* Structure Information
1. Primary Information
Length: 5037 aa
Average Mass: 565.253 kDa
Monoisotopic Mass: 564.892 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| Ins145_P3_rec 1. | 9 | 211 | 355.4 | 1.1e-103 |
| MIR 1. | 212 | 391 | 262.5 | 9.8e-76 |
| RYDR_ITPR 1. | 440 | 644 | 327.9 | 2e-95 |
| SPRY 1. | 659 | 797 | 139.6 | 9.5e-39 |
| RyR 1. | 850 | 944 | 222.3 | 1.2e-63 |
| RyR 2. | 964 | 1058 | 212.3 | 1.3e-60 |
| SPRY 2. | 1085 | 1208 | 161.6 | 2.4e-45 |
| --- cleavage 1400 --- |
| SPRY 3. | 1430 | 1570 | 156.9 | 6.2e-44 |
| ICln_channel 1. | 1807 | 1895 | -24.0 | 5.6 |
| RIIa 1. | 1937 | 1974 | -8.8 | 6.8 |
| RcsC 1. | 2026 | 2106 | -42.3 | 7.9 |
| RYDR_ITPR 2. | 2157 | 2365 | 305.4 | 1.2e-88 |
| RyR 3. | 2734 | 2828 | 217.3 | 4e-62 |
| --- cleavage 2843 --- |
| RyR 4. | 2854 | 2942 | 184.4 | 3.2e-52 |
| Hpt 1. | 3090 | 3164 | -9.0 | 6 |
| Transposase_12 1. | 3326 | 3386 | -59.5 | 7.2 |
| DUF1081 1. | 3505 | 3594 | -34.0 | 5.5 |
| Osmo_CC 1. | 3726 | 3771 | 3.2 | 5.4 |
| HTH_DeoR 1. | 3813 | 3862 | -17.5 | 5.4 |
| RIH_assoc 1. | 3871 | 4004 | 326.0 | 7.8e-95 |
| W2 1. | 4041 | 4121 | -28.1 | 4.3 |
| KNOX2 1. | 4150 | 4199 | -15.1 | 9 |
| Sigma70_r2 1. | 4242 | 4318 | -13.6 | 6.7 |
| RR_TM4-6 1. | 4381 | 4670 | 462.1 | 8.2e-136 |
| Ion_trans 1. | 4761 | 4936 | 36.2 | 1.4e-07 |
| zf-C2H2 1. | 4956 | 4983 | 2.3 | 6.9 |
3. Sequence Information
Fasta Sequence: XSB2341.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Known Structures in PDB:
2BCX (X-ray; 200 A; B=3614-3643)
* Cleavage Information
2 [sites]
Cleavage sites (±10aa)
[Site 1] FKAKKAAMMT1400-QPPATPALPR
Thr1400 
Gln
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Phe1391 | Lys1392 | Ala1393 | Lys1394 | Lys1395 | Ala1396 | Ala1397 | Met1398 | Met1399 | Thr1400 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Gln1401 | Pro1402 | Pro1403 | Ala1404 | Thr1405 | Pro1406 | Ala1407 | Leu1408 | Pro1409 | Arg1410 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
VRAENEKDATTEKNKKRGFLFKAKKAAMMTQPPATPALPRLPHDVVPADNRDDPEIILNT
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
N/A |
91.30 |
4 |
1 |
| 2 |
Oryctolagus cuniculus |
91.30 |
1 |
RYR1_RABIT Ryanodine receptor 1 (Skeletal muscle-t |
| 3 |
Homo sapiens |
89.70 |
6 |
skeletal muscle ryanodine receptor isoform 1 |
| 4 |
