XSB0577 : unnamed protein product [Rattus norvegicus]
[ CaMP Format ]
This entry is computationally expanded from SB0039
* Basic Information
| Organism | Rattus norvegicus (Norway rat) |
| Protein Names | Protein kinase C beta type; PKC-beta; PKC-B; 2.7.11.13 |
| Gene Names | Pkcb, Prkcb1; Pkcb; Prkcb1 |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 671 aa
Average Mass: 76.783 kDa
Monoisotopic Mass: 76.733 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| C1_1 1. | 37 | 89 | 80.1 | 8.2e-21 |
| C1_1 2. | 102 | 154 | 97.3 | 5.4e-26 |
| C2 1. | 173 | 260 | 128.3 | 2.5e-35 |
| --- cleavage 311 --- | ||||
| --- cleavage 320 --- | ||||
| Pkinase 1. | 342 | 600 | 256.0 | 9e-74 |
| Pkinase_C 1. | 620 | 666 | 71.9 | 2.4e-18 |
3. Sequence Information
Fasta Sequence: XSB0577.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Known Structures in PDB: 1A25 (X-ray; 270 A; A/B=157-289)
* Cleavage Information
2 [sites]
Cleavage sites (±10aa)
[Site 1] RQKFERAKIG311-QGTKAPEEKT
Gly311 
Gln
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Arg302 | Gln303 | Lys304 | Phe305 | Glu306 | Arg307 | Ala308 | Lys309 | Ile310 | Gly311 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Gln312 | Gly313 | Thr314 | Lys315 | Ala316 | Pro317 | Glu318 | Glu319 | Lys320 | Thr321 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| EGEYFNVPVPPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTD |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | N/A | 126.00 | 10 | K |
| 2 | Mus musculus | 126.00 | 4 | protein kinase C, beta 1 |
| 3 | Rattus norvegicus | 126.00 | 4 | unnamed protein product |
| 4 | Oryctolagus cuniculus | 123.00 | 3 | KPCB_RABIT Protein kinase C beta type (PKC-beta) ( |
| 5 | Macaca mulatta | 120.00 | 6 | PREDICTED: protein kinase C, beta isoform 1 |
| 6 | Canis familiaris | 120.00 | 2 | PREDICTED: similar to Protein kinase C, beta type |
| 7 | Bos taurus | 119.00 | 3 | Unknown (protein for MGC:148660) |
| 8 | Homo sapiens | 118.00 | 9 | protein kinase C, beta isoform 1 |
| 9 | Monodelphis domestica | 116.00 | 3 | PREDICTED: similar to Protein kinase C beta type ( |
| 10 | Gallus gallus | 110.00 | 3 | PREDICTED: similar to protein kinase C beta-1 |
| 11 | Latimeria chalumnae | 102.00 | 2 | protein kinase C beta 1 |
| 12 | Protopterus dolloi | 100.00 | 2 | protein kinase C beta 1 |
| 13 | Tetraodon nigroviridis | 95.10 | 3 | unnamed protein product |
| 14 | Danio rerio | 92.80 | 7 | protein kinase C, beta 1 |
| 15 | Scyliorhinus canicula | 89.40 | 2 | protein kinase C |
| 16 | Petromyzon marinus | 63.50 | 1 | protein kinase C |
| 17 | synthetic construct | 56.20 | 1 | protein kinase C alpha |
| 18 | Takifugu rubripes | 53.90 | 1 | protein kinase C, alpha type |
| 19 | Xenopus tropicalis | 52.80 | 1 | hypothetical protein LOC780209 |
| 20 | Xenopus laevis | 50.40 | 1 | protein kinase C, alpha |
| 21 | Myxine glutinosa | 46.60 | 1 | protein kinase C |
| 22 | Caenorhabditis briggsae | 39.70 | 1 | Hypothetical protein CBG16150 |
| 23 | Aplysia californica | 35.80 | 1 | KPC1_APLCA Calcium-dependent protein kinase C (APL |
