XSB0628 : epidermal growth factor receptor isoform a variant [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0050
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | epidermal growth factor receptor isoform a variant |
| Gene Names | Not available |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 1081 aa
Average Mass: 119.952 kDa
Monoisotopic Mass: 119.874 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Furin-like 1. | 55 | 209 | 264.9 | 1.9e-76 |
| Recep_L_domain 1. | 232 | 352 | 155.1 | 2e-43 |
| SapA 1. | 382 | 411 | -13.3 | 6.4 |
| NinF 1. | 420 | 485 | 0.1 | 2.4 |
| Gram_pos_anchor 1. | 506 | 543 | 0.6 | 2.7 |
| Pkinase_Tyr 1. | 583 | 839 | 439.6 | 4.7e-129 |
| --- cleavage 604 (inside Pkinase_Tyr 583..839) --- | ||||
3. Sequence Information
Fasta Sequence: XSB0628.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
4 [sites]
Cleavage sites (±10aa)
[Site 1] VQPTCVNSTF1022-DSPAHWAQKG
Phe1022 
Asp
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Val1013 | Gln1014 | Pro1015 | Thr1016 | Cys1017 | Val1018 | Asn1019 | Ser1020 | Thr1021 | Phe1022 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Asp1023 | Ser1024 | Pro1025 | Ala1026 | His1027 | Trp1028 | Ala1029 | Gln1030 | Lys1031 | Gly1032 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| DPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEA |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 136.00 | 9 | epidermal growth factor receptor isoform a variant |
| 2 | Pan troglodytes | 136.00 | 6 | PREDICTED: epidermal growth factor receptor isofor |
| 3 | synthetic construct | 136.00 | 1 | epidermal growth factor receptor |
| 4 | N/A | 110.00 | 7 | - |
| 5 | Mus musculus | 110.00 | 6 | epidermal growth factor receptor isoform 1 |
| 6 | Rattus norvegicus | 108.00 | 4 | epidermal growth factor receptor |
| 7 | Equus caballus | 108.00 | 1 | epidermal growth factor receptor |
| 8 | Sus scrofa | 105.00 | 2 | epidermal growth factor receptor |
| 9 | Canis familiaris | 103.00 | 2 | PREDICTED: similar to Epidermal growth factor rece |
| 10 | Bos taurus | 97.40 | 1 | PREDICTED: similar to epidermal growth factor rece |
| 11 | Monodelphis domestica | 74.70 | 2 | PREDICTED: similar to Epidermal growth factor rece |
| 12 | Xenopus laevis | 70.50 | 1 | epidermal growth factor receptor |
| 13 | Tetraodon nigroviridis | 38.90 | 1 | unnamed protein product |
| 14 | Gallus gallus | 38.10 | 3 | v-erb-a erythroblastic leukemia viral oncogene hom |
| 15 | Xiphophorus xiphidium | 37.40 | 1 | epidermal growth factor receptor |
| 16 | Rous-associated virus type 1 | 35.00 | 2 | polyprotein |
| 17 | Danio rerio | 32.30 | 1 | epidermal growth factor receptor |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 993 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1052 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 993 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1052 |
| Pan troglodytes | Query 993 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1052 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 993 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1052 |
| synthetic construct | Query 993 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1052 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 993 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1052 |
| N/A | Query 993 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKE 1051 | |||+||| |||||||||| ||||++| |#+||| | ||||||+||||||||||||||| Sbjct 1122 DLHYQNPHSNAVGNPEYLNTAQPTCLSSGF#NSPALWIQKGSHQMSLDNPDYQQDFFPKE 1180 |
