CaMPDB :: Substrate

XSB0601 : mKIAA4219 protein [Mus musculus]

This entry is computationally expanded from SB0052

* Basic Information

Organism	Mus musculus (house mouse)
Protein Names	mKIAA4219 protein
Gene Names	mKIAA4219
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
BAD90537	N/A	N/A	Q5DTG9	N/A	N/A	N/A	mmu:

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 918 aa

Average Mass: 105.263 kDa

Monoisotopic Mass: 105.198 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Spectrin 1.	67	171	75.8	1.6e-19
Spectrin 2.	173	277	89.8	9.4e-24
Spectrin 3.	279	384	115.7	1.5e-31
Spectrin 4.	386	490	85.3	2.2e-22
Spectrin 5.	492	596	100.5	5.8e-27
Spectrin 6.	598	707	27.0	7.9e-05
--- cleavage 650 (inside Spectrin 598..707) ---
PH 1.	769	878	75.1	2.5e-19

3. Sequence Information

Fasta Sequence: XSB0601.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] EAFEKSTASW⁶⁵⁰-AERFAALEKP

Trp⁶⁵⁰ Ala

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Glu⁶⁴¹	Ala⁶⁴²	Phe⁶⁴³	Glu⁶⁴⁴	Lys⁶⁴⁵	Ser⁶⁴⁶	Thr⁶⁴⁷	Ala⁶⁴⁸	Ser⁶⁴⁹	Trp⁶⁵⁰

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Ala⁶⁵¹	Glu⁶⁵²	Arg⁶⁵³	Phe⁶⁵⁴	Ala⁶⁵⁵	Ala⁶⁵⁶	Leu⁶⁵⁷	Glu⁶⁵⁸	Lys⁶⁵⁹	Pro⁶⁶⁰

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
LASRDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQTPERPTEEPGP

Summary

#	organism	max score	hits	top seq
1	Mus musculus	94.00	47	mKIAA4219 protein
2	Homo sapiens	91.30	61	AF465439_1 beta I spectrin form betaI sigma3
3	N/A	91.30	15	-
4	Danio rerio	72.40	9	spectrin, beta, erythrocytic
5	Gallus gallus	70.50	6	PREDICTED: similar to spectrin, beta, non-erythroc
6	Canis familiaris	69.30	19	PREDICTED: similar to spectrin, beta, non-erythroc
7	Pan troglodytes	69.30	14	PREDICTED: spectrin, beta, non-erythrocytic 1 isof
8	Rattus norvegicus	69.30	13	Spnb2 protein
9	Macaca mulatta	69.30	5	PREDICTED: spectrin, beta, non-erythrocytic 1 isof
10	Bos taurus	69.30	5	PREDICTED: similar to spectrin, beta, non-erythroc
11	Macaca fascicularis	69.30	2	unnamed protein product
12	mice, brain, Peptide Partial, 332 aa	69.30	1	beta-spectrin subunit
13	Tetraodon nigroviridis	63.90	8	unnamed protein product
14	Drosophila melanogaster	63.20	8	beta Spectrin CG5870-PA
15	Aedes aegypti	63.20	3	beta chain spectrin
16	Drosophila pseudoobscura	63.20	3	GA19192-PA
17	Anopheles gambiae str. PEST	63.20	3	ENSANGP00000012507
18	Tribolium castaneum	62.00	4	PREDICTED: similar to Spectrin beta chain isoform
19	Apis mellifera	62.00	3	PREDICTED: similar to Spectrin beta chain
20	Strongylocentrotus purpuratus	57.80	5	PREDICTED: similar to spectrin beta 2
21	Caenorhabditis briggsae	55.10	2	Hypothetical protein CBG19038
22	Brugia malayi	53.90	1	beta-G spectrin
23	Caenorhabditis elegans	53.50	5	UNCoordinated family member (unc-70)
24	Sus scrofa	41.60	1	spectrin alpha non-erythrocytic 1
25	Monodelphis domestica	35.80	4	PREDICTED: similar to spectrin, beta, erythrocytic
26	Mus sp.	34.70	1	SPTB1_MOUSE Spectrin beta chain, erythrocyte (Beta
27	Xenopus tropicalis	32.30	1	hypothetical protein LOC100036647

