logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB1014 : Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

[ CaMP Format ]

This entry is computationally expanded from SB0004

* Basic Information

OrganismBos taurus (cattle)
Protein NamesCam-PDE 1A; 3.1.4.17; 61 kDa Cam-PDE
Gene NamesPDE1A
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
P14100 N/A N/A P14100 N/A N/A N/A bta:281969

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 530 aa

Average Mass: 60.843 kDa

Monoisotopic Mass: 60.805 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
L27_N 1. 2368-11.27.3
PDEase_I_N 1. 73133125.81.4e-34
--- cleavage 126 (inside PDEase_I_N 73..133) ---
PDEase_I 1. 218449512.36.3e-151

3. Sequence Information

Fasta Sequence: XSB1014.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] RFRSIVHVVQ126-AGIFVERMYR

Gln126 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Arg117Phe118Arg119Ser120Ile121Val122His123Val124Val125Gln126
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala127Gly128Ile129Phe130Val131Glu132Arg133Met134Tyr135Arg136

Sequence conservation (by blast)

* References

[PubMed ID: 7678006] Sonnenburg WK, Seger D, Beavo JA, Molecular cloning of a cDNA encoding the "61-kDa" calmodulin-stimulated cyclic nucleotide phosphodiesterase. Tissue-specific expression of structurally related isoforms. J Biol Chem. 1993 Jan 5;268(1):645-52.

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