| Mus musculus | Query 993 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKE 1051 | |||+||| |||||||||| ||||++| |#+||| | ||||||+||||||||||||||| Sbjct 1122 DLHYQNPHSNAVGNPEYLNTAQPTCLSSGF#NSPALWIQKGSHQMSLDNPDYQQDFFPKE 1180 |
| Rattus norvegicus | Query 993 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1052 | |||+||| || ||||||| ||||++| |#|| | | ||||||+|||||||||||||||| Sbjct 1121 DLHYQNPHSNAVSNPEYLNTAQPTCLSSGF#DSSALWIQKGSHQMSLDNPDYQQDFFPKEA 1180 |
| Equus caballus | Query 993 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1052 |||||+||| |+ ||||||| | |||| #| | |||||+||||||||||||||||||| Sbjct 17 DPHYQNPHSNAMDNPEYLNTTHPDCVNSVL#DGTALWAQKGNHQISLDNPDYQQDFFPKEA 76 |
| Sus scrofa | Query 993 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1052 |||||+ || |||||||||| +| |+| #| || ||| |||||+|||||||| |||||| Sbjct 1116 DPHYQNSHSNAVGNPEYLNTPRPACINGGL#DGPAFWAQTGSHQINLDNPDYQQAFFPKEA 1175 |
| Canis familiaris | Query 993 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1052 |||||+||| || ||||||| |||||| #| |+ | |+ +||||||||||||||||||| Sbjct 1508 DPHYQNPHSNAVDNPEYLNT-HPTCVNSVL#DRPSLWTQEANHQISLDNPDYQQDFFPKEA 1566 |
| Bos taurus | Query 993 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1052 || ||+ | || ||||||| | |+| #| || |||||||| ||||||||| |||||| Sbjct 1097 DPQYQNSLSNAVDNPEYLNTTHPACINGVL#DGPALWAQKGSHQFSLDNPDYQQAFFPKEA 1156 |
| Monodelphis domestica | Query 993 DPHYQDPHS-TAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKE 1051 | ||+ |+ +|| ||||||| || |#|| + | | |+||||||||||||+| Sbjct 1148 DSLYQNSHNNSAVDNPEYLNTTQPNLAKKAF#DSNSCWNPTAKHPINLDNPDYQQDFFPQE 1207 Query 1052 A 1052 | Query 1052 A 1052 |
| Xenopus laevis | Query 996 YQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKE 1051 ||+ || + |||||| | + |#| + | || + ||+|||||||||||||| Sbjct 708 YQNSHSNGLNNPEYLNAGQTFVPKTDF#DYSSIWDQKANIQINLDNPDYQQDFFPKE 763 |
| Tetraodon nigroviridis | Query 1007 PEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFP 1049 ||||| | |+ | |# || + | |+||||||||| | Sbjct 1035 PEYLNEV-PSSSNFPF#TPNT---QKYAPQNSIDNPDYQQDFTP 1073 |
| Gallus gallus | Query 993 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPK 1050 +| | + ++ + | ||| | |#|+| +| + +| +||| |++ | Sbjct 1176 EPLYLNTFASTLENAEYLKNNLPEKAKKAF#DNPDYWNHSLPPRSTLQHPDYLQEYSTK 1233 |
| Xiphophorus xiphidium | Query 993 DPHYQDPHSTAVGNPEYLNTV-QPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFP 1049 + | + ||||| + | + #++ | | | |+||||||||| | Sbjct 1130 ESEYPNYFKNRANGPEYLNELPSSTALPLNS#NNTAIGGQNYRPQNSMDNPDYQQDFTP 1187 |
| Rous-associated virus type 1 | Query 993 DPHYQDPHSTAVGNPEYLN---TVQPTCVNS 1020 | ||+ ||||| |||||| | || | Sbjct 698 DSRYQNSHSTAVDNPEYLNMAVRTLPECVVS 728 |
| Danio rerio | Query 993 DPHYQDPHS---TAVGNPEYLNTVQPTCVNSTF#DSPA-----HWAQKGSHQI-------S 1037 +| || || | + + |+ + +| |# ||| + |+ | Sbjct 1096 NPVYQQPHGPPRTLLHSSPALDETEEEYLNC-F#KSPAPASVVEYLNTSHTQLLSTKPFFS 1154 Query 1038 LDNPDYQQDFFPKE 1051 +||||||||| | | Sbjct 1155 MDNPDYQQDFCPLE 1168 |
[Site 2] GTVYKGLWIP604-EGEKVKIPVA
Pro604 Glu
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gly595 | Thr596 | Val597 | Tyr598 | Lys599 | Gly600 | Leu601 | Trp602 | Ile603 | Pro604 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Glu605 | Gly606 | Glu607 | Lys608 | Val609 | Lys610 | Ile611 | Pro612 | Val613 | Ala614 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| LRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEA |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | N/A | 120.00 | 21 | - |
