XSB2363 : protein kinase C, beta isoform I [Oryctolagus cuniculus]
[ CaMP Format ]
This entry is computationally expanded from SB0039
* Basic Information
| Organism | Oryctolagus cuniculus (rabbit) |
| Protein Names | Protein kinase C beta type; PKC-beta; PKC-B; 2.7.11.13; protein kinase C; beta isoform I; beta 1 |
| Gene Names | PRKCB; PRKCB1; protein kinase C, beta |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_001095195 | NM_001101725 | 100037719 | KPCB_RABIT | N/A | N/A | N/A | N/A |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 671 aa
Average Mass: 76.828 kDa
Monoisotopic Mass: 76.778 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| C1_1 1. | 37 | 89 | 80.1 | 8.2e-21 |
| C1_1 2. | 102 | 154 | 97.3 | 5.4e-26 |
| C2 1. | 173 | 260 | 128.3 | 2.5e-35 |
| --- cleavage 311 --- | ||||
| --- cleavage 320 --- | ||||
| Pkinase 1. | 342 | 600 | 260.9 | 3.1e-75 |
| Pkinase_C 1. | 620 | 666 | 71.9 | 2.4e-18 |
3. Sequence Information
Fasta Sequence: XSB2363.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
2 [sites]
Cleavage sites (±10aa)
[Site 1] RQKFERAKIG311-QGTKTPEEKT
Gly311 
Gln
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Arg302 | Gln303 | Lys304 | Phe305 | Glu306 | Arg307 | Ala308 | Lys309 | Ile310 | Gly311 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Gln312 | Gly313 | Thr314 | Lys315 | Thr316 | Pro317 | Glu318 | Glu319 | Lys320 | Thr321 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| EGEYFNVPVPPEGSEGNEELRQKFERAKIGQGTKTPEEKTTNTISKFDNNGNRDRMKLTD |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Oryctolagus cuniculus | 127.00 | 3 | KPCB_RABIT Protein kinase C beta type (PKC-beta) ( |
| 2 | N/A | 123.00 | 10 | K |
| 3 | Rattus norvegicus | 123.00 | 4 | unnamed protein product |
| 4 | Mus musculus | 123.00 | 4 | protein kinase C, beta 1 |
| 5 | Macaca mulatta | 122.00 | 6 | PREDICTED: protein kinase C, beta isoform 1 |
| 6 | Bos taurus | 122.00 | 3 | Unknown (protein for MGC:148660) |
| 7 | Homo sapiens | 120.00 | 9 | protein kinase C, beta isoform 1 |
| 8 | Canis familiaris | 120.00 | 2 | PREDICTED: similar to Protein kinase C, beta type |
| 9 | Monodelphis domestica | 114.00 | 3 | PREDICTED: similar to Protein kinase C beta type ( |
| 10 | Gallus gallus | 110.00 | 3 | PREDICTED: similar to protein kinase C beta-1 |
| 11 | Latimeria chalumnae | 100.00 | 2 | protein kinase C beta 1 |
| 12 | Protopterus dolloi | 97.40 | 2 | protein kinase C beta 1 |
| 13 | Tetraodon nigroviridis | 94.40 | 3 | unnamed protein product |
| 14 | Danio rerio | 93.60 | 7 | protein kinase C, beta 1 |
| 15 | Scyliorhinus canicula | 87.80 | 2 | protein kinase C |
| 16 | Petromyzon marinus | 60.50 | 1 | protein kinase C |
| 17 | synthetic construct | 55.80 | 1 | protein kinase C alpha |
| 18 | Takifugu rubripes | 55.50 | 1 | protein kinase C, alpha type |
| 19 | Xenopus tropicalis | 53.10 | 1 | hypothetical protein LOC780209 |
| 20 | Xenopus laevis | 49.70 | 1 | protein kinase C, alpha |
| 21 | Myxine glutinosa | 47.40 | 1 | protein kinase C |
| 22 | Caenorhabditis briggsae | 38.10 | 1 | Hypothetical protein CBG16150 |
| 23 | Aplysia californica | 35.80 | 1 | KPC1_APLCA Calcium-dependent protein kinase C (APL |
| 24 | Plasmodium berghei strain ANKA | 34.30 | 1 | mitotic control protein |
| 25 | Apis mellifera | 33.10 | 1 | PREDICTED: similar to Protein C kinase 53E CG6622- |
| 26 | Branchiostoma lanceolatum | 32.30 | 1 | protein kinase C |
Top-ranked sequences
| organism | matching |
|---|---|
| Oryctolagus cuniculus | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLTD 341 |
