logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB1021 : thiol-specific antioxidant protein [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0091

* Basic Information

OrganismHomo sapiens (human)
Protein NamesPeroxiredoxin-2; 1.11.1.15; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1; Thiol-specific antioxidant protein; TSA; PRP; Natural killer cell-enhancing factor B; NKEF-B
Gene NamesNKEFB, TDPX1; NKEFB; TDPX1
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
CAA80269 N/A N/A P32119 N/A 9353 N/A hsa:7001

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 198 aa

Average Mass: 21.857 kDa

Monoisotopic Mass: 21.843 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
AhpC-TSA 1. 8141203.55.5e-58
1-cysPrx_C 1. 15119483.01.1e-21
--- cleavage 181 (inside 1-cysPrx_C 151..194) ---
--- cleavage 193 (inside 1-cysPrx_C 151..194) ---
--- cleavage 183 (inside 1-cysPrx_C 151..194) ---
--- cleavage 182 (inside 1-cysPrx_C 151..194) ---
--- cleavage 194 (inside 1-cysPrx_C 151..194) ---

3. Sequence Information

Fasta Sequence: XSB1021.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1QMV (X-ray; 170 A; A/B/C/D/E/F/G/H/I/J=2-198)

* Cleavage Information

5 [sites]

Cleavage sites (±10aa)

[Site 1] CPAAWKPGRD181-TIKPNVDDSK

Asp181 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Cys172Pro173Ala174Ala175Trp176Lys177Pro178Gly179Arg180Asp181
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Thr182Ile183Lys184Pro185Asn186Val187Asp188Asp189Ser190Lys191

Sequence conservation (by blast)

[Site 2] KPNVDDSKEY193-FSKHN

Tyr193 Phe

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys184Pro185Asn186Val187Asp188Asp189Ser190Lys191Glu192Tyr193
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Phe194Ser195Lys196His197Asn198-----

Sequence conservation (by blast)

[Site 3] AAWKPGRDTI183-KPNVDDSKEY

Ile183 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ala174Ala175Trp176Lys177Pro178Gly179Arg180Asp181Thr182Ile183
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys184Pro185Asn186Val187Asp188Asp189Ser190Lys191Glu192Tyr193

Sequence conservation (by blast)

[Site 4] PAAWKPGRDT182-IKPNVDDSKE

Thr182 Ile

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Pro173Ala174Ala175Trp176Lys177Pro178Gly179Arg180Asp181Thr182
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ile183Lys184Pro185Asn186Val187Asp188Asp189Ser190Lys191Glu192

Sequence conservation (by blast)

[Site 5] PNVDDSKEYF194-SKHN

Phe194 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Pro185Asn186Val187Asp188Asp189Ser190Lys191Glu192Tyr193Phe194
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser195Lys196His197Asn198------

Sequence conservation (by blast)

* References

[PubMed ID: 8144038] Lim YS, Cha MK, Kim HK, Kim IH, The thiol-specific antioxidant protein from human brain: gene cloning and analysis of conserved cysteine regions. Gene. 1994 Mar 25;140(2):279-84.