XSB0514 : insulin-like growth factor binding protein 4 [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0070
* Basic Information
Organism | Homo sapiens (human) |
Protein Names | Insulin-like growth factor-binding protein 4; IGF-binding protein 4; IGFBP-4; IBP-4; insulin-like growth factor binding protein 4 |
Gene Names | IBP4 |
Gene Locus | Not available |
GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 258 aa
Average Mass: 28.006 kDa
Monoisotopic Mass: 27.987 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
domain name | begin | end | score | e-value |
---|---|---|---|---|
--- cleavage 23 --- | ||||
IGFBP 1. | 27 | 85 | 102.0 | 2.1e-27 |
--- cleavage 107 --- | ||||
Thyroglobulin_1 1. | 174 | 249 | 144.0 | 4.7e-40 |
3. Sequence Information
Fasta Sequence: XSB0514.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
* Cleavage Information
2 [sites]
Cleavage sites (±10aa)
[Site 1] AGPGPSLGDE23-AIHCPPCSEE
Glu23 Ala
P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
---|---|---|---|---|---|---|---|---|---|
Ala14 | Gly15 | Pro16 | Gly17 | Pro18 | Ser19 | Leu20 | Gly21 | Asp22 | Glu23 |
P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
Ala24 | Ile25 | His26 | Cys27 | Pro28 | Pro29 | Cys30 | Ser31 | Glu32 | Glu33 |
Sequence conservation (by blast) Sequence conservation (by blast)
Reference peptide (cleaved bond±30 residues) |
---|
MLPLCLVAALLLAAGPGPSLGDEAIHCPPCSEEKLARCRPPVGCEELVREPGC |
Summary
# | organism | max score | hits | top seq |
---|---|---|---|---|
1 | Homo sapiens | 77.00 | 16 | insulin-like growth factor binding protein 4 |
2 | N/A | 77.00 | 14 | B |
3 | Mus musculus | 77.00 | 14 | insulin-like growth factor binding protein-4 |
4 | synthetic construct | 77.00 | 8 | insulin-like growth factor binding protein 4 |
5 | Rattus norvegicus | 77.00 | 7 | insulin-like growth factor binding protein 4 |
6 | Sus scrofa | 77.00 | 6 | IBP4 |
7 | Bos taurus | 77.00 | 5 | insulin-like growth factor binding protein 4 |
8 | Pan troglodytes | 77.00 | 2 | PREDICTED: similar to Insulin-like growth factor-b |
9 | Ovis aries | 77.00 | 2 | IBP4_SHEEP Insulin-like growth factor-binding prot |
10 | Equus caballus | 77.00 | 1 | insulin-like growth factor binding protein-4 |
11 | Canis familiaris | 73.90 | 4 | PREDICTED: similar to Insulin-like growth factor b |
12 | Monodelphis domestica | 73.90 | 4 | PREDICTED: similar to SWI/SNF-related matrix-assoc |
13 | Tetraodon nigroviridis | 60.10 | 5 | unnamed protein product |
14 | Gallus gallus | 58.20 | 3 | insulin-like growth factor binding protein 4 |
15 | human, TE85 osteosarcoma cells, Peptide Partial, 21 aa | 48.10 | 1 | insulin-like growth factor binding protein 4, IGFB |
16 | Xenopus laevis | 45.40 | 4 | insulin-like growth factor binding protein 1 |
17 | Danio rerio | 44.30 | 9 | insulin-like growth factor binding protein 1 |
18 | Macaca mulatta | 42.70 | 8 | PREDICTED: similar to insulin-like growth factor b |
19 | Xenopus tropicalis | 42.00 | 4 | Unknown (protein for MGC:144994) |
20 | Spermophilus tridecemlineatus | 39.70 | 1 | IBP1_SPETR Insulin-like growth factor-binding prot |
21 | Salmo salar | 37.70 | 5 | IGF binding protein 5 |
22 | Oncorhynchus mykiss | 37.70 | 4 | insulin-like growth factor binding protein 5 |
23 | Papio anubis | 37.70 | 1 | insulin-like growth factor binding protein-1 |
24 | Oncorhynchus tshawytscha | 37.70 | 1 | insulin-like growth factor binding protein-1 |
25 | chickens, eye, Peptide Partial, 51 aa | 36.60 | 1 | insulin-like growth factor binding protein-5, IGFB |