| 2 | Homo sapiens | 120.00 | 15 | epidermal growth factor receptor isoform a variant |
| 3 | Mus musculus | 120.00 | 8 | epidermal growth factor receptor isoform 1 |
| 4 | Rattus norvegicus | 120.00 | 7 | epidermal growth factor receptor |
| 5 | Pan troglodytes | 120.00 | 7 | PREDICTED: epidermal growth factor receptor isofor |
| 6 | synthetic construct | 120.00 | 4 | epidermal growth factor receptor |
| 7 | Monodelphis domestica | 120.00 | 3 | PREDICTED: similar to Epidermal growth factor rece |
| 8 | Canis familiaris | 120.00 | 3 | PREDICTED: similar to Epidermal growth factor rece |
| 9 | Macaca mulatta | 120.00 | 3 | PREDICTED: epidermal growth factor receptor, parti |
| 10 | Rous-associated virus type 1 | 119.00 | 2 | polyprotein |
| 11 | Sus scrofa | 119.00 | 2 | epidermal growth factor receptor |
| 12 | Bos taurus | 119.00 | 1 | PREDICTED: similar to epidermal growth factor rece |
| 13 | Xenopus laevis | 115.00 | 3 | epidermal growth factor receptor |
| 14 | Avian erythroblastosis virus | 115.00 | 2 | gag,v-erb-A,v-erb-B |
| 15 | Danio rerio | 112.00 | 4 | epidermal growth factor receptor |
| 16 | Tetraodon nigroviridis | 111.00 | 3 | unnamed protein product |
| 17 | Xiphophorus xiphidium | 110.00 | 2 | epidermal growth factor receptor |
| 18 | Gallus gallus | 107.00 | 4 | erbB-2 |
| 19 | Felis catus | 106.00 | 2 | v-erb-b2 erythroblastic leukemia viral oncogene ho |
| 20 | Mesocricetus auratus | 106.00 | 1 | ERBB2_MESAU Receptor tyrosine-protein kinase erbB- |
| 21 | Canis lupus familiaris | 106.00 | 1 | erbB-2 |
| 22 | Xiphophorus sp. | 102.00 | 1 | XMRK_XIPMA Melanoma receptor tyrosine-protein kina |
| 23 | Ovis aries | 94.00 | 1 | erythroblastic leukemia viral oncogene-like 2 |
| 24 | Strongylocentrotus purpuratus | 80.90 | 1 | PREDICTED: similar to v-erb-a erythroblastic leuke |
| 25 | Drosophila melanogaster | 80.10 | 147 | mutant epidermal growth factor receptor |
| 26 | Drosophila simulans | 78.20 | 1 | epidermal growth factor receptor |
Top-ranked sequences
| organism | matching |
|---|---|
| N/A | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 |
| Homo sapiens | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 |
| Mus musculus | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 |
| Rattus norvegicus | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 |
| Pan troglodytes | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 |
| synthetic construct | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 |
| Monodelphis domestica | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 |
| Canis familiaris | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 |
| Macaca mulatta | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 |
| Rous-associated virus type 1 | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 |||||||||||+||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 278 LRILKETEFKKVKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 337 |
| Sus scrofa | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 |||||||||||+||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 699 LRILKETEFKKVKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 758 |
| Bos taurus | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 |||||||||||+||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 681 LRILKETEFKKVKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 740 |