| N/A | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||||||||||||||||||||#|||| ||||| ||||||||||||||||||| Sbjct 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 |
| Rattus norvegicus | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||||||||||||||||||||#|||| ||||| ||||||||||||||||||| Sbjct 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 |
| Mus musculus | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||||||||||||||||||||#|||| ||||| ||||||||||||||||||| Sbjct 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 |
| Macaca mulatta | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||||||||||||||||||| #|||| ||||||||+|||||||||||||||| Sbjct 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIS#QGTKVPEEKTTNTVSKFDNNGNRDRMKLTD 341 |
| Bos taurus | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||||||||||||||||||||# | ||||||||||||||||||||||||||| Sbjct 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLTD 341 |
| Homo sapiens | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||||| ||||||||||||| #|||| ||||||||+|||||||||||||||| Sbjct 282 EGEYFNVPVPPEGSEANEELRQKFERAKIS#QGTKVPEEKTTNTVSKFDNNGNRDRMKLTD 341 |
| Canis familiaris | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||||||||||||||||||| #|||| ||||||||||| ||||||||||||| Sbjct 274 EGEYFNVPVPPEGSEGNEELRQKFERAKIS#QGTKAPEEKTTNTISKLDNNGNRDRMKLTD 333 |
| Monodelphis domestica | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||| ||||||||||||||||#|||| |||| | ||| ||||||||||||| Sbjct 279 EGEYFNVPVPPEGEEGNEELRQKFERAKIG#QGTKVTEEKTANAISKIDNNGNRDRMKLTD 338 |
| Gallus gallus | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||| ||||||||||||||||# |+| +||||| ||||||||+||||||+| Sbjct 281 EGEYFNVPVPPEGEEGNEELRQKFERAKIG#TGSKAADEKTTNAISKFDNNGSRDRMKLSD 340 |
| Latimeria chalumnae | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||| |||||||+||||||||# |+| |+| |+ ||| |||||||+||+| Sbjct 204 EGEYFNVPVPPEGEEGNEELRKKFERAKIG#PGSKATEDKVKNSSSKFGNNGNRDRIKLSD 263 |
| Protopterus dolloi | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||| ||||||||||||||||# | + |+| | +||||||||||+||+| Sbjct 213 EGEYFNVPVPPEGEEGNEELRQKFERAKIG#PGAEAAEDKIANA-AKFDNNGNRDRVKLSD 271 |
| Tetraodon nigroviridis | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||| ||||||||||||||||# | | + |+ | |+||+|||+||||| | Sbjct 218 EGEYFNVPVPPEGEEGNEELRQKFERAKIG#PG-KNTDGKSANAASRFDSNGNQDRMKLAD 276 |
| Danio rerio | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||||||||||| ||||||||||||||||# +|| + ++| |||||+|||||||||+| Sbjct 281 EGEYFNVPVPPEGEEGNEELRQKFERAKIG#P-SKT-DGSSSNAISKFDSNGNRDRMKLSD 338 |
| Scyliorhinus canicula | Query 282 EGEYFNVPVPPE-GSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLT 340 ||||+||||||| ||||||||||||||+||# |+| ||| +++ || | ||||||||| Sbjct 202 EGEYYNVPVPPEEDSEGNEELRQKFERARIG#PGSKAAEEKRSSSWSKID-NGNRDRMKLA 260 Query 341 D 341 | Query 341 D 341 |
| Petromyzon marinus | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTK--TPEEKTTNTISKFDNNGNRDRMKL 339 ||||+|||+ |+ +|+ |+|+|||+|++|# | +|+ |++| || | ||+| Sbjct 212 EGEYYNVPIAPDIEDGDTEMRRKFEKARLG#PSVKPRASDERRANSLSAILNNANVDRVKA 271 Query 340 TD 341 | Sbjct 272 DD 273 |
| synthetic construct | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG-#QGTK--TPEEKTTNTISKFDNNGNRDRMK 338 ||||+|||+| ||| |||||||+||+| # | | +| | + + | ||+| Sbjct 282 EGEYYNVPIPEGDEEGNMELRQKFEKAKLGP#AGNKVISPSE------DRKQPSNNLDRVK 335 Query 339 LTD 341 ||| Query 339 LTD 341 |
