logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB0593 : KIAA0581 protein [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0008

* Basic Information

OrganismHomo sapiens (human)
Protein Names1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1; 3.1.4.11; Phosphoinositide phospholipase C; Phospholipase C-beta-1; PLC-beta-1; PLC-I; PLC-154; KIAA0581 protein
Gene NamesKIAA0581
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
BAA25507 N/A N/A Q9NQ66 N/A N/A N/A hsa:23236

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 1218 aa

Average Mass: 138.766 kDa

Monoisotopic Mass: 138.679 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Chitin_synth_1 1. 94183-119.63.6
efhand_like 1. 226317160.26e-45
PI-PLC-X 1. 320470327.62.6e-95
PI-PLC-Y 1. 541658297.82.3e-86
C2 1. 68076363.95.9e-16
Big_4 1. 837899-11.85.7
--- cleavage 882 (inside Big_4 837..899) ---
DUF1154 1. 9059486.20.0036
PLC-beta_C 1. 9991191414.41.9e-121

3. Sequence Information

Fasta Sequence: XSB0593.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] TPKPPSQALH882-SQPAPGSVKA

His882 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Thr873Pro874Lys875Pro876Pro877Ser878Gln879Ala880Leu881His882
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser883Gln884Pro885Ala886Pro887Gly888Ser889Val890Lys891Ala892

Sequence conservation (by blast)

* References

[PubMed ID: 9628581] Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O, Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 1998 Feb 28;5(1):31-9.