XSB2233 : glucagon, isoform CRA_a [Mus musculus]
[ CaMP Format ]
This entry is computationally expanded from SB0054
* Basic Information
| Organism | Mus musculus (house mouse) |
| Protein Names | glucagon; isoform CRA_a |
| Gene Names | Gcg |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 240 aa
Average Mass: 27.425 kDa
Monoisotopic Mass: 27.407 kDa
2. Domain Information
Annotated Domains: Not Available.
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Equine_IAV_S2 1. | 32 | 88 | -21.9 | 3.6 |
| Hormone_2 1. | 113 | 140 | 66.4 | 1.1e-16 |
| --- cleavage 134 (inside Hormone_2 113..140) --- | ||||
| --- cleavage 129 (inside Hormone_2 113..140) --- | ||||
| --- cleavage 137 (inside Hormone_2 113..140) --- | ||||
| --- cleavage 127 (inside Hormone_2 113..140) --- | ||||
| --- cleavage 139 (inside Hormone_2 113..140) --- | ||||
| Hormone_2 2. | 158 | 185 | 52.6 | 1.5e-12 |
| Hormone_2 3. | 206 | 233 | 46.6 | 9.8e-11 |
3. Sequence Information
Fasta Sequence: XSB2233.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
5 [sites]
Cleavage sites (±10aa)
[Site 1] YLDSRRAQDF134-VQWLMNTKRN
Phe134 
Val
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Tyr125 | Leu126 | Asp127 | Ser128 | Arg129 | Arg130 | Ala131 | Gln132 | Asp133 | Phe134 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Val135 | Gln136 | Trp137 | Leu138 | Met139 | Asn140 | Thr141 | Lys142 | Arg143 | Asn144 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| DEMNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFT |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 128.00 | 10 | glucagon, isoform CRA_b |
| 2 | N/A | 79.70 | 44 | 0 |
| 3 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | 64.70 | 1 | AAB31092.1 |
| 4 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | 61.60 | 1 | glucagon=proglucagon-derived 3.5 kda peptide |
| 5 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | 60.80 | 1 | glucagon II |
| 6 | Contains: Glucagon; Glucagon-like peptide | 60.10 | 4 | GLUC_AMICA Glucagon precursor |
| 7 | Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | 60.10 | 1 | glucagon |
| 8 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | 58.50 | 1 | glucagon G-29 |
| 9 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | 57.80 | 1 | GLUC1_ORENI Glucagon-1 (Glucagon I) gb |
| 10 | Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | 56.20 | 1 | GLUC_LAMFL Glucagon gb |
| 11 | deshis1, Desphe6, Glu9 | 53.50 | 1 | A Chain A, Nmr Solution Structure Of The Glucagon |
| 12 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | 53.50 | 1 | glucagon |
| 13 | Monodelphis domestica | 48.90 | 3 | PREDICTED: similar to Gastric inhibitory polypepti |
| 14 | Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | 48.90 | 1 | GLUC1_PETMA Glucagon-1 precursor |
| 15 | Xenopus laevis | 47.00 | 5 | proglucagon II |
| 16 | Hoplobatrachus rugulosus | 46.60 | 1 | AF324209_1 proglucagon |
| 17 | Gallus gallus | 46.20 | 4 | glucagon isoform 1 |
| 18 | Meleagris gallopavo | 46.20 | 2 | preproglucagon B |
| 19 | Bufo marinus | 44.70 | 1 | proglucagon |
| 20 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | 44.70 | 1 | GLUC_HELSU Glucagon precursor |
| 21 | Capra hircus | 43.90 | 1 | glucagon |
| 22 | Oncorhynchus tshawytscha | 43.50 | 1 | S78474_1 proglucagon |
| 23 | Ictalurus punctatus | 43.10 | 3 | proglucagon I |
| 24 | Canis familiaris | 43.10 | 2 | PREDICTED: similar to Vasoactive intestinal peptid |
| 25 | Bos taurus | 42.70 | 5 | vasoactive intestinal peptide |
| 26 | Rattus norvegicus | 42.70 | 5 | Glucose-dependent insulinotropic peptide |
| 27 | Macaca mulatta | 42.40 | 3 | PREDICTED: vasoactive intestinal peptide |
| 28 | Xenopus tropicalis | 42.40 | 2 | glucagon |
| 29 | Pan troglodytes | 42.40 | 2 | PREDICTED: fibroblast activation protein, alpha su |
| 30 | Danio rerio | 42.00 | 6 | hypothetical protein LOC494052 |
| 31 | Heloderma suspectum | 41.60 | 2 | proglucagon |
| 32 | Squalus acanthias | 41.60 | 1 | proglucagon |
| 33 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | 41.20 | 1 | glucagon-like peptide, GLP |
| 34 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | 41.20 | 1 | GLUC2_LOPAM Glucagon-2 precursor (Glucagon II) |
| 35 | Sebastes caurinus | 40.80 | 4 | proglucagon I |
| 36 | Tetraodon nigroviridis | 40.00 | 3 | unnamed protein product |
| 37 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | 40.00 | 2 | GLUC_CARAU Glucagon precursor |
| 38 | Heloderma horridum | 40.00 | 1 | EXE3_HELHO Exendin-3 precursor emb |
| 39 | Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | 40.00 | 1 | GLUC1_ONCMY Glucagon-1 precursor (Glucagon I) |
| 40 | Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | 40.00 | 1 | GLUC2_ONCMY Glucagon-2 precursor (Glucagon II) |
| 41 | Mus musculus | 39.70 | 6 | gastric inhibitory polypeptide |
| 42 | Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | 39.30 | 1 | VIP_MOUSE VIP peptides precursor |
| 43 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | 38.90 | 1 | glucagon-like peptide-2, GLP-2=proglucagon-derived |
| 44 | Protopterus dolloi | 38.90 | 1 | proglucagon |
| 45 | Arvicanthis ansorgei | 38.50 | 1 | vasoactive intestinal polypeptide |
| 46 | Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | 38.10 | 1 | GLUC2_PETMA Glucagon-2 precursor |
| 47 | Ambloplites rupestris | 37.70 | 1 | proglucagon |
| 48 | synthetic construct | 37.00 | 1 | Homo sapiens glucagon |
| 49 | Phodopus sungorus | 36.60 | 1 | glucagon precursor |
| 50 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | 36.60 | 1 | GLUC1_LOPAM Glucagon-1 precursor (Glucagon I) |
| 51 | Sus scrofa | 36.20 | 1 | glucagon |
| 52 | Neoceratodus forsteri | 36.20 | 1 | proglucagon |
| 53 | Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | 35.80 | 1 | GLUC_LEPSP Glucagon precursor |
| 54 | Canis lupus familiaris | 35.80 | 1 | glucagon |
| 55 | Hydrolagus colliei | 35.40 | 1 | proglucagon |
| 56 | Heloderma suspectum, venom, Peptide, 39 aa | 35.40 | 1 | A Chain A, Solution Structure Of Exendin-4 In 30-V |
| 57 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | 34.70 | 1 | glucagon-like peptide-1, GLP-1=proglucagon-derived |
| 58 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | 34.70 | 1 | GLUC2_ORENI Glucagon-2 (Glucagon II) gb |
| 59 | Agkistrodon piscivorus | 33.50 | 1 | proglucagon |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 105 DEMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 |+||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 128 DQMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 187 |
| N/A | Query 113 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIA 149 ||||||||||||||||||||||#||||||||||+|||| Sbjct 1 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNKNNIA 37 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRN 144 ||+||||||||||+|+|||+||#|||||+|||| Sbjct 1 HSEGTFTSDYSKYMDNRRAKDF#VQWLMSTKRN 32 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNT 141 |||||||||||||||+||||||#+||||+| Sbjct 1 HSQGTFTSDYSKYLDNRRAQDF#IQWLMST 29 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRN 144 ||+|||++||||||++||||||#|||| |+||| Sbjct 1 HSEGTFSNDYSKYLETRRAQDF#VQWLKNSKRN 32 |
| Contains: Glucagon; Glucagon-like peptide | Query 113 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNT 141 |||||||+|||||+|+||||||#|||||+| Sbjct 1 HSQGTFTNDYSKYMDTRRAQDF#VQWLMST 29 |
| Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNT 141 |||||||+|||||+|+||||||#|||||+| Sbjct 1 HSQGTFTNDYSKYMDTRRAQDF#VQWLMST 29 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNT 141 ||+||||||||||+|+|||+||#|||||+| Sbjct 1 HSEGTFTSDYSKYMDNRRAKDF#VQWLMST 29 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRN 144 ||+|||++||||||+ |+||||#|+|||| ||+ Sbjct 1 HSEGTFSNDYSKYLEDRKAQDF#VRWLMNNKRS 32 |
| Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNT 141 ||||+|||||||||||++|+||#| ||||| Sbjct 1 HSQGSFTSDYSKYLDSKQAKDF#VIWLMNT 29 |
| deshis1, Desphe6, Glu9 | Query 114 SQGTFTSDYSKYLDSRRAQDF#VQWLMNT 141 |||| ||+|||||||||||||#||||||| Sbjct 1 SQGT-TSEYSKYLDSRRAQDF#VQWLMNT 27 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDF#VQWLMN 140 ||+|||||||||||++++|+||#|+|||| Sbjct 1 HSEGTFTSDYSKYLENKQAKDF#VRWLMN 28 |
| Monodelphis domestica | Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGT 162 +|+++||| |||| +| |||#| ||++ | +| + ||+ || |+|| Sbjct 51 QRYAEGTFISDYSITMDKIMQQDF#VNWLLSQKGKKN--SWRHNITERKADGT 100 |
| Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 ||||+|||||||||||++++|+||#|+|||| || + + + |||+|||| Sbjct 41 KRHSEGTFTSDYSKYLENKQAKDF#VRWLMNAKRGGSELQR------RHADGTFT 88 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNR---NNIAKRHDEFERHAE 160 +||+ ||||+| + |||++ |+||#| || + ++| + + | +|||| Sbjct 80 RRHADGTFTNDMTSYLDAKAARDF#VSWLARSDKSRRDGGDHLAENSEDKRHAE 132 |
| Xenopus laevis | Query 105 DEMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 +++ | ||||||||||||||||||||||||#|||||||||+ +++|+ ++||||||||| Sbjct 45 EQLKEVKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRS-GGLSRRNADYERHAEGTFT 103 Query 109 EDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 | +||++||+|+| ++||+ + + |#++||+ | + + |||||||| Sbjct 138 EIERHAEGTYTNDVTEYLEEKATKAF#IEWLIKGK-------PKKIRYSRHAEGTFT 186 Query 112 RHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRH 152 ||++||||+| + ||+ + |++|#| ||+| + | ++ + | Sbjct 179 RHAEGTFTNDMTNYLEEKAAKEF#VGWLINGRPKRKDLLEEH 219 |
| Hoplobatrachus rugulosus | Query 105 DEMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 | || ||||||||||||||||||||||||#||||||+||+ |+||+ +||||||||+| Sbjct 45 DHHNEVKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNSKRS-GGISKRNVQFERHAEGTYT 103 Query 112 RHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFE-RHAEGTFT 164 ||++|||||| + ||+ + |++|#| ||+ + || +| + |||+|+|| Sbjct 134 RHAEGTFTSDMTSYLEEKAAKEF#VDWLIKGRPKRNFPDISAEEMDRRHADGSFT 187 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 +||++||+|+| +++|+ + |++|#+ ||+ | + ++ |||||||| Sbjct 95 ERHAEGTYTNDVTQFLEEKAAKEF#IDWLIKGKPKKQRLS-------RHAEGTFT 141 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNT 141 |+||+ |+||||++| || + ||+|#+ |++|| Sbjct 178 DRRHADGSFTSDFNKALDIKAAQEF#LDWIINT 209 |
| Gallus gallus | Query 106 EMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRN------------------RNN 147 ++|| ||||||||||||||||||||||||#|||||+|||| | Sbjct 48 QLNEVKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMSTKRNGQQGQEDKENDKFPDQLSSNA 107 Query 148 IAKRHDEFERHAEGTFT 164 |+||| |||||||||+| Sbjct 108 ISKRHSEFERHAEGTYT 124 Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAK---RHDEFERHAEGTFT 164 +| +||++||+||| + ||+ + |++|#+ ||+| + |+ | + |||+|||| Sbjct 113 SEFERHAEGTYTSDITSYLEGQAAKEF#IAWLVNGRGRRDFPEKALMAEEMGRRHADGTFT 172 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNI 148 +||+ |||||| +| || |++|#++||+||| + ++ Sbjct 164 RRHADGTFTSDINKILDDMAAKEF#LKWLINTKVTQRDL 201 |
| Meleagris gallopavo | Query 106 EMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRN------------------RNN 147 ++|| ||||||||||||||||||||||||#|||||+|||| | Sbjct 48 QLNEVKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMSTKRNGQQGQEDKENDEFPDQLSSNA 107 Query 148 IAKRHDEFERHAEGTFT 164 |+||| |||||||||+| Sbjct 108 ISKRHSEFERHAEGTYT 124 Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAK---RHDEFERHAEGTFT 164 +| +||++||+||| + ||+ + |++|#+ ||+| + |+ | + |||+|||| Sbjct 113 SEFERHAEGTYTSDITSYLEGQAAKEF#IAWLVNGRGRRDFPEKALMAEEMGRRHADGTFT 172 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNI 148 +||+ |||||| +| || |++|#++||+||| + ++ Sbjct 164 RRHADGTFTSDINKILDDMAAKEF#LKWLINTKVTQRDL 201 |
| Bufo marinus | Query 112 RHSQGTFTSDYSKYLDSRRAQDF#VQWLM--NTKRNRNNIAKRHDEFERHAEGTFT 164 ||++|||||| + +|+ + |++|#| ||+ ||| ++++ | |||+|+|| Sbjct 62 RHAEGTFTSDMTSFLEEKAAKEF#VDWLIKGRPKRNFSDVSAADDMDRRHADGSFT 116 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 +||++||+|+| +++|+ + |++|#+ ||+ | |+ |||||||| Sbjct 23 ERHAEGTYTNDVTQFLEEKAAKEF#IDWLL------KGIPKK-QRLSRHAEGTFT 69 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNT 141 |+||+ |+||||++| || + ||+|#+ |++|| Sbjct 107 DRRHADGSFTSDFNKALDIKAAQEF#LDWIINT 138 Query 133 DF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 ||# |||||+||+ +++|+ +||||||||+| Sbjct 1 DF#AQWLMNSKRS-GGMSRRNVQFERHAEGTYT 31 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | Query 106 EMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKR------------------NRNN 147 ++|| |||||||||||||||||+||||||#||||||||| + | Sbjct 46 QLNEVKRHSQGTFTSDYSKYLDTRRAQDF#VQWLMNTKRSGQQGVEEREKENLLDQLSSNG 105 Query 148 IAKRHDEFERHAEGTFT 164 +|+ | |+||||+| +| Sbjct 106 LARHHAEYERHADGRYT 122 Query 109 EDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAK---RHDEFERHAEGTFT 164 | +||+ | +||| | ||+ + |++|#+ ||+| + |+ + + | |||+|||| Sbjct 112 EYERHADGRYTSDISSYLEGQAAKEF#IAWLVNGRGRRDFLEEAGTADDIGRRHADGTFT 170 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNI 148 +||+ |||||||++ || |+|#++||+| | + ++ Sbjct 162 RRHADGTFTSDYNQLLDDIATQEF#LKWLINQKVTQRDL 199 |
| Capra hircus | Query 146 NNIAKRHDEFERHAEGTFT 164 ||||||||||||||||||| Query 146 NNIAKRHDEFERHAEGTFT 164 Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNR 145 +| +||++|||||| | ||+ + |++|#+ ||+ + | Sbjct 8 DEFERHAEGTFTSDVSSYLEGQAAKEF#IAWLVKGRGRR 45 |
| Oncorhynchus tshawytscha | Query 114 SQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 | |||++||||| + | ||||#||||||+||+ +|||+||+| Sbjct 2 SXGTFSNDYSKYQEERMAQDF#VQWLMNSKRS-------GAPSKRHADGTYT 45 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNR 145 |||+ ||+||| | || + |+||#| || + + | Sbjct 37 KRHADGTYTSDVSTYLQDQAAKDF#VSWLKSGRARR 71 |
| Ictalurus punctatus | Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 +|||+|||++||||||++||||||#||||||+||+ |||+||+| Sbjct 49 RRHSEGTFSNDYSKYLETRRAQDF#VQWLMNSKRS-------DSPARRHADGTYT 95 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEF--ERHAEGTFT 164 +||+ ||+||| | || + |+||#+ || + + + + | + || +|+|| Sbjct 87 RRHADGTYTSDVSSYLQDQAAKDF#ITWLKSGQPKPDAVETRSVDTLRRRHVDGSFT 142 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRH 152 +|| |+|||| +| ||| |+++#+||+||+ + + ||| Sbjct 134 RRHVDGSFTSDVNKVLDSLAAKEY#LQWVMNSPSSAS--GKRH 173 |
| Canis familiaris | Query 106 EMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 +++ + ||+ | ||||+|+ | |+ +#++ |+ || |||++ +||++ || Sbjct 74 DVSRNARHADGVFTSDFSRLLGQLSAKKY#LESLIG-KRVGNNISEDQGPIKRHSDAVFT 131 |
| Bos taurus | Query 106 EMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 +++ + ||+ | ||||||+ | |+ +#++ |+ || |+|++ +||++ || Sbjct 74 DVSRNVRHADGVFTSDYSRLLGQLSAKKY#LESLIG-KRVSNSISEDQGPIKRHSDAVFT 131 |
| Rattus norvegicus | Query 112 RHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHA 159 |+++||| |||| +| | |||#| ||+ | +|+ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKIRQQDF#VNWLLAQKGKKND--WKHNLTQREA 88 |
| Macaca mulatta | Query 106 EMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 +++ + ||+ | ||||+|| | |+ +#++ || || +||++ +||++ || Sbjct 74 DVSRNARHADGVFTSDFSKLLGQLSAKKY#LESLMG-KRVSSNISEDPVPVKRHSDAVFT 131 |
| Xenopus tropicalis | Query 106 EMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 ++ | ||||||||||||||||||||||||#+||||||||+ +++|+ ++||||||||| Sbjct 46 QLKEVKRHSQGTFTSDYSKYLDSRRAQDF#IQWLMNTKRS-GGLSRRNADYERHAEGTFT 103 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 +||++|||||| +++|| + |++|#+ ||+| ++ |++|+ + |||||||+| Sbjct 95 ERHAEGTFTSDVTQHLDEKAAKEF#IDWLINGGPSKEIISRRNADVERHAEGTYT 148 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 +||++||+|+| ++||+ + |++|#++||+| | + + |||||||| Sbjct 140 ERHAEGTYTNDVTEYLEEKAAKEF#IEWLINGK-------PKKIRYSRHAEGTFT 186 Query 112 RHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFE---RHAEGTFT 164 ||++||||+| + ||+ + |++|#| ||+ | + | ++ | | |||+|+|| Sbjct 179 RHAEGTFTNDMTNYLEEKAAKEF#VGWLIK-GRPKRNFSEAHSVEEMDRRHADGSFT 233 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTK 142 |+||+ |+||+| +| || ||+|#+ |++||+ Sbjct 224 DRRHADGSFTNDINKVLDIIAAQEF#LDWVINTQ 256 |
| Pan troglodytes | Query 105 DEMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 |+||||||||||||||||||||||||||||#|||||||||| +++| |||||||| Sbjct 967 DQMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRN-SSVA------YRHAEGTFT 1019 Query 112 RHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNR 145 ||++|||||| | ||+ + |++|#+ ||+ + | Sbjct 1012 RHAEGTFTSDVSSYLEGQAAKEF#IAWLVKGRGRR 1045 |
| Danio rerio | Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 ||||+|||++||||||++||||||#|||||| ||| ++ +||||||+| Sbjct 48 KRHSEGTFSNDYSKYLETRRAQDF#VQWLMNAKRNGGSV-------KRHAEGTYT 94 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWL 138 |||++||+||| | || + || |#| || Sbjct 86 KRHAEGTYTSDVSSYLQDQAAQSF#VAWL 113 |
| Heloderma suspectum | Query 106 EMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKR------------------NRNN 147 ++|| |||||||||||||||||+||||||#||||||||| + | Sbjct 46 QLNEVKRHSQGTFTSDYSKYLDTRRAQDF#VQWLMNTKRSGQQGVEEREKENLLDQLSSNG 105 Query 148 IAKRHDEFERHAEGTFT 164 +|+ | |+||||+| +| Sbjct 106 LARHHAEYERHADGRYT 122 Query 109 EDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNR 145 | +||+ | +||| | ||+ + |++|#+ ||+| + | Sbjct 112 EYERHADGRYTSDISSYLEGQAAKEF#IAWLVNGRGRR 148 |