| Takifugu rubripes | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTK--TPEEKTTNTISKFDNNGNRDRMKL 339 ||||+|||+| | + | |||||||+||+|#|| | || + ++ +|| ||++| Sbjct 280 EGEYYNVPIP-EVDDVNLELRQKFEKAKLG#QGKKVITPSDHRRFSLP----SGNMDRVRL 334 Query 340 TD 341 | Sbjct 335 ND 336 |
| Xenopus tropicalis | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG-#QGTKTPEEKTTNTISKFDNNGNRDRMKLT 340 ||||+|||+| | +|| |||||||+||+| # | | |+ + + | | ++|| Sbjct 286 EGEYYNVPIPEEEDDGNIELRQKFEKAKLGP#AGNKV--ISPTDERRPYVPSNNIDSVRLT 343 Query 341 D 341 | Query 341 D 341 |
| Xenopus laevis | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||+|||+| | +|| |||||||+||+|# | +| | | ++||| Sbjct 286 EGEYYNVPIP-EADDGNLELRQKFEKAKLG#PAGNKVINPTGERRPYIPSN-NIDSIRLTD 343 |
| Myxine glutinosa | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||+|||| ||| || ||||+ +|++| #+ | + + | + ||+ | | Sbjct 203 EGEYYNVPVAPEGEEG-LELRQRLQRSQIA#RSDKNKQSPAKDQPSDSASLSGLDRVNLED 261 |
| Caenorhabditis briggsae | Query 282 EGEYFNVPVPPEGSEGNEELRQKF-ERAKIG#QGTKT--PEEKTTNTISKFDNNGNRDRMK 338 |||++|+ + || | |++|+| + || #+ + | | | | | ||| +| Sbjct 352 EGEFYNINITPEYDEDMEKVRKKMNDNFKIS#RDSSAGKPRESTPRATSTSLTNTNRDVIK 411 Query 339 LTD 341 +| Sbjct 412 ASD 414 |
| Aplysia californica | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFD 329 |||++ ||| + +| +|++ | |+ | # + || +|| | Sbjct 266 EGEFYGVPVTDDITESIQEIKSKMHRSSIS#SEKRYPEPDKVQNMSKQD 313 |
| Plasmodium berghei strain ANKA | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGN 333 | +|| | |+ | || ++ ||| |#+ || | |+| +| | Sbjct 347 ESDYFEELVDPDEKEEEEEEEEEEERADDG#EEKKTNNMNKTPCIAKSENEQN 398 |
| Apis mellifera | Query 282 EGEYFNVPVPPEGSEGNE-ELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLT 340 ||||+||||| || + | +++ ++ + #+ | | ++| | | | ++ + Sbjct 299 EGEYYNVPVPEEGVDLAELKMKPSPQKTSVT#KKTTTTQDKEVP-----HNMGKSDLIRAS 353 Query 341 D 341 | Query 341 D 341 |
| Branchiostoma lanceolatum | Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLTD 341 ||||+|||+ | | +|++ ++ |+ #+ | ++ |+ | |+ | || | Sbjct 213 EGEYYNVPIADE-EENVAKLKEHLQKQKLD#EQRKQKSKR-----SEECNIGSLDHMKAAD 266 |
[Site 2] GQGTKTPEEK320-TTNTISKFDN
Lys320 Thr
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gly311 | Gln312 | Gly313 | Thr314 | Lys315 | Thr316 | Pro317 | Glu318 | Glu319 | Lys320 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Thr321 | Thr322 | Asn323 | Thr324 | Ile325 | Ser326 | Lys327 | Phe328 | Asp329 | Asn330 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| PPEGSEGNEELRQKFERAKIGQGTKTPEEKTTNTISKFDNNGNRDRMKLTDFNFLMVLGK |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Oryctolagus cuniculus | 125.00 | 3 | KPCB_RABIT Protein kinase C beta type (PKC-beta) ( |
| 2 | N/A | 122.00 | 10 | K |
| 3 | Rattus norvegicus | 122.00 | 4 | unnamed protein product |
| 4 | Mus musculus | 122.00 | 4 | protein kinase C, beta 1 |
| 5 | Macaca mulatta | 121.00 | 7 | PREDICTED: protein kinase C, beta isoform 1 |
| 6 | Bos taurus | 121.00 | 3 | Unknown (protein for MGC:148660) |
| 7 | Homo sapiens | 119.00 | 8 | protein kinase C, beta isoform 1 |
| 8 | Canis familiaris | 119.00 | 3 | PREDICTED: similar to Protein kinase C, beta type |
| 9 | Monodelphis domestica | 113.00 | 3 | PREDICTED: similar to Protein kinase C beta type ( |
| 10 | Gallus gallus | 108.00 | 3 | PREDICTED: similar to protein kinase C beta-1 |
| 11 | Latimeria chalumnae | 99.00 | 2 | protein kinase C beta 1 |
| 12 | Protopterus dolloi | 95.90 | 2 | protein kinase C beta 1 |
| 13 | Tetraodon nigroviridis | 92.80 | 2 | unnamed protein product |
| 14 | Danio rerio | 92.00 | 6 | protein kinase C, beta 1 |
