logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB1042 : hypothetical protein [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0063

* Basic Information

OrganismHomo sapiens (human)
Protein NamesIntegrin beta-1; Fibronectin receptor subunit beta; Integrin VLA-4 subunit beta; hypothetical protein
Gene NamesDKFZp686D0452; FNRB, MDF2, MSK12; FNRB; MDF2; MSK12
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
CAD97649 N/A N/A Q7Z3V1 N/A 6153 N/A hsa:

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 823 aa

Average Mass: 91.131 kDa

Monoisotopic Mass: 91.071 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Integrin_beta 1. 594891127.90
EGF_2 1. 49152511.80.13
EGF_2 2. 54157821.30.0041
EGF_2 3. 58561521.90.0027
EGF_2 4. 62465533.77.6e-07
Integrin_B_tail 1. 665753159.01.4e-44
Integrin_b_cyt 1. 777822112.31.6e-30
--- cleavage 814 (inside Integrin_b_cyt 777..822) ---
--- cleavage 816 (inside Integrin_b_cyt 777..822) ---
--- cleavage 803 (inside Integrin_b_cyt 777..822) ---
--- cleavage 802 (inside Integrin_b_cyt 777..822) ---

3. Sequence Information

Fasta Sequence: XSB1042.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1K11 (Model; -; B=786-797), 1LHA (Model; -; A=86-543)

* Cleavage Information

4 [sites]

Cleavage sites (±10aa)

[Site 1] NPIYKSAVTT814-VVNPKYEGK

Thr814 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Asn805Pro806Ile807Tyr808Lys809Ser810Ala811Val812Thr813Thr814
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Val815Val816Asn817Pro818Lys819Tyr820Glu821Gly822Lys823-

Sequence conservation (by blast)

[Site 2] IYKSAVTTVV816-NPKYEGK

Val816 Asn

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ile807Tyr808Lys809Ser810Ala811Val812Thr813Thr814Val815Val816
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Asn817Pro818Lys819Tyr820Glu821Gly822Lys823---

Sequence conservation (by blast)

[Site 3] EKMNAKWDTG803-ENPIYKSAVT

Gly803 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu794Lys795Met796Asn797Ala798Lys799Trp800Asp801Thr802Gly803
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu804Asn805Pro806Ile807Tyr808Lys809Ser810Ala811Val812Thr813

Sequence conservation (by blast)

[Site 4] KEKMNAKWDT802-GENPIYKSAV

Thr802 Gly

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys793Glu794Lys795Met796Asn797Ala798Lys799Trp800Asp801Thr802
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gly803Glu804Asn805Pro806Ile807Tyr808Lys809Ser810Ala811Val812

Sequence conservation (by blast)

* References

None.