| 24 | Branchiostoma lanceolatum | 32.30 | 1 | protein kinase C |
Top-ranked sequences
| organism | matching |
|---|---|
| N/A | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 |
| Mus musculus | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 |
| Rattus norvegicus | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 |
| Oryctolagus cuniculus | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 ||||||||||||||||||||||||||||||#|||| ||||| ||||||||||||||||||| Sbjct 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLTD 341 |
| Macaca mulatta | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 ||||||||||||||||||||||||||||| #|||| ||||| ||+|||||||||||||||| Sbjct 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIS#QGTKVPEEKTTNTVSKFDNNGNRDRMKLTD 341 |
| Canis familiaris | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 ||||||||||||||||||||||||||||| #|||||||||| ||||| ||||||||||||| Sbjct 274 EGEYFNVPVPPEGSEGNEELRQKFERAKIS#QGTKAPEEKTTNTISKLDNNGNRDRMKLTD 333 |
| Bos taurus | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 ||||||||||||||||||||||||||||||# | | ||||| ||||||||||||||||||| Sbjct 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLTD 341 |
| Homo sapiens | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 ||||||||||||||| ||||||||||||| #|||| ||||| ||+|||||||||||||||| Sbjct 282 EGEYFNVPVPPEGSEANEELRQKFERAKIS#QGTKVPEEKTTNTVSKFDNNGNRDRMKLTD 341 |
| Monodelphis domestica | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 ||||||||||||| ||||||||||||||||#|||| |||||| ||| ||||||||||||| Sbjct 279 EGEYFNVPVPPEGEEGNEELRQKFERAKIG#QGTKVTEEKTANAISKIDNNGNRDRMKLTD 338 |
| Gallus gallus | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 ||||||||||||| ||||||||||||||||# |+|| +||| | ||||||||+||||||+| Sbjct 281 EGEYFNVPVPPEGEEGNEELRQKFERAKIG#TGSKAADEKTTNAISKFDNNGSRDRMKLSD 340 |
| Latimeria chalumnae | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 ||||||||||||| |||||||+||||||||# |+|| |+| |+ ||| |||||||+||+| Sbjct 204 EGEYFNVPVPPEGEEGNEELRKKFERAKIG#PGSKATEDKVKNSSSKFGNNGNRDRIKLSD 263 |
| Protopterus dolloi | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 ||||||||||||| ||||||||||||||||# | +| |+| || +||||||||||+||+| Sbjct 213 EGEYFNVPVPPEGEEGNEELRQKFERAKIG#PGAEAAEDKIANA-AKFDNNGNRDRVKLSD 271 |
| Tetraodon nigroviridis | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 ||||||||||||| ||||||||||||||||# | | + |+|| |+||+|||+||||| | Sbjct 218 EGEYFNVPVPPEGEEGNEELRQKFERAKIG#PG-KNTDGKSANAASRFDSNGNQDRMKLAD 276 |
| Danio rerio | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 ||||||||||||| ||||||||||||||| # | + ++| |||||+|||||||||+| Sbjct 281 EGEYFNVPVPPEGEEGNEELRQKFERAKI-#-GPSKTDGSSSNAISKFDSNGNRDRMKLSD 338 |
| Scyliorhinus canicula | Query 282 EGEYFNVPVPPE-GSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLT 340 ||||+||||||| ||||||||||||||+||# |+|| ||| +++ || | ||||||||| Sbjct 202 EGEYYNVPVPPEEDSEGNEELRQKFERARIG#PGSKAAEEKRSSSWSKID-NGNRDRMKLA 260 Query 341 D 341 | Query 341 D 341 |
| Petromyzon marinus | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTK--APEEKTANTISKFDNNGNRDRMKL 339 ||||+|||+ |+ +|+ |+|+|||+|++|# | | +|+ ||++| || | ||+| Sbjct 212 EGEYYNVPIAPDIEDGDTEMRRKFEKARLG#PSVKPRASDERRANSLSAILNNANVDRVKA 271 Query 340 TD 341 | Sbjct 272 DD 273 |