Rattus norvegicus |
86.70 |
2 |
PREDICTED: similar to ryanodine receptor 1, skelet |
| 5 |
Mus musculus |
86.70 |
2 |
ryanodine receptor 1, skeletal muscle |
| 6 |
Sus scrofa |
85.10 |
4 |
ryanodine receptor |
| 7 |
Monodelphis domestica |
81.60 |
1 |
PREDICTED: hypothetical protein |
| 8 |
Tetraodon nigroviridis |
62.40 |
2 |
unnamed protein product |
| 9 |
Rana catesbeiana |
62.00 |
1 |
ryanodine receptor alpha isoform |
| 10 |
Danio rerio |
58.20 |
2 |
PREDICTED: similar to ryanodine receptor RyR1 |
Top-ranked sequences
| organism | matching |
|---|
| N/A |
Query 1371 VRAENEKDATTEKNKKRGFLFKAKKXXXXX#XXXXXXXXXRLPHDVVPADNRDDPEIILNT 1430
||||||||||||||||||||||||| # |||||||||||||||||||||
Sbjct 1371 VRAENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPALPRLPHDVVPADNRDDPEIILNT 1430
|
| Oryctolagus cuniculus |
Query 1371 VRAENEKDATTEKNKKRGFLFKAKKXXXXX#XXXXXXXXXRLPHDVVPADNRDDPEIILNT 1430
||||||||||||||||||||||||| # |||||||||||||||||||||
Sbjct 1371 VRAENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPALPRLPHDVVPADNRDDPEIILNT 1430
|
| Homo sapiens |
Query 1372 RAENEKDATTEKNKKRGFLFKAKKXXXXX#XXXXXXXXXRLPHDVVPADNRDDPEIILNT 1430
|||||||||||||||||||||||| # |||||||||||||||||||||
Sbjct 1371 RAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPATPTLPRLPHDVVPADNRDDPEIILNT 1429
|
| Rattus norvegicus |
Query 1372 RAENEKDATTEKNKKRGFLFKAKKXXXXX#XXXXXXXXXRLPHDVVPADNRDDPEIILNT 1430
|||||||||||||||||||||||| # ||| |||||||||||||||||
Sbjct 1373 RAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPSTPALPRLPRDVVPADNRDDPEIILNT 1431
|
| Mus musculus |
Query 1372 RAENEKDATTEKNKKRGFLFKAKKXXXXX#XXXXXXXXXRLPHDVVPADNRDDPEIILNT 1430
|||||||||||||||||||||||| # ||| |||||||||||||||||
Sbjct 1373 RAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPSTPALPRLPRDVVPADNRDDPEIILNT 1431
|
| Sus scrofa |
Query 1372 RAENEKDATTEKNKKRGFLFKAKKXXXXX#XXXXXXXXXRLPHDVVPADNRDDPEIILNT 1430
|||||||||||||||||||||||| # ||||+|||||+||||+|||||
Sbjct 1372 RAENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPTLPRLPHEVVPADDRDDPDIILNT 1430
|
| Monodelphis domestica |
Query 1372 RAENEKDATTEKNKKRGFLFKAKKXXXXX#XXXXXXXXXRLPHDVVPADNRDDPEIILNT 1430
|||||||+ |||+||||||||||| # ||| |||||||||||||||||
Sbjct 1299 RAENEKDSATEKSKKRGFLFKAKKAAMMT#QAPATPALPRLPRDVVPADNRDDPEIILNT 1357
|
| Tetraodon nigroviridis |