| Squalus acanthias | Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWL--MNTKRNRNNIAKRHDEFERHAEGTF 163 ++ |||++||+||| | +|+ |#| | | ++| +|+||| | || ||++ Sbjct 20 DKTKRHAEGTYTSDVDSLSDYFKAKRF#VDSLTSYNKRQNGRSISKRHVESTRHTEGSY 77 Query 127 DSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 |+|||+||#|||||+|||| |+ +||||||+| Sbjct 1 DNRRAKDF#VQWLMSTKRN-------GDKTKRHAEGTYT 31 Query 109 EDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRN---------NIAKRHDEFERHA 159 | ||++|++ | | ||+++ |+||#+ ||+ + | | + ||| Sbjct 68 ESTRHTEGSYR-DISSYLEAKAAKDF#INWLIKGRGRREFPEESKEIVNEVIPEEMDRRHA 126 Query 160 EGTFT 164 +|||| Sbjct 127 DGTFT 131 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFE 156 |+||+ |||||+ + ||+ |++|#+ |++|+| | | | | Sbjct 122 DRRHADGTFTSEINIVLDTIAAKEF#LNWILNSK----TIQSRDSEIE 164 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRN 144 |+ ||||+| + |||++ |+||#| || + ++ Sbjct 1 HADGTFTNDMTSYLDAKAARDF#VSWLARSDKS 32 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 ||||+|||++||||||++||||||#|||| |+||| | |||+||+| Sbjct 50 KRHSEGTFSNDYSKYLETRRAQDF#VQWLKNSKRN--------GLFRRHADGTYT 95 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWL 138 +||+ ||+||| | || + |+||#| || Sbjct 87 RRHADGTYTSDVSSYLQDQAAKDF#VSWL 114 |
| Sebastes caurinus | Query 105 DEMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 ||++ ||||+|||++|||+||+ |+||||#|+|||| ||+ || +|||+|||| Sbjct 42 DELSNMKRHSEGTFSNDYSRYLEERKAQDF#VRWLMNNKRS------GADE-KRHADGTFT 94 Query 109 EDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDE--FERHAEGTFT 164 ++|||+ |||||| | || + +||#| | + + | + + | || +|+|| Sbjct 84 DEKRHADGTFTSDVSSYLKDQAIKDF#VNRLKSGQVRRESETEWRGEAFSRRHVDGSFT 141 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDE 154 +|| |+|||| +| ||| |+++#+ |+| +| + + ++ |+ Sbjct 133 RRHVDGSFTSDVNKVLDSMAAKEY#LLWVMTSKPSGESKKRQEDQ 176 |
| Tetraodon nigroviridis | Query 106 EMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 +++ ||||+|||++||||||++||||||#|||| |+||| + | |||+||+| Sbjct 782 DLSNMKRHSEGTFSNDYSKYLETRRAQDF#VQWLKNSKRNGS-------LFRRHADGTYT 833 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNR 145 +||+ ||+||| | || + |++|#| || + | Sbjct 825 RRHADGTYTSDVSAYLQDQAAKEF#VSWLKTGRGRR 859 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 ||||+|||++||||||++||||||#|+||||+| | + +||||||+| Sbjct 48 KRHSEGTFSNDYSKYLETRRAQDF#VEWLMNSKSNGGSA-------KRHAEGTYT 94 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWL 138 |||++||+||| | +| + ||+|#| || Sbjct 86 KRHAEGTYTSDISSFLRDQAAQNF#VAWL 113 |
| Heloderma horridum | Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMN 140 |||| |||||| || ++ + |#++|| | Sbjct 46 KRHSDGTFTSDLSKQMEEEAVRLF#IEWLKN 75 |
| Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 ||||+|||++||||| + | ||||#||||||+||+ +|||+||+| Sbjct 50 KRHSEGTFSNDYSKYQEERMAQDF#VQWLMNSKRS-------GAPSKRHADGTYT 96 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNI--AKRHDEFERHAEGTFT 164 |||+ ||+||| | || + |+||#| || + + | + ++ || +|+|| Sbjct 88 KRHADGTYTSDVSTYLQDQAAKDF#VSWLKSGRARRESAEESRNGPMSRRHVDGSFT 143 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHD 153 +|| |+|||| +| ||| |+++#+ |+| +| + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLDSLAAKEY#LLWVMTSKTSGKSNKRQED 177 |
| Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 || |+|||++ |||| + | |+||#+ ||||+||+ +|||+||+| Sbjct 50 KRQSEGTFSNYYSKYQEERMARDF#LHWLMNSKRS-------GAPSKRHADGTYT 96 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHD--EFERHAEGTFT 164 |||+ ||+||| | || + |+||#| || + | + + + || +|+|| Sbjct 88 KRHADGTYTSDVSTYLQDQAAKDF#VSWLKSGPARRESAEESMNGPMSRRHVDGSFT 143 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHD 153 +|| |+|||| +| ||| |+++#+ |+| +| + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLDSLAAKEY#LLWVMTSKTSGKSNKRQED 177 |
| Mus musculus | Query 112 RHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHA 159 |+++||| |||| +| | |||#| ||+ + +++ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKIRQQDF#VNWLLAQRGKKSD--WKHNITQREA 88 |
| Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | Query 106 EMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 +++ + ||+ | ||||||+ | |+ +#++ |+ || ++|++ +||++ || Sbjct 74 DVSRNARHADGVFTSDYSRLLGQISAKKY#LESLIG-KRISSSISEDPVPIKRHSDAVFT 131 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTK 142 |+ |+|||| +| ||+ |++|#+ ||++|| Sbjct 1 HADGSFTSDINKVLDTIAAKEF#LNWLISTK 30 |
| Protopterus dolloi | Query 106 EMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 | | |||||||| |||+| |+++ | | #|| ||+||| ++|||+| |||||||+| Sbjct 25 EHTEAKRHSQGTFMSDYAKLLEAKHALDL#VQRLMSTKRT-GAVSKRHNEIERHAEGTYT 82 Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFE-RHAEGTFT 164 || +||++||+||| | ||+ + +|#++||| + |+ +| + |||+|| | Sbjct 71 NEIERHAEGTYTSDISSYLEGQAVNEF#IRWLMKGRGRRDFSETDIEEMDRRHADGTVT 128 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTK 142 |+||+ || ||| + |+| ++|#+ ||+| | Sbjct 119 DRRHADGTVTSDINSVLESIATREF#LNWLINAK 151 |
| Arvicanthis ansorgei | Query 106 EMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 +++ + ||+ | ||||||+ | |+ +#++ |+ || ++| + +||++ || Sbjct 57 DVSRNARHADGVFTSDYSRLLGQISAKKY#LESLIG-KRISSSILEDPVPIKRHSDAVFT 114 |
| Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | Query 106 EMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 |++ |||||+|||||||+|| ++|+||#| ||+|||| + + +||++|+|| Sbjct 37 EISLANRHSQGSFTSDYSKHLDVKQAKDF#VTWLLNTKRRGVDAQAGANLEKRHSDGSFT 95 Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKR 143 | +|||| |+||+| + || |++|#++|| | Sbjct 84 NLEKRHSDGSFTNDMNVMLDRMSAKNF#LEWLKQQGR 119 |
| Ambloplites rupestris | Query 113 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 |||||||+||+ ||+ |+||||#++|||| | |+ |++ |||+|||| Sbjct 1 HSQGTFTNDYTNYLEDRQAQDF#IRWLMNNK--RSGAAEK-----RHADGTFT 45 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDE--FERHAEGTFT 164 +|||+ |||| | | + +||#| | + + | | | || ||+|| Sbjct 36 EKRHADGTFTDDASSDFYDQAIKDF#VAKLKSGQDRREPETDRRREAFSRRHVEGSFT 92 |
| synthetic construct | Query 105 DEMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 |+||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 45 DQMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 104 Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRN---NIAKRHDEFERHAEGTFT 164 +| +||++|||||| | ||+ + |++|#+ ||+ + |+ +| + |||+|+|+ Sbjct 93 DEFERHAEGTFTSDVSSYLEGQAAKEF#IAWLVKGRGRRDFPEEVAIVEELGRRHADGSFS 152 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTK 142 +||+ |+|+ + + ||+ |+||#+ ||+ || Sbjct 144 RRHADGSFSDEMNTILDNLAARDF#INWLIQTK 175 |
| Phodopus sungorus | Query 116 GTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRN---NIAKRHDEFERHAEGTFT 164 |||||| | ||+ + |++|#+ ||+ + |+ + + |||+|+|+ Sbjct 1 GTFTSDVSSYLEGQAAKEF#IAWLVKGRGRRDFPEEVTIVEELGRRHADGSFS 52 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTK 142 +||+ |+|+ + + ||| +||#+ ||+ || Sbjct 44 RRHADGSFSDEMNTILDSLATRDF#INWLIQTK 75 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | Query 106 EMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 |++ ||||+|||++||||||+ |+||+|#|+|||| | |+ +|++ |||+|||| Sbjct 46 ELSNMKRHSEGTFSNDYSKYLEDRKAQEF#VRWLMNNK--RSGVAEK-----RHADGTFT 97 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDF#VQWL 138 +|||+ |||||| | || + +||#| | Sbjct 88 EKRHADGTFTSDVSSYLKDQAIKDF#VDRL 116 |
| Sus scrofa | Query 105 DEMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 |+| ||||||||||||||||||||||||||#||||||||||+||||||||||||||||||| Sbjct 45 DQMTEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNKNNIAKRHDEFERHAEGTFT 104 Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRN---NIAKRHDEFERHAEGTFT 164 +| +||++|||||| | ||+ + |++|#+ ||+ + |+ + + |||+|+|+ Sbjct 93 DEFERHAEGTFTSDVSSYLEGQAAKEF#IAWLVKGRGRRDFPEEVTIVEELRRRHADGSFS 152 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTK 142 +||+ |+|+ + + ||+ +||#+ ||++|| Sbjct 144 RRHADGSFSDEMNTVLDNLATRDF#INWLLHTK 175 |
| Neoceratodus forsteri | Query 106 EMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 | | |||||||| |||+| |++| | ||#|| ||||||| ++||| | |||||||+| Sbjct 17 EHTEAKRHSQGTFMSDYAKLLEARHALDF#VQRLMNTKRN-GGVSKRHSEIERHAEGTYT 74 Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEF-ERHAEGTFT 164 +| +||++||+||| | ||+ + | +|#|+||+ + |+ +| |||+|| | Sbjct 63 SEIERHAEGTYTSDISSYLEGQAANEF#VRWLLKGRGRRDFSDTDAEEMGRRHADGTIT 120 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTK 142 +||+ || |+| + |+| ++|#+ ||+|+| Sbjct 112 RRHADGTITNDMNNVLESIATREF#LNWLINSK 143 |
| Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | Query 113 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 |||||||+|||||||+||||||#|||||+|||+ | ||+||+| Sbjct 1 HSQGTFTNDYSKYLDTRRAQDF#VQWLMSTKRS-GGITXXXXXXXXHADGTYT 51 Query 113 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNR 145 |+ ||+||| | || + |+ |#| || + | Sbjct 45 HADGTYTSDVSSYLQDQAAKKF#VTWLKQGQDRR 77 |
| Canis lupus familiaris | Query 105 DEMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 |+||||||||||||||||||||||||||||#||||||||||+||||||||||||||||||| Sbjct 45 DQMNEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNKNNIAKRHDEFERHAEGTFT 104 Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRN---NIAKRHDEFERHAEGTFT 164 +| +||++|||||| | ||+ + |++|#+ ||+ + |+ +| + |||+|+|+ Sbjct 93 DEFERHAEGTFTSDVSSYLEGQAAKEF#IAWLVKGRGRRDFPEEVAIVEEFRRRHADGSFS 152 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTK 142 +||+ |+|+ + + ||+ +||#+ ||+ || Sbjct 144 RRHADGSFSDEMNTVLDTLATRDF#INWLLQTK 175 |
| Hydrolagus colliei | Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 |||+ | |+||||||||+|| +||#||||++|||| | |+ +|||+| +| Sbjct 30 KRHTDGIFSSDYSKYLDNRRTKDF#VQWLLSTKRNGANT----DKTKRHADGIYT 79 Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNN--IAKRHDEFERHAE 160 ++ |||+ | +||| + | +++ |#|+ | | + +|+ ++||| | | | Sbjct 68 DKTKRHADGIYTSDVASLTDYLKSKRF#VESLSNYNKRQNDRRMSKRHVEGARRTE 122 Query 109 EDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFE 156 | | ++ + +|+| ||+++ |+||#+ ||+ + | + |+ | | Sbjct 116 EGARRTEEDYPNDFSSYLEAKAAKDF#IDWLIK-GQGRRDFAEESREIE 162 |
| Heloderma suspectum, venom, Peptide, 39 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDF#VQWLMN 140 | +|||||| || ++ + |#++|| | Sbjct 1 HGEGTFTSDLSKQMEEEAVRLF#IEWLKN 28 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNR 145 |+ || ||| | +|+ + ++|#+ ||++ + | Sbjct 1 HADGTLTSDISSFLEKQATKEF#IAWLVSGRGRR 33 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | Query 116 GTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRN 146 ||+||| | || + |++|#| || + |+ Sbjct 3 GTYTSDVSSYLQDQAAKEF#VSWLKTGRGRRD 33 |
| Agkistrodon piscivorus | Query 109 EDKRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNIAKRH---DEFERHAEGTFT 164 | +||+ ||+||| | ||+ + |++|#+ ||+| + |+ | | |||+|||| Sbjct 32 EYERHADGTYTSDISSYLEGQAAKEF#IAWLVNGRGRRDFSEGAHTGEDLGRRHADGTFT 90 Query 111 KRHSQGTFTSDYSKYLDSRRAQDF#VQWLMNTKRNRNNI 148 +||+ |||||||+| || |+|#++||+| | + ++ Sbjct 82 RRHADGTFTSDYNKLLDDIATQEF#LKWLINQKVTQRDL 119 Query 126 LDSRRAQDF#VQWLMNTKRNRNNIAKRHDEFERHAEGTFT 164 |+ | ++|#+ | + | +|+ | |+||||+||+| Sbjct 9 LEDREKENF#LDQLAS-----NGLARPHAEYERHADGTYT 42 |
[Site 2] SDYSKYLDSR129-RAQDFVQWLM
Arg129 Arg
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ser120 | Asp121 | Tyr122 | Ser123 | Lys124 | Tyr125 | Leu126 | Asp127 | Ser128 | Arg129 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Arg130 | Ala131 | Gln132 | Asp133 | Phe134 | Val135 | Gln136 | Trp137 | Leu138 | Met139 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| AHEDPDEMNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHA |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 123.00 | 10 | glucagon, isoform CRA_b |
| 2 | Pan troglodytes | 95.90 | 2 | PREDICTED: fibroblast activation protein, alpha su |
| 3 | N/A | 79.70 | 44 | 0 |
| 4 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | 64.70 | 1 | AAB31092.1 |
| 5 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | 61.60 | 1 | glucagon=proglucagon-derived 3.5 kda peptide |
| 6 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | 60.80 | 1 | glucagon II |
| 7 | Contains: Glucagon; Glucagon-like peptide | 60.10 | 4 | GLUC_AMICA Glucagon precursor |
| 8 | Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | 60.10 | 1 | glucagon |
| 9 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | 58.50 | 1 | glucagon G-29 |
| 10 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | 57.80 | 1 | GLUC1_ORENI Glucagon-1 (Glucagon I) gb |
| 11 | Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | 56.20 | 1 | GLUC_LAMFL Glucagon gb |
| 12 | deshis1, Desphe6, Glu9 | 53.50 | 1 | A Chain A, Nmr Solution Structure Of The Glucagon |
| 13 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | 53.50 | 1 | glucagon |
| 14 | Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | 47.00 | 1 | GLUC1_PETMA Glucagon-1 precursor |
| 15 | Agkistrodon piscivorus | 45.10 | 1 | proglucagon |
| 16 | Gallus gallus | 44.30 | 4 | glucagon isoform 1 |
| 17 | Meleagris gallopavo | 44.30 | 2 | preproglucagon B |
| 18 | Monodelphis domestica | 43.90 | 3 | PREDICTED: similar to Gastric inhibitory polypepti |
| 19 | Oncorhynchus tshawytscha | 43.50 | 1 | S78474_1 proglucagon |
| 20 | Rattus norvegicus | 42.70 | 5 | Glucose-dependent insulinotropic peptide |
| 21 | Canis familiaris | 42.70 | 2 | PREDICTED: similar to Gastric inhibitory polypepti |
| 22 | Xenopus laevis | 42.40 | 5 | proglucagon I |
| 23 | Xenopus tropicalis | 42.40 | 2 | glucagon |
| 24 | Danio rerio | 42.00 | 4 | hypothetical protein LOC494052 |
| 25 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | 42.00 | 1 | GLUC_HELSU Glucagon precursor |
| 26 | Heloderma suspectum | 41.60 | 2 | proglucagon |
| 27 | Hoplobatrachus rugulosus | 41.60 | 1 | AF324209_1 proglucagon |
| 28 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | 41.20 | 1 | glucagon-like peptide, GLP |
| 29 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | 41.20 | 1 | GLUC2_LOPAM Glucagon-2 precursor (Glucagon II) |
| 30 | Macaca mulatta | 40.80 | 3 | PREDICTED: gastric inhibitory polypeptide |
| 31 | Bos taurus | 40.40 | 5 | PREDICTED: similar to Gastric inhibitory polypepti |
| 32 | Ictalurus punctatus | 40.40 | 3 | proglucagon I |
| 33 | Sebastes caurinus | 40.00 | 4 | proglucagon II |
| 34 | Tetraodon nigroviridis | 40.00 | 2 | unnamed protein product |
| 35 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | 40.00 | 2 | GLUC_CARAU Glucagon precursor |
| 36 | Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | 40.00 | 1 | GLUC2_ONCMY Glucagon-2 precursor (Glucagon II) |
| 37 | Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | 40.00 | 1 | GLUC1_ONCMY Glucagon-1 precursor (Glucagon I) |
| 38 | Heloderma horridum | 40.00 | 1 | EXE3_HELHO Exendin-3 precursor emb |
| 39 | Mus musculus | 39.70 | 6 | Gastric inhibitory polypeptide |
| 40 | Protopterus dolloi | 39.70 | 1 | proglucagon |
| 41 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | 38.90 | 1 | glucagon-like peptide-2, GLP-2=proglucagon-derived |
| 42 | Neoceratodus forsteri | 38.10 | 1 | proglucagon |
| 43 | Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | 38.10 | 1 | GLUC2_PETMA Glucagon-2 precursor |
| 44 | synthetic construct | 37.00 | 1 | Homo sapiens glucagon |
| 45 | Phodopus sungorus | 36.60 | 1 | glucagon precursor |
| 46 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | 36.60 | 1 | GLUC1_LOPAM Glucagon-1 precursor (Glucagon I) |
| 47 | Sus scrofa | 36.20 | 1 | glucagon |
| 48 | Canis lupus familiaris | 35.80 | 1 | glucagon |
| 49 | Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | 35.80 | 1 | GLUC_LEPSP Glucagon precursor |
| 50 | Heloderma suspectum, venom, Peptide, 39 aa | 35.40 | 1 | A Chain A, Solution Structure Of Exendin-4 In 30-V |
| 51 | Squalus acanthias | 35.40 | 1 | proglucagon |
| 52 | Hydrolagus colliei | 35.40 | 1 | proglucagon |
| 53 | Bufo marinus | 35.40 | 1 | proglucagon |
| 54 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | 34.70 | 1 | glucagon-like peptide-1, GLP-1=proglucagon-derived |
| 55 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | 34.70 | 1 | GLUC2_ORENI Glucagon-2 (Glucagon II) gb |
| 56 | Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | 34.30 | 1 | VIP_MOUSE VIP peptides precursor |
| 57 | Capra hircus | 34.30 | 1 | glucagon |
| 58 | Arvicanthis ansorgei | 33.50 | 1 | vasoactive intestinal polypeptide |
| 59 | Ambloplites rupestris | 32.30 | 1 | proglucagon |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 103 DPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 159 |||+|||||||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 126 DPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 182 |
| Pan troglodytes | Query 103 DPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDE 154 |||+|||||||||||||||||||||||#||||||||||||||| +++| || | Sbjct 965 DPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRN-SSVAYRHAE 1015 |
