWD 3. | 867 | 1013 | 160.9 | 3.7e-45 |
| C8 3. | 1053 | 1127 | 117.8 | 3.5e-32 |
| TIL 4. | 1142 | 1196 | 30.3 | 7.7e-06 |
| VWA 1. | 1277 | 1453 | 105.3 | 2.1e-28 |
| VWA 2. | 1498 | 1664 | 161.8 | 2e-45 |
| VWA 3. | 1691 | 1864 | 147.4 | 4.3e-41 |
| VWD 4. | 1950 | 2102 | 141.3 | 2.9e-39 |
| C8 4. | 2132 | 2200 | 92.5 | 1.5e-24 |
| TIL 5. | 2203 | 2254 | 12.6 | 0.0024 |
| VWC 1. | 2257 | 2325 | 83.0 | 1.1e-21 |
| Toxin_23 1. | 2404 | 2428 | -3.3 | 4.7 |
| VWC 2. | 2431 | 2494 | 89.7 | 1e-23 |
| Antistasin 1. | 2549 | 2576 | -3.3 | 3.7 |
| VWC 3. | 2582 | 2644 | 73.1 | 9.9e-19 |
| FeS 1. | 2710 | 2742 | -4.5 | 2.1 |
3. Sequence Information
Fasta Sequence: XSB0481.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] SSPRSHRSKR763-SLSCRPPMVK
Arg763 
Ser
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ser754 | Ser755 | Pro756 | Arg757 | Ser758 | His759 | Arg760 | Ser761 | Lys762 | Arg763 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ser764 | Leu765 | Ser766 | Cys767 | Arg768 | Pro769 | Pro770 | Met771 | Val772 | Lys773 |
Sequence conservation (by blast)
* References
[PubMed ID: 16774914] Shen Y, Cranmer SL, Aprico A, Whisstock JC, Jackson SP, Berndt MC, Andrews RK, Leucine-rich repeats 2-4 (Leu60-Glu128) of platelet glycoprotein Ibalpha regulate shear-dependent cell adhesion to von Willebrand factor. J Biol Chem. 2006 Sep 8;281(36):26419-23. Epub 2006 Jun 14.