XSB2252 : gap junction membrane channel protein alpha 8 [Rattus norvegicus]
[ CaMP Format ]
This entry is computationally expanded from SB0016
* Basic Information
| Organism | Rattus norvegicus (Norway rat) |
| Protein Names | Gap junction protein; gap junction membrane channel protein alpha 8 |
| Gene Names | Gja8 |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein |
Entrez Nucleotide |
Entrez Gene |
UniProt |
OMIM |
HGNC |
HPRD |
KEGG |
| ACA49112 |
N/A |
N/A |
B1PL11_RAT |
N/A |
N/A |
N/A |
rno: |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 440 aa
Average Mass: 49.415 kDa
Monoisotopic Mass: 49.384 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| Connexin 1. | 3 | 129 | 311.9 | 1.3e-90 |
| Connexin_CCC 1. | 168 | 234 | 165.8 | 1.3e-46 |
| Connexin50 1. | 267 | 333 | 187.1 | 5e-53 |
| --- cleavage 290 (inside Connexin50 267..333) --- |
| HIRA_B 1. | 385 | 417 | -5.7 | 9 |
3. Sequence Information
Fasta Sequence: XSB2252.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] IVSHYFPLTE290-VGMVETSPLS
Glu290 
Val
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Ile281 | Val282 | Ser283 | His284 | Tyr285 | Phe286 | Pro287 | Leu288 | Thr289 | Glu290 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Val291 | Gly292 | Met293 | Val294 | Glu295 | Thr296 | Ser297 | Pro298 | Leu299 | Ser300 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
SIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLSAKPFSQFEEKIGTGPLADMS
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Rattus norvegicus |
119.00 |
1 |
gap junction membrane channel protein alpha 8 |
| 2 |
Mesocricetus auratus |
119.00 |
1 |
connexin50 |
| 3 |
Mus musculus |
119.00 |
1 |
gap junction membrane channel protein alpha 8 |
| 4 |
Cricetulus griseus |
119.00 |
1 |
connexin50 |
| 5 |
Canis familiaris |
115.00 |
6 |
PREDICTED: similar to gap junction membrane channe |
| 6 |
N/A |
112.00 |
1 |
C |
| 7 |
Ovis aries |
112.00 |
1 |
AF177913_1 connexin 49 protein |
| 8 |
Bos taurus |
112.00 |
1 |
PREDICTED: similar to Gap junction alpha-8 protein |
| 9 |
Homo sapiens |
111.00 |
3 |
gap junction protein, alpha 8, 50kDa (connexin 50) |
| 10 |
Pan troglodytes |
111.00 |
1 |
PREDICTED: gap junction protein, alpha 8, 50kDa (c |
| 11 |
Monodelphis domestica |
105.00 |
1 |
PREDICTED: similar to Gap junction alpha-8 protein |
| 12 |
Macaca mulatta |
97.40 |
1 |
PREDICTED: gap junction protein, alpha 8, 50kDa (c |
| 13 |
Gallus gallus |
82.40 |
1 |
gap junction protein, alpha 8, 50kDa (connexin 50) |
| 14 |
Danio rerio |
63.90 |
3 |
AF288817_1 gap junction protein connexin 44.1 |
| 15 |
Tetraodon nigroviridis |
47.80 |
1 |
unnamed protein product |
Top-ranked sequences
| organism | matching |
|---|
| Rattus norvegicus |
Query 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVETSPLSAKPFSQFEEKIGTGPLADMS 320
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVETSPLSAKPFSQFEEKIGTGPLADMS 320
|
| Mesocricetus auratus |
Query 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVETSPLSAKPFSQFEEKIGTGPLADMS 320
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVETSPLSAKPFSQFEEKIGTGPLADMS 320
|
| Mus musculus |
Query 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVETSPLSAKPFSQFEEKIGTGPLADMS 320
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVETSPLSAKPFSQFEEKIGTGPLADMS 320