26 | Sparus aurata | 35.00 | 1 | AF377998_1 insulin-like growth factor binding prot |
Top-ranked sequences
organism | matching |
---|---|
Homo sapiens | Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 ||#|||||||||||||||||||||||||||||| Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 |
N/A | Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 ||#|||||||||||||||||||||||||||||| Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 |
Mus musculus | Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 ||#|||||||||||||||||||||||||||||| Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 |
synthetic construct | Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 ||#|||||||||||||||||||||||||||||| Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 |
Rattus norvegicus | Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 ||#|||||||||||||||||||||||||||||| Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 |
Sus scrofa | Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 ||#|||||||||||||||||||||||||||||| Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 |
Bos taurus | Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 ||#|||||||||||||||||||||||||||||| Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 |
Pan troglodytes | Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 ||#|||||||||||||||||||||||||||||| Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 |
Ovis aries | Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 ||#|||||||||||||||||||||||||||||| Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 |
Equus caballus | Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 ||#|||||||||||||||||||||||||||||| Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 |
Canis familiaris | Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 ||#||||| |||||||||||||||||||||||| Sbjct 215 DE#AIHCPSCSEEKLARCRPPVGCEELVREPGC 246 |
Monodelphis domestica | Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 ||#|||||||||||||||+|| ||||||||||| Sbjct 22 DE#AIHCPPCSEEKLARCQPPTGCEELVREPGC 53 |
Tetraodon nigroviridis | Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 |+#|| || ||||+||||| | |||| |||||| Sbjct 31 DQ#AIRCPVCSEERLARCRLPEGCEETVREPGC 62 |
Gallus gallus | Query 22 DE#AIHCPPCSEEKLARCRPPVGCEELVREPGC 53 +|#| |||||||+||||+ | || | |||||| Sbjct 27 EE#ATQCPPCSEERLARCKAPQGCTESVREPGC 58 |
human, TE85 osteosarcoma cells, Peptide Partial, 21 aa | Query 22 DE#AIHCPPCSEEKLARCRPPV 42 ||#|||||| |||||||||||| Sbjct 1 DE#AIHCPPXSEEKLARCRPPV 21 |
Xenopus laevis | Query 23 E#AIHCPPCSEEKLARCRP-PVGCEELVREPGC 53 |#++|| |+||+|| | | | | || ||||| Sbjct 26 E#SLHCAQCTEERLALCPPVPSDCPELAREPGC 57 |
Danio rerio | Query 23 E#AIHCPPCSEEKLARCRPPV--GCEELVREPGC 53 |# | | ||| |+|| | | | ||||++||||| Sbjct 32 E#PIRCAPCSPERLAEC-PAVDAGCEEVLREPGC 63 |
Macaca mulatta | Query 25 IHCPPCSEEKLARCRP-PVGCEELVREPGC 53 +|| || |+ |+ | | |+|| |||+|||| Sbjct 25 VHCEPCDEKALSMCPPSPLGC-ELVKEPGC 53 |
Xenopus tropicalis | Query 25 IHCPPCSEEKLARCRP-PVGCEELVREPGC 53 +|| || ++ ++ | | |||| |||+|||| Sbjct 25 VHCEPCDDKAMSMCPPTPVGC-ELVKEPGC 53 |
Spermophilus tridecemlineatus | Query 26 HCPPCSEEKLARCRP-PVGCEELVREPGC 53 || ||| |||| | | | | || | || Sbjct 31 HCAPCSAEKLALCPPVPSSCPELSRPAGC 59 |
Salmo salar | Query 25 IHCPPCSEEKLARCRP-PVGCEELVREPGC 53 + | || ++ |+ | | |||| +||+|||| Sbjct 23 VPCEPCDQKALSMCPPVPVGC-QLVKEPGC 51 |
Oncorhynchus mykiss | Query 25 IHCPPCSEEKLARCRP-PVGCEELVREPGC 53 + | || ++ |+ | | |||| +||+|||| Sbjct 23 VPCEPCDQKALSMCPPVPVGC-QLVKEPGC 51 |
