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XSB0514 : insulin-like growth factor binding protein 4 [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0070

* Basic Information

OrganismHomo sapiens (human)
Protein NamesInsulin-like growth factor-binding protein 4; IGF-binding protein 4; IGFBP-4; IBP-4; insulin-like growth factor binding protein 4
Gene NamesIBP4
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
AAV38694 N/A N/A Q5U012 N/A N/A N/A hsa:3487

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 258 aa

Average Mass: 28.006 kDa

Monoisotopic Mass: 27.987 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 23 ---
IGFBP 1. 2785102.02.1e-27
--- cleavage 107 ---
Thyroglobulin_1 1. 174249144.04.7e-40

3. Sequence Information

Fasta Sequence: XSB0514.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1WQJ (X-ray; 160 A; B=24-103), 2DSP (X-ray; 250 A; B=22-113), 2DSQ (X-ray; 280 A; A/B=22-113), 2DSR (X-ray; 210 A; G=172-253, B=24-103)

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] AGPGPSLGDE23-AIHCPPCSEE

Glu23 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ala14Gly15Pro16Gly17Pro18Ser19Leu20Gly21Asp22Glu23
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala24Ile25His26Cys27Pro28Pro29Cys30Ser31Glu32Glu33

Sequence conservation (by blast)

[Site 2] GVCMELAEIE107-AIQESLQPSD

Glu107 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gly98Val99Cys100Met101Glu102Leu103Ala104Glu105Ile106Glu107
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala108Ile109Gln110Glu111Ser112Leu113Gln114Pro115Ser116Asp117

Sequence conservation (by blast)

* References

None.