| N/A | Query 113 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIA 149 |||||||||||||||||#|||||||||||||||+|||| Sbjct 1 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNKNNIA 37 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | Query 113 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRN 144 ||+||||||||||+|+|#||+|||||||+|||| Sbjct 1 HSEGTFTSDYSKYMDNR#RAKDFVQWLMSTKRN 32 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNT 141 |||||||||||||||+|#|||||+||||+| Sbjct 1 HSQGTFTSDYSKYLDNR#RAQDFIQWLMST 29 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | Query 113 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRN 144 ||+|||++||||||++|#||||||||| |+||| Sbjct 1 HSEGTFSNDYSKYLETR#RAQDFVQWLKNSKRN 32 |
| Contains: Glucagon; Glucagon-like peptide | Query 113 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNT 141 |||||||+|||||+|+|#||||||||||+| Sbjct 1 HSQGTFTNDYSKYMDTR#RAQDFVQWLMST 29 |
| Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNT 141 |||||||+|||||+|+|#||||||||||+| Sbjct 1 HSQGTFTNDYSKYMDTR#RAQDFVQWLMST 29 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNT 141 ||+||||||||||+|+|#||+|||||||+| Sbjct 1 HSEGTFTSDYSKYMDNR#RAKDFVQWLMST 29 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | Query 113 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRN 144 ||+|||++||||||+ |#+|||||+|||| ||+ Sbjct 1 HSEGTFSNDYSKYLEDR#KAQDFVRWLMNNKRS 32 |
| Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNT 141 ||||+|||||||||||+#+|+||| ||||| Sbjct 1 HSQGSFTSDYSKYLDSK#QAKDFVIWLMNT 29 |
| deshis1, Desphe6, Glu9 | Query 114 SQGTFTSDYSKYLDSR#RAQDFVQWLMNT 141 |||| ||+||||||||#|||||||||||| Sbjct 1 SQGT-TSEYSKYLDSR#RAQDFVQWLMNT 27 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLDSR#RAQDFVQWLMN 140 ||+|||||||||||+++#+|+|||+|||| Sbjct 1 HSEGTFTSDYSKYLENK#QAKDFVRWLMN 28 |
| Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | Query 102 EDPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 152 +| | ||||+|||||||||||+++#+|+|||+|||| || + + +|| Sbjct 32 DDSAERPLSKRHSEGTFTSDYSKYLENK#QAKDFVRWLMNAKRGGSELQRRH 82 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNR---------NNIAKRHDE 154 +||+ ||||+| + |||++# |+||| || + ++| |+ ||| | Sbjct 80 RRHADGTFTNDMTSYLDAK#AARDFVSWLARSDKSRRDGGDHLAENSEDKRHAE 132 |
| Agkistrodon piscivorus | Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNI 148 +||+ |||||||+| || # |+|++||+| | + ++ Sbjct 82 RRHADGTFTSDYNKLLDDI#ATQEFLKWLINQKVTQRDL 119 Query 109 EDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH---DEFERHA 159 | +||+ ||+||| | ||+ +# |++|+ ||+| + |+ | | ||| Sbjct 32 EYERHADGTYTSDISSYLEGQ#AAKEFIAWLVNGRGRRDFSEGAHTGEDLGRRHA 85 |
| Gallus gallus | Query 102 EDPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRN----------------- 144 ++ ++|| |||||||||||||||||||#||||||||||+|||| Sbjct 44 DESRQLNEVKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMSTKRNGQQGQEDKENDKFPDQL 103 Query 145 -RNNIAKRHDEFERHA 159 | |+||| |||||| Sbjct 104 SSNAISKRHSEFERHA 119 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNI 148 +||+ |||||| +| || # |++|++||+||| + ++ Sbjct 164 RRHADGTFTSDINKILDDM#AAKEFLKWLINTKVTQRDL 201 Query 108 NEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRN 146 +| +||++||+||| + ||+ +# |++|+ ||+| + |+ Sbjct 113 SEFERHAEGTYTSDITSYLEGQ#AAKEFIAWLVNGRGRRD 151 |
| Meleagris gallopavo | Query 102 EDPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRN----------------- 144 ++ ++|| |||||||||||||||||||#||||||||||+|||| Sbjct 44 DESRQLNEVKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMSTKRNGQQGQEDKENDEFPDQL 103 Query 145 -RNNIAKRHDEFERHA 159 | |+||| |||||| Sbjct 104 SSNAISKRHSEFERHA 119 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNI 148 +||+ |||||| +| || # |++|++||+||| + ++ Sbjct 164 RRHADGTFTSDINKILDDM#AAKEFLKWLINTKVTQRDL 201 Query 108 NEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRN 146 +| +||++||+||| + ||+ +# |++|+ ||+| + |+ Sbjct 113 SEFERHAEGTYTSDITSYLEGQ#AAKEFIAWLVNGRGRRD 151 |
| Monodelphis domestica | Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 159 +|+++||| |||| +| # |||| ||++ | +| + ||+ || | Sbjct 51 QRYAEGTFISDYSITMDKI#MQQDFVNWLLSQKGKKN--SWRHNITERKA 97 |
| Oncorhynchus tshawytscha | Query 114 SQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 152 | |||++||||| + |# ||||||||||+||+ +||| Sbjct 2 SXGTFSNDYSKYQEER#MAQDFVQWLMNSKRS-GAPSKRH 39 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNR 145 |||+ ||+||| | || +# |+||| || + + | Sbjct 37 KRHADGTYTSDVSTYLQDQ#AAKDFVSWLKSGRARR 71 |
| Rattus norvegicus | Query 112 RHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 159 |+++||| |||| +| #| |||| ||+ | +|+ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKI#RQQDFVNWLLAQKGKKND--WKHNLTQREA 88 |
| Canis familiaris | Query 112 RHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 159 |+++||| |||| +| #| |||| ||+ | +|+ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKI#RQQDFVNWLLAQKGKKND--WKHNITQREA 88 |
| Xenopus laevis | Query 100 AHEDPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 159 | +| +++ | |||||||||||||||||||#||||||||||||||+ +++|+ ++|||| Sbjct 40 AVDDSEQLKEVKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRS-GELSRRNADYERHA 98 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 159 +||++|||||| ++ || +# |++|+ ||+| ++ |++|+ |||||| Sbjct 95 ERHAEGTFTSDVTQQLDEK#AAKEFIDWLINGGPSKEIISRRNAEFERHA 143 Query 112 RHSQGTFTSDYSKYLDSR#RAQDFVQWLM--NTKRNRNNIAKRHDEFERHA 159 ||++||||+| + ||+ +# |++|| ||+ ||| + + + ||| Sbjct 179 RHAEGTFTNDMTNYLEEK#AAKEFVGWLIKGRPKRNFSEVHSVEEMDRRHA 228 Query 110 DKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNI 148 |+||+ |+||+| +| || # ||+|+ |++||+ ++ Sbjct 224 DRRHADGSFTNDINKVLDII#AAQEFLDWVINTQETERDL 262 Query 109 EDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDE 154 | +||++||+|+| ++||+ +# |++|++||+ | + + || | Sbjct 138 EFERHAEGTYTNDVTEYLEEK#AAKEFIEWLIKGKPKKIRYS-RHAE 182 |
| Xenopus tropicalis | Query 100 AHEDPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 159 | +| ++ | |||||||||||||||||||#|||||+||||||||+ +++|+ ++|||| Sbjct 40 AVDDSQQLKEVKRHSQGTFTSDYSKYLDSR#RAQDFIQWLMNTKRS-GGLSRRNADYERHA 98 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 159 +||++|||||| +++|| +# |++|+ ||+| ++ |++|+ + |||| Sbjct 95 ERHAEGTFTSDVTQHLDEK#AAKEFIDWLINGGPSKEIISRRNADVERHA 143 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDE 154 +||++||+|+| ++||+ +# |++|++||+| | + + || | Sbjct 140 ERHAEGTYTNDVTEYLEEK#AAKEFIEWLINGKPKKIRYS-RHAE 182 Query 112 RHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRN 146 ||++||||+| + ||+ +# |++|| ||+ + || Sbjct 179 RHAEGTFTNDMTNYLEEK#AAKEFVGWLIKGRPKRN 213 Query 110 DKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTK 142 |+||+ |+||+| +| || # ||+|+ |++||+ Sbjct 224 DRRHADGSFTNDINKVLDII#AAQEFLDWVINTQ 256 |
| Danio rerio | Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDE 154 ||||+|||++||||||++|#||||||||||| ||| ++ ||| | Sbjct 48 KRHSEGTFSNDYSKYLETR#RAQDFVQWLMNAKRNGGSV-KRHAE 90 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWL 138 |||++||+||| | || +# || || || Sbjct 86 KRHAEGTYTSDVSSYLQDQ#AAQSFVAWL 113 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | Query 102 EDPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKR------------------ 143 +| ++|| |||||||||||||||||+|#|||||||||||||| Sbjct 42 DDSRQLNEVKRHSQGTFTSDYSKYLDTR#RAQDFVQWLMNTKRSGQQGVEEREKENLLDQL 101 Query 144 NRNNIAKRHDEFERHA 159 + | +|+ | |+|||| Sbjct 102 SSNGLARHHAEYERHA 117 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNI 148 +||+ |||||||++ || # |+|++||+| | + ++ Sbjct 162 RRHADGTFTSDYNQLLDDI#ATQEFLKWLINQKVTQRDL 199 Query 109 EDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRN 146 | +||+ | +||| | ||+ +# |++|+ ||+| + |+ Sbjct 112 EYERHADGRYTSDISSYLEGQ#AAKEFIAWLVNGRGRRD 149 |
| Heloderma suspectum | Query 102 EDPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKR------------------ 143 +| ++|| |||||||||||||||||+|#|||||||||||||| Sbjct 42 DDSRQLNEVKRHSQGTFTSDYSKYLDTR#RAQDFVQWLMNTKRSGQQGVEEREKENLLDQL 101 Query 144 NRNNIAKRHDEFERHA 159 + | +|+ | |+|||| Sbjct 102 SSNGLARHHAEYERHA 117 Query 109 EDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNR 145 | +||+ | +||| | ||+ +# |++|+ ||+| + | Sbjct 112 EYERHADGRYTSDISSYLEGQ#AAKEFIAWLVNGRGRR 148 |
| Hoplobatrachus rugulosus | Query 100 AHEDPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 159 | +| | || |||||||||||||||||||#|||||||||||+||+ |+||+ +||||| Sbjct 40 ALDDSDHHNEVKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNSKRS-GGISKRNVQFERHA 98 Query 110 DKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNT 141 |+||+ |+||||++| || +# ||+|+ |++|| Sbjct 178 DRRHADGSFTSDFNKALDIK#AAQEFLDWIINT 209 Query 112 RHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRN 146 ||++|||||| + ||+ +# |++|| ||+ + || Sbjct 134 RHAEGTFTSDMTSYLEEK#AAKEFVDWLIKGRPKRN 168 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDE 154 +||++||+|+| +++|+ +# |++|+ ||+ | + ++ || | Sbjct 95 ERHAEGTYTNDVTQFLEEK#AAKEFIDWLIKGKPKKQRLS-RHAE 137 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | Query 113 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRN 144 |+ ||||+| + |||++# |+||| || + ++ Sbjct 1 HADGTFTNDMTSYLDAK#AARDFVSWLARSDKS 32 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | Query 103 DPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 152 +| | ||||+|||++||||||++|#||||||||| |+| || + +|| Sbjct 42 EPIEPLNMKRHSEGTFSNDYSKYLETR#RAQDFVQWLKNSK--RNGLFRRH 89 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWL 138 +||+ ||+||| | || +# |+||| || Sbjct 87 RRHADGTYTSDVSSYLQDQ#AAKDFVSWL 114 |
| Macaca mulatta | Query 112 RHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 159 |+++||| |||| +| # |||| ||+ | +|+ +|+ +| | Sbjct 51 RYAEGTFISDYSIAMDKI#HQQDFVNWLLAQKGKKND--WKHNITQREA 96 |
| Bos taurus | Query 112 RHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNN 147 |+++||| |||| +| #| |||| ||+ | +++ Sbjct 81 RYAEGTFISDYSIAMDKI#RQQDFVNWLLAQKGKKSD 116 |
| Ictalurus punctatus | Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 152 +|||+|||++||||||++|#|||||||||||+||+ ++ |+|| Sbjct 49 RRHSEGTFSNDYSKYLETR#RAQDFVQWLMNSKRS-DSPARRH 89 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 152 +|| |+|||| +| ||| # |++++||+||+ + + ||| Sbjct 134 RRHVDGSFTSDVNKVLDSL#AAKEYLQWVMNSPSSAS--GKRH 173 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWL 138 +||+ ||+||| | || +# |+||+ || Sbjct 87 RRHADGTYTSDVSSYLQDQ#AAKDFITWL 114 |
| Sebastes caurinus | Query 103 DPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 152 +| |+ ||||+|||++||||||++|#||||||||| |+||| ++ +|| Sbjct 42 EPIELPNMKRHSEGTFSNDYSKYLETR#RAQDFVQWLKNSKRN-GSLFRRH 90 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNR 145 +||+ ||+||| | || +# |++|| || + | Sbjct 88 RRHADGTYTSDVSSYLQDQ#AAKEFVYWLKTGRGRR 122 |
| Tetraodon nigroviridis | Query 103 DPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 152 +| +++ ||||+|||++||||||++|#||||||||| |+||| ++ +|| Sbjct 779 EPSDLSNMKRHSEGTFSNDYSKYLETR#RAQDFVQWLKNSKRN-GSLFRRH 827 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNR 145 +||+ ||+||| | || +# |++|| || + | Sbjct 825 RRHADGTYTSDVSAYLQDQ#AAKEFVSWLKTGRGRR 859 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDE 154 ||||+|||++||||||++|#||||||+||||+| | + |||| | Sbjct 48 KRHSEGTFSNDYSKYLETR#RAQDFVEWLMNSKSNGGS-AKRHAE 90 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWL 138 |||++||+||| | +| +# ||+|| || Sbjct 86 KRHAEGTYTSDISSFLRDQ#AAQNFVAWL 113 |
| Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | Query 102 EDPDEMNED-------KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 152 | | + || || |+|||++ |||| + |# |+||+ ||||+||+ +||| Sbjct 34 ETADSLLEDLRGVPNMKRQSEGTFSNYYSKYQEER#MARDFLHWLMNSKRS-GAPSKRH 90 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNN 147 |||+ ||+||| | || +# |+||| || + | + Sbjct 88 KRHADGTYTSDVSTYLQDQ#AAKDFVSWLKSGPARRES 124 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHD 153 +|| |+|||| +| ||| # |++++ |+| +| + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLDSL#AAKEYLLWVMTSKTSGKSNKRQED 177 |
| Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | Query 102 EDPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 152 || ++ ||||+|||++||||| + |# ||||||||||+||+ +||| Sbjct 41 EDLMGVSNVKRHSEGTFSNDYSKYQEER#MAQDFVQWLMNSKRS-GAPSKRH 90 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNN 147 |||+ ||+||| | || +# |+||| || + + | + Sbjct 88 KRHADGTYTSDVSTYLQDQ#AAKDFVSWLKSGRARRES 124 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHD 153 +|| |+|||| +| ||| # |++++ |+| +| + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLDSL#AAKEYLLWVMTSKTSGKSNKRQED 177 |
| Heloderma horridum | Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMN 140 |||| |||||| || ++ # + |++|| | Sbjct 46 KRHSDGTFTSDLSKQMEEE#AVRLFIEWLKN 75 |
| Mus musculus | Query 112 RHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 159 |+++||| |||| +| #| |||| ||+ + +++ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKI#RQQDFVNWLLAQRGKKSD--WKHNITQREA 88 |
| Protopterus dolloi | Query 100 AHEDPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 159 | ++ | | |||||||| |||+| |+++# | | || ||+||| ++|||+| |||| Sbjct 19 AVDESREHTEAKRHSQGTFMSDYAKLLEAK#HALDLVQRLMSTKRT-GAVSKRHNEIERHA 77 Query 108 NEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFER 157 || +||++||+||| | ||+ +# +|++||| + |+ +| +| Sbjct 71 NEIERHAEGTYTSDISSYLEGQ#AVNEFIRWLMKGRGRRDFSETDIEEMDR 120 Query 103 DPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTK 142 | +|| |+||+ || ||| + |+| # ++|+ ||+| | Sbjct 114 DIEEM--DRRHADGTVTSDINSVLESI#ATREFLNWLINAK 151 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | Query 113 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTK 142 |+ |+|||| +| ||+ # |++|+ ||++|| Sbjct 1 HADGSFTSDINKVLDTI#AAKEFLNWLISTK 30 |
| Neoceratodus forsteri | Query 106 EMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 159 | | |||||||| |||+| |++|# | |||| ||||||| ++||| | |||| Sbjct 17 EHTEAKRHSQGTFMSDYAKLLEAR#HALDFVQRLMNTKRN-GGVSKRHSEIERHA 69 Query 108 NEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRN 146 +| +||++||+||| | ||+ +# | +||+||+ + |+ Sbjct 63 SEIERHAEGTYTSDISSYLEGQ#AANEFVRWLLKGRGRRD 101 Query 103 DPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTK 142 | | +||+ || |+| + |+| # ++|+ ||+|+| Sbjct 104 DTDAEEMGRRHADGTITNDMNNVLESI#ATREFLNWLINSK 143 |
| Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | Query 101 HEDPD-----EMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRN------RNNIA 149 || | |++ |||||+|||||||+|| +#+|+||| ||+|||| |+ Sbjct 27 HETDDGDLNAEISLANRHSQGSFTSDYSKHLDVK#QAKDFVTWLLNTKRRGVDAQAGANLE 86 Query 150 KRHDE 154 ||| + Sbjct 87 KRHSD 91 Query 108 NEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKR 143 | +|||| |+||+| + || # |++|++|| | Sbjct 84 NLEKRHSDGSFTNDMNVMLDRM#SAKNFLEWLKQQGR 119 |
| synthetic construct | Query 103 DPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 159 |||+|||||||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 43 DPDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 99 Query 108 NEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRN 146 +| +||++|||||| | ||+ +# |++|+ ||+ + |+ Sbjct 93 DEFERHAEGTFTSDVSSYLEGQ#AAKEFIAWLVKGRGRRD 131 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTK 142 +||+ |+|+ + + ||+ # |+||+ ||+ || Sbjct 144 RRHADGSFSDEMNTILDNL#AARDFINWLIQTK 175 |
| Phodopus sungorus | Query 116 GTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRN 146 |||||| | ||+ +# |++|+ ||+ + |+ Sbjct 1 GTFTSDVSSYLEGQ#AAKEFIAWLVKGRGRRD 31 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTK 142 +||+ |+|+ + + ||| # +||+ ||+ || Sbjct 44 RRHADGSFSDEMNTILDSL#ATRDFINWLIQTK 75 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | Query 102 EDPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 152 ++| |++ ||||+|||++||||||+ |#+||+||+|||| ||+ ||| Sbjct 42 DEPRELSNMKRHSEGTFSNDYSKYLEDR#KAQEFVRWLMNNKRS-GVAEKRH 91 Query 110 DKRHSQGTFTSDYSKYLDSR#RAQDFVQWL 138 +|||+ |||||| | || +# +||| | Sbjct 88 EKRHADGTFTSDVSSYLKDQ#AIKDFVDRL 116 |
| Sus scrofa | Query 102 EDPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 159 +|||+| |||||||||||||||||||||#|||||||||||||||+|||||||||||||| Sbjct 42 DDPDQMTEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNKNNIAKRHDEFERHA 99 Query 108 NEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRN 146 +| +||++|||||| | ||+ +# |++|+ ||+ + |+ Sbjct 93 DEFERHAEGTFTSDVSSYLEGQ#AAKEFIAWLVKGRGRRD 131 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTK 142 +||+ |+|+ + + ||+ # +||+ ||++|| Sbjct 144 RRHADGSFSDEMNTVLDNL#ATRDFINWLLHTK 175 |
| Canis lupus familiaris | Query 103 DPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 159 | |+|||||||||||||||||||||||#|||||||||||||||+|||||||||||||| Sbjct 43 DLDQMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNKNNIAKRHDEFERHA 99 Query 108 NEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRN 146 +| +||++|||||| | ||+ +# |++|+ ||+ + |+ Sbjct 93 DEFERHAEGTFTSDVSSYLEGQ#AAKEFIAWLVKGRGRRD 131 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTK 142 +||+ |+|+ + + ||+ # +||+ ||+ || Sbjct 144 RRHADGSFSDEMNTVLDTL#ATRDFINWLLQTK 175 |
| Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | Query 113 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRN 144 |||||||+|||||||+|#||||||||||+|||+ Sbjct 1 HSQGTFTNDYSKYLDTR#RAQDFVQWLMSTKRS 32 Query 113 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNR 145 |+ ||+||| | || +# |+ || || + | Sbjct 45 HADGTYTSDVSSYLQDQ#AAKKFVTWLKQGQDRR 77 |
| Heloderma suspectum, venom, Peptide, 39 aa | Query 113 HSQGTFTSDYSKYLDSR#RAQDFVQWLMN 140 | +|||||| || ++ # + |++|| | Sbjct 1 HGEGTFTSDLSKQMEEE#AVRLFIEWLKN 28 |
| Squalus acanthias | Query 104 PDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFE 156 |+|| |+||+ |||||+ + ||+ # |++|+ |++|+| | | | | Sbjct 118 PEEM--DRRHADGTFTSEINIVLDTI#AAKEFLNWILNSK----TIQSRDSEIE 164 Query 108 NEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWL--MNTKRNRNNIAKRHDEFERH 158 ++ |||++||+||| | #+|+ || | | ++| +|+||| | || Sbjct 20 DKTKRHAEGTYTSDVDSLSDYF#KAKRFVDSLTSYNKRQNGRSISKRHVESTRH 72 Query 127 DSR#RAQDFVQWLMNTKRNRNNIAKRHDE 154 |+|#||+|||||||+|||| + ||| | Sbjct 1 DNR#RAKDFVQWLMSTKRNGDK-TKRHAE 27 Query 109 EDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNR 145 | ||++|++ | | ||+++# |+||+ ||+ + | Sbjct 68 ESTRHTEGSYR-DISSYLEAK#AAKDFINWLIKGRGRR 103 |
| Hydrolagus colliei | Query 103 DPDEMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 159 +| + + |||+ | |+||||||||+|#| +||||||++|||| | |+ +||| Sbjct 22 NPSTVTDVKRHTDGIFSSDYSKYLDNR#RTKDFVQWLLSTKRNGANT----DKTKRHA 74 Query 108 NEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNN--IAKRHDEFER 157 ++ |||+ | +||| + | #+++ ||+ | | + +|+ ++||| | | Sbjct 68 DKTKRHADGIYTSDVASLTDYL#KSKRFVESLSNYNKRQNDRRMSKRHVEGAR 119 Query 109 EDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFE 156 | | ++ + +|+| ||+++# |+||+ ||+ + | + |+ | | Sbjct 116 EGARRTEEDYPNDFSSYLEAK#AAKDFIDWLIK-GQGRRDFAEESREIE 162 |
| Bufo marinus | Query 112 RHSQGTFTSDYSKYLDSR#RAQDFVQWLM--NTKRNRNNIAKRHDEFERHA 159 ||++|||||| + +|+ +# |++|| ||+ ||| ++++ | ||| Sbjct 62 RHAEGTFTSDMTSFLEEK#AAKEFVDWLIKGRPKRNFSDVSAADDMDRRHA 111 Query 110 DKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNT 141 |+||+ |+||||++| || +# ||+|+ |++|| Sbjct 107 DRRHADGSFTSDFNKALDIK#AAQEFLDWIINT 138 Query 111 KRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDE 154 +||++||+|+| +++|+ +# |++|+ ||+ + ++ || | Sbjct 23 ERHAEGTYTNDVTQFLEEK#AAKEFIDWLLKGIPKKQRLS-RHAE 65 Query 133 DFVQWLMNTKRNRNNIAKRHDEFERHA 159 || |||||+||+ +++|+ +||||| Sbjct 1 DFAQWLMNSKRS-GGMSRRNVQFERHA 26 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | Query 113 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNR 145 |+ || ||| | +|+ +# ++|+ ||++ + | Sbjct 1 HADGTLTSDISSFLEKQ#ATKEFIAWLVSGRGRR 33 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | Query 116 GTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRN 146 ||+||| | || +# |++|| || + |+ Sbjct 3 GTYTSDVSSYLQDQ#AAKEFVSWLKTGRGRRD 33 |
| Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | Query 106 EMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 159 +++ + ||+ | ||||||+ | # |+ +++ |+ || ++|++ +||+ Sbjct 74 DVSRNARHADGVFTSDYSRLLGQI#SAKKYLESLIG-KRISSSISEDPVPIKRHS 126 |
| Capra hircus | Query 108 NEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNR 145 +| +||++|||||| | ||+ +# |++|+ ||+ + | Sbjct 8 DEFERHAEGTFTSDVSSYLEGQ#AAKEFIAWLVKGRGRR 45 Query 146 NNIAKRHDEFERHA 159 |||||||||||||| Query 146 NNIAKRHDEFERHA 159 |
| Arvicanthis ansorgei | Query 106 EMNEDKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRHDEFERHA 159 +++ + ||+ | ||||||+ | # |+ +++ |+ || ++| + +||+ Sbjct 57 DVSRNARHADGVFTSDYSRLLGQI#SAKKYLESLIG-KRISSSILEDPVPIKRHS 109 |
| Ambloplites rupestris | Query 113 HSQGTFTSDYSKYLDSR#RAQDFVQWLMNTKRNRNNIAKRH 152 |||||||+||+ ||+ |#+||||++|||| ||+ ||| Sbjct 1 HSQGTFTNDYTNYLEDR#QAQDFIRWLMNNKRS-GAAEKRH 39 Query 110 DKRHSQGTFTSDYSKYLDSR#RAQDFVQWLMN--------TKRNRNNIAKRHDE 154 +|||+ |||| | | +# +||| | + | | | ++|| | Sbjct 36 EKRHADGTFTDDASSDFYDQ#AIKDFVAKLKSGQDRREPETDRRREAFSRRHVE 88 |
[Site 3] SRRAQDFVQW137-LMNTKRNRNN
Trp137 Leu
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ser128 | Arg129 | Arg130 | Ala131 | Gln132 | Asp133 | Phe134 | Val135 | Gln136 | Trp137 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Leu138 | Met139 | Asn140 | Thr141 | Lys142 | Arg143 | Asn144 | Arg145 | Asn146 | Asn147 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| NEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDV |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 127.00 | 10 | glucagon, isoform CRA_b |
| 2 | N/A | 79.70 | 45 | 0 |
| 3 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | 64.70 | 1 | AAB31092.1 |
| 4 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | 61.60 | 1 | glucagon=proglucagon-derived 3.5 kda peptide |
| 5 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | 60.80 | 1 | glucagon II |
| 6 | Contains: Glucagon; Glucagon-like peptide | 60.10 | 4 | GLUC_AMICA Glucagon precursor |
| 7 | Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | 60.10 | 1 | glucagon |
| 8 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | 58.50 | 1 | glucagon G-29 |
| 9 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | 57.80 | 1 | GLUC1_ORENI Glucagon-1 (Glucagon I) gb |
| 10 | Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | 56.20 | 1 | GLUC_LAMFL Glucagon gb |
| 11 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | 53.50 | 1 | glucagon |
| 12 | deshis1, Desphe6, Glu9 | 53.50 | 1 | A Chain A, Nmr Solution Structure Of The Glucagon |
| 13 | Monodelphis domestica | 48.90 | 3 | PREDICTED: similar to Gastric inhibitory polypepti |
| 14 | Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | 48.90 | 1 | GLUC1_PETMA Glucagon-1 precursor |
| 15 | Xenopus laevis | 47.00 | 5 | proglucagon II |
| 16 | Hoplobatrachus rugulosus | 46.60 | 1 | AF324209_1 proglucagon |
| 17 | Bufo marinus | 46.60 | 1 | proglucagon |
| 18 | Gallus gallus | 46.20 | 4 | glucagon isoform 1 |
| 19 | Meleagris gallopavo | 46.20 | 2 | preproglucagon B |
| 20 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | 44.70 | 1 | GLUC_HELSU Glucagon precursor |
| 21 | Capra hircus | 43.90 | 1 | glucagon |
| 22 | Oncorhynchus tshawytscha | 43.50 | 1 | S78474_1 proglucagon |
| 23 | Ictalurus punctatus | 43.10 | 3 | proglucagon I |
| 24 | Rattus norvegicus | 42.70 | 6 | Glucose-dependent insulinotropic peptide |
| 25 | Canis familiaris | 42.70 | 2 | PREDICTED: similar to Gastric inhibitory polypepti |
| 26 | Ambloplites rupestris | 42.70 | 1 | proglucagon |
| 27 | Pan troglodytes | 42.40 | 2 | PREDICTED: fibroblast activation protein, alpha su |
| 28 | Xenopus tropicalis | 42.40 | 2 | glucagon |
| 29 | Danio rerio | 42.00 | 6 | hypothetical protein LOC494052 |
| 30 | Bos taurus | 42.00 | 5 | vasoactive intestinal peptide |
| 31 | Macaca mulatta | 41.60 | 3 | PREDICTED: vasoactive intestinal peptide |
| 32 | Heloderma suspectum | 41.60 | 2 | proglucagon |
| 33 | Squalus acanthias | 41.60 | 1 | proglucagon |
| 34 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | 41.20 | 1 | glucagon-like peptide, GLP |
| 35 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | 41.20 | 1 | GLUC2_LOPAM Glucagon-2 precursor (Glucagon II) |
| 36 | Sebastes caurinus | 40.80 | 4 | proglucagon I |
| 37 | Tetraodon nigroviridis | 40.00 | 3 | unnamed protein product |
| 38 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | 40.00 | 2 | GLUC_CARAU Glucagon precursor |
| 39 | Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | 40.00 | 1 | GLUC2_ONCMY Glucagon-2 precursor (Glucagon II) |
| 40 | Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | 40.00 | 1 | GLUC1_ONCMY Glucagon-1 precursor (Glucagon I) |
| 41 | Heloderma horridum | 40.00 | 1 | EXE3_HELHO Exendin-3 precursor emb |
| 42 | Mus musculus | 39.70 | 6 | Gastric inhibitory polypeptide |
| 43 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | 38.90 | 1 | glucagon-like peptide-2, GLP-2=proglucagon-derived |
| 44 | Protopterus dolloi | 38.90 | 1 | proglucagon |
| 45 | Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | 38.50 | 1 | VIP_MOUSE VIP peptides precursor |
| 46 | Agkistrodon piscivorus | 38.50 | 1 | proglucagon |
| 47 | Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | 38.10 | 1 | GLUC2_PETMA Glucagon-2 precursor |
| 48 | Arvicanthis ansorgei | 37.70 | 1 | vasoactive intestinal polypeptide |
| 49 | synthetic construct | 37.00 | 1 | Homo sapiens glucagon |
| 50 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | 36.60 | 1 | GLUC1_LOPAM Glucagon-1 precursor (Glucagon I) |
| 51 | Phodopus sungorus | 36.60 | 1 | glucagon precursor |
| 52 | Neoceratodus forsteri | 36.20 | 1 | proglucagon |
| 53 | Sus scrofa | 36.20 | 1 | glucagon |
| 54 | Canis lupus familiaris | 35.80 | 1 | glucagon |
| 55 | Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | 35.80 | 1 | GLUC_LEPSP Glucagon precursor |
| 56 | Hydrolagus colliei | 35.40 | 1 | proglucagon |
| 57 | Heloderma suspectum, venom, Peptide, 39 aa | 35.40 | 1 | A Chain A, Solution Structure Of Exendin-4 In 30-V |
| 58 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | 34.70 | 1 | GLUC2_ORENI Glucagon-2 (Glucagon II) gb |
| 59 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | 34.70 | 1 | glucagon-like peptide-1, GLP-1=proglucagon-derived |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSD 166 ||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||| Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSD 166 |
| N/A | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIA 149 |||||||||||||||||||||||||#|||||||+|||| Sbjct 1 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNKNNIA 37 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRN 144 ||+||||||||||+|+|||+|||||#||+|||| Sbjct 1 HSEGTFTSDYSKYMDNRRAKDFVQW#LMSTKRN 32 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNT 141 |||||||||||||||+||||||+||#||+| Sbjct 1 HSQGTFTSDYSKYLDNRRAQDFIQW#LMST 29 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRN 144 ||+|||++||||||++|||||||||#| |+||| Sbjct 1 HSEGTFSNDYSKYLETRRAQDFVQW#LKNSKRN 32 |
| Contains: Glucagon; Glucagon-like peptide | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNT 141 |||||||+|||||+|+|||||||||#||+| Sbjct 1 HSQGTFTNDYSKYMDTRRAQDFVQW#LMST 29 |
| Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNT 141 |||||||+|||||+|+|||||||||#||+| Sbjct 1 HSQGTFTNDYSKYMDTRRAQDFVQW#LMST 29 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNT 141 ||+||||||||||+|+|||+|||||#||+| Sbjct 1 HSEGTFTSDYSKYMDNRRAKDFVQW#LMST 29 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRN 144 ||+|||++||||||+ |+|||||+|#||| ||+ Sbjct 1 HSEGTFSNDYSKYLEDRKAQDFVRW#LMNNKRS 32 |
| Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNT 141 ||||+|||||||||||++|+||| |#|||| Sbjct 1 HSQGSFTSDYSKYLDSKQAKDFVIW#LMNT 29 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQW#LMN 140 ||+|||||||||||++++|+|||+|#||| Sbjct 1 HSEGTFTSDYSKYLENKQAKDFVRW#LMN 28 |
| deshis1, Desphe6, Glu9 | Query 114 SQGTFTSDYSKYLDSRRAQDFVQW#LMNT 141 |||| ||+||||||||||||||||#|||| Sbjct 1 SQGT-TSEYSKYLDSRRAQDFVQW#LMNT 27 |
| Monodelphis domestica | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGT 162 +|+++||| |||| +| |||| |#|++ | +| + ||+ || |+|| Sbjct 51 QRYAEGTFISDYSITMDKIMQQDFVNW#LLSQKGKKN--SWRHNITERKADGT 100 |
| Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 ||||+|||||||||||++++|+|||+|#||| || + + + |||+||||+|+ Sbjct 41 KRHSEGTFTSDYSKYLENKQAKDFVRW#LMNAKRGGSELQR------RHADGTFTNDM 91 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNR---NNIAKRHDEFERHAE 160 +||+ ||||+| + |||++ |+||| |#| + ++| + + | +|||| Sbjct 80 RRHADGTFTNDMTSYLDAKAARDFVSW#LARSDKSRRDGGDHLAENSEDKRHAE 132 |
| Xenopus laevis | Query 109 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 | |||||||||||||||||||||||||||#||||||+ +++|+ ++|||||||||||| Sbjct 49 EVKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRS-GGLSRRNADYERHAEGTFTSDV 106 Query 109 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 | +||++||+|+| ++||+ + + |++|#|+ | + + ||||||||+|+ Sbjct 138 EIERHAEGTYTNDVTEYLEEKATKAFIEW#LIKGK-------PKKIRYSRHAEGTFTNDM 189 Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRH 152 ||++||||+| + ||+ + |++|| |#|+| + | ++ + | Sbjct 179 RHAEGTFTNDMTNYLEEKAAKEFVGW#LINGRPKRKDLLEEH 219 |
| Hoplobatrachus rugulosus | Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 || |||||||||||||||||||||||||||#|||+||+ |+||+ +||||||||+|+|| Sbjct 48 NEVKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNSKRS-GGISKRNVQFERHAEGTYTNDV 106 Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFE-RHAEGTFTSD 166 ||++|||||| + ||+ + |++|| |#|+ + || +| + |||+|+|||| Sbjct 134 RHAEGTFTSDMTSYLEEKAAKEFVDW#LIKGRPKRNFPDISAEEMDRRHADGSFTSD 189 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 +||++||+|+| +++|+ + |++|+ |#|+ | + ++ ||||||||||+ Sbjct 95 ERHAEGTYTNDVTQFLEEKAAKEFIDW#LIKGKPKKQRLS-------RHAEGTFTSDM 144 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNT 141 |+||+ |+||||++| || + ||+|+ |#++|| Sbjct 178 DRRHADGSFTSDFNKALDIKAAQEFLDW#IINT 209 |
| Bufo marinus | Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQW#LM--NTKRNRNNIAKRHDEFERHAEGTFTSD 166 ||++|||||| + +|+ + |++|| |#|+ ||| ++++ | |||+|+|||| Sbjct 62 RHAEGTFTSDMTSFLEEKAAKEFVDW#LIKGRPKRNFSDVSAADDMDRRHADGSFTSD 118 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 +||++||+|+| +++|+ + |++|+ |#|+ | |+ ||||||||||+ Sbjct 23 ERHAEGTYTNDVTQFLEEKAAKEFIDW#LL------KGIPKK-QRLSRHAEGTFTSDM 72 Query 133 DFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 || ||#|||+||+ +++|+ +||||||||+|+|| Sbjct 1 DFAQW#LMNSKRS-GGMSRRNVQFERHAEGTYTNDV 34 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNT 141 |+||+ |+||||++| || + ||+|+ |#++|| Sbjct 107 DRRHADGSFTSDFNKALDIKAAQEFLDW#IINT 138 |
| Gallus gallus | Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRN------------------RNNIA 149 || |||||||||||||||||||||||||||#||+|||| | |+ Sbjct 50 NEVKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMSTKRNGQQGQEDKENDKFPDQLSSNAIS 109 Query 150 KRHDEFERHAEGTFTSDV 167 ||| |||||||||+|||+ Sbjct 110 KRHSEFERHAEGTYTSDI 127 Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAK---RHDEFERHAEGTFT 164 +| +||++||+||| + ||+ + |++|+ |#|+| + |+ | + |||+|||| Sbjct 113 SEFERHAEGTYTSDITSYLEGQAAKEFIAW#LVNGRGRRDFPEKALMAEEMGRRHADGTFT 172 Query 165 SDV 167 ||+ Sbjct 173 SDI 175 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNI 148 +||+ |||||| +| || |++|++|#|+||| + ++ Sbjct 164 RRHADGTFTSDINKILDDMAAKEFLKW#LINTKVTQRDL 201 |
| Meleagris gallopavo | Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRN------------------RNNIA 149 || |||||||||||||||||||||||||||#||+|||| | |+ Sbjct 50 NEVKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMSTKRNGQQGQEDKENDEFPDQLSSNAIS 109 Query 150 KRHDEFERHAEGTFTSDV 167 ||| |||||||||+|||+ Sbjct 110 KRHSEFERHAEGTYTSDI 127 Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAK---RHDEFERHAEGTFT 164 +| +||++||+||| + ||+ + |++|+ |#|+| + |+ | + |||+|||| Sbjct 113 SEFERHAEGTYTSDITSYLEGQAAKEFIAW#LVNGRGRRDFPEKALMAEEMGRRHADGTFT 172 Query 165 SDV 167 ||+ Sbjct 173 SDI 175 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNI 148 +||+ |||||| +| || |++|++|#|+||| + ++ Sbjct 164 RRHADGTFTSDINKILDDMAAKEFLKW#LINTKVTQRDL 201 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKR------------------NRNNIA 149 || |||||||||||||||||+|||||||||#|||||| + | +| Sbjct 48 NEVKRHSQGTFTSDYSKYLDTRRAQDFVQW#LMNTKRSGQQGVEEREKENLLDQLSSNGLA 107 Query 150 KRHDEFERHAEGTFTSDV 167 + | |+||||+| +|||+ Sbjct 108 RHHAEYERHADGRYTSDI 125 Query 109 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAK---RHDEFERHAEGTFTS 165 | +||+ | +||| | ||+ + |++|+ |#|+| + |+ + + | |||+||||| Sbjct 112 EYERHADGRYTSDISSYLEGQAAKEFIAW#LVNGRGRRDFLEEAGTADDIGRRHADGTFTS 171 Query 166 D 166 | Query 166 D 166 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNI 148 +||+ |||||||++ || |+|++|#|+| | + ++ Sbjct 162 RRHADGTFTSDYNQLLDDIATQEFLKW#LINQKVTQRDL 199 |
| Capra hircus | Query 146 NNIAKRHDEFERHAEGTFTSDV 167 |||||||||||||||||||||| Query 146 NNIAKRHDEFERHAEGTFTSDV 167 Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNR 145 +| +||++|||||| | ||+ + |++|+ |#|+ + | Sbjct 8 DEFERHAEGTFTSDVSSYLEGQAAKEFIAW#LVKGRGRR 45 |
| Oncorhynchus tshawytscha | Query 114 SQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 | |||++||||| + | |||||||#|||+||+ +|||+||+|||| Sbjct 2 SXGTFSNDYSKYQEERMAQDFVQW#LMNSKRS-------GAPSKRHADGTYTSDV 48 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNR 145 |||+ ||+||| | || + |+||| |#| + + | Sbjct 37 KRHADGTYTSDVSTYLQDQAAKDFVSW#LKSGRARR 71 |
| Ictalurus punctatus | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 +|||+|||++||||||++|||||||||#|||+||+ |||+||+|||| Sbjct 49 RRHSEGTFSNDYSKYLETRRAQDFVQW#LMNSKRS-------DSPARRHADGTYTSDV 98 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEF--ERHAEGTFTSDV 167 +||+ ||+||| | || + |+||+ |#| + + + + | + || +|+||||| Sbjct 87 RRHADGTYTSDVSSYLQDQAAKDFITW#LKSGQPKPDAVETRSVDTLRRRHVDGSFTSDV 145 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRH 152 +|| |+|||| +| ||| |++++||#+||+ + + ||| Sbjct 134 RRHVDGSFTSDVNKVLDSLAAKEYLQW#VMNSPSSAS--GKRH 173 |