| Xenopus laevis | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 ||||||||||||||||||||||||+|||||#||| +||||||||||||||||||||||||| Sbjct 289 LRILKETEFKKIKVLGSGAFGTVYQGLWIP#EGEGIKIPVAIKELREATSPKANKEILDEA 348 |
| Avian erythroblastosis virus | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 |||||||||||+|||| |||||||||||||#||||| |||||||||||||||||||||||| Sbjct 546 LRILKETEFKKVKVLGFGAFGTVYKGLWIP#EGEKVTIPVAIKELREATSPKANKEILDEA 605 |
| Danio rerio | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 |||||||||||||||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |
| Tetraodon nigroviridis | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 |||||| |||||||||||||||||||||+|#||| |||||||| |||||||||||+||||| Sbjct 674 LRILKEPEFKKIKVLGSGAFGTVYKGLWVP#EGEDVKIPVAIKVLREATSPKANKDILDEA 733 |
| Xiphophorus xiphidium | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 |||||| |||||||||||||||||||||+|#||| |||||||| ||||||||||+|||||| Sbjct 714 LRILKEPEFKKIKVLGSGAFGTVYKGLWVP#EGEDVKIPVAIKVLREATSPKANQEILDEA 773 |
| Gallus gallus | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 +||||||| ||+||||||||||||||+|||#+|| |||||||| ||| ||||||||||||| Sbjct 701 MRILKETELKKVKVLGSGAFGTVYKGIWIP#DGESVKIPVAIKVLRENTSPKANKEILDEA 760 |
| Felis catus | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 +||||||| +|+||||||||||||||+|||#+|| |||||||| ||| ||||||||||||| Sbjct 712 MRILKETELRKVKVLGSGAFGTVYKGIWIP#DGENVKIPVAIKVLRENTSPKANKEILDEA 771 |
| Mesocricetus auratus | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 +||||||| +|+||||||||||||||+|||#+|| |||||||| ||| ||||||||||||| Sbjct 712 MRILKETELRKVKVLGSGAFGTVYKGIWIP#DGENVKIPVAIKVLRENTSPKANKEILDEA 771 |
| Canis lupus familiaris | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 +||||||| +|+||||||||||||||+|||#+|| |||||||| ||| ||||||||||||| Sbjct 711 MRILKETELRKVKVLGSGAFGTVYKGIWIP#DGENVKIPVAIKVLRENTSPKANKEILDEA 770 |
| Xiphophorus sp. | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 ||||||||||| +||||||||||||||| |#+|| ++|||||| |||||||| |+|+|||| Sbjct 702 LRILKETEFKKDRVLGSGAFGTVYKGLWNP#DGENIRIPVAIKVLREATSPKVNQEVLDEA 761 |
| Ovis aries | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKAN 627 +||||||| +|+||||||||||||||+|||#+|| |||||||| ||| |||||| Sbjct 63 MRILKETELRKVKVLGSGAFGTVYKGIWIP#DGENVKIPVAIKVLRENTSPKAN 115 |
| Strongylocentrotus purpuratus | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILD 632 |+|+|+|| | |||||||||||||||||#+|||++|||||| ||| || | +|+|+ Sbjct 1012 LKIIKDTELKLGPVLGSGAFGTVYKGLWIP#DGEKIRIPVAIKALRE-VSPHAAEELLE 1068 |
| Drosophila melanogaster | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 |||+|+|| +| ||| |||| ||||+|+|#||| |||||||||| ++| ++++| | || Sbjct 830 LRIVKDTELRKGGVLGMGAFGRVYKGVWVP#EGENVKIPVAIKELLKSTGAESSEEFLREA 889 |
| Drosophila simulans | Query 575 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 634 |||+|+ | +| ||| |||| ||||+|+|#||| |||||||||| ++| ++++| | || Sbjct 829 LRIVKDAELRKGGVLGMGAFGRVYKGVWVP#EGENVKIPVAIKELLKSTGAESSEEFLREA 888 |
[Site 3] FFPKEAKPNG1056-IFKGSTAENA
Gly1056 Ile
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Phe1047 | Phe1048 | Pro1049 | Lys1050 | Glu1051 | Ala1052 | Lys1053 | Pro1054 | Asn1055 | Gly1056 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ile1057 | Phe1058 | Lys1059 | Gly1060 | Ser1061 | Thr1062 | Ala1063 | Glu1064 | Asn1065 | Ala1066 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| HWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 118.00 | 5 | epidermal growth factor receptor isoform a variant |
