logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB0949 : integrin beta chain, beta 3 [Canis lupus familiaris]

[ CaMP Format ]

This entry is computationally expanded from SB0043

* Basic Information

OrganismCanis lupus familiaris (dog)
Protein NamesIntegrin beta; integrin beta chain; beta 3; glycoprotein GPIIIa
Gene NamesITGB3; GPIIIa; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Gene Locus9; chromosome 9
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001003162 NM_001003162 403788 Q9TUN7 N/A N/A N/A cfa:403788

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 784 aa

Average Mass: 86.417 kDa

Monoisotopic Mass: 86.360 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Integrin_beta 1. 344571019.11.7e-303
EGF_2 1. 45949313.80.076
EGF_2 2. 50854332.22.2e-06
EGF_2 3. 55058022.80.0014
EGF_2 4. 58962029.31.6e-05
Integrin_B_tail 1. 630714128.03e-35
Integrin_b_cyt 1. 738783106.87.1e-29
--- cleavage 757 (inside Integrin_b_cyt 738..783) ---
--- cleavage 763 (inside Integrin_b_cyt 738..783) ---
--- cleavage 781 (inside Integrin_b_cyt 738..783) ---
--- cleavage 769 (inside Integrin_b_cyt 738..783) ---

3. Sequence Information

Fasta Sequence: XSB0949.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

4 [sites]

Cleavage sites (±10aa)

[Site 1] EFAKFEEERA757-RAKWDTANNP

Ala757 Arg

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu748Phe749Ala750Lys751Phe752Glu753Glu754Glu755Arg756Ala757
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Arg758Ala759Lys760Trp761Asp762Thr763Ala764Asn765Asn766Pro767

Sequence conservation (by blast)

[Site 2] EERARAKWDT763-ANNPLYKEAT

Thr763 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu754Glu755Arg756Ala757Arg758Ala759Lys760Trp761Asp762Thr763
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala764Asn765Asn766Pro767Leu768Tyr769Lys770Glu771Ala772Thr773

Sequence conservation (by blast)

[Site 3] ATSTFTNITY781-RGT

Tyr781 Arg

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ala772Thr773Ser774Thr775Phe776Thr777Asn778Ile779Thr780Tyr781
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Arg782Gly783Thr784-------

Sequence conservation (by blast)

[Site 4] KWDTANNPLY769-KEATSTFTNI

Tyr769 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys760Trp761Asp762Thr763Ala764Asn765Asn766Pro767Leu768Tyr769
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys770Glu771Ala772Thr773Ser774Thr775Phe776Thr777Asn778Ile779

Sequence conservation (by blast)

* References

[PubMed ID: 10482317] Lipscomb DL, Bourne C, Boudreaux MK, DNA sequence of the canine platelet beta3 gene from cDNA: comparison of canine and mouse beta3 to segments that encode alloantigenic sites and functional domains of beta3 in human beings. J Lab Clin Med. 1999 Sep;134(3):313-21.