| 15 | Scyliorhinus canicula | 89.00 | 2 | protein kinase C |
| 16 | Petromyzon marinus | 60.80 | 1 | protein kinase C |
| 17 | synthetic construct | 57.00 | 1 | protein kinase C alpha |
| 18 | Takifugu rubripes | 56.60 | 1 | protein kinase C, alpha type |
| 19 | Xenopus tropicalis | 51.20 | 1 | hypothetical protein LOC780209 |
| 20 | Xenopus laevis | 50.80 | 1 | protein kinase C, alpha |
| 21 | Caenorhabditis briggsae | 41.60 | 1 | Hypothetical protein CBG16150 |
| 22 | Myxine glutinosa | 41.60 | 1 | protein kinase C |
| 23 | Branchiostoma lanceolatum | 35.80 | 1 | protein kinase C |
| 24 | Aplysia californica | 35.80 | 1 | KPC1_APLCA Calcium-dependent protein kinase C (APL |
| 25 | Aedes aegypti | 33.50 | 1 | protein kinase c |
Top-ranked sequences
| organism | matching |
|---|---|
| Oryctolagus cuniculus | Query 291 PPEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 291 PPEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |
| N/A | Query 291 PPEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 ||||||||||||||||||||||||| ||||#| |||||||||||||||||||||||||||| Sbjct 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |
| Rattus norvegicus | Query 291 PPEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 ||||||||||||||||||||||||| ||||#| |||||||||||||||||||||||||||| Sbjct 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |
| Mus musculus | Query 291 PPEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 ||||||||||||||||||||||||| ||||#| |||||||||||||||||||||||||||| Sbjct 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |
| Macaca mulatta | Query 291 PPEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||||||||||||||||||| |||| ||||#||||+||||||||||||||||||||||||| Sbjct 291 PPEGSEGNEELRQKFERAKISQGTKVPEEK#TTNTVSKFDNNGNRDRMKLTDFNFLMVLGK 350 |
| Bos taurus | Query 291 PPEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 ||||||||||||||||||||| | ||||||#|||||||||||||||||||||||||||||| Sbjct 291 PPEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |
| Homo sapiens | Query 291 PPEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||||| ||||||||||||| |||| ||||#||||+||||||||||||||||||||||||| Sbjct 291 PPEGSEANEELRQKFERAKISQGTKVPEEK#TTNTVSKFDNNGNRDRMKLTDFNFLMVLGK 350 |
| Canis familiaris | Query 291 PPEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||||||||||||||||||| |||| ||||#||||||| |||||||||||||||||||||| Sbjct 283 PPEGSEGNEELRQKFERAKISQGTKAPEEK#TTNTISKLDNNGNRDRMKLTDFNFLMVLGK 342 |
| Monodelphis domestica | Query 291 PPEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||| |||||||||||||||||||| |||#| | ||| |||||||||||||||||||||| Sbjct 288 PPEGEEGNEELRQKFERAKIGQGTKVTEEK#TANAISKIDNNGNRDRMKLTDFNFLMVLGK 347 |
| Gallus gallus | Query 291 PPEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||| |||||||||||||||| |+| +||#||| ||||||||+||||||+|||||||||| Sbjct 290 PPEGEEGNEELRQKFERAKIGTGSKAADEK#TTNAISKFDNNGSRDRMKLSDFNFLMVLGK 349 |
| Latimeria chalumnae | Query 291 PPEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||| |||||||+|||||||| |+| |+|# |+ ||| |||||||+||+|||||||||| Sbjct 213 PPEGEEGNEELRKKFERAKIGPGSKATEDK#VKNSSSKFGNNGNRDRIKLSDFNFLMVLGK 272 |
| Protopterus dolloi | Query 291 PPEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||| |||||||||||||||| | + |+|# | +||||||||||+||+|||||||||| Sbjct 222 PPEGEEGNEELRQKFERAKIGPGAEAAEDK#IANA-AKFDNNGNRDRVKLSDFNFLMVLGK 280 |
| Tetraodon nigroviridis | Query 291 PPEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||| |||||||||||||||| | | + |#+ | |+||+|||+||||| |||||||||| Sbjct 227 PPEGEEGNEELRQKFERAKIGPGKNT-DGK#SANAASRFDSNGNQDRMKLADFNFLMVLGK 285 |