|
| Cricetulus griseus |
Query 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVETSPLSAKPFSQFEEKIGTGPLADMS 320
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVETSPLSAKPFSQFEEKIGTGPLADMS 320
|
| Canis familiaris |
Query 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVETSPLSAKPFSQFEEKIGTGPLADMS 320
||||||||||||||||||||||||||||||#||||||||||||||||||||+||||| |+|
Sbjct 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVETSPLSAKPFSQFEEKMGTGPLGDLS 320
|
| N/A |
Query 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVETSPLSAKPFSQFEEKIGTGPLADMS 320
||||||||||||||||||||||||||||||#||||| ||||||||||||||+| ||| |+|
Sbjct 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVEASPLSAKPFSQFEEKVGPGPLGDLS 320
|
| Ovis aries |
Query 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVETSPLSAKPFSQFEEKIGTGPLADMS 320
||||||||||||||||||||||||||||||#||||| ||||||||||||||+| ||| |+|
Sbjct 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVEASPLSAKPFSQFEEKVGPGPLGDLS 320
|
| Bos taurus |
Query 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVETSPLSAKPFSQFEEKIGTGPLADMS 320
||||||||||||||||||||||||||||||#||||| ||||||||||||||+| ||| |+|
Sbjct 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVEASPLSAKPFSQFEEKVGPGPLGDLS 320
|
| Homo sapiens |
Query 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVETSPLSAKPFSQFEEKIGTGPLADMS 320
||||||||||||||||||||||||||||||#||||||||| ||||+|||||| |||| |+|
Sbjct 255 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVETSPLPAKPFNQFEEKISTGPLGDLS 314
|
| Pan troglodytes |
Query 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVETSPLSAKPFSQFEEKIGTGPLADMS 320
||||||||||||||||||||||||||||||#||||||||| ||||+|||||| |||| |+|
Sbjct 254 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVETSPLPAKPFNQFEEKISTGPLGDLS 313
|
| Monodelphis domestica |
Query 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVETSPLSAKPFSQFEEKIGTGPLADMS 320
||||||||||||||||||||||||||||||#||+||| ||+| |||+||||| |||| |+|
Sbjct 260 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGVVETRPLAATPFSRFEEKISTGPLGDLS 319
|
| Macaca mulatta |
Query 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVETSPLSAKPFSQFEEKIGTGPLADMS 320
||||||||||||||||||||||||||||||#|||||| ||||||||||| ||| |+|
Sbjct 260 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVET----AKPFSQFEEKITTGPPEDLS 315
|
| Gallus gallus |
Query 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVETSPLSAKPFSQFEEKIGTGPLADMS 320
+|||||| |||||+|||||| |||||||||#|| || ||| + |++|||||| ||| |+|
Sbjct 256 AIAVSSIPKAKGYKLLEEEKPVSHYFPLTE#VG-VEPSPLPS-AFNEFEEKIGMGPLEDLS 313
|
| Danio rerio |
Query 261 SIAVSSIQKAKGYQLLEEEKIVSHYFPLTE#VGMVETSPLSAKPFSQFEEKI--GTGPLAD 318
||| |||||||||+||||+| ||+|||||#|| +| | | + |||| | |
Sbjct 262 SIAASSIQKAKGYKLLEEDKSTSHFFPLTE#VGGMEAGRLPAS-YEPFEEKSDEAMAPKKD 320
Query 319 MS 320
||
Query 319 MS 320
|
| Tetraodon nigroviridis |
Query 261 SIAVSSIQKAKGYQLLEEEKI--VSHYFPLTE#VGMVETSPLSAKPFSQFEEK 310
|+|| |+|+ |||+|||||| ++| +|| |#||| + + || |||
Sbjct 268 SLAVPSMQRVKGYRLLEEEKAPPITHLYPLAE#VGM--EAGRGSPPFQGLEEK 317
|
* References
[PubMed ID: 18470322] Liska F, Chylikova B, Martinek J, Kren V, Microphthalmia and cataract in rats with a novel point mutation in connexin 50 - L7Q. Mol Vis. 2008 May 7;14:823-8.