| Rattus norvegicus | Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHA 159 |+++||| |||| +| | |||| |#|+ | +|+ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKIRQQDFVNW#LLAQKGKKND--WKHNLTQREA 88 |
| Canis familiaris | Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHA 159 |+++||| |||| +| | |||| |#|+ | +|+ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKIRQQDFVNW#LLAQKGKKND--WKHNITQREA 88 |
| Ambloplites rupestris | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSD 166 |||||||+||+ ||+ |+||||++|#||| | |+ |++ |||+|||| | Sbjct 1 HSQGTFTNDYTNYLEDRQAQDFIRW#LMNNK--RSGAAEK-----RHADGTFTDD 47 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDE--FERHAEGTFTSDV 167 +|||+ |||| | | + +||| #| + + | | | || ||+||||+ Sbjct 36 EKRHADGTFTDDASSDFYDQAIKDFVAK#LKSGQDRREPETDRRREAFSRRHVEGSFTSDI 95 |
| Pan troglodytes | Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 ||||||||||||||||||||||||||||||#||||||| +++| ||||||||||| Sbjct 970 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRN-SSVA------YRHAEGTFTSDV 1022 Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNR 145 ||++|||||| | ||+ + |++|+ |#|+ + | Sbjct 1012 RHAEGTFTSDVSSYLEGQAAKEFIAW#LVKGRGRR 1045 |
| Xenopus tropicalis | Query 109 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 | ||||||||||||||||||||||||+||#||||||+ +++|+ ++|||||||||||| Sbjct 49 EVKRHSQGTFTSDYSKYLDSRRAQDFIQW#LMNTKRS-GGLSRRNADYERHAEGTFTSDV 106 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 +||++||+|+| ++||+ + |++|++|#|+| | + + ||||||||+|+ Sbjct 140 ERHAEGTYTNDVTEYLEEKAAKEFIEW#LINGK-------PKKIRYSRHAEGTFTNDM 189 Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFE---RHAEGTFTSDV 167 ||++||||+| + ||+ + |++|| |#|+ | + | ++ | | |||+|+||+|+ Sbjct 179 RHAEGTFTNDMTNYLEEKAAKEFVGW#LIK-GRPKRNFSEAHSVEEMDRRHADGSFTNDI 236 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTK 142 |+||+ |+||+| +| || ||+|+ |#++||+ Sbjct 224 DRRHADGSFTNDINKVLDIIAAQEFLDW#VINTQ 256 |
| Danio rerio | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 ||||+|||++||||||++|||||||||#||| ||| ++ +||||||+|||| Sbjct 48 KRHSEGTFSNDYSKYLETRRAQDFVQW#LMNAKRNGGSV-------KRHAEGTYTSDV 97 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#L 138 |||++||+||| | || + || || |#| Sbjct 86 KRHAEGTYTSDVSSYLQDQAAQSFVAW#L 113 |
| Bos taurus | Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSD 166 ||+ | ||||||+ | |+ +++ #|+ || |+|++ +||++ || + Sbjct 80 RHADGVFTSDYSRLLGQLSAKKYLES#LIG-KRVSNSISEDQGPIKRHSDAVFTDN 133 |
| Macaca mulatta | Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSD 166 + + ||+ | ||||+|| | |+ +++ #|| || +||++ +||++ || + Sbjct 76 SRNARHADGVFTSDFSKLLGQLSAKKYLES#LMG-KRVSSNISEDPVPVKRHSDAVFTDN 133 |
| Heloderma suspectum | Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKR------------------NRNNIA 149 || |||||||||||||||||+|||||||||#|||||| + | +| Sbjct 48 NEVKRHSQGTFTSDYSKYLDTRRAQDFVQW#LMNTKRSGQQGVEEREKENLLDQLSSNGLA 107 Query 150 KRHDEFERHAEGTFTSDV 167 + | |+||||+| +|||+ Sbjct 108 RHHAEYERHADGRYTSDI 125 Query 109 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNR 145 | +||+ | +||| | ||+ + |++|+ |#|+| + | Sbjct 112 EYERHADGRYTSDISSYLEGQAAKEFIAW#LVNGRGRR 148 |
| Squalus acanthias | Query 127 DSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 |+|||+|||||#||+|||| |+ +||||||+|||| Sbjct 1 DNRRAKDFVQW#LMSTKRN-------GDKTKRHAEGTYTSDV 34 Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#L--MNTKRNRNNIAKRHDEFERHAEGTF 163 ++ |||++||+||| | +|+ || #| | ++| +|+||| | || ||++ Sbjct 20 DKTKRHAEGTYTSDVDSLSDYFKAKRFVDS#LTSYNKRQNGRSISKRHVESTRHTEGSY 77 Query 109 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRN---------NIAKRHDEFERHA 159 | ||++|++ | | ||+++ |+||+ |#|+ + | | + ||| Sbjct 68 ESTRHTEGSYR-DISSYLEAKAAKDFINW#LIKGRGRREFPEESKEIVNEVIPEEMDRRHA 126 Query 160 EGTFTSDV 167 +|||||++ Sbjct 127 DGTFTSEI 134 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFE 156 |+||+ |||||+ + ||+ |++|+ |#++|+| | | | | Sbjct 122 DRRHADGTFTSEINIVLDTIAAKEFLNW#ILNSK----TIQSRDSEIE 164 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRN 144 |+ ||||+| + |||++ |+||| |#| + ++ Sbjct 1 HADGTFTNDMTSYLDAKAARDFVSW#LARSDKS 32 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 ||||+|||++||||||++|||||||||#| |+||| | |||+||+|||| Sbjct 50 KRHSEGTFSNDYSKYLETRRAQDFVQW#LKNSKRN--------GLFRRHADGTYTSDV 98 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#L 138 +||+ ||+||| | || + |+||| |#| Sbjct 87 RRHADGTYTSDVSSYLQDQAAKDFVSW#L 114 |
| Sebastes caurinus | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 ||||+|||++|||+||+ |+|||||+|#||| ||+ || +|||+||||||| Sbjct 48 KRHSEGTFSNDYSRYLEERKAQDFVRW#LMNNKRS------GADE-KRHADGTFTSDV 97 Query 109 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDE--FERHAEGTFTSD 166 ++|||+ |||||| | || + +||| #| + + | + + | || +|+|||| Sbjct 84 DEKRHADGTFTSDVSSYLKDQAIKDFVNR#LKSGQVRRESETEWRGEAFSRRHVDGSFTSD 143 Query 167 V 167 | Query 167 V 167 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDE 154 +|| |+|||| +| ||| |++++ |#+| +| + + ++ |+ Sbjct 133 RRHVDGSFTSDVNKVLDSMAAKEYLLW#VMTSKPSGESKKRQEDQ 176 |
| Tetraodon nigroviridis | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 ||||+|||++||||||++|||||||||#| |+||| + | |||+||+|||| Sbjct 787 KRHSEGTFSNDYSKYLETRRAQDFVQW#LKNSKRNGS-------LFRRHADGTYTSDV 836 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNR 145 +||+ ||+||| | || + |++|| |#| + | Sbjct 825 RRHADGTYTSDVSAYLQDQAAKEFVSW#LKTGRGRR 859 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 ||||+|||++||||||++|||||||+|#|||+| | + +||||||+|||+ Sbjct 48 KRHSEGTFSNDYSKYLETRRAQDFVEW#LMNSKSNGGSA-------KRHAEGTYTSDI 97 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#L 138 |||++||+||| | +| + ||+|| |#| Sbjct 86 KRHAEGTYTSDISSFLRDQAAQNFVAW#L 113 |
| Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 || |+|||++ |||| + | |+||+ |#|||+||+ +|||+||+|||| Sbjct 50 KRQSEGTFSNYYSKYQEERMARDFLHW#LMNSKRS-------GAPSKRHADGTYTSDV 99 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHD--EFERHAEGTFTSDV 167 |||+ ||+||| | || + |+||| |#| + | + + + || +|+||||| Sbjct 88 KRHADGTYTSDVSTYLQDQAAKDFVSW#LKSGPARRESAEESMNGPMSRRHVDGSFTSDV 146 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHD 153 +|| |+|||| +| ||| |++++ |#+| +| + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLDSLAAKEYLLW#VMTSKTSGKSNKRQED 177 |
| Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 ||||+|||++||||| + | |||||||#|||+||+ +|||+||+|||| Sbjct 50 KRHSEGTFSNDYSKYQEERMAQDFVQW#LMNSKRS-------GAPSKRHADGTYTSDV 99 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNI--AKRHDEFERHAEGTFTSDV 167 |||+ ||+||| | || + |+||| |#| + + | + ++ || +|+||||| Sbjct 88 KRHADGTYTSDVSTYLQDQAAKDFVSW#LKSGRARRESAEESRNGPMSRRHVDGSFTSDV 146 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHD 153 +|| |+|||| +| ||| |++++ |#+| +| + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLDSLAAKEYLLW#VMTSKTSGKSNKRQED 177 |
| Heloderma horridum | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMN 140 |||| |||||| || ++ + |++|#| | Sbjct 46 KRHSDGTFTSDLSKQMEEEAVRLFIEW#LKN 75 |
| Mus musculus | Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHA 159 |+++||| |||| +| | |||| |#|+ + +++ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKIRQQDFVNW#LLAQRGKKSD--WKHNITQREA 88 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTK 142 |+ |+|||| +| ||+ |++|+ |#|++|| Sbjct 1 HADGSFTSDINKVLDTIAAKEFLNW#LISTK 30 |
| Protopterus dolloi | Query 109 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 | |||||||| |||+| |+++ | | || #||+||| ++|||+| |||||||+|||+ Sbjct 28 EAKRHSQGTFMSDYAKLLEAKHALDLVQR#LMSTKRT-GAVSKRHNEIERHAEGTYTSDI 85 Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFE-RHAEGTFTSD 166 || +||++||+||| | ||+ + +|++|#|| + |+ +| + |||+|| ||| Sbjct 71 NEIERHAEGTYTSDISSYLEGQAVNEFIRW#LMKGRGRRDFSETDIEEMDRRHADGTVTSD 130 Query 167 V 167 + Sbjct 131 I 131 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTK 142 |+||+ || ||| + |+| ++|+ |#|+| | Sbjct 119 DRRHADGTVTSDINSVLESIATREFLNW#LINAK 151 |
| Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSD 166 + + ||+ | ||||||+ | |+ +++ #|+ || ++|++ +||++ || + Sbjct 76 SRNARHADGVFTSDYSRLLGQISAKKYLES#LIG-KRISSSISEDPVPIKRHSDAVFTDN 133 |
| Agkistrodon piscivorus | Query 109 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRH---DEFERHAEGTFTS 165 | +||+ ||+||| | ||+ + |++|+ |#|+| + |+ | | |||+||||| Sbjct 32 EYERHADGTYTSDISSYLEGQAAKEFIAW#LVNGRGRRDFSEGAHTGEDLGRRHADGTFTS 91 Query 166 D 166 | Query 166 D 166 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNI 148 +||+ |||||||+| || |+|++|#|+| | + ++ Sbjct 82 RRHADGTFTSDYNKLLDDIATQEFLKW#LINQKVTQRDL 119 Query 126 LDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 |+ | ++|+ #| + | +|+ | |+||||+||+|||+ Sbjct 9 LEDREKENFLDQ#LAS-----NGLARPHAEYERHADGTYTSDI 45 |
| Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 |||||+|||||||+|| ++|+||| |#|+|||| + + +||++|+||+|+ Sbjct 43 RHSQGSFTSDYSKHLDVKQAKDFVTW#LLNTKRRGVDAQAGANLEKRHSDGSFTNDM 98 Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKR 143 | +|||| |+||+| + || |++|++|#| | Sbjct 84 NLEKRHSDGSFTNDMNVMLDRMSAKNFLEW#LKQQGR 119 |
| Arvicanthis ansorgei | Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSD 166 + + ||+ | ||||||+ | |+ +++ #|+ || ++| + +||++ || + Sbjct 59 SRNARHADGVFTSDYSRLLGQISAKKYLES#LIG-KRISSSILEDPVPIKRHSDAVFTDN 116 |
| synthetic construct | Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRN---NIAKRHDEFERHAEGTFT 164 +| +||++|||||| | ||+ + |++|+ |#|+ + |+ +| + |||+|+|+ Sbjct 93 DEFERHAEGTFTSDVSSYLEGQAAKEFIAW#LVKGRGRRDFPEEVAIVEELGRRHADGSFS 152 Query 165 SDV 167 ++ Sbjct 153 DEM 155 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTK 142 +||+ |+|+ + + ||+ |+||+ |#|+ || Sbjct 144 RRHADGSFSDEMNTILDNLAARDFINW#LIQTK 175 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 ||||+|||++||||||+ |+||+||+|#||| | |+ +|++ |||+||||||| Sbjct 51 KRHSEGTFSNDYSKYLEDRKAQEFVRW#LMNNK--RSGVAEK-----RHADGTFTSDV 100 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQW#L 138 +|||+ |||||| | || + +||| #| Sbjct 88 EKRHADGTFTSDVSSYLKDQAIKDFVDR#L 116 |
| Phodopus sungorus | Query 116 GTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRN---NIAKRHDEFERHAEGTFTSDV 167 |||||| | ||+ + |++|+ |#|+ + |+ + + |||+|+|+ ++ Sbjct 1 GTFTSDVSSYLEGQAAKEFIAW#LVKGRGRRDFPEEVTIVEELGRRHADGSFSDEM 55 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTK 142 +||+ |+|+ + + ||| +||+ |#|+ || Sbjct 44 RRHADGSFSDEMNTILDSLATRDFINW#LIQTK 75 |
| Neoceratodus forsteri | Query 109 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 | |||||||| |||+| |++| | |||| #||||||| ++||| | |||||||+|||+ Sbjct 20 EAKRHSQGTFMSDYAKLLEARHALDFVQR#LMNTKRN-GGVSKRHSEIERHAEGTYTSDI 77 Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEF-ERHAEGTFTSD 166 +| +||++||+||| | ||+ + | +||+|#|+ + |+ +| |||+|| |+| Sbjct 63 SEIERHAEGTYTSDISSYLEGQAANEFVRW#LLKGRGRRDFSDTDAEEMGRRHADGTITND 122 Query 167 V 167 + Sbjct 123 M 123 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTK 142 +||+ || |+| + |+| ++|+ |#|+|+| Sbjct 112 RRHADGTITNDMNNVLESIATREFLNW#LINSK 143 |
| Sus scrofa | Query 109 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 |||||||||||||||||||||||||||||#|||||||+|||||||||||||||||||||| Sbjct 49 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNKNNIAKRHDEFERHAEGTFTSDV 107 Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRN---NIAKRHDEFERHAEGTFT 164 +| +||++|||||| | ||+ + |++|+ |#|+ + |+ + + |||+|+|+ Sbjct 93 DEFERHAEGTFTSDVSSYLEGQAAKEFIAW#LVKGRGRRDFPEEVTIVEELRRRHADGSFS 152 Query 165 SDV 167 ++ Sbjct 153 DEM 155 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTK 142 +||+ |+|+ + + ||+ +||+ |#|++|| Sbjct 144 RRHADGSFSDEMNTVLDNLATRDFINW#LLHTK 175 |
| Canis lupus familiaris | Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 ||||||||||||||||||||||||||||||#|||||||+|||||||||||||||||||||| Sbjct 48 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNKNNIAKRHDEFERHAEGTFTSDV 107 Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRN---NIAKRHDEFERHAEGTFT 164 +| +||++|||||| | ||+ + |++|+ |#|+ + |+ +| + |||+|+|+ Sbjct 93 DEFERHAEGTFTSDVSSYLEGQAAKEFIAW#LVKGRGRRDFPEEVAIVEEFRRRHADGSFS 152 Query 165 SDV 167 ++ Sbjct 153 DEM 155 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTK 142 +||+ |+|+ + + ||+ +||+ |#|+ || Sbjct 144 RRHADGSFSDEMNTVLDTLATRDFINW#LLQTK 175 |
| Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 |||||||+|||||||+|||||||||#||+|||+ | ||+||+|||| Sbjct 1 HSQGTFTNDYSKYLDTRRAQDFVQW#LMSTKRS-GGITXXXXXXXXHADGTYTSDV 54 Query 113 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNR 145 |+ ||+||| | || + |+ || |#| + | Sbjct 45 HADGTYTSDVSSYLQDQAAKKFVTW#LKQGQDRR 77 |
| Hydrolagus colliei | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFERHAEGTFTSDV 167 |||+ | |+||||||||+|| +|||||#|++|||| | |+ +|||+| +|||| Sbjct 30 KRHTDGIFSSDYSKYLDNRRTKDFVQW#LLSTKRNGANT----DKTKRHADGIYTSDV 82 Query 108 NEDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNN--IAKRHDEFERHAEGTFTS 165 ++ |||+ | +||| + | +++ ||+ #| | + +|+ ++||| | | | + + Sbjct 68 DKTKRHADGIYTSDVASLTDYLKSKRFVES#LSNYNKRQNDRRMSKRHVEGARRTEEDYPN 127 Query 166 D 166 | Query 166 D 166 Query 109 EDKRHSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRNNIAKRHDEFE 156 | | ++ + +|+| ||+++ |+||+ |#|+ + | + |+ | | Sbjct 116 EGARRTEEDYPNDFSSYLEAKAAKDFIDW#LIK-GQGRRDFAEESREIE 162 |
| Heloderma suspectum, venom, Peptide, 39 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQW#LMN 140 | +|||||| || ++ + |++|#| | Sbjct 1 HGEGTFTSDLSKQMEEEAVRLFIEW#LKN 28 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | Query 116 GTFTSDYSKYLDSRRAQDFVQW#LMNTKRNRN 146 ||+||| | || + |++|| |#| + |+ Sbjct 3 GTYTSDVSSYLQDQAAKEFVSW#LKTGRGRRD 33 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQW#LMNTKRNR 145 |+ || ||| | +|+ + ++|+ |#|++ + | Sbjct 1 HADGTLTSDISSFLEKQATKEFIAW#LVSGRGRR 33 |
[Site 4] FTSDYSKYLD127-SRRAQDFVQW
Asp127 Ser
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Phe118 | Thr119 | Ser120 | Asp121 | Tyr122 | Ser123 | Lys124 | Tyr125 | Leu126 | Asp127 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ser128 | Arg129 | Arg130 | Ala131 | Gln132 | Asp133 | Phe134 | Val135 | Gln136 | Trp137 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| TEAHEDPDEMNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFER |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 118.00 | 10 | glucagon, isoform CRA_b |
| 2 | Pan troglodytes | 95.90 | 2 | PREDICTED: fibroblast activation protein, alpha su |
| 3 | N/A | 79.70 | 45 | 0 |
| 4 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | 64.70 | 1 | AAB31092.1 |
| 5 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | 61.60 | 1 | glucagon=proglucagon-derived 3.5 kda peptide |
| 6 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | 60.80 | 1 | glucagon II |
| 7 | Contains: Glucagon; Glucagon-like peptide | 60.10 | 4 | GLUC_AMICA Glucagon precursor |
| 8 | Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | 60.10 | 1 | glucagon |
| 9 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | 58.50 | 1 | glucagon G-29 |
| 10 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | 57.80 | 1 | GLUC1_ORENI Glucagon-1 (Glucagon I) gb |
| 11 | Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | 56.20 | 1 | GLUC_LAMFL Glucagon gb |
| 12 | deshis1, Desphe6, Glu9 | 53.50 | 1 | A Chain A, Nmr Solution Structure Of The Glucagon |
| 13 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | 53.50 | 1 | glucagon |
| 14 | Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | 47.00 | 1 | GLUC1_PETMA Glucagon-1 precursor |
| 15 | Meleagris gallopavo | 44.70 | 2 | preproglucagon B |
| 16 | Gallus gallus | 44.30 | 4 | glucagon isoform 1 |
| 17 | Agkistrodon piscivorus | 44.30 | 1 | proglucagon |
| 18 | Capra hircus | 43.90 | 1 | glucagon |
| 19 | Oncorhynchus tshawytscha | 43.50 | 1 | S78474_1 proglucagon |
| 20 | Monodelphis domestica | 42.70 | 3 | PREDICTED: similar to Gastric inhibitory polypepti |
| 21 | Xenopus tropicalis | 42.70 | 2 | glucagon |
| 22 | Rattus norvegicus | 42.40 | 5 | Glucose-dependent insulinotropic peptide |
| 23 | Xenopus laevis | 42.40 | 5 | proglucagon I |
| 24 | Canis familiaris | 42.40 | 2 | PREDICTED: similar to Gastric inhibitory polypepti |
| 25 | Danio rerio | 42.00 | 4 | hypothetical protein LOC494052 |
| 26 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | 42.00 | 1 | GLUC_HELSU Glucagon precursor |
| 27 | Heloderma suspectum | 41.60 | 2 | proglucagon |
| 28 | Hoplobatrachus rugulosus | 41.60 | 1 | AF324209_1 proglucagon |
| 29 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | 41.20 | 1 | GLUC2_LOPAM Glucagon-2 precursor (Glucagon II) |
| 30 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | 41.20 | 1 | glucagon-like peptide, GLP |
| 31 | Bos taurus | 40.40 | 5 | PREDICTED: similar to Gastric inhibitory polypepti |
| 32 | Macaca mulatta | 40.40 | 3 | PREDICTED: gastric inhibitory polypeptide |
| 33 | Ictalurus punctatus | 40.40 | 3 | proglucagon I |
| 34 | Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | 40.40 | 1 | GLUC1_ONCMY Glucagon-1 precursor (Glucagon I) |