| 2 | Pan troglodytes | 118.00 | 4 | PREDICTED: epidermal growth factor receptor isofor |
| 3 | synthetic construct | 118.00 | 1 | epidermal growth factor receptor |
| 4 | N/A | 106.00 | 5 | - |
| 5 | Mus musculus | 106.00 | 3 | epidermal growth factor receptor isoform 1 |
| 6 | Rattus norvegicus | 105.00 | 1 | epidermal growth factor receptor |
| 7 | Equus caballus | 103.00 | 1 | epidermal growth factor receptor |
| 8 | Canis familiaris | 98.60 | 1 | PREDICTED: similar to Epidermal growth factor rece |
| 9 | Bos taurus | 95.50 | 1 | PREDICTED: similar to epidermal growth factor rece |
| 10 | Sus scrofa | 89.70 | 2 | epidermal growth factor receptor |
| 11 | Monodelphis domestica | 82.40 | 1 | PREDICTED: similar to Epidermal growth factor rece |
| 12 | Xenopus laevis | 68.20 | 1 | epidermal growth factor receptor |
| 13 | Danio rerio | 36.60 | 2 | epidermal growth factor receptor |
| 14 | Tetraodon nigroviridis | 36.60 | 1 | unnamed protein product |
| 15 | Xiphophorus xiphidium | 35.00 | 1 | epidermal growth factor receptor |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 1027 HWAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1081 ||||||||||||||||||||||||||||||#||||||||||||||||||||||||| Query 1027 HWAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1081 |
| Pan troglodytes | Query 1027 HWAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1081 ||||||||||||||||||||||||||||||#||||||||||||||||||||||||| Query 1027 HWAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1081 |
| synthetic construct | Query 1027 HWAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1081 ||||||||||||||||||||||||||||||#||||||||||||||||||||||||| Query 1027 HWAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1081 |
| N/A | Query 1028 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1081 | ||||||+||||||||||||||| ||||#|||| |||||||||||| ||||||| Sbjct 1157 WIQKGSHQMSLDNPDYQQDFFPKETKPNG#IFKGPTAENAEYLRVAPPSSEFIGA 1210 |
| Mus musculus | Query 1028 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1081 | ||||||+||||||||||||||| ||||#|||| |||||||||||| ||||||| Sbjct 1157 WIQKGSHQMSLDNPDYQQDFFPKETKPNG#IFKGPTAENAEYLRVAPPSSEFIGA 1210 |
| Rattus norvegicus | Query 1028 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1081 | ||||||+||||||||||||||||||||#|||| |||||||||||| |||| || Sbjct 1156 WIQKGSHQMSLDNPDYQQDFFPKEAKPNG#IFKGPTAENAEYLRVAPPSSEFSGA 1209 |
| Equus caballus | Query 1028 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIG 1080 |||||+|||||||||||||||||||| ||#|||| ||||||||||| |||||| Sbjct 52 WAQKGNHQISLDNPDYQQDFFPKEAKSNG#IFKGPAAENAEYLRVAPPSSEFIG 104 |
| Canis familiaris | Query 1028 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1081 | |+ +|||||||||||||||||||| ||#|||| ||||+|||||| ||||||| Sbjct 1542 WTQEANHQISLDNPDYQQDFFPKEAKSNG#IFKGPAAENADYLRVAPPSSEFIGA 1595 |
| Bos taurus | Query 1028 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1081 |||||||| ||||||||| ||||||| ||#|||| |||||||| || |+| || Sbjct 1132 WAQKGSHQFSLDNPDYQQAFFPKEAKSNG#IFKGPAAENAEYLRAAPAGSDFTGA 1185 |
| Sus scrofa | Query 1028 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1081 ||| |||||+|||||||| ||||||| ||#| || |||||||| || ||+ || Sbjct 1151 WAQTGSHQINLDNPDYQQAFFPKEAKSNG#ICKGPAAENAEYLRAAPASSDLTGA 1204 |
| Monodelphis domestica | Query 1028 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1081 | | |+||||||||||||+||||||#+|| ||| |||||| | |||| | Sbjct 1184 WNPTAKHPINLDNPDYQQDFFPQEAKPNG#VFKVPAAENPEYLRVAAQQSEFIQA 1237 |