| Danio rerio | Query 291 PPEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 |||| |||||||||||||||| +|| + #++| |||||+|||||||||+|||||||||| Sbjct 290 PPEGEEGNEELRQKFERAKIGP-SKT-DGS#SSNAISKFDSNGNRDRMKLSDFNFLMVLGK 347 |
| Scyliorhinus canicula | Query 291 PPEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 | | ||||||||||||||+|| |+| |||# +++ || | ||||||||| |||||||||| Sbjct 212 PEEDSEGNEELRQKFERARIGPGSKAAEEK#RSSSWSKID-NGNRDRMKLADFNFLMVLGK 270 |
| Petromyzon marinus | Query 292 PEGSEGNEELRQKFERAKIGQGTK--TPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLG 349 |+ +|+ |+|+|||+|++| | +|+# |++| || | ||+| ||||||||| Sbjct 222 PDIEDGDTEMRRKFEKARLGPSVKPRASDER#RANSLSAILNNANVDRVKADDFNFLMVLG 281 Query 350 K 350 | Query 350 K 350 |
| synthetic construct | Query 292 PEGSE-GNEELRQKFERAKIGQ-GTK--TPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMV 347 ||| | || |||||||+||+| | | +| | # + + | ||+|||||||||| Sbjct 291 PEGDEEGNMELRQKFEKAKLGPAGNKVISPSE-#-----DRKQPSNNLDRVKLTDFNFLMV 344 Query 348 LGK 350 ||| Query 348 LGK 350 |
| Takifugu rubripes | Query 292 PEGSEGNEELRQKFERAKIGQGTK--TPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLG 349 || + | |||||||+||+||| | || + # ++ +|| ||++| ||||| +|| Sbjct 289 PEVDDVNLELRQKFEKAKLGQGKKVITPSDH#RRFSLP----SGNMDRVRLNDFNFLALLG 344 Query 350 K 350 | Query 350 K 350 |
| Xenopus tropicalis | Query 291 PPEGSEGNEELRQKFERAKIG-QGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLG 349 | | +|| |||||||+||+| | | # |+ + + | | ++||||+|||||| Sbjct 295 PEEEDDGNIELRQKFEKAKLGPAGNKV--IS#PTDERRPYVPSNNIDSVRLTDFSFLMVLG 352 Query 350 K 350 | Query 350 K 350 |
| Xenopus laevis | Query 292 PEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 || +|| |||||||+||+| #| +| | | ++|||| ||||||| Sbjct 295 PEADDGNLELRQKFEKAKLGPAGNKVINP#TGERRPYIPSN-NIDSIRLTDFCFLMVLGK 352 |
| Caenorhabditis briggsae | Query 292 PEGSEGNEELRQKF-ERAKIGQGTKT--PEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVL 348 || | |++|+| + || + + | | #| | | ||| +| +||||| || Sbjct 362 PEYDEDMEKVRKKMNDNFKISRDSSAGKPRES#TPRATSTSLTNTNRDVIKASDFNFLTVL 421 Query 349 GK 350 || Query 349 GK 350 |
| Myxine glutinosa | Query 292 PEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 ||| || | |||+ +|++| + | + # + | + ||+ | || || |||| Sbjct 213 PEGEEGLE-LRQRLQRSQIARSDKNKQSP#AKDQPSDSASLSGLDRVNLEDFVFLTVLGK 270 |
| Branchiostoma lanceolatum | Query 296 EGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 | +|++ ++ |+ + | ++#+ | |+ | || |||||||||| Sbjct 226 ENVAKLKEHLQKQKLDEQRKQKSKR#SEEC-----NIGSLDHMKAADFNFLMVLGK 275 |
| Aplysia californica | Query 295 SEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 +| +|++ | |+ | + || # +|| +| ++ +||||| |||| Sbjct 279 TESIQEIKSKMHRSSISSEKRYPEPD#KVQNMSK------QDIVRASDFNFLTVLGK 328 |
| Aedes aegypti | Query 292 PEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350 | || + ++ | + | | | # + | | +| ++ ||||||||||| Sbjct 237 PVPEEGTDLVQLKSQMRKTSISKKAPVLC#DKDVPH---NMGKKDVIRATDFNFLMVLGK 292 |
* References
[PubMed ID: 8900191] Li Y, Davis KL, Sytkowski AJ, Protein kinase C-epsilon is necessary for erythropoietin's up-regulation of c-myc and for factor-dependent DNA synthesis. Evidence for discrete signals for growth and differentiation. J Biol Chem. 1996 Oct 25;271(43):27025-30.
[PubMed ID: 3808073] ... Ohno S, Kawasaki H, Imajoh S, Suzuki K, Inagaki M, Yokokura H, Sakoh T, Hidaka H, Tissue-specific expression of three distinct types of rabbit protein kinase C. Nature. 1987 Jan 8-14;325(7000):161-6.