Query 1374 ENEKDATTEKNKKRGFLFKAKKXXXXX#XXXXXXXXXRLPHDVVPADNRDDPEIILNT 1430
||||||+|||+||+|||||||| # || |||| |+||| +|||||
Sbjct 1329 ENEKDASTEKSKKKGFLFKAKKAALIN#PPPVVPTMPRLVEDVVP-DDRDDVDIILNT 1384
|
| Rana catesbeiana |
Query 1372 RAENEKDATTEKNKKRGFLFKAKKXXXXX#XXXXXXXXXRLPHDVVPADNRDDPEIILNT 1430
+ ||||| |||| |||||||| || # || +||| |+||||||| ||
Sbjct 1362 KPENEKDTTTEKTKKRGFLFKPKKPAFIS#TTPVVPTMPRLMKEVVP-DDRDDPEIIRNT 1419
|
| Danio rerio |
Query 1373 AENEKDATTEKNKKRGFLFKAKKXXXXX#XXXXXXXXXRLPHDVVPADNRDDPEIILNT 1430
+||||| ||||+||||| |||| # || |||| |+||| ||| ||
Sbjct 1369 SENEKDTTTEKSKKRGFFSKAKKAAFIA#PPPVVPTMPRLMEDVVP-DDRDDVEIISNT 1425
|
[Site 2] TEKKKTRKIS2843-QTAQTYDPRE
Ser2843 Gln
|
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Thr2834 | Glu2835 | Lys2836 | Lys2837 | Lys2838 | Thr2839 | Arg2840 | Lys2841 | Ile2842 | Ser2843 |
|
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Gln2844 | Thr2845 | Ala2846 | Gln2847 | Thr2848 | Tyr2849 | Asp2850 | Pro2851 | Arg2852 | Glu2853 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
KAMIAWEWTIEKAREGEEERTEKKKTRKISQTAQTYDPREGYNPQPPDLSGVTLSRELQA
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
N/A |
80.10 |
6 |
1 |
| 2 |
Oryctolagus cuniculus |
80.10 |
3 |
RYR1_RABIT Ryanodine receptor 1 (Skeletal muscle-t |
| 3 |
Mus musculus |
76.60 |
4 |
ryanodine receptor |
| 4 |
Rattus norvegicus |
76.60 |
2 |
PREDICTED: similar to ryanodine receptor 1, skelet |
| 5 |
Homo sapiens |
76.30 |
12 |
skeletal muscle ryanodine receptor isoform 1 |
| 6 |
Sus scrofa |
75.50 |
4 |
ryanodine receptor |
| 7 |
Bos taurus |
63.50 |
2 |
PREDICTED: similar to Ryanodine receptor 1 (Skelet |
| 8 |
Danio rerio |
62.40 |
2 |
PREDICTED: similar to ryanodine receptor RyR1 |
| 9 |
Tetraodon nigroviridis |
59.70 |
3 |
unnamed protein product |
| 10 |
Prot=RyR1 isform from fish |
56.60 |
1 |
- |
| 11 |
Macaca mulatta |
55.10 |
1 |
PREDICTED: similar to ryanodine receptor 1 (skelet |
| 12 |
Rana catesbeiana |
46.60 |
2 |
ryanodine receptor alpha isoform |
| 13 |
Monodelphis domestica |
36.60 |
2 |
PREDICTED: similar to cardiac muscle ryanodine rec |
| 14 |
Canis familiaris |
36.60 |
1 |
PREDICTED: similar to Ryanodine receptor 2 (Cardia |
| 15 |
Pan troglodytes |
36.60 |
1 |
PREDICTED: cardiac muscle ryanodine receptor |
| 16 |
Hemicentrotus pulcherrimus |