Top-ranked sequences

organism	matching
Mus musculus	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 666 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 666
Homo sapiens	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 666 \|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 697 LASGDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 742
N/A	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 666 \|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 978 LASGDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 1023
Danio rerio	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLEL 665 +\|\|+\| \| \|\|\| \|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|+\|# \|\|\|+\|\|\|+ \|\|\|\|\| Sbjct 2051 VASKDVGQTVDEVEKLLKRHEAFEKSTATW#EERFSALERLTTLEL 2095
Gallus gallus	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLEL 665 \|+\|\|+ \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| \|+\|# \|\|\|\|\|\|\|+ \|\|\|\|\| Sbjct 2039 LSSREIGQSVDEVEKLIKRHEAFEKSAATW#DERFAALERLTTLEL 2083
Canis familiaris	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLEL 665 \|+\|\|+ \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| \|+\|# \|\|\|+\|\|\|+ \|\|\|\|\| Sbjct 2040 LSSREIGQSVDEVEKLIKRHEAFEKSAATW#DERFSALERLTTLEL 2084
Pan troglodytes	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLEL 665 \|+\|\|+ \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| \|+\|# \|\|\|+\|\|\|+ \|\|\|\|\| Sbjct 2040 LSSREIGQSVDEVEKLIKRHEAFEKSAATW#DERFSALERLTTLEL 2084
Rattus norvegicus	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLEL 665 \|+\|\|+ \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| \|+\|# \|\|\|+\|\|\|+ \|\|\|\|\| Sbjct 193 LSSREIGQSVDEVEKLIKRHEAFEKSAATW#DERFSALERLTTLEL 237
Macaca mulatta	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLEL 665 \|+\|\|+ \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| \|+\|# \|\|\|+\|\|\|+ \|\|\|\|\| Sbjct 2027 LSSREIGQSVDEVEKLIKRHEAFEKSAATW#DERFSALERLTTLEL 2071
Bos taurus	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLEL 665 \|+\|\|+ \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| \|+\|# \|\|\|+\|\|\|+ \|\|\|\|\| Sbjct 2039 LSSREIGQSVDEVEKLIKRHEAFEKSAATW#DERFSALERLTTLEL 2083
Macaca fascicularis	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLEL 665 \|+\|\|+ \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| \|+\|# \|\|\|+\|\|\|+ \|\|\|\|\| Sbjct 370 LSSREIGQSVDEVEKLIKRHEAFEKSAATW#DERFSALERLTTLEL 414
mice, brain, Peptide Partial, 332 aa	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLEL 665 \|+\|\|+ \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| \|+\|# \|\|\|+\|\|\|+ \|\|\|\|\| Sbjct 166 LSSREIGQSVDEVEKLIKRHEAFEKSAATW#DERFSALERLTTLEL 210
Tetraodon nigroviridis	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTL 663 \|+\|\|+ \| +\|\| \|\|\|\|+\|\|\|\|\|\|\|\|\| \|+\|# \|\|\|+\|\|\|+ \|\|+ Sbjct 1940 LSSREVGRSVDQVEKLLKRHEAFEKSAATW#EERFSALERLTTV 1982
Drosophila melanogaster	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 666 \| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| \|+ # \|\|\|+\|\|\|+ \|\| \|\|\| Sbjct 2041 LLSSELGHTIDEVENLIKKHEAFEKSAAAQ#EERFSALERLTTFELK 2086
Aedes aegypti	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 666 \| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| \|+ # \|\|\|+\|\|\|+ \|\| \|\|\| Sbjct 2041 LMSTELGHTIDEVENLIKKHEAFEKSAAAQ#EERFSALERLTTFELK 2086
