logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2236 : unnamed protein product [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0062

* Basic Information

OrganismHomo sapiens (human)
Protein NamesIntegrin beta
Gene NamesNot available
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
BAH12742 N/A N/A B7Z506_HUMAN N/A N/A N/A hsa:

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 626 aa

Average Mass: 68.024 kDa

Monoisotopic Mass: 67.979 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Integrin_beta 1. 1319657.41.3e-194
EGF_2 1. 32135411.80.13
EGF_2 2. 37040214.30.067
EGF_2 3. 40943920.20.0088
EGF_2 4. 44847831.63.1e-06
Integrin_B_tail 1. 48855149.61.2e-11
Integrin_b_cyt 1. 57562081.92.3e-21
--- cleavage 602 (inside Integrin_b_cyt 575..620) ---
--- cleavage 597 (inside Integrin_b_cyt 575..620) ---
--- cleavage 598 (inside Integrin_b_cyt 575..620) ---
--- cleavage 606 (inside Integrin_b_cyt 575..620) ---
--- cleavage 601 (inside Integrin_b_cyt 575..620) ---
--- cleavage 593 (inside Integrin_b_cyt 575..620) ---
--- cleavage 612 (inside Integrin_b_cyt 575..620) ---
--- cleavage 594 (inside Integrin_b_cyt 575..620) ---
--- cleavage 613 (inside Integrin_b_cyt 575..620) ---

3. Sequence Information

Fasta Sequence: XSB2236.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

9 [sites]

Cleavage sites (±10aa)

[Site 1] QQQLNWKQDS602-NPLYKSAITT

Ser602 Asn

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gln593Gln594Gln595Leu596Asn597Trp598Lys599Gln600Asp601Ser602
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Asn603Pro604Leu605Tyr606Lys607Ser608Ala609Ile610Thr611Thr612

Sequence conservation (by blast)

[Site 2] RFEKEQQQLN597-WKQDSNPLYK

Asn597 Trp

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Arg588Phe589Glu590Lys591Glu592Gln593Gln594Gln595Leu596Asn597
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Trp598Lys599Gln600Asp601Ser602Asn603Pro604Leu605Tyr606Lys607

Sequence conservation (by blast)

[Site 3] FEKEQQQLNW598-KQDSNPLYKS

Trp598 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Phe589Glu590Lys591Glu592Gln593Gln594Gln595Leu596Asn597Trp598
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys599Gln600Asp601Ser602Asn603Pro604Leu605Tyr606Lys607Ser608

Sequence conservation (by blast)

[Site 4] NWKQDSNPLY606-KSAITTTINP

Tyr606 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Asn597Trp598Lys599Gln600Asp601Ser602Asn603Pro604Leu605Tyr606
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys607Ser608Ala609Ile610Thr611Thr612Thr613Ile614Asn615Pro616

Sequence conservation (by blast)

[Site 5] EQQQLNWKQD601-SNPLYKSAIT

Asp601 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu592Gln593Gln594Gln595Leu596Asn597Trp598Lys599Gln600Asp601
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser602Asn603Pro604Leu605Tyr606Lys607Ser608Ala609Ile610Thr611

Sequence conservation (by blast)

[Site 6] REYSRFEKEQ593-QQLNWKQDSN

Gln593 Gln

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Arg584Glu585Tyr586Ser587Arg588Phe589Glu590Lys591Glu592Gln593
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gln594Gln595Leu596Asn597Trp598Lys599Gln600Asp601Ser602Asn603

Sequence conservation (by blast)

[Site 7] NPLYKSAITT612-TINPRFQEAD

Thr612 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Asn603Pro604Leu605Tyr606Lys607Ser608Ala609Ile610Thr611Thr612
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Thr613Ile614Asn615Pro616Arg617Phe618Gln619Glu620Ala621Asp622

Sequence conservation (by blast)

[Site 8] EYSRFEKEQQ594-QLNWKQDSNP

Gln594 Gln

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu585Tyr586Ser587Arg588Phe589Glu590Lys591Glu592Gln593Gln594
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gln595Leu596Asn597Trp598Lys599Gln600Asp601Ser602Asn603Pro604

Sequence conservation (by blast)

[Site 9] PLYKSAITTT613-INPRFQEADS

Thr613 Ile

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Pro604Leu605Tyr606Lys607Ser608Ala609Ile610Thr611Thr612Thr613
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ile614Asn615Pro616Arg617Phe618Gln619Glu620Ala621Asp622Ser623

Sequence conservation (by blast)

* References

None.