36.20 |
1 |
ryanodine receptor |
| 17 |
Gallus gallus |
35.40 |
1 |
PREDICTED: similar to cardiac muscle ryanodine rec |
Top-ranked sequences
| organism | matching |
|---|
| N/A |
Query 2814 KAMIAWEWXXXXXXXXXXXXXXXXXXXXIS#QTAQTYDPREGYNPQPPDLSGVTLSRELQA 2873
|||||||| ||#||||||||||||||||||||||||||||||
Sbjct 2814 KAMIAWEWTIEKAREGEEERTEKKKTRKIS#QTAQTYDPREGYNPQPPDLSGVTLSRELQA 2873
|
| Oryctolagus cuniculus |
Query 2814 KAMIAWEWXXXXXXXXXXXXXXXXXXXXIS#QTAQTYDPREGYNPQPPDLSGVTLSRELQA 2873
|||||||| ||#||||||||||||||||||||||||||||||
Sbjct 2814 KAMIAWEWTIEKAREGEEERTEKKKTRKIS#QTAQTYDPREGYNPQPPDLSGVTLSRELQA 2873
|
| Mus musculus |
Query 2814 KAMIAWEWXXXXXXXXXXXXXXXXXXXXIS#QTAQTYDPREGYNPQPPDLSGVTLSRELQA 2873
|||||||| ||#|||||||||||||||||||| |||||||||
Sbjct 2815 KAMIAWEWTVEKAREGEEEKTEKKKTRKIS#QTAQTYDPREGYNPQPPDLSVVTLSRELQA 2874
|
| Rattus norvegicus |
Query 2814 KAMIAWEWXXXXXXXXXXXXXXXXXXXXIS#QTAQTYDPREGYNPQPPDLSGVTLSRELQA 2873
|||||||| ||#|||||||||||||||||||| |||||||||
Sbjct 2815 KAMIAWEWTVEKAREGEEEKTEKKKTRKIS#QTAQTYDPREGYNPQPPDLSVVTLSRELQA 2874
|
| Homo sapiens |
Query 2814 KAMIAWEWXXXXXXXXXXXXXXXXXXXXIS#QTAQTYDPREGYNPQPPDLSGVTLSRELQA 2873
|||||||| ||#|+|||||||||||||||||| |||||||||
Sbjct 2814 KAMIAWEWTIEKAREGEEEKTEKKKTRKIS#QSAQTYDPREGYNPQPPDLSAVTLSRELQA 2873
|
| Sus scrofa |
Query 2814 KAMIAWEWXXXXXXXXXXXXXXXXXXXXIS#QTAQTYDPREGYNPQPPDLSGVTLSRELQA 2873
|||||||| ||#|+||||| ||||||||||||||||||||||
Sbjct 2815 KAMIAWEWTIEKAREGEEEKTEKKKTRKIS#QSAQTYDAREGYNPQPPDLSGVTLSRELQA 2874
|
| Bos taurus |
Query 2814 KAMIAWEWXXXXXXXXXXXXXXXXXXXXIS#QTAQTYDPREGYNPQPPDLSGVT 2866
|||||||| ||#|+||||| |||||||||||||||
Sbjct 966 KAMIAWEWTIEKAREGEEEKTEKKKTRKIS#QSAQTYDAREGYNPQPPDLSGVT 1018
|
| Danio rerio |
Query 2814 KAMIAWEWXXXXXXXXXXXXXXXXXXXXIS#QTAQ-TYDPREGYNPQPPDLSGVTLSRELQ 2872
|||||||| ||#|||| |||| ||+||| |+||+|||||||
Sbjct 2852 KAMIAWEWTLDKARDGEDEKVEKKTARKIS#QTAQATYDPSHGYSPQPIDISGMTLSRELQ 2911
Query 2873 A 2873
+
Sbjct 2912 S 2912
|
| Tetraodon nigroviridis |
Query 2814 KAMIAWEWXXXXXXXXXXXXXXXXXXXXIS#QTAQ-TYDPREGYNPQPPDLSGVTLSRELQ 2872
|||+|||| ||#|||| |||| ||+||| |+||+ ||||||
Sbjct 2341 KAMLAWEWTLEKARDGEGEVEKKAATRKIS#QTAQATYDPSHGYSPQPIDISGMALSRELQ 2400
Query 2873 A 2873
+
Sbjct 2401 S 2401
|
| Prot=RyR1 isform from fish |
Query 2814 KAMIAWEWXXXXXXXXXXXXXXXXXXXXIS#QTAQ-TYDPREGYNPQPPDLSGVTLSRELQ 2872
