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XSB1017 : peroxiredoxin 2 [Rattus norvegicus]

[ CaMP Format ]

This entry is computationally expanded from SB0091

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein NamesPeroxiredoxin-2; 1.11.1.15; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1; Thiol-specific antioxidant protein; TSA; peroxiredoxin 2
Gene NamesPrdx2; Tdpx1; peroxiredoxin 2
Gene Locus19q11; chromosome 19
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_058865 NM_017169 29338 P35704 N/A N/A N/A rno:29338

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 198 aa

Average Mass: 21.784 kDa

Monoisotopic Mass: 21.770 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
AhpC-TSA 1. 8141218.81.4e-62
1-cysPrx_C 1. 15119487.64.5e-23
--- cleavage 181 (inside 1-cysPrx_C 151..194) ---
--- cleavage 193 (inside 1-cysPrx_C 151..194) ---
--- cleavage 183 (inside 1-cysPrx_C 151..194) ---
--- cleavage 182 (inside 1-cysPrx_C 151..194) ---
--- cleavage 194 (inside 1-cysPrx_C 151..194) ---

3. Sequence Information

Fasta Sequence: XSB1017.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

5 [sites]

Cleavage sites (±10aa)

[Site 1] CPAGWKPGSD181-TIKPNVDDSK

Asp181 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Cys172Pro173Ala174Gly175Trp176Lys177Pro178Gly179Ser180Asp181
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Thr182Ile183Lys184Pro185Asn186Val187Asp188Asp189Ser190Lys191

Sequence conservation (by blast)

[Site 2] KPNVDDSKEY193-FSKHN

Tyr193 Phe

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys184Pro185Asn186Val187Asp188Asp189Ser190Lys191Glu192Tyr193
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Phe194Ser195Lys196His197Asn198-----

Sequence conservation (by blast)

[Site 3] AGWKPGSDTI183-KPNVDDSKEY

Ile183 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ala174Gly175Trp176Lys177Pro178Gly179Ser180Asp181Thr182Ile183
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys184Pro185Asn186Val187Asp188Asp189Ser190Lys191Glu192Tyr193

Sequence conservation (by blast)

[Site 4] PAGWKPGSDT182-IKPNVDDSKE

Thr182 Ile

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Pro173Ala174Gly175Trp176Lys177Pro178Gly179Ser180Asp181Thr182
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ile183Lys184Pro185Asn186Val187Asp188Asp189Ser190Lys191Glu192

Sequence conservation (by blast)

[Site 5] PNVDDSKEYF194-SKHN

Phe194 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Pro185Asn186Val187Asp188Asp189Ser190Lys191Glu192Tyr193Phe194
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser195Lys196His197Asn198------

Sequence conservation (by blast)

* References

[PubMed ID: 18491044] Botia B, Seyer D, Ravni A, Benard M, Falluel-Morel A, Cosette P, Jouenne T, Fournier A, Vaudry H, Gonzalez BJ, Vaudry D, Peroxiredoxin 2 is involved in the neuroprotective effects of PACAP in cultured cerebellar granule neurons. J Mol Neurosci. 2008 Nov;36(1-3):61-72. Epub 2008 May 20.

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