logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB0959 : integrin, beta 2 (complement component 3 receptor 3 and 4 subunit), isoform CRA_b [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0002

* Basic Information

OrganismHomo sapiens (human)
Protein Namesintegrin; beta 2 (complement component 3 receptor 3 and 4 subunit); isoform CRA_b
Gene NamesITGB2
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
EAX09383 N/A 3689 N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 712 aa

Average Mass: 78.354 kDa

Monoisotopic Mass: 78.303 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Integrin_beta 1. 32390810.79.5e-241
EGF_2 1. 39242418.70.02
EGF_2 2. 44047711.80.13
EGF_2 3. 48451616.00.042
EGF_2 4. 52555525.70.00019
Integrin_B_tail 1. 565643132.01.8e-36
Integrin_b_cyt 1. 66771187.83.9e-23
--- cleavage 687 (inside Integrin_b_cyt 667..711) ---
--- cleavage 705 (inside Integrin_b_cyt 667..711) ---
--- cleavage 703 (inside Integrin_b_cyt 667..711) ---
--- cleavage 697 (inside Integrin_b_cyt 667..711) ---

3. Sequence Information

Fasta Sequence: XSB0959.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

4 [sites]

Cleavage sites (±10aa)

[Site 1] YRRFEKEKLK687-SQWNNDNPLF

Lys687 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Tyr678Arg679Arg680Phe681Glu682Lys683Glu684Lys685Leu686Lys687
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser688Gln689Trp690Asn691Asn692Asp693Asn694Pro695Leu696Phe697

Sequence conservation (by blast)

[Site 2] LFKSATTTVM705-NPKFAES

Met705 Asn

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Leu696Phe697Lys698Ser699Ala700Thr701Thr702Thr703Val704Met705
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Asn706Pro707Lys708Phe709Ala710Glu711Ser712---

Sequence conservation (by blast)

[Site 3] NPLFKSATTT703-VMNPKFAES

Thr703 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Asn694Pro695Leu696Phe697Lys698Ser699Ala700Thr701Thr702Thr703
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Val704Met705Asn706Pro707Lys708Phe709Ala710Glu711Ser712-

Sequence conservation (by blast)

[Site 4] SQWNNDNPLF697-KSATTTVMNP

Phe697 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ser688Gln689Trp690Asn691Asn692Asp693Asn694Pro695Leu696Phe697
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys698Ser699Ala700Thr701Thr702Thr703Val704Met705Asn706Pro707

Sequence conservation (by blast)

* References

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