logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB0600 : RecName: Full=Tyrosine-protein kinase transforming protein erbB

[ CaMP Format ]

This entry is computationally expanded from SB0050

* Basic Information

OrganismAvian leukosis virus
Protein NamesTyrosine-protein kinase transforming protein erbB; 2.7.10.1
Gene NamesV-ERBB
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
P00534 N/A N/A P00534 N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 634 aa

Average Mass: 70.891 kDa

Monoisotopic Mass: 70.846 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
GSu_C4xC__C2xCH 1. 1542-13.44.8
Adeno_E3_CR2 1. 5797-2.41.6
Pkinase_Tyr 1. 132388449.54.9e-132
--- cleavage 153 (inside Pkinase_Tyr 132..388) ---
CRT-like 1. 449555-77.83.5

3. Sequence Information

Fasta Sequence: XSB0600.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] GTVYKGLWIP153-EGEKVKIPVA

Pro153 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gly144Thr145Val146Tyr147Lys148Gly149Leu150Trp151Ile152Pro153
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu154Gly155Glu156Lys157Val158Lys159Ile160Pro161Val162Ala163

Sequence conservation (by blast)

* References

[PubMed ID: 2988784] Nilsen TW, Maroney PA, Goodwin RG, Rottman FM, Crittenden LB, Raines MA, Kung HJ, c-erbB activation in ALV-induced erythroblastosis: novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor. Cell. 1985 Jul;41(3):719-26.