| synthetic construct | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 ||||+|||+| ||| |||||||+||+|# | + + + + + | ||+|||| Sbjct 282 EGEYYNVPIPEGDEEGNMELRQKFEKAKLG#---PAGNKVISPSEDRKQPSNNLDRVKLTD 338 |
| Takifugu rubripes | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 ||||+|||+| | + | |||||||+||+|#|| | | +|| ||++| | Sbjct 280 EGEYYNVPIP-EVDDVNLELRQKFEKAKLG#QGKKVITPSDHRRFSL--PSGNMDRVRLND 336 |
| Xenopus tropicalis | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 ||||+|||+| | +|| |||||||+||+|# | +| | | ++||| Sbjct 286 EGEYYNVPIPEEEDDGNIELRQKFEKAKLG#PAGNKVISPTDERRPYVPSN-NIDSVRLTD 344 |
| Xenopus laevis | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 ||||+|||+| | +|| |||||||+||+|# | +| | | ++||| Sbjct 286 EGEYYNVPIP-EADDGNLELRQKFEKAKLG#PAGNKVINPTGERRPYIPSN-NIDSIRLTD 343 |
| Myxine glutinosa | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 ||||+|||| ||| || ||||+ +|++| #+ | + + | + ||+ | | Sbjct 203 EGEYYNVPVAPEGEEG-LELRQRLQRSQIA#RSDKNKQSPAKDQPSDSASLSGLDRVNLED 261 |
| Caenorhabditis briggsae | Query 282 EGEYFNVPVPPEGSEGNEELRQKF-ERAKIG#QGTKA--PEEKTANTISKFDNNGNRDRMK 338 |||++|+ + || | |++|+| + || #+ + | | | | | | ||| +| Sbjct 352 EGEFYNINITPEYDEDMEKVRKKMNDNFKIS#RDSSAGKPRESTPRATSTSLTNTNRDVIK 411 Query 339 LTD 341 +| Sbjct 412 ASD 414 |
| Aplysia californica | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFD 329 |||++ ||| + +| +|++ | |+ | # + || +|| | Sbjct 266 EGEFYGVPVTDDITESIQEIKSKMHRSSIS#SEKRYPEPDKVQNMSKQD 313 |
| Branchiostoma lanceolatum | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 ||||+|||+ | | +|++ ++ |+ #+ | ++ |+ | |+ | || | Sbjct 213 EGEYYNVPIADE-EENVAKLKEHLQKQKLD#EQRKQKSKR-----SEECNIGSLDHMKAAD 266 |
[Site 2] GQGTKAPEEK320-TANTISKFDN
Lys320 Thr
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gly311 | Gln312 | Gly313 | Thr314 | Lys315 | Ala316 | Pro317 | Glu318 | Glu319 | Lys320 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Thr321 | Ala322 | Asn323 | Thr324 | Ile325 | Ser326 | Lys327 | Phe328 | Asp329 | Asn330 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| PPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGK |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | N/A | 125.00 | 10 | K |
| 2 | Rattus norvegicus | 125.00 | 4 | unnamed protein product |
| 3 | Mus musculus | 125.00 | 4 | protein kinase C, beta 1 |
| 4 | Oryctolagus cuniculus | 122.00 | 3 | KPCB_RABIT Protein kinase C beta type (PKC-beta) ( |
| 5 | Macaca mulatta | 119.00 | 6 | PREDICTED: protein kinase C, beta isoform 1 |
| 6 | Canis familiaris | 119.00 | 3 | PREDICTED: similar to Protein kinase C, beta type |
| 7 | Homo sapiens | 117.00 | 8 | protein kinase C, beta isoform 1 |
| 8 | Bos taurus | 117.00 | 3 | Unknown (protein for MGC:148660) |
| 9 | Monodelphis domestica | 114.00 | 3 | PREDICTED: similar to Protein kinase C beta type ( |
| 10 | Gallus gallus | 108.00 | 3 | PREDICTED: similar to protein kinase C beta-1 |
| 11 | Latimeria chalumnae | 100.00 | 2 | protein kinase C beta 1 |