|||+|||| ||#|||| |||| ||+||| |+| | |||+||
Sbjct 2853 KAMLAWEWNIEKAREEEESEKKKATSRKIS#QTAQATYDPSHGYSPQPIDISHVALSRDLQ 2912
Query 2873 A 2873
+
Sbjct 2913 S 2913
|
| Macaca mulatta |
Query 2847 QTYDPREGYNPQPPDLSGVTLSRELQ 2872
+|||||||||||||||| ||||||||
Sbjct 820 KTYDPREGYNPQPPDLSAVTLSRELQ 845
|
| Rana catesbeiana |
Query 2814 KAMIAWEWXXXXXXXXXXXXXXXXXXXX-IS#QTAQ-TYDPR-EGYNPQPPDLSGVTLSRE 2870
|||||||| ||#|||| |||| + ++| | ||+|+|||||
Sbjct 2800 KAMIAWEWLVEKAREGEEDRTEKKTKTRKIS#QTAQQTYDPMVQTFSPTPIDLTGLTLSRE 2859
Query 2871 LQA 2873
||+
Sbjct 2860 LQS 2862
|
| Monodelphis domestica |
Query 2814 KAMIAWEWXXXXXXXXXXXXXXXXXXXXIS#QTAQ-TYDPREGYNPQPPDLSGVTLSRELQ 2872
| |+|| | ||#||+| + | ||+|+ |+| |||||+|
Sbjct 2850 KTMLAWGWRIERTREGDSMALYTRTRR-IS#QTSQVSIDTAHGYSPRAIDMSNVTLSRDLH 2908
Query 2873 A 2873
|
Query 2873 A 2873
|
| Canis familiaris |
Query 2814 KAMIAWEWXXXXXXXXXXXXXXXXXXXXIS#QTAQ-TYDPREGYNPQPPDLSGVTLSRELQ 2872
| |+|| | ||#||+| + | ||+|+ |+| |||||+|
Sbjct 2774 KTMLAWGWRIERTREGDSMALYNRTRR-IS#QTSQVSVDAAHGYSPRAIDMSNVTLSRDLH 2832
Query 2873 A 2873
|
Query 2873 A 2873
|
| Pan troglodytes |
Query 2814 KAMIAWEWXXXXXXXXXXXXXXXXXXXXIS#QTAQ-TYDPREGYNPQPPDLSGVTLSRELQ 2872
| |+|| | ||#||+| + | ||+|+ |+| |||||+|
Sbjct 2826 KTMLAWGWRIERTREGDSMALYNRTRR-IS#QTSQVSVDAAHGYSPRAIDMSNVTLSRDLH 2884
Query 2873 A 2873
|
Query 2873 A 2873
|
| Hemicentrotus pulcherrimus |
Query 2814 KAMIAWEWXXXXXXXXXXXXXXXXXXXXIS#QTAQTYDPREGYNPQPPDLSGVTLSRELQ 2872
||++|| | # + + ||||+| |+| +||+||+|
Sbjct 2985 KALLAWGWSVERSKASEQQSQAHRPRRLSK#ASLGAMESPHGYNPRPIDVSNITLTREMQ 3043
|
| Gallus gallus |
Query 2814 KAMIAWEWXXXXXXXXXXXXXXXXXXXXIS#QTAQ-TYDPREGYNPQPPDLSGVTLSRELQ 2872
| |+|| | ||#||+| + | ||+|+ |+| |||||++
Sbjct 614 KTMLAWGWRIERTREGDSMALYNRTRR-IS#QTSQISVDAAHGYSPRAIDMSNVTLSRDVH 672
Query 2873 A 2873
|
Query 2873 A 2873
|
* References
[PubMed ID: 8097730] Takeshima H, Nishimura S, Nishi M, Ikeda M, Sugimoto T, A brain-specific transcript from the 3'-terminal region of the skeletal muscle ryanodine receptor gene. FEBS Lett. 1993 May 10;322(2):105-10.
» More (1) « Hide Below
[PubMed ID: 2725677] ... Takeshima H, Nishimura S, Matsumoto T, Ishida H, Kangawa K, Minamino N, Matsuo H, Ueda M, Hanaoka M, Hirose T, et al., Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor. Nature. 1989 Jun 8;339(6224):439-45.
