XSB2228 : Angiotensinogen
[ CaMP Format ]
This entry is computationally expanded from SB0027
* Basic Information
| Organism | Mus musculus (house mouse) |
| Protein Names | Serpin A8; Angiotensin I; Ang I; Angiotensin II; Ang II; Angiotensin III; Ang III; Des-Asp[1]-angiotensin II; Angiotensin-1; Angiotensin-2; Angiotensin-3 |
| Gene Names | Serpina8 |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein |
Entrez Nucleotide |
Entrez Gene |
UniProt |
OMIM |
HGNC |
HPRD |
KEGG |
| P11859 |
N/A |
N/A |
ANGT_MOUSE |
N/A |
N/A |
N/A |
mmu: |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 477 aa
Average Mass: 51.990 kDa
Monoisotopic Mass: 51.958 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| --- cleavage 28 --- |
| Serpin 1. | 90 | 473 | 390.9 | 2.2e-114 |
3. Sequence Information
Fasta Sequence: XSB2228.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] VSLTAGDRVY28-IHPFHLLYHN
Tyr28 
Ile
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Val19 | Ser20 | Leu21 | Thr22 | Ala23 | Gly24 | Asp25 | Arg26 | Val27 | Tyr28 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Ile29 | His30 | Pro31 | Phe32 | His33 | Leu34 | Leu35 | Tyr36 | His37 | Asn38 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
MTPTGAGLKATIFCILTWVSLTAGDRVYIHPFHLLYHNKSTCAQLENPSVETLPESTF
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Contains: Angiotensin-1 (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin III) (Ang III) (Des-Asp[1 |
125.00 |
5 |
ANGT_MOUSE Angiotensinogen precursor (Serpin A8) |
| 2 |
Mus musculus |
125.00 |
2 |
Angiotensinogen (serpin peptidase inhibitor, clade |
| 3 |
Rattus norvegicus |
119.00 |
1 |
angiotensinogen |
| 4 |
Bos taurus |
82.40 |
1 |
hypothetical protein LOC527114 |
| 5 |
N/A |
80.10 |
3 |
2 |
| 6 |
Homo sapiens |
74.30 |
5 |
angiotensinogen precursor variant |
| 7 |
synthetic construct |
74.30 |
1 |
Homo sapiens angiotensinogen (serine (or cysteine) |
| 8 |
Pongo pygmaeus |
73.90 |
1 |
hypothetical protein |
| 9 |
Pan troglodytes |
73.20 |
2 |
angiotensinogen |
| 10 |
Macaca fascicularis |
70.10 |
1 |
unnamed protein product |
| 11 |
Macaca mulatta |
70.10 |
1 |
PREDICTED: angiotensinogen isoform 1 |
| 12 |
Canis familiaris |
67.40 |
2 |
PREDICTED: similar to Angiotensinogen precursor |
| 13 |
Monodelphis domestica |
53.50 |
1 |
PREDICTED: hypothetical protein |
| 14 |
Gallus gallus |
38.10 |
1 |
PREDICTED: similar to angiotensinogen |
Top-ranked sequences
| organism | matching |
|---|
| Contains: Angiotensin-1 (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin III) (Ang III) (Des-Asp[1 |
Query 1 MTPTGAGLKATIFCILTWVSLTAGDRVY#IHPFHLLYHNKSTCAQLENPSVETLPESTF 58
||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 1 MTPTGAGLKATIFCILTWVSLTAGDRVY#IHPFHLLYHNKSTCAQLENPSVETLPESTF 58
|
| Mus musculus |
Query 1 MTPTGAGLKATIFCILTWVSLTAGDRVY#IHPFHLLYHNKSTCAQLENPSVETLPESTF 58