Papio anubis | Query 27 CPPCSEEKLARCRP-PVGCEELVREPGC 53 | ||| |||| | | | | |+ | || Sbjct 30 CAPCSAEKLALCPPVPASCSEVTRSAGC 57 |
Oncorhynchus tshawytscha | Query 23 E#AIHCPPCSEEKLARCRPPVG--CEELVREPGC 53 |# | | ||++||| | | + |++++||||| Sbjct 32 E#PIRCAPCTQEKLDEC-PAISPDCKQVLREPGC 63 |
chickens, eye, Peptide Partial, 51 aa | Query 25 IHCPPCSEEKLARCRPP-VGCEELVREPGC 53 + | || + |+ | || +||| ||+|||| Sbjct 5 VQCEPCDGKALSLCPPPPLGCE-LVKEPGC 33 |
Sparus aurata | Query 22 DE#AIHCPPCSEEKLARC-RPPVGCEELVREPGC 53 | #| || |+ |+|| | + | |+||| || Sbjct 23 DL#AFRCPSCTAERLAACPKVTAMCPEIVRELGC 55 |
[Site 2] GVCMELAEIE107-AIQESLQPSD
Glu107 Ala
P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
---|---|---|---|---|---|---|---|---|---|
Gly98 | Val99 | Cys100 | Met101 | Glu102 | Leu103 | Ala104 | Glu105 | Ile106 | Glu107 |
P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
Ala108 | Ile109 | Gln110 | Glu111 | Ser112 | Leu113 | Gln114 | Pro115 | Ser116 | Asp117 |
Sequence conservation (by blast) Sequence conservation (by blast)
Reference peptide (cleaved bond±30 residues) |
---|
LRCYPPRGVEKPLHTLMHGQGVCMELAEIEAIQESLQPSDKDEGDHPNNSFSPCSAHDRR |
Summary
# | organism | max score | hits | top seq |
---|---|---|---|---|
1 | Homo sapiens | 132.00 | 13 | insulin-like growth factor binding protein 4 |
2 | N/A | 132.00 | 10 | - |
3 | synthetic construct | 132.00 | 7 | insulin-like growth factor binding protein 4 |
4 | Canis familiaris | 131.00 | 5 | PREDICTED: similar to Insulin-like growth factor b |
5 | Pan troglodytes | 131.00 | 2 | PREDICTED: similar to Insulin-like growth factor-b |
6 | Equus caballus | 131.00 | 2 | insulin-like growth factor binding protein-4 |
7 | Bos taurus | 129.00 | 5 | insulin-like growth factor binding protein 4 |
8 | Ovis aries | 127.00 | 3 | IBP4_SHEEP Insulin-like growth factor-binding prot |
9 | Sus scrofa | 126.00 | 6 | IBP4 |
10 | Mus musculus | 115.00 | 9 | insulin-like growth factor binding protein 4 |
11 | Rattus norvegicus | 115.00 | 5 | insulin-like growth factor binding protein 4 |
12 | Monodelphis domestica | 115.00 | 4 | PREDICTED: similar to SWI/SNF-related matrix-assoc |
13 | Gallus gallus | 110.00 | 3 | insulin-like growth factor binding protein 4 |
14 | Tetraodon nigroviridis | 71.20 | 6 | unnamed protein product |
15 | Xenopus tropicalis | 45.40 | 3 | Unknown (protein for MGC:144994) |
16 | Xenopus laevis | 44.30 | 3 | insulin-like growth factor binding protein 5 |
17 | Danio rerio | 41.60 | 9 | insulin-like growth factor binding protein 5 |
18 | Oncorhynchus mykiss | 41.20 | 1 | insulin-like growth factor binding protein 5 |
19 | Salmo salar | 41.20 | 1 | IGF binding protein 5 |
20 | Macaca mulatta | 40.40 | 5 | PREDICTED: similar to insulin-like growth factor b |
21 | Bubalus bubalis | 39.70 | 1 | insulin-like growth factor binding protein-5 |
22 | Coturnix japonica | 39.30 | 1 | AF293839_1 insulin-like growth factor binding prot |
Top-ranked sequences
organism | matching |
---|---|
Homo sapiens | Query 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 |
N/A | Query 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 |
synthetic construct | Query 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 |
Canis familiaris | Query 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||||||||||| Sbjct 271 LRCYPPRGVEKPLHTLMHGQGVCMELSEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 330 |
