XSB2377 : solute carrier family 6 (neurotransmitter transporter, glycine), member 5, isoform CRA_b [Rattus norvegicus]
[ CaMP Format ]
This entry is computationally expanded from SB0013
* Basic Information
| Organism | Rattus norvegicus (Norway rat) |
| Protein Names | solute carrier family 6 (neurotransmitter transporter; glycine); member 5; isoform CRA_b |
| Gene Names | Slc6a5 |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein |
Entrez Nucleotide |
Entrez Gene |
UniProt |
OMIM |
HGNC |
HPRD |
KEGG |
| EDM07218 |
N/A |
171148 |
N/A |
N/A |
N/A |
N/A |
N/A |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 460 aa
Average Mass: 48.979 kDa
Monoisotopic Mass: 48.947 kDa
2. Domain Information
Annotated Domains: Not Available.
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| --- cleavage 164 --- |
| --- cleavage 156 --- |
| DUP 1. | 283 | 390 | -46.4 | 1.8 |
3. Sequence Information
Fasta Sequence: XSB2377.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
2 [sites]
Cleavage sites (±10aa)
[Site 1] NMSQSTVVLG164-TDGIASVLPG
Gly164 
Thr
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Asn155 | Met156 | Ser157 | Gln158 | Ser159 | Thr160 | Val161 | Val162 | Leu163 | Gly164 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Thr165 | Asp166 | Gly167 | Ile168 | Ala169 | Ser170 | Val171 | Leu172 | Pro173 | Gly174 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
NVSVGKGTLEHNNTPAVGWVNMSQSTVVLGTDGIASVLPGSVATTTIPEDEQGDENKARG
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Mus musculus |
123.00 |
7 |
PREDICTED: similar to Sodium- and chloride-depende |
| 2 |
Rattus norvegicus |
119.00 |
2 |
sodium dependent glycine type 2b transporter |
| 3 |
Macaca mulatta |
110.00 |
1 |
PREDICTED: solute carrier family 6 (neurotransmitt |
| 4 |
Bos taurus |
110.00 |
1 |
PREDICTED: similar to glycine transporter GLYT2 is |
| 5 |
Homo sapiens |
108.00 |
6 |
Solute carrier family 6 (neurotransmitter transpor |
| 6 |
N/A |
108.00 |
1 |
S |
| 7 |
Pan troglodytes |
107.00 |
1 |
PREDICTED: solute carrier family 6 (neurotransmitt |
| 8 |
Monodelphis domestica |
98.60 |
1 |
PREDICTED: similar to glycine transporter GLYT2 |
| 9 |
Canis familiaris |
98.20 |
1 |
PREDICTED: similar to Sodium- and chloride-depende |
| 10 |
Gallus gallus |
73.20 |
1 |
PREDICTED: similar to glycine transporter GLYT2 |
| 11 |
Tetraodon nigroviridis |
60.50 |
1 |
unnamed protein product |
Top-ranked sequences
| organism | matching |
|---|
| Mus musculus |
Query 135 NVSVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 135 NVSVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
|
| Rattus norvegicus |
Query 135 NVSVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
|||| |||||||||| ||||||||||||||#||||||||||||||||||||||||||||||
Sbjct 127 NVSVAKGTLEHNNTPPVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 186
|
| Macaca mulatta |
Query 135 NVSVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
|||||||||| |||||||||||||||||||#|||| ||||||||| ||||||||||||
Sbjct 177 NVSVGKGTLERNNTPAVGWVNMSQSTVVLG#TDGITSVLPGSVATVATQEDEQGDENKARG 236
|
| Bos taurus |
Query 135 NVSVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
|||||||||| |||||||||||||||||||#|||| ||||||||| ||||||||||||
Sbjct 134 NVSVGKGTLERNNTPAVGWVNMSQSTVVLG#TDGITSVLPGSVATAATQEDEQGDENKARG 193
|
| Homo sapiens |
Query 135 NVSVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
|||||||||| |||| ||||||||||||||#|||| ||||||||| ||||||||||||
Sbjct 133 NVSVGKGTLERNNTPVVGWVNMSQSTVVLG#TDGITSVLPGSVATVATQEDEQGDENKARG 192
|
| N/A |
Query 135 NVSVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
|||||||||| |||| ||||||||||||||#|||| ||||||||| ||||||||||||
Sbjct 133 NVSVGKGTLERNNTPVVGWVNMSQSTVVLG#TDGITSVLPGSVATVATQEDEQGDENKARG 192
|
| Pan troglodytes |
Query 135 NVSVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
|||||||||| |||| |||||+||||||||#|||| ||||||||| ||||||||||||
Sbjct 133 NVSVGKGTLERNNTPVVGWVNVSQSTVVLG#TDGITSVLPGSVATVATQEDEQGDENKARG 192
|
| Monodelphis domestica |
Query 137 SVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