| 35 | Sebastes caurinus | 40.00 | 4 | proglucagon II |
| 36 | Tetraodon nigroviridis | 40.00 | 2 | unnamed protein product |
| 37 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | 40.00 | 2 | GLUC_CARAU Glucagon precursor |
| 38 | Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | 40.00 | 1 | GLUC2_ONCMY Glucagon-2 precursor (Glucagon II) |
| 39 | Heloderma horridum | 40.00 | 1 | EXE3_HELHO Exendin-3 precursor emb |
| 40 | Protopterus dolloi | 39.70 | 1 | proglucagon |
| 41 | Mus musculus | 39.30 | 6 | Gastric inhibitory polypeptide |
| 42 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | 38.90 | 1 | glucagon-like peptide-2, GLP-2=proglucagon-derived |
| 43 | Bufo marinus | 38.90 | 1 | proglucagon |
| 44 | Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | 38.10 | 1 | GLUC2_PETMA Glucagon-2 precursor |
| 45 | Neoceratodus forsteri | 38.10 | 1 | proglucagon |
| 46 | synthetic construct | 37.00 | 1 | Homo sapiens glucagon |
| 47 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | 36.60 | 1 | GLUC1_LOPAM Glucagon-1 precursor (Glucagon I) |
| 48 | Phodopus sungorus | 36.60 | 1 | glucagon precursor |
| 49 | Sus scrofa | 36.20 | 1 | glucagon |
| 50 | Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | 35.80 | 1 | GLUC_LEPSP Glucagon precursor |
| 51 | Canis lupus familiaris | 35.80 | 1 | glucagon |
| 52 | Hydrolagus colliei | 35.40 | 1 | proglucagon |
| 53 | Squalus acanthias | 35.40 | 1 | proglucagon |
| 54 | Heloderma suspectum, venom, Peptide, 39 aa | 35.40 | 1 | A Chain A, Solution Structure Of Exendin-4 In 30-V |
| 55 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | 34.70 | 1 | glucagon-like peptide-1, GLP-1=proglucagon-derived |
| 56 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | 34.70 | 1 | GLUC2_ORENI Glucagon-2 (Glucagon II) gb |
| 57 | swine, intestines, Peptide Partial, 56 aa | 32.30 | 1 | secretin precursor, N-prosecretin, secretin-(-9 to |
| 58 | Ambloplites rupestris | 32.30 | 1 | proglucagon |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 103 DPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 157 |||+|||||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 126 DPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 180 |
| Pan troglodytes | Query 103 DPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDE 154 |||+|||||||||||||||||||||#||||||||||||||||| +++| || | Sbjct 965 DPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRN-SSVAYRHAE 1015 |
| N/A | Query 113 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIA 149 |||||||||||||||#|||||||||||||||||+|||| Sbjct 1 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNKNNIA 37 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | Query 113 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRN 144 ||+||||||||||+|#+|||+|||||||+|||| Sbjct 1 HSEGTFTSDYSKYMD#NRRAKDFVQWLMSTKRN 32 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNT 141 |||||||||||||||#+||||||+||||+| Sbjct 1 HSQGTFTSDYSKYLD#NRRAQDFIQWLMST 29 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | Query 113 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRN 144 ||+|||++||||||+#+|||||||||| |+||| Sbjct 1 HSEGTFSNDYSKYLE#TRRAQDFVQWLKNSKRN 32 |
| Contains: Glucagon; Glucagon-like peptide | Query 113 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNT 141 |||||||+|||||+|#+|||||||||||+| Sbjct 1 HSQGTFTNDYSKYMD#TRRAQDFVQWLMST 29 |
| Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNT 141 |||||||+|||||+|#+|||||||||||+| Sbjct 1 HSQGTFTNDYSKYMD#TRRAQDFVQWLMST 29 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNT 141 ||+||||||||||+|#+|||+|||||||+| Sbjct 1 HSEGTFTSDYSKYMD#NRRAKDFVQWLMST 29 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | Query 113 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRN 144 ||+|||++||||||+# |+|||||+|||| ||+ Sbjct 1 HSEGTFSNDYSKYLE#DRKAQDFVRWLMNNKRS 32 |
| Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNT 141 ||||+||||||||||#|++|+||| ||||| Sbjct 1 HSQGSFTSDYSKYLD#SKQAKDFVIWLMNT 29 |
| deshis1, Desphe6, Glu9 | Query 114 SQGTFTSDYSKYLD#SRRAQDFVQWLMNT 141 |||| ||+||||||#|||||||||||||| Sbjct 1 SQGT-TSEYSKYLD#SRRAQDFVQWLMNT 27 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLD#SRRAQDFVQWLMN 140 ||+|||||||||||+#+++|+|||+|||| Sbjct 1 HSEGTFTSDYSKYLE#NKQAKDFVRWLMN 28 |
| Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | Query 102 EDPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 152 +| | ||||+|||||||||||+#+++|+|||+|||| || + + +|| Sbjct 32 DDSAERPLSKRHSEGTFTSDYSKYLE#NKQAKDFVRWLMNAKRGGSELQRRH 82 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNR---------NNIAKRHDE 154 +||+ ||||+| + |||#++ |+||| || + ++| |+ ||| | Sbjct 80 RRHADGTFTNDMTSYLD#AKAARDFVSWLARSDKSRRDGGDHLAENSEDKRHAE 132 |
| Meleagris gallopavo | Query 98 TEAHEDPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRN------------- 144 +| ++ ++|| |||||||||||||||||#||||||||||||+|||| Sbjct 40 SEPLDESRQLNEVKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMSTKRNGQQGQEDKENDEF 99 Query 145 -----RNNIAKRHDEFER 157 | |+||| |||| Sbjct 100 PDQLSSNAISKRHSEFER 117 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNI 148 +||+ |||||| +| ||# |++|++||+||| + ++ Sbjct 164 RRHADGTFTSDINKILD#DMAAKEFLKWLINTKVTQRDL 201 Query 99 EAHEDPDEMN---------EDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 146 | | ||+++ | +||++||+||| + ||+# + |++|+ ||+| + |+ Sbjct 95 ENDEFPDQLSSNAISKRHSEFERHAEGTYTSDITSYLE#GQAAKEFIAWLVNGRGRRD 151 |
| Gallus gallus | Query 98 TEAHEDPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRN------------- 144 +| ++ ++|| |||||||||||||||||#||||||||||||+|||| Sbjct 40 SEPLDESRQLNEVKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMSTKRNGQQGQEDKENDKF 99 Query 145 -----RNNIAKRHDEFER 157 | |+||| |||| Sbjct 100 PDQLSSNAISKRHSEFER 117 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNI 148 +||+ |||||| +| ||# |++|++||+||| + ++ Sbjct 164 RRHADGTFTSDINKILD#DMAAKEFLKWLINTKVTQRDL 201 Query 108 NEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 146 +| +||++||+||| + ||+# + |++|+ ||+| + |+ Sbjct 113 SEFERHAEGTYTSDITSYLE#GQAAKEFIAWLVNGRGRRD 151 |
| Agkistrodon piscivorus | Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNI 148 +||+ |||||||+| ||# |+|++||+| | + ++ Sbjct 82 RRHADGTFTSDYNKLLD#DIATQEFLKWLINQKVTQRDL 119 Query 109 EDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 146 | +||+ ||+||| | ||+# + |++|+ ||+| + |+ Sbjct 32 EYERHADGTYTSDISSYLE#GQAAKEFIAWLVNGRGRRD 69 |
| Capra hircus | Query 108 NEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNR 145 +| +||++|||||| | ||+# + |++|+ ||+ + | Sbjct 8 DEFERHAEGTFTSDVSSYLE#GQAAKEFIAWLVKGRGRR 45 |
| Oncorhynchus tshawytscha | Query 114 SQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 152 | |||++||||| +# | ||||||||||+||+ +||| Sbjct 2 SXGTFSNDYSKYQE#ERMAQDFVQWLMNSKRS-GAPSKRH 39 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNR 145 |||+ ||+||| | || # + |+||| || + + | Sbjct 37 KRHADGTYTSDVSTYLQ#DQAAKDFVSWLKSGRARR 71 |
| Monodelphis domestica | Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 157 +|+++||| |||| +|# |||| ||++ | +| + ||+ || Sbjct 51 QRYAEGTFISDYSITMD#KIMQQDFVNWLLSQKGKKN--SWRHNITER 95 |
| Xenopus tropicalis | Query 99 EAHEDPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 157 || +| ++ | |||||||||||||||||#|||||||+||||||||+ +++|+ ++|| Sbjct 39 EAVDDSQQLKEVKRHSQGTFTSDYSKYLD#SRRAQDFIQWLMNTKRS-GGLSRRNADYER 96 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 157 +||++|||||| +++||# + |++|+ ||+| ++ |++|+ + || Sbjct 95 ERHAEGTFTSDVTQHLD#EKAAKEFIDWLINGGPSKEIISRRNADVER 141 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDE 154 +||++||+|+| ++||+# + |++|++||+| | + + || | Sbjct 140 ERHAEGTYTNDVTEYLE#EKAAKEFIEWLINGKPKKIRYS-RHAE 182 Query 98 TEAHEDPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTK 142 +||| +|| |+||+ |+||+| +| ||# ||+|+ |++||+ Sbjct 215 SEAHS-VEEM--DRRHADGSFTNDINKVLD#IIAAQEFLDWVINTQ 256 Query 112 RHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 146 ||++||||+| + ||+# + |++|| ||+ + || Sbjct 179 RHAEGTFTNDMTNYLE#EKAAKEFVGWLIKGRPKRN 213 |
| Rattus norvegicus | Query 112 RHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNN 147 |+++||| |||| +|# | |||| ||+ | +|+ Sbjct 43 RYAEGTFISDYSIAMD#KIRQQDFVNWLLAQKGKKND 78 |
| Xenopus laevis | Query 99 EAHEDPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 157 || +| +++ | |||||||||||||||||#||||||||||||||||+ +++|+ ++|| Sbjct 39 EAVDDSEQLKEVKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRS-GELSRRNADYER 96 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 157 +||++|||||| ++ ||# + |++|+ ||+| ++ |++|+ |||| Sbjct 95 ERHAEGTFTSDVTQQLD#EKAAKEFIDWLINGGPSKEIISRRNAEFER 141 Query 110 DKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNI 148 |+||+ |+||+| +| ||# ||+|+ |++||+ ++ Sbjct 224 DRRHADGSFTNDINKVLD#IIAAQEFLDWVINTQETERDL 262 Query 112 RHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 146 ||++||||+| + ||+# + |++|| ||+ + || Sbjct 179 RHAEGTFTNDMTNYLE#EKAAKEFVGWLIKGRPKRN 213 Query 109 EDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDE 154 | +||++||+|+| ++||+# + |++|++||+ | + + || | Sbjct 138 EFERHAEGTYTNDVTEYLE#EKAAKEFIEWLIKGKPKKIRYS-RHAE 182 |
| Canis familiaris | Query 112 RHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNN 147 |+++||| |||| +|# | |||| ||+ | +|+ Sbjct 43 RYAEGTFISDYSIAMD#KIRQQDFVNWLLAQKGKKND 78 |
| Danio rerio | Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDE 154 ||||+|||++||||||+#+|||||||||||| ||| ++ ||| | Sbjct 48 KRHSEGTFSNDYSKYLE#TRRAQDFVQWLMNAKRNGGSV-KRHAE 90 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWL 138 |||++||+||| | || # + || || || Sbjct 86 KRHAEGTYTSDVSSYLQ#DQAAQSFVAWL 113 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | Query 99 EAHEDPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKR--------------- 143 | +| ++|| |||||||||||||||||#+||||||||||||||| Sbjct 39 EPLDDSRQLNEVKRHSQGTFTSDYSKYLD#TRRAQDFVQWLMNTKRSGQQGVEEREKENLL 98 Query 144 ---NRNNIAKRHDEFER 157 + | +|+ | |+|| Sbjct 99 DQLSSNGLARHHAEYER 115 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNI 148 +||+ |||||||++ ||# |+|++||+| | + ++ Sbjct 162 RRHADGTFTSDYNQLLD#DIATQEFLKWLINQKVTQRDL 199 Query 109 EDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 146 | +||+ | +||| | ||+# + |++|+ ||+| + |+ Sbjct 112 EYERHADGRYTSDISSYLE#GQAAKEFIAWLVNGRGRRD 149 |
| Heloderma suspectum | Query 99 EAHEDPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKR--------------- 143 | +| ++|| |||||||||||||||||#+||||||||||||||| Sbjct 39 EPLDDSRQLNEVKRHSQGTFTSDYSKYLD#TRRAQDFVQWLMNTKRSGQQGVEEREKENLL 98 Query 144 ---NRNNIAKRHDEFER 157 + | +|+ | |+|| Sbjct 99 DQLSSNGLARHHAEYER 115 Query 109 EDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNR 145 | +||+ | +||| | ||+# + |++|+ ||+| + | Sbjct 112 EYERHADGRYTSDISSYLE#GQAAKEFIAWLVNGRGRR 148 |
| Hoplobatrachus rugulosus | Query 98 TEAHEDPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 157 ||| +| | || |||||||||||||||||#|||||||||||||+||+ |+||+ +||| Sbjct 38 TEALDDSDHHNEVKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNSKRS-GGISKRNVQFER 96 Query 110 DKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNT 141 |+||+ |+||||++| ||# + ||+|+ |++|| Sbjct 178 DRRHADGSFTSDFNKALD#IKAAQEFLDWIINT 209 Query 112 RHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 146 ||++|||||| + ||+# + |++|| ||+ + || Sbjct 134 RHAEGTFTSDMTSYLE#EKAAKEFVDWLIKGRPKRN 168 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDE 154 +||++||+|+| +++|+# + |++|+ ||+ | + ++ || | Sbjct 95 ERHAEGTYTNDVTQFLE#EKAAKEFIDWLIKGKPKKQRLS-RHAE 137 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | Query 103 DPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 152 +| | ||||+|||++||||||+#+|||||||||| |+| || + +|| Sbjct 42 EPIEPLNMKRHSEGTFSNDYSKYLE#TRRAQDFVQWLKNSK--RNGLFRRH 89 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWL 138 +||+ ||+||| | || # + |+||| || Sbjct 87 RRHADGTYTSDVSSYLQ#DQAAKDFVSWL 114 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | Query 113 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRN 144 |+ ||||+| + |||#++ |+||| || + ++ Sbjct 1 HADGTFTNDMTSYLD#AKAARDFVSWLARSDKS 32 |
| Bos taurus | Query 112 RHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNN 147 |+++||| |||| +|# | |||| ||+ | +++ Sbjct 81 RYAEGTFISDYSIAMD#KIRQQDFVNWLLAQKGKKSD 116 |
| Macaca mulatta | Query 112 RHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNN 147 |+++||| |||| +|# |||| ||+ | +|+ Sbjct 51 RYAEGTFISDYSIAMD#KIHQQDFVNWLLAQKGKKND 86 |
| Ictalurus punctatus | Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 152 +|||+|||++||||||+#+||||||||||||+||+ ++ |+|| Sbjct 49 RRHSEGTFSNDYSKYLE#TRRAQDFVQWLMNSKRS-DSPARRH 89 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 152 +|| |+|||| +| ||#| |++++||+||+ + + ||| Sbjct 134 RRHVDGSFTSDVNKVLD#SLAAKEYLQWVMNSPSSAS--GKRH 173 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWL 138 +||+ ||+||| | || # + |+||+ || Sbjct 87 RRHADGTYTSDVSSYLQ#DQAAKDFITWL 114 |
| Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | Query 102 EDPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 152 || ++ ||||+|||++||||| +# | ||||||||||+||+ +||| Sbjct 41 EDLMGVSNVKRHSEGTFSNDYSKYQE#ERMAQDFVQWLMNSKRS-GAPSKRH 90 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNN 147 |||+ ||+||| | || # + |+||| || + + | + Sbjct 88 KRHADGTYTSDVSTYLQ#DQAAKDFVSWLKSGRARRES 124 Query 99 EAHEDPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHD 153 |+ |+ +|| |+|||| +| ||#| |++++ |+| +| + + ++ | Sbjct 123 ESAEESRNGPMSRRHVDGSFTSDVNKVLD#SLAAKEYLLWVMTSKTSGKSNKRQED 177 |
| Sebastes caurinus | Query 103 DPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 152 +| |+ ||||+|||++||||||+#+|||||||||| |+||| ++ +|| Sbjct 42 EPIELPNMKRHSEGTFSNDYSKYLE#TRRAQDFVQWLKNSKRN-GSLFRRH 90 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNR 145 +||+ ||+||| | || # + |++|| || + | Sbjct 88 RRHADGTYTSDVSSYLQ#DQAAKEFVYWLKTGRGRR 122 |
| Tetraodon nigroviridis | Query 103 DPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 152 +| +++ ||||+|||++||||||+#+|||||||||| |+||| ++ +|| Sbjct 779 EPSDLSNMKRHSEGTFSNDYSKYLE#TRRAQDFVQWLKNSKRN-GSLFRRH 827 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNR 145 +||+ ||+||| | || # + |++|| || + | Sbjct 825 RRHADGTYTSDVSAYLQ#DQAAKEFVSWLKTGRGRR 859 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDE 154 ||||+|||++||||||+#+|||||||+||||+| | + |||| | Sbjct 48 KRHSEGTFSNDYSKYLE#TRRAQDFVEWLMNSKSNGGS-AKRHAE 90 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWL 138 |||++||+||| | +| # + ||+|| || Sbjct 86 KRHAEGTYTSDISSFLR#DQAAQNFVAWL 113 |
| Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | Query 102 EDPDEMNED-------KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 152 | | + || || |+|||++ |||| +# | |+||+ ||||+||+ +||| Sbjct 34 ETADSLLEDLRGVPNMKRQSEGTFSNYYSKYQE#ERMARDFLHWLMNSKRS-GAPSKRH 90 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNN 147 |||+ ||+||| | || # + |+||| || + | + Sbjct 88 KRHADGTYTSDVSTYLQ#DQAAKDFVSWLKSGPARRES 124 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHD 153 +|| |+|||| +| ||#| |++++ |+| +| + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLD#SLAAKEYLLWVMTSKTSGKSNKRQED 177 |
| Heloderma horridum | Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMN 140 |||| |||||| || ++# + |++|| | Sbjct 46 KRHSDGTFTSDLSKQME#EEAVRLFIEWLKN 75 |
| Protopterus dolloi | Query 99 EAHEDPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 157 || ++ | | |||||||| |||+| |+#++ | | || ||+||| ++|||+| || Sbjct 18 EAVDESREHTEAKRHSQGTFMSDYAKLLE#AKHALDLVQRLMSTKRT-GAVSKRHNEIER 75 Query 108 NEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 157 || +||++||+||| | ||+# + +|++||| + |+ +| +| Sbjct 71 NEIERHAEGTYTSDISSYLE#GQAVNEFIRWLMKGRGRRDFSETDIEEMDR 120 Query 103 DPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTK 142 | +|| |+||+ || ||| + |+#| ++|+ ||+| | Sbjct 114 DIEEM--DRRHADGTVTSDINSVLE#SIATREFLNWLINAK 151 |
| Mus musculus | Query 112 RHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNN 147 |+++||| |||| +|# | |||| ||+ + +++ Sbjct 43 RYAEGTFISDYSIAMD#KIRQQDFVNWLLAQRGKKSD 78 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | Query 113 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTK 142 |+ |+|||| +| ||#+ |++|+ ||++|| Sbjct 1 HADGSFTSDINKVLD#TIAAKEFLNWLISTK 30 |
| Bufo marinus | Query 110 DKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNT 141 |+||+ |+||||++| ||# + ||+|+ |++|| Sbjct 107 DRRHADGSFTSDFNKALD#IKAAQEFLDWIINT 138 Query 112 RHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 146 ||++|||||| + +|+# + |++|| ||+ + || Sbjct 62 RHAEGTFTSDMTSFLE#EKAAKEFVDWLIKGRPKRN 96 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDE 154 +||++||+|+| +++|+# + |++|+ ||+ + ++ || | Sbjct 23 ERHAEGTYTNDVTQFLE#EKAAKEFIDWLLKGIPKKQRLS-RHAE 65 |
| Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | Query 101 HEDPD-----EMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRN------RNNIA 149 || | |++ |||||+|||||||+||# ++|+||| ||+|||| |+ Sbjct 27 HETDDGDLNAEISLANRHSQGSFTSDYSKHLD#VKQAKDFVTWLLNTKRRGVDAQAGANLE 86 Query 150 KRHDE 154 ||| + Sbjct 87 KRHSD 91 Query 108 NEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKR 143 | +|||| |+||+| + ||# |++|++|| | Sbjct 84 NLEKRHSDGSFTNDMNVMLD#RMSAKNFLEWLKQQGR 119 |