Pan troglodytes | Query 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 |||||||||||||||||||||+||||||||#|||||||||||||||||||||||||||||| Sbjct 78 LRCYPPRGVEKPLHTLMHGQGLCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 |
Equus caballus | Query 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 ||||||||||||||||||||||||||||||#||||+||||||||||||||||||||||||| Sbjct 57 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQENLQPSDKDEGDHPNNSFSPCSAHDRR 116 |
Bos taurus | Query 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 ||||||||||||||||+|||||||||||||#|||||||||||||||||||||||||||||+ Sbjct 78 LRCYPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRK 137 |
Ovis aries | Query 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 |||+||||||||||||+|||||||||||||#|||||||||||||||||||||||||||||+ Sbjct 57 LRCHPPRGVEKPLHTLVHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRK 116 |
Sus scrofa | Query 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 |||||||||||||||||||||+||||||||#||||||||||||||||||||||||| ||| Sbjct 79 LRCYPPRGVEKPLHTLMHGQGLCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSPQDRR 138 |
Mus musculus | Query 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 +|||||||||||| ||||||||| ||+|||#||||||| ||||| +||||||+|||||| | Sbjct 78 MRCYPPRGVEKPLRTLMHGQGVCTELSEIE#AIQESLQTSDKDESEHPNNSFNPCSAHDHR 137 |
Rattus norvegicus | Query 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 +|||||||||||| ||||||||| ||+|||#||||||| ||||| +||||||+|||||| | Sbjct 78 MRCYPPRGVEKPLRTLMHGQGVCTELSEIE#AIQESLQTSDKDESEHPNNSFNPCSAHDHR 137 |
Monodelphis domestica | Query 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 ||||||||||||||||||||| |||||+||#||||||| ++|+| +||||||||||+|||+ Sbjct 78 LRCYPPRGVEKPLHTLMHGQGECMELADIE#AIQESLQTTEKEESEHPNNSFSPCSSHDRK 137 |
Gallus gallus | Query 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 ||||||||| +|||||||||||| +||++|#|||||||| +|+| +|||||||||| |||+ Sbjct 83 LRCYPPRGVPRPLHTLMHGQGVCTDLADVE#AIQESLQPPEKEEIEHPNNSFSPCSIHDRK 142 |
Tetraodon nigroviridis | Query 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDRR 137 ||||||||||+|||+|||||||| + |+|# + |+ +||||| || |+| Sbjct 87 LRCYPPRGVERPLHSLMHGQGVCTDEREVE#E-NSATDRQDEIIPEHPNNSNIRCSQQDKR 145 |
Xenopus tropicalis | Query 78 LRCYPPRGVEKPLHTLMHGQGVCMEL------AEIE#AIQE 111 ||| | +| ||||| |+||+|||+ | ++|+#+|+| Sbjct 78 LRCLPEQGEEKPLHALLHGRGVCLNLKNHRDQSKID#SIEE 117 |
Xenopus laevis | Query 78 LRCYPPRGVEKPLHTLMHGQGVCMEL 103 ||| | +| ||||| |+||+|||+ | Sbjct 79 LRCLPEQGEEKPLHALLHGRGVCLNL 104 |
Danio rerio | Query 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNSFSPCSAHDR 136 ||| | | ||||| |+||+||| +# + | |++ +| +++ | + |+ Sbjct 74 LRCLPRNGEEKPLHALLHGRGVC---TNEK#GYKPPHPPIDRESIEH-DDTVKPDTTEDQ 128 |
Oncorhynchus mykiss | Query 78 LRCYPPRGVEKPLHTLMHGQGVC 100 ||| | | ||||| |+||+||| Sbjct 76 LRCLPRNGEEKPLHALLHGRGVC 98 |
Salmo salar | Query 78 LRCYPPRGVEKPLHTLMHGQGVC 100 ||| | | ||||| |+||+||| Sbjct 76 LRCLPRNGEEKPLHALLHGRGVC 98 |
Macaca mulatta | Query 78 LRCYPPRGVEKPLHTLMHGQGVCME----LAEIE#AIQESLQPSDKDEGDHPNNSFSP 130 ||| | + ||||| |+||+|||+ +++# ++| + + + ++|| Sbjct 78 LRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVK#IERDSREHEEPTTSEMAEETYSP 134 |
Bubalus bubalis | Query 78 LRCYPPRGVEKPLHTLMHGQGVCM 101 ||| | + ||||| |+||+|||+ Sbjct 34 LRCLPRQDEEKPLHALLHGRGVCL 57 |
Coturnix japonica | Query 78 LRCYPPRGVEKPLHTLMHGQGVCMELAEIE#AIQESLQPSDKDEGDHPNNS 127 +|| | +| ||||| |+|| || |+| # +++ + | + | | Sbjct 34 VRCLPRQGEEKPLHALLHGTAVC--LSEKS#YREQAKAERESREHEEPTTS 81 |
* References
None.