| 12 | Protopterus dolloi | 99.00 | 2 | protein kinase C beta 1 |
| 13 | Tetraodon nigroviridis | 93.60 | 2 | unnamed protein product |
| 14 | Danio rerio | 91.30 | 6 | protein kinase C, beta 1 |
| 15 | Scyliorhinus canicula | 90.50 | 2 | protein kinase C |
| 16 | Petromyzon marinus | 63.90 | 1 | protein kinase C |
| 17 | synthetic construct | 57.40 | 1 | protein kinase C alpha |
| 18 | Takifugu rubripes | 55.10 | 1 | protein kinase C, alpha type |
| 19 | Xenopus laevis | 51.60 | 1 | protein kinase C, alpha |
| 20 | Xenopus tropicalis | 50.80 | 1 | hypothetical protein LOC780209 |
| 21 | Caenorhabditis briggsae | 43.10 | 1 | Hypothetical protein CBG16150 |
| 22 | Myxine glutinosa | 40.80 | 1 | protein kinase C |
| 23 | Branchiostoma lanceolatum | 35.80 | 1 | protein kinase C |
| 24 | Aplysia californica | 35.80 | 1 | KPC1_APLCA Calcium-dependent protein kinase C (APL |
| 25 | Aedes aegypti | 35.00 | 1 | protein kinase c |
Top-ranked sequences
| organism | matching |
|---|---|
| N/A | Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |
| Rattus norvegicus | Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |
| Mus musculus | Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |
| Oryctolagus cuniculus | Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 ||||||||||||||||||||||||| ||||#| |||||||||||||||||||||||||||| Sbjct 291 PPEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |
| Macaca mulatta | Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||||||||||||||||||| |||| ||||#| ||+||||||||||||||||||||||||| Sbjct 291 PPEGSEGNEELRQKFERAKISQGTKVPEEK#TTNTVSKFDNNGNRDRMKLTDFNFLMVLGK 350 |
| Canis familiaris | Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||||||||||||||||||| |||||||||#| ||||| |||||||||||||||||||||| Sbjct 283 PPEGSEGNEELRQKFERAKISQGTKAPEEK#TTNTISKLDNNGNRDRMKLTDFNFLMVLGK 342 |
| Homo sapiens | Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||||| ||||||||||||| |||| ||||#| ||+||||||||||||||||||||||||| Sbjct 291 PPEGSEANEELRQKFERAKISQGTKVPEEK#TTNTVSKFDNNGNRDRMKLTDFNFLMVLGK 350 |
| Bos taurus | Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 ||||||||||||||||||||| | | ||||#| |||||||||||||||||||||||||||| Sbjct 291 PPEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |
| Monodelphis domestica | Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||| |||||||||||||||||||| |||#||| ||| |||||||||||||||||||||| Sbjct 288 PPEGEEGNEELRQKFERAKIGQGTKVTEEK#TANAISKIDNNGNRDRMKLTDFNFLMVLGK 347 |
| Gallus gallus | Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||| |||||||||||||||| |+|| +||#| | ||||||||+||||||+|||||||||| Sbjct 290 PPEGEEGNEELRQKFERAKIGTGSKAADEK#TTNAISKFDNNGSRDRMKLSDFNFLMVLGK 349 |
| Latimeria chalumnae | Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||| |||||||+|||||||| |+|| |+|# |+ ||| |||||||+||+|||||||||| Sbjct 213 PPEGEEGNEELRKKFERAKIGPGSKATEDK#VKNSSSKFGNNGNRDRIKLSDFNFLMVLGK 272 |
| Protopterus dolloi | Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||| |||||||||||||||| | +| |+|# || +||||||||||+||+|||||||||| Sbjct 222 PPEGEEGNEELRQKFERAKIGPGAEAAEDK#IANA-AKFDNNGNRDRVKLSDFNFLMVLGK 280 |