| Xenopus laevis | Query 1028 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQS 1075 | || + ||+|||||||||||||| | ||# || |+| ||| +|| | Sbjct 740 WDQKANIQINLDNPDYQQDFFPKEPKTNG#HFKIPAAQNPEYLGLAPVS 787 |
| Danio rerio | Query 1037 SLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYL 1069 |+||||||||| | | | + # |+| ||+ Sbjct 1154 SMDNPDYQQDFCPLELKTHT#NGHLPAAQNQEYM 1186 |
| Tetraodon nigroviridis | Query 1030 QKGSHQISLDNPDYQQDFFPK-EAKPNG#IFKGSTAENAEYLRV 1071 || + | |+||||||||| | + ||# ||| || | Sbjct 1054 QKYAPQNSIDNPDYQQDFTPTFKTHTNG#HI--PAAENTEYTSV 1094 |
| Xiphophorus xiphidium | Query 1035 QISLDNPDYQQDFFPK-EAKPNG#IFKGSTAENAEYL 1069 | |+||||||||| | + ||# ||| ||| Sbjct 1173 QNSMDNPDYQQDFTPTFKTHTNG#HI--PAAENVEYL 1206 |
[Site 4] LTEDSIDDTF957-LPVPEYINQS
Phe957 Leu
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Leu948 | Thr949 | Glu950 | Asp951 | Ser952 | Ile953 | Asp954 | Asp955 | Thr956 | Phe957 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Leu958 | Pro959 | Val960 | Pro961 | Glu962 | Tyr963 | Ile964 | Asn965 | Gln966 | Ser967 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| SCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLN |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 128.00 | 13 | epidermal growth factor receptor isoform a variant |
| 2 | Pan troglodytes | 128.00 | 6 | PREDICTED: epidermal growth factor receptor isofor |
| 3 | synthetic construct | 128.00 | 2 | epidermal growth factor receptor |
| 4 | Canis familiaris | 122.00 | 2 | PREDICTED: similar to Epidermal growth factor rece |
| 5 | Sus scrofa | 119.00 | 2 | epidermal growth factor receptor |
| 6 | N/A | 117.00 | 10 | - |
| 7 | Mus musculus | 117.00 | 4 | epidermal growth factor receptor isoform 1 |
| 8 | Bos taurus | 117.00 | 1 | PREDICTED: similar to epidermal growth factor rece |
| 9 | Rattus norvegicus | 116.00 | 1 | epidermal growth factor receptor |
| 10 | Monodelphis domestica | 100.00 | 2 | PREDICTED: similar to Epidermal growth factor rece |
| 11 | Rous-associated virus type 1 | 79.30 | 2 | polyprotein |
| 12 | Macaca mulatta | 74.30 | 3 | PREDICTED: epidermal growth factor receptor, parti |
| 13 | Xenopus laevis | 72.40 | 1 | epidermal growth factor receptor |
| 14 | Avian erythroblastosis virus | 38.90 | 2 | gag,v-erb-A,v-erb-B |
| 15 | Gallus gallus | 36.60 | 3 | AF121963_1 receptor tyrosine kinase precursor |
| 16 | Canis lupus familiaris | 35.00 | 1 | erbB-2 |
| 17 | Felis catus | 32.70 | 1 | v-erb-b2 erythroblastic leukemia viral oncogene ho |
| 18 | Leishmania braziliensis | 32.30 | 1 | mitochondrial exoribonuclease DSS-1, putative |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 928 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 987 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 928 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 987 |
| Pan troglodytes | Query 928 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 987 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 928 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 987 |
| synthetic construct | Query 928 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 987 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 928 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 987 |
| Canis familiaris | Query 928 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 987 +||+||||||||||||||| ||||+|||||#|| ||||||||||||||||||||||||||| Sbjct 1443 TCPLKEDSFLQRYSSDPTGTLTEDNIDDTF#LPAPEYINQSVPKRPAGSVQNPVYHNQPLN 1502 |
