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XSB0960 : integrin, beta 2 [Pan troglodytes]

[ CaMP Format ]

This entry is computationally expanded from SB0002

* Basic Information

OrganismPan troglodytes (chimpanzee)
Protein NamesIntegrin beta; integrin; beta 2
Gene NamesITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Gene Locus21; chromosome 21
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001029294 NM_001034122 458607 Q5NKT5 N/A N/A N/A ptr:458607

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 769 aa

Average Mass: 84.819 kDa

Monoisotopic Mass: 84.763 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Integrin_beta 1. 324471050.00
EGF_2 1. 44948118.70.02
EGF_2 2. 49753411.80.13
EGF_2 3. 54157316.00.042
EGF_2 4. 58261225.70.00019
Integrin_B_tail 1. 622700132.01.8e-36
Integrin_b_cyt 1. 72476887.83.9e-23
--- cleavage 744 (inside Integrin_b_cyt 724..768) ---
--- cleavage 762 (inside Integrin_b_cyt 724..768) ---
--- cleavage 760 (inside Integrin_b_cyt 724..768) ---
--- cleavage 754 (inside Integrin_b_cyt 724..768) ---

3. Sequence Information

Fasta Sequence: XSB0960.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

4 [sites]

Cleavage sites (±10aa)

[Site 1] YRRFEKEKLK744-SQWNNDNPLF

Lys744 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Tyr735Arg736Arg737Phe738Glu739Lys740Glu741Lys742Leu743Lys744
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser745Gln746Trp747Asn748Asn749Asp750Asn751Pro752Leu753Phe754

Sequence conservation (by blast)

[Site 2] LFKSATTTVM762-NPKFAES

Met762 Asn

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Leu753Phe754Lys755Ser756Ala757Thr758Thr759Thr760Val761Met762
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Asn763Pro764Lys765Phe766Ala767Glu768Ser769---

Sequence conservation (by blast)

[Site 3] NPLFKSATTT760-VMNPKFAES

Thr760 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Asn751Pro752Leu753Phe754Lys755Ser756Ala757Thr758Thr759Thr760
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Val761Met762Asn763Pro764Lys765Phe766Ala767Glu768Ser769-

Sequence conservation (by blast)

[Site 4] SQWNNDNPLF754-KSATTTVMNP

Phe754 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ser745Gln746Trp747Asn748Asn749Asp750Asn751Pro752Leu753Phe754
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys755Ser756Ala757Thr758Thr759Thr760Val761Met762Asn763Pro764

Sequence conservation (by blast)

* References

[PubMed ID: 15572059] Walter NA, Stebbing J, Messier W, The potential significance of adaptive evolution and dimerization in chimpanzee intercellular cell adhesion molecules (ICAMs). J Theor Biol. 2005 Feb 7;232(3):339-46.