logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB0496 : beta-1 integrin subunit

[ CaMP Format ]

This entry is computationally expanded from SB0063

* Basic Information

OrganismBos taurus (cattle)
Protein NamesIntegrin beta-1; Fibronectin receptor subunit beta; Integrin VLA-4 subunit beta
Gene NamesITGB1
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
AAA80571 N/A N/A P53712 N/A N/A N/A bta:281876

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 773 aa

Average Mass: 85.323 kDa

Monoisotopic Mass: 85.267 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Integrin_beta 1. 114411113.30
EGF_2 1. 4434778.00.37
EGF_2 2. 49353021.30.0041
EGF_2 3. 53756721.90.0027
EGF_2 4. 57660734.93.2e-07
Integrin_B_tail 1. 617705157.24.8e-44
Integrin_b_cyt 1. 729773106.96.7e-29
--- cleavage 768 (inside Integrin_b_cyt 729..773) ---
--- cleavage 766 (inside Integrin_b_cyt 729..773) ---
--- cleavage 755 (inside Integrin_b_cyt 729..773) ---
--- cleavage 748 (inside Integrin_b_cyt 729..773) ---
--- cleavage 754 (inside Integrin_b_cyt 729..773) ---

3. Sequence Information

Fasta Sequence: XSB0496.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

5 [sites]

Cleavage sites (±10aa)

[Site 1] IYKSAVTTVV768-NPKYE

Val768 Asn

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ile759Tyr760Lys761Ser762Ala763Val764Thr765Thr766Val767Val768
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Asn769Pro770Lys771Tyr772Glu773-----

Sequence conservation (by blast)

[Site 2] NPIYKSAVTT766-VVNPKYE

Thr766 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Asn757Pro758Ile759Tyr760Lys761Ser762Ala763Val764Thr765Thr766
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Val767Val768Asn769Pro770Lys771Tyr772Glu773---

Sequence conservation (by blast)

[Site 3] EKMNAKWDTG755-ENPIYKSAVT

Gly755 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu746Lys747Met748Asn749Ala750Lys751Trp752Asp753Thr754Gly755
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu756Asn757Pro758Ile759Tyr760Lys761Ser762Ala763Val764Thr765

Sequence conservation (by blast)

[Site 4] EFAKFEKEKM748-NAKWDTGENP

Met748 Asn

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu739Phe740Ala741Lys742Phe743Glu744Lys745Glu746Lys747Met748
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Asn749Ala750Lys751Trp752Asp753Thr754Gly755Glu756Asn757Pro758

Sequence conservation (by blast)

[Site 5] KEKMNAKWDT754-GENPIYKSAV

Thr754 Gly

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys745Glu746Lys747Met748Asn749Ala750Lys751Trp752Asp753Thr754
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gly755Glu756Asn757Pro758Ile759Tyr760Lys761Ser762Ala763Val764

Sequence conservation (by blast)

* References

[PubMed ID: 7545439] MacLaren LA, Wildeman AG, Fibronectin receptors in preimplantation development: cloning, expression, and localization of the alpha 5 and beta 1 integrin subunits in bovine trophoblast. Biol Reprod. 1995 Jul;53(1):153-65.