| Sus scrofa | Query 928 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 987 | |+|||||||||||||||||||||+||||#|| |||+||||||||||||||||||||||+ Sbjct 1051 SYPLKEDSFLQRYSSDPTGALTEDSLDDTF#LPAPEYVNQSVPKRPAGSVQNPVYHNQPLS 1110 |
| N/A | Query 928 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 987 || +|||+||||||||||||+|||+||| |#||||||+||||||||||||||||||||||+ Sbjct 1057 SCRVKEDAFLQRYSSDPTGAVTEDNIDDAF#LPVPEYVNQSVPKRPAGSVQNPVYHNQPLH 1116 |
| Mus musculus | Query 928 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 987 || +|||+||||||||||||+|||+||| |#||||||+||||||||||||||||||||||+ Sbjct 1057 SCRVKEDAFLQRYSSDPTGAVTEDNIDDAF#LPVPEYVNQSVPKRPAGSVQNPVYHNQPLH 1116 |
| Bos taurus | Query 928 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPL 986 | |+||||||||||||||||| |||+||||#||||||+|||||||||||||||||||||| Sbjct 1032 SYPLKEDSFLQRYSSDPTGALIEDSMDDTF#LPVPEYVNQSVPKRPAGSVQNPVYHNQPL 1090 |
| Rattus norvegicus | Query 928 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 987 || +|||+|||||||||| ||||+|||||#|||||||||||||||||||||||||||||+ Sbjct 1056 SCRVKEDAFLQRYSSDPTSVLTEDNIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLH 1115 |
| Monodelphis domestica | Query 928 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGS-VQNPVYHNQPL 986 +|| ||++|+|||||||| ||||++||+|# ||||||||| || | || +|||||||||| Sbjct 1082 TCPGKEENFIQRYSSDPTTVLTEDNVDDSF#QPVPEYINQSAPKNPTGSAIQNPVYHNQPL 1141 Query 987 N 987 | Query 987 N 987 |
| Rous-associated virus type 1 | Query 930 PIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPA-GSVQNPVYHN 983 |++||||+||||||||| |+|||| |#|| |||+|| +||+|+ ||| +|+| Sbjct 632 PVREDSFVQRYSSDPTGNFLEESIDDGF#LPAPEYVNQLMPKKPSTAMVQNQIYNN 686 |
| Macaca mulatta | Query 928 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVP-EYI-------NQSVPKRPAGSVQNP 979 ||||||||||||||||||||||||||||||#|||| |++ + |+ | |+ +| Sbjct 1057 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPGEWLVWKHSCSSASLTHSAAASLHHP 1116 Query 980 V 980 | Query 980 V 980 |
| Xenopus laevis | Query 930 PIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHN 983 | +||||+||||+||| + |||||| |#|| |||+|| ||| + |||| | Sbjct 641 PAREDSFVQRYSTDPT-VILEDSIDDEF#LPAPEYVNQMVPKPVVETQTNPVYQN 693 |
| Avian erythroblastosis virus | Query 954 DDTF#LPVPEYINQSVPKRPA-GSVQNPVYH 982 +| |#|| |||+|| +||+|+ ||| +|+ Sbjct 902 EDGF#LPAPEYVNQLMPKKPSTAMVQNQIYN 931 |
| Gallus gallus | Query 932 KEDSFLQRYSSDPT---------GALTEDSI---------DDTF#LPVPEYINQSVPKRPA 973 |||| ||||+||| | | || | # || | | | +| Sbjct 952 KEDSSTQRYSADPTVFIPERVIRGELDEDGYMTPMRDKPKTDYL#NPVEE--NPFVSRRKN 1009 Query 974 GSVQ---NPVYHNQP 985 | +| || ||| | Sbjct 1010 GDLQAVDNPEYHNAP 1024 |
| Canis lupus familiaris | Query 928 SCPIKEDSFLQRYSSDPTGALTEDSIDD----TF#LPVPEYINQ-SVPKRPAGSVQNPVYH 982 | | ++ | ||||| ||| | ++ | # | |||+|| | +| +++ |+ Sbjct 1099 SLPSQDPSPLQRYSEDPTVPLPPETDGKVAPLTC#SPQPEYVNQPEVWPQPPLALEGPLPP 1158 Query 983 NQP 985 ++| Sbjct 1159 SRP 1161 |
| Felis catus | Query 932 KEDSFLQRYSSDPTGALTEDS----IDDTF#LPVPEYINQ-SVPKRPAGSVQNPVYHNQP 985 ++ | ||||| ||| | ++ | # | |||+|| | +| ++ |+ ++| Sbjct 1104 QDPSPLQRYSEDPTVPLPPETDGYVAPLTC#SPQPEYVNQPEVWPKPPSPLEGPLPPSRP 1162 |
| Leishmania braziliensis | Query 931 IKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 987 + | + || ++| | | |+| + #+ + | + || | +| +||+ ||+ Sbjct 521 LSSDHLVARYYTEPEGVQTLTSLDASH#IFLAEAMQSSV--RRLSTVTRAIYHHVPLH 575 |
* References
None.