||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 1 MTPTGAGLKATIFCILTWVSLTAGDRVY#IHPFHLLYHNKSTCAQLENPSVETLPESTF 58
|
| Rattus norvegicus |
Query 1 MTPTGAGLKATIFCILTWVSLTAGDRVY#IHPFHLLYHNKSTCAQLENPSVETLPESTF 58
||||||||||||||||||||||||||||#||||||||++||||||||||||||||| ||
Sbjct 1 MTPTGAGLKATIFCILTWVSLTAGDRVY#IHPFHLLYYSKSTCAQLENPSVETLPEPTF 58
|
| Bos taurus |
Query 1 MTPTGAGLKATIFCILTWVSLTAGDRVY#IHPFHLLYHNKSTCAQLENPSVETLPESTF 58
| | | | | | |+| | | ||||||#+|||||| ++|| | ||| ||||| |+ ||
Sbjct 1 MAPAGLSLGAAILCLLAWAGLAAGDRVY#VHPFHLLVYSKSNCDQLEKPSVETPPDPTF 58
|
| N/A |
Query 1 MTPTGAGLKATIFCILTWVSLTAGDRVY#IHPFHLLYHNKSTCAQLENPSVETLPEST 57
| | | | ||| |+| | | ||||||#||||||| |+|| | ||| |||| + |
Sbjct 1 MAPAGLSLGATILCLLAWAGLAAGDRVY#IHPFHLLVHSKSNCDQLEKPSVEPTADPT 57
|
| Homo sapiens |
Query 1 MTPTGAGLKATIFCILTWVSLTAGDRVY#IHPFHLLYHNKSTCAQLENPSVETLPESTF 58
| | | |+||| |+| | | ||||||#||||||+ ||+||| || + + ||
Sbjct 10 MAPAGVSLRATILCLLAWAGLAAGDRVY#IHPFHLVIHNESTCEQLAKANAGKPKDPTF 67
|
| synthetic construct |
Query 1 MTPTGAGLKATIFCILTWVSLTAGDRVY#IHPFHLLYHNKSTCAQLENPSVETLPESTF 58
| | | |+||| |+| | | ||||||#||||||+ ||+||| || + + ||
Sbjct 10 MAPAGVSLRATILCLLAWAGLAAGDRVY#IHPFHLVIHNESTCEQLAKANAGKPKDPTF 67
|
| Pongo pygmaeus |
Query 1 MTPTGAGLKATIFCILTWVSLTAGDRVY#IHPFHLLYHNKSTCAQLENPSVETLPESTF 58
| | | |+||| |+| | | ||||||#||||||+ ||+||| || + + ||
Sbjct 10 MAPAGMSLRATILCLLAWAGLAAGDRVY#IHPFHLVIHNESTCEQLAKANAGKPKDPTF 67
|
| Pan troglodytes |
Query 1 MTPTGAGLKATIFCILTWVSLTAGDRVY#IHPFHLLYHNKSTCAQLENPSVETLPESTF 58
| | | |+||| |++ | | ||||||#||||||+ ||+||| || + + ||
Sbjct 10 MAPAGVSLRATILCLVAWAGLAAGDRVY#IHPFHLVIHNESTCEQLAKANAGKPKDPTF 67
|
| Macaca fascicularis |
Query 1 MTPTGAGLKATIFCILTWVSLTAGDRVY#IHPFHLLYHNKSTCAQLENPSVETLPESTF 58
| | |+||| |+| | | |||||#||||||+ ||+||| || + ||
Sbjct 10 MAPASVSLRATILCLLAWAGLATGDRVY#IHPFHLVIHNESTCEQLAKADAGKPKDPTF 67
|
| Macaca mulatta |
Query 1 MTPTGAGLKATIFCILTWVSLTAGDRVY#IHPFHLLYHNKSTCAQLENPSVETLPESTF 58
| | |+||| |+| | | |||||#||||||+ ||+||| || + ||
Sbjct 10 MAPASVSLRATILCLLAWAGLATGDRVY#IHPFHLVIHNESTCEQLAKADAGKPKDPTF 67
|
| Canis familiaris |
Query 1 MTPTGAGLKATIFCILTWVSLTAGDRVY#IHPFHLLYHNKSTCAQLENPSVETLPESTF 58
| | | | |+ |+| | ||||||#||||||| ++||+| ||| + | + ||
Sbjct 15 MAPAGVSLVVTVLCLLAGAGLAAGDRVY#IHPFHLLVYSKSSCEQLEKSNTEMPKDLTF 72
|
| Monodelphis domestica |
Query 9 KATIFCILTWVSLTAGDRVY#IHPFHLLYHNKSTCAQLENPSVETLPESTF 58
+ | +| | + | ||||#+|||||| +|+|+| +|+| | ||
Sbjct 34 RLTTLLLLAWAASVASDRVY#VHPFHLLTNNQSSCDELKNKDAMASEEQTF 83
|
| Gallus gallus |
Query 8 LKATIFCILTWVSLTAGDRVY#IHPFHLLYHNKSTCAQLENPSVE 51
| | + |+| + ||||#+||| | |+| | +|| + |
Sbjct 3 LAAGLLCLLLCFTAVGCDRVY#VHPFSLNAINESACEELERLAQE 46
|
* References
[PubMed ID: 3397061] Clouston WM, Evans BA, Haralambidis J, Richards RI, Molecular cloning of the mouse angiotensinogen gene. Genomics. 1988 Apr;2(3):240-8.