Drosophila pseudoobscura	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 666 \| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| \|+ # \|\|\|+\|\|\|+ \|\| \|\|\| Sbjct 2041 LLSSELGHTIDEVENLIKKHEAFEKSAAAQ#EERFSALERLTTFELK 2086
Anopheles gambiae str. PEST	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 666 \| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| \|+ # \|\|\|+\|\|\|+ \|\| \|\|\| Sbjct 2041 LMSTELGHTIDEVENLIKKHEAFEKSAAAQ#EERFSALERLTTFELK 2086
Tribolium castaneum	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 666 \| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| \|+ # \|\|\|+\|\|\|+ \|\| \|\|+ Sbjct 2040 LMSTELGHTIDDVENLIKKHEAFEKSAAAQ#EERFSALERLTTFELR 2085
Apis mellifera	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 666 \| \|++ \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| \|+ # \|\|\|+\|\| + \|\| \|\|\| Sbjct 2039 LMSQELGHTIDEVENLIKKHEAFEKSAAAQ#EERFSALHRLTTFELK 2084
Strongylocentrotus purpuratus	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 666 \| \| \|+\| ++\| \|\|\|\|\|\|\|\|\|\|\|\|\|+ # \|\|\| \|\|\|\| \|\| \|\|+ Sbjct 2029 LRSDDYGDSLDEVEKLIKRHEAFEKALYCQ#EERFTALEKLTTFELR 2074
Caenorhabditis briggsae	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 666 \| \|\|++\| ++ \|\|\|\|+\|\|\|\|\|\|\| + # \|\|\| \|\|\|\| \|\| \|\|\| Sbjct 2027 LISREYGRNLEETIKLIKKHEAFEKSALAQ#EERFLALEKLTTFELK 2072
Brugia malayi	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 666 \| \|+++\| ++ \|\|\|\|+\|\|\|\|\|\|\| + # \|\|\| \|\|\|\| \|\| \|\|\| Sbjct 2036 LVSKEYGRNLEETIKLIKKHEAFEKSANAQ#EERFLALEKLTTFELK 2081
Caenorhabditis elegans	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 666 \| \|+++\| ++ \|\|\|\|+\|\|\|\|\|\|\| + # \|\|\| \|\|\|\| \|\| \|\|\| Sbjct 2030 LISKEYGRNLEETIKLIKKHEAFEKSAFAQ#EERFLALEKLTTFELK 2075
Sus scrofa	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTT 662 \| + \| \| ++\|\|\|\| \|+\|+\|\| \|\|\|\| ++ # \|+ \|\|++ \| Sbjct 27 LLNEDLGDSLDSVEALLKKHEDFEKSLSAQ#EEKITALDEFVT 68
Monodelphis domestica	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 666 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2028 LASRDFGHTVDSVEKLIKRHEAFEKSTAPW#AERFAALEKPTTLELK 2073 Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALE 658 +\| +\|\|+ + +\|\| \|+\|\|\| \| \|\|++# \|\| \|\|\| Sbjct 444 VAQDNFGYDLAAVEAAKKKHEAIETDTAAY#EERVKALE 481
Mus sp.	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 666 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTTLELK 666 Query 625 DFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALE 658 +\|\|+ + +\|\| \|+\|\|\| \| \|\|++# \|\| \|\|\| Sbjct 441 NFGYDLAAVEAAKKKHEAIETDTAAY#EERVKALE 474
Xenopus tropicalis	Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALEKPTT 662 \| + \| \| ++\|\|\|\| \|+\|+\|\| \|\|\|\| ++ # \|+ \|\|++ \| Sbjct 490 LLNEDLGDSLDSVEALLKKHEDFEKSLSAQ#EEKITALDEFAT 531 Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAALE 658 \| \| \| \| ++\|\|\|\| \|\|\|+\|\| \|+\|+ # \|+ \|\|\|+ Sbjct 1467 LNSEDKGDSLDSVEALIKKHEDFDKAINVQ#EEKIAALQ 1504 Query 621 LASRDFGHTVDSVEKLIKRHEAFEKSTASW#AERFAAL 657 +\|\| \|\|\| + \|\|+ \|+++\|\| \|+ \|+ # \|+ \|\| Sbjct 278 MASDDFGRDLASVQALLRKHEGLERDLAAL#EEKVKAL 314 Query 621 LASRDFGHTVDSVEKLIKRHEAFE 644 +\|\| \|+\| \|+ +++ \|+\|+\|\|\|\|\| Sbjct 1892 VASEDYGDTLAAIQGLLKKHEAFE 1915

* References

None.