| Neoceratodus forsteri | Query 106 EMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 157 | | |||||||| |||+| |+#+| | |||| ||||||| ++||| | || Sbjct 17 EHTEAKRHSQGTFMSDYAKLLE#ARHALDFVQRLMNTKRN-GGVSKRHSEIER 67 Query 108 NEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 146 +| +||++||+||| | ||+# + | +||+||+ + |+ Sbjct 63 SEIERHAEGTYTSDISSYLE#GQAANEFVRWLLKGRGRRD 101 Query 103 DPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTK 142 | | +||+ || |+| + |+#| ++|+ ||+|+| Sbjct 104 DTDAEEMGRRHADGTITNDMNNVLE#SIATREFLNWLINSK 143 |
| synthetic construct | Query 103 DPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 157 |||+|||||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 43 DPDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 97 Query 108 NEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 146 +| +||++|||||| | ||+# + |++|+ ||+ + |+ Sbjct 93 DEFERHAEGTFTSDVSSYLE#GQAAKEFIAWLVKGRGRRD 131 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTK 142 +||+ |+|+ + + ||#+ |+||+ ||+ || Sbjct 144 RRHADGSFSDEMNTILD#NLAARDFINWLIQTK 175 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | Query 102 EDPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 152 ++| |++ ||||+|||++||||||+# |+||+||+|||| ||+ ||| Sbjct 42 DEPRELSNMKRHSEGTFSNDYSKYLE#DRKAQEFVRWLMNNKRS-GVAEKRH 91 Query 110 DKRHSQGTFTSDYSKYLD#SRRAQDFVQWL 138 +|||+ |||||| | || # + +||| | Sbjct 88 EKRHADGTFTSDVSSYLK#DQAIKDFVDRL 116 |
| Phodopus sungorus | Query 116 GTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 146 |||||| | ||+# + |++|+ ||+ + |+ Sbjct 1 GTFTSDVSSYLE#GQAAKEFIAWLVKGRGRRD 31 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTK 142 +||+ |+|+ + + ||#| +||+ ||+ || Sbjct 44 RRHADGSFSDEMNTILD#SLATRDFINWLIQTK 75 |
| Sus scrofa | Query 98 TEAHEDPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 157 |+ +|||+| |||||||||||||||||||#|||||||||||||||||+|||||||||||| Sbjct 38 TDPLDDPDQMTEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNKNNIAKRHDEFER 97 Query 108 NEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 146 +| +||++|||||| | ||+# + |++|+ ||+ + |+ Sbjct 93 DEFERHAEGTFTSDVSSYLE#GQAAKEFIAWLVKGRGRRD 131 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTK 142 +||+ |+|+ + + ||#+ +||+ ||++|| Sbjct 144 RRHADGSFSDEMNTVLD#NLATRDFINWLLHTK 175 |
| Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | Query 113 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRN 144 |||||||+|||||||#+|||||||||||+|||+ Sbjct 1 HSQGTFTNDYSKYLD#TRRAQDFVQWLMSTKRS 32 Query 113 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNR 145 |+ ||+||| | || # + |+ || || + | Sbjct 45 HADGTYTSDVSSYLQ#DQAAKKFVTWLKQGQDRR 77 |
| Canis lupus familiaris | Query 98 TEAHEDPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFER 157 || | |+|||||||||||||||||||||#|||||||||||||||||+|||||||||||| Sbjct 38 TEPLNDLDQMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNKNNIAKRHDEFER 97 Query 108 NEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 146 +| +||++|||||| | ||+# + |++|+ ||+ + |+ Sbjct 93 DEFERHAEGTFTSDVSSYLE#GQAAKEFIAWLVKGRGRRD 131 Query 111 KRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTK 142 +||+ |+|+ + + ||#+ +||+ ||+ || Sbjct 144 RRHADGSFSDEMNTVLD#TLATRDFINWLLQTK 175 |
| Hydrolagus colliei | Query 99 EAHEDPDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNI--AKRH 152 |+ +| + + |||+ | |+||||||||#+|| +||||||++|||| | ||| Sbjct 18 ESVSNPSTVTDVKRHTDGIFSSDYSKYLD#NRRTKDFVQWLLSTKRNGANTDKTKRH 73 Query 108 NEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNN--IAKRHDEFER 157 ++ |||+ | +||| + |# +++ ||+ | | + +|+ ++||| | | Sbjct 68 DKTKRHADGIYTSDVASLTD#YLKSKRFVESLSNYNKRQNDRRMSKRHVEGAR 119 Query 109 EDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFE 156 | | ++ + +|+| ||+#++ |+||+ ||+ + | + |+ | | Sbjct 116 EGARRTEEDYPNDFSSYLE#AKAAKDFIDWLIK-GQGRRDFAEESREIE 162 |
| Squalus acanthias | Query 104 PDEMNEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRHDEFE 156 |+|| |+||+ |||||+ + ||#+ |++|+ |++|+| | | | | Sbjct 118 PEEM--DRRHADGTFTSEINIVLD#TIAAKEFLNWILNSK----TIQSRDSEIE 164 Query 127 D#SRRAQDFVQWLMNTKRNRNNIAKRHDE 154 |#+|||+|||||||+|||| + ||| | Sbjct 1 D#NRRAKDFVQWLMSTKRNGDK-TKRHAE 27 Query 108 NEDKRHSQGTFTSDYSKYLD#SRRAQDFVQWL--MNTKRNRNNIAKRHDEFER 157 ++ |||++||+||| |# +|+ || | | ++| +|+||| | | Sbjct 20 DKTKRHAEGTYTSDVDSLSD#YFKAKRFVDSLTSYNKRQNGRSISKRHVESTR 71 Query 109 EDKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNR 145 | ||++|++ | | ||+#++ |+||+ ||+ + | Sbjct 68 ESTRHTEGSYR-DISSYLE#AKAAKDFINWLIKGRGRR 103 |
| Heloderma suspectum, venom, Peptide, 39 aa | Query 113 HSQGTFTSDYSKYLD#SRRAQDFVQWLMN 140 | +|||||| || ++# + |++|| | Sbjct 1 HGEGTFTSDLSKQME#EEAVRLFIEWLKN 28 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | Query 113 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNR 145 |+ || ||| | +|+# + ++|+ ||++ + | Sbjct 1 HADGTLTSDISSFLE#KQATKEFIAWLVSGRGRR 33 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | Query 116 GTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRN 146 ||+||| | || # + |++|| || + |+ Sbjct 3 GTYTSDVSSYLQ#DQAAKEFVSWLKTGRGRRD 33 |
| swine, intestines, Peptide Partial, 56 aa | Query 112 RHSQGTFTSDYSKYLD#SRRAQDFVQWLM 139 ||| |||||+ |+ |#| | | +| |+ Sbjct 29 RHSDGTFTSELSRLRD#SARLQRLLQGLV 56 |
| Ambloplites rupestris | Query 113 HSQGTFTSDYSKYLD#SRRAQDFVQWLMNTKRNRNNIAKRH 152 |||||||+||+ ||+# |+||||++|||| ||+ ||| Sbjct 1 HSQGTFTNDYTNYLE#DRQAQDFIRWLMNNKRS-GAAEKRH 39 Query 110 DKRHSQGTFTSDYSKYLD#SRRAQDFVQWLMN--------TKRNRNNIAKRHDE 154 +|||+ |||| | | # + +||| | + | | | ++|| | Sbjct 36 EKRHADGTFTDDASSDFY#DQAIKDFVAKLKSGQDRREPETDRRREAFSRRHVE 88 |
[Site 5] RAQDFVQWLM139-NTKRNRNNIA
Met139 Asn
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Arg130 | Ala131 | Gln132 | Asp133 | Phe134 | Val135 | Gln136 | Trp137 | Leu138 | Met139 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Asn140 | Thr141 | Lys142 | Arg143 | Asn144 | Arg145 | Asn146 | Asn147 | Ile148 | Ala149 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| DKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSS |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 123.00 | 10 | glucagon, isoform CRA_b |
| 2 | N/A | 79.70 | 45 | 0 |
| 3 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | 64.70 | 1 | AAB31092.1 |
| 4 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | 61.60 | 1 | glucagon=proglucagon-derived 3.5 kda peptide |
| 5 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | 60.80 | 1 | glucagon II |
| 6 | Contains: Glucagon; Glucagon-like peptide | 60.10 | 4 | GLUC_AMICA Glucagon precursor |
| 7 | Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | 60.10 | 1 | glucagon |
| 8 | Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | 58.50 | 1 | glucagon G-29 |
| 9 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | 57.80 | 1 | GLUC1_ORENI Glucagon-1 (Glucagon I) gb |
| 10 | Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | 56.20 | 1 | GLUC_LAMFL Glucagon gb |
| 11 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | 53.50 | 1 | glucagon |
| 12 | deshis1, Desphe6, Glu9 | 53.50 | 1 | A Chain A, Nmr Solution Structure Of The Glucagon |
| 13 | Monodelphis domestica | 48.90 | 3 | PREDICTED: similar to Gastric inhibitory polypepti |
| 14 | Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | 48.90 | 1 | GLUC1_PETMA Glucagon-1 precursor |
| 15 | Xenopus laevis | 47.00 | 5 | proglucagon II |
| 16 | Hoplobatrachus rugulosus | 46.60 | 1 | AF324209_1 proglucagon |
| 17 | Bufo marinus | 46.60 | 1 | proglucagon |
| 18 | Gallus gallus | 46.20 | 4 | glucagon isoform 1 |
| 19 | Meleagris gallopavo | 46.20 | 2 | preproglucagon B |
| 20 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | 44.70 | 1 | GLUC_HELSU Glucagon precursor |
| 21 | Oncorhynchus tshawytscha | 43.50 | 1 | S78474_1 proglucagon |
| 22 | Ictalurus punctatus | 43.10 | 3 | proglucagon I |
| 23 | Ambloplites rupestris | 43.10 | 1 | proglucagon |
| 24 | Rattus norvegicus | 42.70 | 6 | Glucose-dependent insulinotropic peptide |
| 25 | Canis familiaris | 42.70 | 2 | PREDICTED: similar to Gastric inhibitory polypepti |
| 26 | Capra hircus | 42.70 | 1 | glucagon |
| 27 | Pan troglodytes | 42.40 | 2 | PREDICTED: fibroblast activation protein, alpha su |
| 28 | Xenopus tropicalis | 42.40 | 2 | glucagon |
| 29 | Danio rerio | 42.00 | 6 | hypothetical protein LOC494052 |
| 30 | Bos taurus | 42.00 | 5 | vasoactive intestinal peptide |
| 31 | Squalus acanthias | 41.60 | 1 | proglucagon |
| 32 | Agkistrodon piscivorus | 41.60 | 1 | proglucagon |
| 33 | Macaca mulatta | 41.20 | 3 | PREDICTED: vasoactive intestinal peptide |
| 34 | Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | 41.20 | 1 | glucagon-like peptide, GLP |
| 35 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | 41.20 | 1 | GLUC2_LOPAM Glucagon-2 precursor (Glucagon II) |
| 36 | Sebastes caurinus | 40.80 | 4 | proglucagon I |
| 37 | Heloderma suspectum | 40.80 | 2 | proglucagon |
| 38 | Tetraodon nigroviridis | 40.00 | 3 | unnamed protein product |
| 39 | Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | 40.00 | 2 | GLUC_CARAU Glucagon precursor |
| 40 | Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | 40.00 | 1 | GLUC2_ONCMY Glucagon-2 precursor (Glucagon II) |
| 41 | Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | 40.00 | 1 | GLUC1_ONCMY Glucagon-1 precursor (Glucagon I) |
| 42 | Heloderma horridum | 40.00 | 1 | EXE3_HELHO Exendin-3 precursor emb |
| 43 | Mus musculus | 39.70 | 6 | Gastric inhibitory polypeptide |
| 44 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | 38.90 | 1 | glucagon-like peptide-2, GLP-2=proglucagon-derived |
| 45 | Protopterus dolloi | 38.90 | 1 | proglucagon |
| 46 | Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | 38.10 | 1 | VIP_MOUSE VIP peptides precursor |
| 47 | Arvicanthis ansorgei | 37.40 | 1 | vasoactive intestinal polypeptide |
| 48 | synthetic construct | 37.00 | 1 | Homo sapiens glucagon |
| 49 | Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | 37.00 | 1 | GLUC2_PETMA Glucagon-2 precursor |
| 50 | Phodopus sungorus | 36.60 | 1 | glucagon precursor |
| 51 | Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | 36.60 | 1 | GLUC1_LOPAM Glucagon-1 precursor (Glucagon I) |
| 52 | Sus scrofa | 36.20 | 1 | glucagon |
| 53 | Neoceratodus forsteri | 36.20 | 1 | proglucagon |
| 54 | Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | 35.80 | 1 | GLUC_LEPSP Glucagon precursor |
| 55 | Canis lupus familiaris | 35.80 | 1 | glucagon |
| 56 | Heloderma suspectum, venom, Peptide, 39 aa | 35.40 | 1 | A Chain A, Solution Structure Of Exendin-4 In 30-V |
| 57 | Hydrolagus colliei | 35.00 | 1 | proglucagon |
| 58 | Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | 34.70 | 1 | GLUC2_ORENI Glucagon-2 (Glucagon II) gb |
| 59 | Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | 34.70 | 1 | glucagon-like peptide-1, GLP-1=proglucagon-derived |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSD 166 ||||||||||||||||||||||||||||||#||||||||||||||||||||||||||| Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSD 166 |
| N/A | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIA 149 |||||||||||||||||||||||||||#|||||+|||| Sbjct 1 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNKNNIA 37 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 33 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRN 144 ||+||||||||||+|+|||+|||||||#+|||| Sbjct 1 HSEGTFTSDYSKYMDNRRAKDFVQWLM#STKRN 32 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NT 141 |||||||||||||||+||||||+||||#+| Sbjct 1 HSQGTFTSDYSKYLDNRRAQDFIQWLM#ST 29 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 32 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRN 144 ||+|||++||||||++|||||||||| #|+||| Sbjct 1 HSEGTFSNDYSKYLETRRAQDFVQWLK#NSKRN 32 |
| Contains: Glucagon; Glucagon-like peptide | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NT 141 |||||||+|||||+|+|||||||||||#+| Sbjct 1 HSQGTFTNDYSKYMDTRRAQDFVQWLM#ST 29 |
| Amia calva=bowfin, pancreatic tissues, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NT 141 |||||||+|||||+|+|||||||||||#+| Sbjct 1 HSQGTFTNDYSKYMDTRRAQDFVQWLM#ST 29 |
| Scyliorhinus canicula=European common dogfish, pancreas, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NT 141 ||+||||||||||+|+|||+|||||||#+| Sbjct 1 HSEGTFTSDYSKYMDNRRAKDFVQWLM#ST 29 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 36 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRN 144 ||+|||++||||||+ |+|||||+|||#| ||+ Sbjct 1 HSEGTFSNDYSKYLEDRKAQDFVRWLM#NNKRS 32 |
| Lampetra fluviatilis=river lamprey, small intestine, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NT 141 ||||+|||||||||||++|+||| |||#|| Sbjct 1 HSQGSFTSDYSKYLDSKQAKDFVIWLM#NT 29 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 29 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQWLM#N 140 ||+|||||||||||++++|+|||+|||#| Sbjct 1 HSEGTFTSDYSKYLENKQAKDFVRWLM#N 28 |
| deshis1, Desphe6, Glu9 | Query 114 SQGTFTSDYSKYLDSRRAQDFVQWLM#NT 141 |||| ||+||||||||||||||||||#|| Sbjct 1 SQGT-TSEYSKYLDSRRAQDFVQWLM#NT 27 |
| Monodelphis domestica | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGT 162 +|+++||| |||| +| |||| ||+#+ | +| + ||+ || |+|| Sbjct 51 QRYAEGTFISDYSITMDKIMQQDFVNWLL#SQKGKKN--SWRHNITERKADGT 100 |
| Contains: Glucagon-1 (Glucagon I); Glucagon-like peptide 1-I (GLP-1I); Glucagon-like peptide 2-I (GLP-2I) | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 ||||+|||||||||||++++|+|||+|||#| || + + + |||+||||+|++| Sbjct 41 KRHSEGTFTSDYSKYLENKQAKDFVRWLM#NAKRGGSELQR------RHADGTFTNDMTS 93 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNR---NNIAKRHDEFERHAE 160 +||+ ||||+| + |||++ |+||| || # + ++| + + | +|||| Sbjct 80 RRHADGTFTNDMTSYLDAKAARDFVSWLA#RSDKSRRDGGDHLAENSEDKRHAE 132 |
| Xenopus laevis | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVS 168 |||||||||||||||||||||||||||||#||||+ +++|+ ++||||||||||||+ Sbjct 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRS-GGLSRRNADYERHAEGTFTSDVT 107 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 +||++||+|+| ++||+ + + |++||+# | + + ||||||||+|+++ Sbjct 140 ERHAEGTYTNDVTEYLEEKATKAFIEWLI#KGK-------PKKIRYSRHAEGTFTNDMTN 191 Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRH 152 ||++||||+| + ||+ + |++|| ||+#| + | ++ + | Sbjct 179 RHAEGTFTNDMTNYLEEKAAKEFVGWLI#NGRPKRKDLLEEH 219 |
| Hoplobatrachus rugulosus | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVS 168 |||||||||||||||||||||||||||||#|+||+ |+||+ +||||||||+|+||+ Sbjct 51 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NSKRS-GGISKRNVQFERHAEGTYTNDVT 107 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 +||++||+|+| +++|+ + |++|+ ||+# | + ++ ||||||||||++| Sbjct 95 ERHAEGTYTNDVTQFLEEKAAKEFIDWLI#KGKPKKQRLS-------RHAEGTFTSDMTS 146 Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFE-RHAEGTFTSD 166 ||++|||||| + ||+ + |++|| ||+# + || +| + |||+|+|||| Sbjct 134 RHAEGTFTSDMTSYLEEKAAKEFVDWLI#KGRPKRNFPDISAEEMDRRHADGSFTSD 189 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NT 141 |+||+ |+||||++| || + ||+|+ |++#|| Sbjct 178 DRRHADGSFTSDFNKALDIKAAQEFLDWII#NT 209 |
| Bufo marinus | Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQWLM--#NTKRNRNNIAKRHDEFERHAEGTFTSD 166 ||++|||||| + +|+ + |++|| ||+ # ||| ++++ | |||+|+|||| Sbjct 62 RHAEGTFTSDMTSFLEEKAAKEFVDWLIKG#RPKRNFSDVSAADDMDRRHADGSFTSD 118 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 +||++||+|+| +++|+ + |++|+ ||+# | |+ ||||||||||++| Sbjct 23 ERHAEGTYTNDVTQFLEEKAAKEFIDWLL#------KGIPKK-QRLSRHAEGTFTSDMTS 74 Query 133 DFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVS 168 || ||||#|+||+ +++|+ +||||||||+|+||+ Sbjct 1 DFAQWLM#NSKRS-GGMSRRNVQFERHAEGTYTNDVT 35 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NT 141 |+||+ |+||||++| || + ||+|+ |++#|| Sbjct 107 DRRHADGSFTSDFNKALDIKAAQEFLDWII#NT 138 |
| Gallus gallus | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRN------------------RNNIAKRH 152 |||||||||||||||||||||||||||||#+|||| | |+||| Sbjct 53 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#STKRNGQQGQEDKENDKFPDQLSSNAISKRH 112 Query 153 DEFERHAEGTFTSDVSS 169 |||||||||+|||++| Sbjct 113 SEFERHAEGTYTSDITS 129 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAK---RHDEFERHAEGTFTSDV 167 +||++||+||| + ||+ + |++|+ ||+#| + |+ | + |||+||||||+ Sbjct 116 ERHAEGTYTSDITSYLEGQAAKEFIAWLV#NGRGRRDFPEKALMAEEMGRRHADGTFTSDI 175 Query 168 S 168 + Sbjct 176 N 176 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNI 148 +||+ |||||| +| || |++|++||+#||| + ++ Sbjct 164 RRHADGTFTSDINKILDDMAAKEFLKWLI#NTKVTQRDL 201 |
