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XSB1047 : integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [Gallus gallus]

[ CaMP Format ]

This entry is computationally expanded from SB0063

* Basic Information

OrganismGallus gallus (chicken)
Protein NamesIntegrin beta-1; CSAT antigen; JG22 antigen; RGD-receptor; integrin; beta 1 (fibronectin receptor; beta polypeptide; antigen CD29 includes MDF2; MSK12)
Gene NamesITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Gene Locus2; chromosome 2
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001034343 NM_001039254 374058 P07228 N/A N/A N/A gga:374058

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 803 aa

Average Mass: 88.554 kDa

Monoisotopic Mass: 88.495 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Integrin_beta 1. 384691136.90
EGF_2 1. 4715059.30.26
EGF_2 2. 52155820.80.0057
EGF_2 3. 56559521.60.0032
EGF_2 4. 60463531.82.8e-06
Integrin_B_tail 1. 645733162.51.2e-45
Integrin_b_cyt 1. 757802112.31.6e-30
--- cleavage 794 (inside Integrin_b_cyt 757..802) ---
--- cleavage 796 (inside Integrin_b_cyt 757..802) ---
--- cleavage 783 (inside Integrin_b_cyt 757..802) ---
--- cleavage 782 (inside Integrin_b_cyt 757..802) ---

3. Sequence Information

Fasta Sequence: XSB1047.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

4 [sites]

Cleavage sites (±10aa)

[Site 1] NPIYKSAVTT794-VVNPKYEGK

Thr794 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Asn785Pro786Ile787Tyr788Lys789Ser790Ala791Val792Thr793Thr794
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Val795Val796Asn797Pro798Lys799Tyr800Glu801Gly802Lys803-

Sequence conservation (by blast)

[Site 2] IYKSAVTTVV796-NPKYEGK

Val796 Asn

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ile787Tyr788Lys789Ser790Ala791Val792Thr793Thr794Val795Val796
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Asn797Pro798Lys799Tyr800Glu801Gly802Lys803---

Sequence conservation (by blast)

[Site 3] EKMNAKWDTG783-ENPIYKSAVT

Gly783 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu774Lys775Met776Asn777Ala778Lys779Trp780Asp781Thr782Gly783
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu784Asn785Pro786Ile787Tyr788Lys789Ser790Ala791Val792Thr793

Sequence conservation (by blast)

[Site 4] KEKMNAKWDT782-GENPIYKSAV

Thr782 Gly

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys773Glu774Lys775Met776Asn777Ala778Lys779Trp780Asp781Thr782
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gly783Glu784Asn785Pro786Ile787Tyr788Lys789Ser790Ala791Val792

Sequence conservation (by blast)

* References

[PubMed ID: 18351655] Pae SH, Dokic D, Dettman RW, Communication between integrin receptors facilitates epicardial cell adhesion and matrix organization. Dev Dyn. 2008 Apr;237(4):962-78.

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