| Tetraodon nigroviridis | Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||| |||||||||||||||| | | + |#+|| |+||+|||+||||| |||||||||| Sbjct 227 PPEGEEGNEELRQKFERAKIGPG-KNTDGK#SANAASRFDSNGNQDRMKLADFNFLMVLGK 285 |
| Danio rerio | Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||| |||||||||||||||| + #++| |||||+|||||||||+|||||||||| Sbjct 290 PPEGEEGNEELRQKFERAKIGPSKT--DGS#SSNAISKFDSNGNRDRMKLSDFNFLMVLGK 347 |
| Scyliorhinus canicula | Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 | | ||||||||||||||+|| |+|| |||# +++ || | ||||||||| |||||||||| Sbjct 212 PEEDSEGNEELRQKFERARIGPGSKAAEEK#RSSSWSKID-NGNRDRMKLADFNFLMVLGK 270 |
| Petromyzon marinus | Query 292 PEGSEGNEELRQKFERAKIGQGTK--APEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLG 349 |+ +|+ |+|+|||+|++| | | +|+# ||++| || | ||+| ||||||||| Sbjct 222 PDIEDGDTEMRRKFEKARLGPSVKPRASDER#RANSLSAILNNANVDRVKADDFNFLMVLG 281 Query 350 K 350 | Query 350 K 350 |
| synthetic construct | Query 292 PEGSE-GNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 ||| | || |||||||+||+| | + # + + + + | ||+||||||||||||| Sbjct 291 PEGDEEGNMELRQKFEKAKLGP---AGNKV#ISPSEDRKQPSNNLDRVKLTDFNFLMVLGK 347 |
| Takifugu rubripes | Query 292 PEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 || + | |||||||+||+||| | # | +|| ||++| ||||| +||| Sbjct 289 PEVDDVNLELRQKFEKAKLGQGKKVITPS#DHRRFSL--PSGNMDRVRLNDFNFLALLGK 345 |
| Xenopus laevis | Query 292 PEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 || +|| |||||||+||+| #| +| | | ++|||| ||||||| Sbjct 295 PEADDGNLELRQKFEKAKLGPAGNKVINP#TGERRPYIPSN-NIDSIRLTDFCFLMVLGK 352 |
| Xenopus tropicalis | Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 | | +|| |||||||+||+| #| +| | | ++||||+||||||| Sbjct 295 PEEEDDGNIELRQKFEKAKLGPAGNKVISP#TDERRPYVPSN-NIDSVRLTDFSFLMVLGK 353 |
| Caenorhabditis briggsae | Query 292 PEGSEGNEELRQKF-ERAKIGQGTKA--PEEK#TANTISKFDNNGNRDRMKLTDFNFLMVL 348 || | |++|+| + || + + | | | #| | | ||| +| +||||| || Sbjct 362 PEYDEDMEKVRKKMNDNFKISRDSSAGKPRES#TPRATSTSLTNTNRDVIKASDFNFLTVL 421 Query 349 GK 350 || Query 349 GK 350 |
| Myxine glutinosa | Query 292 PEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 ||| || | |||+ +|++| + | + # + | + ||+ | || || |||| Sbjct 213 PEGEEGLE-LRQRLQRSQIARSDKNKQSP#AKDQPSDSASLSGLDRVNLEDFVFLTVLGK 270 |
| Branchiostoma lanceolatum | Query 296 EGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 | +|++ ++ |+ + | ++#+ | |+ | || |||||||||| Sbjct 226 ENVAKLKEHLQKQKLDEQRKQKSKR#SEEC-----NIGSLDHMKAADFNFLMVLGK 275 |
| Aplysia californica | Query 295 SEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 +| +|++ | |+ | + || # +|| +| ++ +||||| |||| Sbjct 279 TESIQEIKSKMHRSSISSEKRYPEPD#KVQNMSK------QDIVRASDFNFLTVLGK 328 |
| Aedes aegypti | Query 292 PEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 | || + ++ | + | ||| # + | | +| ++ ||||||||||| Sbjct 237 PVPEEGTDLVQLKSQMRKTSISKKAPVLC#DKDVPH---NMGKKDVIRATDFNFLMVLGK 292 |
* References
[PubMed ID: 2428667] Ono Y, Kurokawa T, Fujii T, Kawahara K, Igarashi K, Kikkawa U, Ogita K, Nishizuka Y, Two types of complementary DNAs of rat brain protein kinase C. Heterogeneity determined by alternative splicing. FEBS Lett. 1986 Oct 6;206(2):347-52.