| Meleagris gallopavo | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRN------------------RNNIAKRH 152 |||||||||||||||||||||||||||||#+|||| | |+||| Sbjct 53 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#STKRNGQQGQEDKENDEFPDQLSSNAISKRH 112 Query 153 DEFERHAEGTFTSDVSS 169 |||||||||+|||++| Sbjct 113 SEFERHAEGTYTSDITS 129 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAK---RHDEFERHAEGTFTSDV 167 +||++||+||| + ||+ + |++|+ ||+#| + |+ | + |||+||||||+ Sbjct 116 ERHAEGTYTSDITSYLEGQAAKEFIAWLV#NGRGRRDFPEKALMAEEMGRRHADGTFTSDI 175 Query 168 S 168 + Sbjct 176 N 176 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNI 148 +||+ |||||| +| || |++|++||+#||| + ++ Sbjct 164 RRHADGTFTSDINKILDDMAAKEFLKWLI#NTKVTQRDL 201 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2) | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKR------------------NRNNIAKRH 152 |||||||||||||||||+|||||||||||#|||| + | +|+ | Sbjct 51 KRHSQGTFTSDYSKYLDTRRAQDFVQWLM#NTKRSGQQGVEEREKENLLDQLSSNGLARHH 110 Query 153 DEFERHAEGTFTSDVSS 169 |+||||+| +|||+|| Sbjct 111 AEYERHADGRYTSDISS 127 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAK---RHDEFERHAEGTFTSD 166 +||+ | +||| | ||+ + |++|+ ||+#| + |+ + + | |||+|||||| Sbjct 114 ERHADGRYTSDISSYLEGQAAKEFIAWLV#NGRGRRDFLEEAGTADDIGRRHADGTFTSD 172 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNI 148 +||+ |||||||++ || |+|++||+#| | + ++ Sbjct 162 RRHADGTFTSDYNQLLDDIATQEFLKWLI#NQKVTQRDL 199 |
| Oncorhynchus tshawytscha | Query 114 SQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 | |||++||||| + | |||||||||#|+||+ +|||+||+|||||+ Sbjct 2 SXGTFSNDYSKYQEERMAQDFVQWLM#NSKRS-------GAPSKRHADGTYTSDVST 50 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNR 145 |||+ ||+||| | || + |+||| || #+ + | Sbjct 37 KRHADGTYTSDVSTYLQDQAAKDFVSWLK#SGRARR 71 |
| Ictalurus punctatus | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 +|||+|||++||||||++|||||||||||#|+||+ |||+||+|||||| Sbjct 49 RRHSEGTFSNDYSKYLETRRAQDFVQWLM#NSKRS-------DSPARRHADGTYTSDVSS 100 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEF--ERHAEGTFTSDVS 168 +||+ ||+||| | || + |+||+ || #+ + + + | + || +|+|||||+ Sbjct 87 RRHADGTYTSDVSSYLQDQAAKDFITWLK#SGQPKPDAVETRSVDTLRRRHVDGSFTSDVN 146 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRH 152 +|| |+|||| +| ||| |++++||+|#|+ + + ||| Sbjct 134 RRHVDGSFTSDVNKVLDSLAAKEYLQWVM#NSPSSAS--GKRH 173 |
| Ambloplites rupestris | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 |||||||+||+ ||+ |+||||++|||#| | |+ |++ |||+|||| | || Sbjct 1 HSQGTFTNDYTNYLEDRQAQDFIRWLM#NNK--RSGAAEK-----RHADGTFTDDASS 50 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDE--FERHAEGTFTSDV 167 +|||+ |||| | | + +||| | #+ + | | | || ||+||||+ Sbjct 36 EKRHADGTFTDDASSDFYDQAIKDFVAKLK#SGQDRREPETDRRREAFSRRHVEGSFTSDI 95 Query 168 S 168 + Sbjct 96 N 96 |
| Rattus norvegicus | Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHA 159 |+++||| |||| +| | |||| ||+# | +|+ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKIRQQDFVNWLL#AQKGKKND--WKHNLTQREA 88 |
| Canis familiaris | Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHA 159 |+++||| |||| +| | |||| ||+# | +|+ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKIRQQDFVNWLL#AQKGKKND--WKHNITQREA 88 |
| Capra hircus | Query 146 NNIAKRHDEFERHAEGTFTSDVSS 169 |||||||||||||||||||||||| Query 146 NNIAKRHDEFERHAEGTFTSDVSS 169 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNR 145 +||++|||||| | ||+ + |++|+ ||+# + | Sbjct 11 ERHAEGTFTSDVSSYLEGQAAKEFIAWLV#KGRGRR 45 |
| Pan troglodytes | Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 ||||||||||||||||||||||||||||||#||||| +++| ||||||||||||| Sbjct 972 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRN-SSVA------YRHAEGTFTSDVSS 1024 Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNR 145 ||++|||||| | ||+ + |++|+ ||+# + | Sbjct 1012 RHAEGTFTSDVSSYLEGQAAKEFIAWLV#KGRGRR 1045 |
| Xenopus tropicalis | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVS 168 ||||||||||||||||||||||||+||||#||||+ +++|+ ++||||||||||||+ Sbjct 51 KRHSQGTFTSDYSKYLDSRRAQDFIQWLM#NTKRS-GGLSRRNADYERHAEGTFTSDVT 107 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 +||++||+|+| ++||+ + |++|++||+#| | + + ||||||||+|+++ Sbjct 140 ERHAEGTYTNDVTEYLEEKAAKEFIEWLI#NGK-------PKKIRYSRHAEGTFTNDMTN 191 Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFE---RHAEGTFTSDVS 168 ||++||||+| + ||+ + |++|| ||+# | + | ++ | | |||+|+||+|++ Sbjct 179 RHAEGTFTNDMTNYLEEKAAKEFVGWLI#K-GRPKRNFSEAHSVEEMDRRHADGSFTNDIN 237 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTK 142 |+||+ |+||+| +| || ||+|+ |++#||+ Sbjct 224 DRRHADGSFTNDINKVLDIIAAQEFLDWVI#NTQ 256 |
| Danio rerio | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 ||||+|||++||||||++|||||||||||#| ||| ++ +||||||+|||||| Sbjct 48 KRHSEGTFSNDYSKYLETRRAQDFVQWLM#NAKRNGGSV-------KRHAEGTYTSDVSS 99 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWL 138 |||++||+||| | || + || || || Sbjct 86 KRHAEGTYTSDVSSYLQDQAAQSFVAWL 113 |
| Bos taurus | Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSD 166 ||+ | ||||||+ | |+ +++ |+# || |+|++ +||++ || + Sbjct 80 RHADGVFTSDYSRLLGQLSAKKYLESLI#G-KRVSNSISEDQGPIKRHSDAVFTDN 133 |
| Squalus acanthias | Query 127 DSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 |+|||+|||||||#+|||| |+ +||||||+|||| | Sbjct 1 DNRRAKDFVQWLM#STKRN-------GDKTKRHAEGTYTSDVDS 36 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWL--M#NTKRNRNNIAKRHDEFERHAEGTFTSDVS 168 |||++||+||| | +|+ || | #| ++| +|+||| | || ||++ |+| Sbjct 23 KRHAEGTYTSDVDSLSDYFKAKRFVDSLTSY#NKRQNGRSISKRHVESTRHTEGSY-RDIS 81 Query 169 S 169 | Query 169 S 169 Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRN---------NIAKRHDEFERHAEGT 162 ||++|++ | | ||+++ |+||+ ||+# + | | + |||+|| Sbjct 71 RHTEGSYR-DISSYLEAKAAKDFINWLI#KGRGRREFPEESKEIVNEVIPEEMDRRHADGT 129 Query 163 FTSDVS 168 |||+++ Sbjct 130 FTSEIN 135 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFE 156 |+||+ |||||+ + ||+ |++|+ |++#|+| | | | | Sbjct 122 DRRHADGTFTSEINIVLDTIAAKEFLNWIL#NSK----TIQSRDSEIE 164 |
| Agkistrodon piscivorus | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRH---DEFERHAEGTFTSD 166 +||+ ||+||| | ||+ + |++|+ ||+#| + |+ | | |||+|||||| Sbjct 34 ERHADGTYTSDISSYLEGQAAKEFIAWLV#NGRGRRDFSEGAHTGEDLGRRHADGTFTSD 92 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNI 148 +||+ |||||||+| || |+|++||+#| | + ++ Sbjct 82 RRHADGTFTSDYNKLLDDIATQEFLKWLI#NQKVTQRDL 119 Query 126 LDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 |+ | ++|+ | #+ | +|+ | |+||||+||+|||+|| Sbjct 9 LEDREKENFLDQLA#S-----NGLARPHAEYERHADGTYTSDISS 47 |
| Macaca mulatta | Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSD 166 ||+ | ||||+|| | |+ +++ ||# || +||++ +||++ || + Sbjct 80 RHADGVFTSDFSKLLGQLSAKKYLESLM#G-KRVSSNISEDPVPVKRHSDAVFTDN 133 |
| Petromyzon marinus=sea lampreys, intestine, parasitic phase, Peptide, 32 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRN 144 |+ ||||+| + |||++ |+||| || # + ++ Sbjct 1 HADGTFTNDMTSYLDAKAARDFVSWLA#RSDKS 32 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-2 (Glucagon II); Glucagon-like peptide 2 (Glucagon-like peptide II) | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 ||||+|||++||||||++|||||||||| #|+||| | |||+||+|||||| Sbjct 50 KRHSEGTFSNDYSKYLETRRAQDFVQWLK#NSKRN--------GLFRRHADGTYTSDVSS 100 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWL 138 +||+ ||+||| | || + |+||| || Sbjct 87 RRHADGTYTSDVSSYLQDQAAKDFVSWL 114 |
| Sebastes caurinus | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 ||||+|||++|||+||+ |+|||||+|||#| ||+ || +|||+||||||||| Sbjct 48 KRHSEGTFSNDYSRYLEERKAQDFVRWLM#NNKRS------GADE-KRHADGTFTSDVSS 99 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDE--FERHAEGTFTSDV 167 +|||+ |||||| | || + +||| | #+ + | + + | || +|+||||| Sbjct 85 EKRHADGTFTSDVSSYLKDQAIKDFVNRLK#SGQVRRESETEWRGEAFSRRHVDGSFTSDV 144 Query 168 S 168 + Sbjct 145 N 145 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDE 154 +|| |+|||| +| ||| |++++ |+|# +| + + ++ |+ Sbjct 133 RRHVDGSFTSDVNKVLDSMAAKEYLLWVM#TSKPSGESKKRQEDQ 176 |
| Heloderma suspectum | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKR------------------NRNNIAKRH 152 |||||||||||||||||+|||||||||||#|||| + | +|+ | Sbjct 51 KRHSQGTFTSDYSKYLDTRRAQDFVQWLM#NTKRSGQQGVEEREKENLLDQLSSNGLARHH 110 Query 153 DEFERHAEGTFTSDVSS 169 |+||||+| +|||+|| Sbjct 111 AEYERHADGRYTSDISS 127 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNR 145 +||+ | +||| | ||+ + |++|+ ||+#| + | Sbjct 114 ERHADGRYTSDISSYLEGQAAKEFIAWLV#NGRGRR 148 |
| Tetraodon nigroviridis | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 ||||+|||++||||||++|||||||||| #|+||| + | |||+||+|||||+ Sbjct 787 KRHSEGTFSNDYSKYLETRRAQDFVQWLK#NSKRNGS-------LFRRHADGTYTSDVSA 838 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNR 145 +||+ ||+||| | || + |++|| || # + | Sbjct 825 RRHADGTYTSDVSAYLQDQAAKEFVSWLK#TGRGRR 859 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 ||||+|||++||||||++|||||||+|||#|+| | + +||||||+|||+|| Sbjct 48 KRHSEGTFSNDYSKYLETRRAQDFVEWLM#NSKSNGGSA-------KRHAEGTYTSDISS 99 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWL 138 |||++||+||| | +| + ||+|| || Sbjct 86 KRHAEGTYTSDISSFLRDQAAQNFVAWL 113 |
| Contains: Glicentin-related polypeptide 2 (GRPP 2); Glucagon-2; Glucagon-like peptide 1-2 (GLP 1-2); Glucagon-like peptide 2 (GLP 2) | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 || |+|||++ |||| + | |+||+ |||#|+||+ +|||+||+|||||+ Sbjct 50 KRQSEGTFSNYYSKYQEERMARDFLHWLM#NSKRS-------GAPSKRHADGTYTSDVST 101 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHD--EFERHAEGTFTSDVS 168 |||+ ||+||| | || + |+||| || #+ | + + + || +|+|||||+ Sbjct 88 KRHADGTYTSDVSTYLQDQAAKDFVSWLK#SGPARRESAEESMNGPMSRRHVDGSFTSDVN 147 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHD 153 +|| |+|||| +| ||| |++++ |+|# +| + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLDSLAAKEYLLWVM#TSKTSGKSNKRQED 177 |
| Contains: Glicentin-related polypeptide 1 (GRPP 1); Glucagon-1; Glucagon-like peptide 1-1 (GLP 1-1); Glucagon-like peptide 2 (GLP 2) | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 ||||+|||++||||| + | |||||||||#|+||+ +|||+||+|||||+ Sbjct 50 KRHSEGTFSNDYSKYQEERMAQDFVQWLM#NSKRS-------GAPSKRHADGTYTSDVST 101 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNI--AKRHDEFERHAEGTFTSDVS 168 |||+ ||+||| | || + |+||| || #+ + | + ++ || +|+|||||+ Sbjct 88 KRHADGTYTSDVSTYLQDQAAKDFVSWLK#SGRARRESAEESRNGPMSRRHVDGSFTSDVN 147 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHD 153 +|| |+|||| +| ||| |++++ |+|# +| + + ++ | Sbjct 135 RRHVDGSFTSDVNKVLDSLAAKEYLLWVM#TSKTSGKSNKRQED 177 |
| Heloderma horridum | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#N 140 |||| |||||| || ++ + |++|| #| Sbjct 46 KRHSDGTFTSDLSKQMEEEAVRLFIEWLK#N 75 |
| Mus musculus | Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHA 159 |+++||| |||| +| | |||| ||+# + +++ +|+ +| | Sbjct 43 RYAEGTFISDYSIAMDKIRQQDFVNWLL#AQRGKKSD--WKHNITQREA 88 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 33 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTK 142 |+ |+|||| +| ||+ |++|+ ||+#+|| Sbjct 1 HADGSFTSDINKVLDTIAAKEFLNWLI#STK 30 |
| Protopterus dolloi | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 |||||||| |||+| |+++ | | || ||#+||| ++|||+| |||||||+|||+|| Sbjct 30 KRHSQGTFMSDYAKLLEAKHALDLVQRLM#STKRT-GAVSKRHNEIERHAEGTYTSDISS 87 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFE-RHAEGTFTSDVSS 169 +||++||+||| | ||+ + +|++|||# + |+ +| + |||+|| |||++| Sbjct 74 ERHAEGTYTSDISSYLEGQAVNEFIRWLM#KGRGRRDFSETDIEEMDRRHADGTVTSDINS 133 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTK 142 |+||+ || ||| + |+| ++|+ ||+#| | Sbjct 119 DRRHADGTVTSDINSVLESIATREFLNWLI#NAK 151 |
| Contains: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide) | Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSD 166 ||+ | ||||||+ | |+ +++ |+# || ++|++ +||++ || + Sbjct 80 RHADGVFTSDYSRLLGQISAKKYLESLI#G-KRISSSISEDPVPIKRHSDAVFTDN 133 |
| Arvicanthis ansorgei | Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSD 166 ||+ | ||||||+ | |+ +++ |+# || ++| + +||++ || + Sbjct 63 RHADGVFTSDYSRLLGQISAKKYLESLI#G-KRISSSILEDPVPIKRHSDAVFTDN 116 |
| synthetic construct | Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRN---NIAKRHDEFERHAEGTFTSDV 167 +||++|||||| | ||+ + |++|+ ||+# + |+ +| + |||+|+|+ ++ Sbjct 96 ERHAEGTFTSDVSSYLEGQAAKEFIAWLV#KGRGRRDFPEEVAIVEELGRRHADGSFSDEM 155 Query 168 SS 169 ++ Sbjct 156 NT 157 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTK 142 +||+ |+|+ + + ||+ |+||+ ||+# || Sbjct 144 RRHADGSFSDEMNTILDNLAARDFINWLI#QTK 175 |
| Contains: Glucagon-2 (Glucagon II) (Glu II); Glucagon-like peptide 2-II (GLP-2II) | Query 112 RHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVS 168 |||||+|||||||+|| ++|+||| ||+#|||| + + +||++|+||+|++ Sbjct 43 RHSQGSFTSDYSKHLDVKQAKDFVTWLL#NTKRRGVDAQAGANLEKRHSDGSFTNDMN 99 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKR 143 +|||| |+||+| + || |++|++|| # | Sbjct 86 EKRHSDGSFTNDMNVMLDRMSAKNFLEWLK#QQGR 119 |
| Phodopus sungorus | Query 116 GTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRN---NIAKRHDEFERHAEGTFTSDVSS 169 |||||| | ||+ + |++|+ ||+# + |+ + + |||+|+|+ ++++ Sbjct 1 GTFTSDVSSYLEGQAAKEFIAWLV#KGRGRRDFPEEVTIVEELGRRHADGSFSDEMNT 57 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTK 142 +||+ |+|+ + + ||| +||+ ||+# || Sbjct 44 RRHADGSFSDEMNTILDSLATRDFINWLI#QTK 75 |
| Contains: Glicentin-related polypeptide (GRPP); Glucagon-1 (Glucagon I); Glucagon-like peptide 1 (Glucagon-like peptide I) | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 ||||+|||++||||||+ |+||+||+|||#| | |+ +|++ |||+||||||||| Sbjct 51 KRHSEGTFSNDYSKYLEDRKAQEFVRWLM#NNK--RSGVAEK-----RHADGTFTSDVSS 102 Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQWL 138 +|||+ |||||| | || + +||| | Sbjct 88 EKRHADGTFTSDVSSYLKDQAIKDFVDRL 116 |
| Sus scrofa | Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 ||||||||||||||||||||||||||||||#|||||+|||||||||||||||||||||||| Sbjct 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNKNNIAKRHDEFERHAEGTFTSDVSS 109 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRN---NIAKRHDEFERHAEGTFTSDV 167 +||++|||||| | ||+ + |++|+ ||+# + |+ + + |||+|+|+ ++ Sbjct 96 ERHAEGTFTSDVSSYLEGQAAKEFIAWLV#KGRGRRDFPEEVTIVEELRRRHADGSFSDEM 155 Query 168 SS 169 ++ Sbjct 156 NT 157 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTK 142 +||+ |+|+ + + ||+ +||+ ||+#+|| Sbjct 144 RRHADGSFSDEMNTVLDNLATRDFINWLL#HTK 175 |
| Neoceratodus forsteri | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 |||||||| |||+| |++| | |||| ||#||||| ++||| | |||||||+|||+|| Sbjct 22 KRHSQGTFMSDYAKLLEARHALDFVQRLM#NTKRN-GGVSKRHSEIERHAEGTYTSDISS 79 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEF-ERHAEGTFTSDVSS 169 +||++||+||| | ||+ + | +||+||+# + |+ +| |||+|| |+|+++ Sbjct 66 ERHAEGTYTSDISSYLEGQAANEFVRWLL#KGRGRRDFSDTDAEEMGRRHADGTITNDMNN 125 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTK 142 +||+ || |+| + |+| ++|+ ||+#|+| Sbjct 112 RRHADGTITNDMNNVLESIATREFLNWLI#NSK 143 |
| Contains: Glucagon; Glucagon-36 (Oxyntomodulin); Glucagon-like peptide | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 |||||||+|||||||+|||||||||||#+|||+ | ||+||+|||||| Sbjct 1 HSQGTFTNDYSKYLDTRRAQDFVQWLM#STKRS-GGITXXXXXXXXHADGTYTSDVSS 56 Query 113 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNR 145 |+ ||+||| | || + |+ || || # + | Sbjct 45 HADGTYTSDVSSYLQDQAAKKFVTWLK#QGQDRR 77 |
| Canis lupus familiaris | Query 110 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 ||||||||||||||||||||||||||||||#|||||+|||||||||||||||||||||||| Sbjct 50 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNKNNIAKRHDEFERHAEGTFTSDVSS 109 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRN---NIAKRHDEFERHAEGTFTSDV 167 +||++|||||| | ||+ + |++|+ ||+# + |+ +| + |||+|+|+ ++ Sbjct 96 ERHAEGTFTSDVSSYLEGQAAKEFIAWLV#KGRGRRDFPEEVAIVEEFRRRHADGSFSDEM 155 Query 168 SS 169 ++ Sbjct 156 NT 157 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTK 142 +||+ |+|+ + + ||+ +||+ ||+# || Sbjct 144 RRHADGSFSDEMNTVLDTLATRDFINWLL#QTK 175 |
| Heloderma suspectum, venom, Peptide, 39 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQWLM#N 140 | +|||||| || ++ + |++|| #| Sbjct 1 HGEGTFTSDLSKQMEEEAVRLFIEWLK#N 28 |
| Hydrolagus colliei | Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFERHAEGTFTSDVSS 169 |||+ | |+||||||||+|| +||||||+#+|||| | |+ +|||+| +||||+| Sbjct 30 KRHTDGIFSSDYSKYLDNRRTKDFVQWLL#STKRNGANT----DKTKRHADGIYTSDVAS 84 Query 111 KRHSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRNN--IAKRHDEFERHAEGTFTSDVS 168 |||+ | +||| + | +++ ||+ | #| + +|+ ++||| | | | + +| | Sbjct 71 KRHADGIYTSDVASLTDYLKSKRFVESLS#NYNKRQNDRRMSKRHVEGARRTEEDYPNDFS 130 Query 169 S 169 | Query 169 S 169 Query 111 KRHSQGT------FTSDYSKYLDSRRAQDFVQWLM#NTKRNRNNIAKRHDEFE 156 ||| +| + +|+| ||+++ |+||+ ||+# + | + |+ | | Sbjct 112 KRHVEGARRTEEDYPNDFSSYLEAKAAKDFIDWLI#K-GQGRRDFAEESREIE 162 |
| Tilapia nilotica=Nile tilapia, Brockmann body, Peptide, 33 aa | Query 116 GTFTSDYSKYLDSRRAQDFVQWLM#NTKRNRN 146 ||+||| | || + |++|| || # + |+ Sbjct 3 GTYTSDVSSYLQDQAAKEFVSWLK#TGRGRRD 33 |
| Amphiuma tridactylum=three-toed amphiumae, pancreas, Peptide, 34 aa | Query 113 HSQGTFTSDYSKYLDSRRAQDFVQWLM#NTKRNR 145 |+ || ||| | +|+ + ++|+ ||+#+ + | Sbjct 1 HADGTLTSDISSFLEKQATKEFIAWLV#SGRGRR 33 |
* References
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