| |||||| |+| | ||+||||||||||#|||| ||||||| ||+ |||++||||||||
Sbjct 134 SSGKGTLERNSTQAAGWINMSQSTVVLG#TDGITSVLPGSVTTTSTPEDDEGDENKARG 191
|
| Canis familiaris |
Query 137 SVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
|||||||| |+||| |||||||| ||||#|||| ||||||||+ ||||||||||||
Sbjct 242 SVGKGTLERNSTPAGGWVNMSQSAVVLG#TDGITSVLPGSVASAAAQEDEQGDENKARG 299
|
| Gallus gallus |
Query 135 NVSVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
| ++|| ||| || + || +||||||||#||| ||||| | + ||+ ||||||||
Sbjct 191 NAALGKSTLEQNNAKST-WVTLSQSTVVLG#TDGNTSVLPGRVEGVSTDEDDVGDENKARG 249
|
| Tetraodon nigroviridis |
Query 140 KGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
+ | | |||| | |||+|++||#||| || ||+| | ++| ||||||||
Sbjct 54 RATAEQNNTPGT-WTAMSQTTIILG#TDGNTSVQPGTV-TANDDDEEGGDENKARG 106
|
[Site 2] NTPAVGWVNM156-SQSTVVLGTD
Met156 Ser
|
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Asn147 | Thr148 | Pro149 | Ala150 | Val151 | Gly152 | Trp153 | Val154 | Asn155 | Met156 |
|
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Ser157 | Gln158 | Ser159 | Thr160 | Val161 | Val162 | Leu163 | Gly164 | Thr165 | Asp166 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
LRGPEEDENVSVGKGTLEHNNTPAVGWVNMSQSTVVLGTDGIASVLPGSVATTTIPEDEQ
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Mus musculus |
121.00 |
7 |
PREDICTED: similar to Sodium- and chloride-depende |
| 2 |
Rattus norvegicus |
119.00 |
2 |
sodium dependent glycine type 2b transporter |
| 3 |
Macaca mulatta |
105.00 |
1 |
PREDICTED: solute carrier family 6 (neurotransmitt |
| 4 |
Homo sapiens |
103.00 |
6 |
Solute carrier family 6 (neurotransmitter transpor |
| 5 |
N/A |
103.00 |
1 |
S |
| 6 |
Pan troglodytes |
102.00 |
1 |
PREDICTED: solute carrier family 6 (neurotransmitt |
| 7 |
Bos taurus |
101.00 |
1 |
PREDICTED: similar to glycine transporter GLYT2 is |
| 8 |
Canis familiaris |
92.40 |
1 |
PREDICTED: similar to Sodium- and chloride-depende |
| 9 |
Monodelphis domestica |
86.30 |
1 |
PREDICTED: similar to glycine transporter GLYT2 |
| 10 |
Gallus gallus |
60.80 |
1 |
PREDICTED: similar to glycine transporter GLYT2 |
| 11 |
Tetraodon nigroviridis |
46.60 |
1 |
unnamed protein product |
| 12 |
Danio rerio |
45.80 |
1 |
solute carrier family 6 (neurotransmitter transpor |
Top-ranked sequences
| organism | matching |
|---|
| Mus musculus |
Query 127 LRGPEEDENVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 186
||||||| ||||||||||||||||||||||#||||||||||||||||||||||||||||||
Sbjct 119 LRGPEEDANVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 178
|
| Rattus norvegicus |
Query 127 LRGPEEDENVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 186
|||||||||||| |||||||||| ||||||#||||||||||||||||||||||||||||||
Sbjct 119 LRGPEEDENVSVAKGTLEHNNTPPVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 178
|
| Macaca mulatta |
Query 127 LRGPEEDENVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 186
||||| | |||||||||| |||||||||||#|||||||||||| ||||||||| ||||
Sbjct 169 LRGPEGDANVSVGKGTLERNNTPAVGWVNM#SQSTVVLGTDGITSVLPGSVATVATQEDEQ 228
|
| Homo sapiens |
Query 127 LRGPEEDENVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 186
||||| | |||||||||| |||| ||||||#|||||||||||| ||||||||| ||||
Sbjct 125 LRGPEGDANVSVGKGTLERNNTPVVGWVNM#SQSTVVLGTDGITSVLPGSVATVATQEDEQ 184
|
| N/A |
Query 127 LRGPEEDENVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 186
||||| | |||||||||| |||| ||||||#|||||||||||| ||||||||| ||||
Sbjct 125 LRGPEGDANVSVGKGTLERNNTPVVGWVNM#SQSTVVLGTDGITSVLPGSVATVATQEDEQ 184
|
| Pan troglodytes |
Query 127 LRGPEEDENVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 186
||||| | |||||||||| |||| |||||+#|||||||||||| ||||||||| ||||
Sbjct 125 LRGPEGDANVSVGKGTLERNNTPVVGWVNV#SQSTVVLGTDGITSVLPGSVATVATQEDEQ 184
|
| Bos taurus |
Query 127 LRGPEEDENVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 186
||| | | |||||||||| |||||||||||#|||||||||||| ||||||||| ||||
Sbjct 126 LRGLEGDANVSVGKGTLERNNTPAVGWVNM#SQSTVVLGTDGITSVLPGSVATAATQEDEQ 185
|
| Canis familiaris |
Query 127 LRGPEEDENVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 186
||||| | |||||||| |+||| |||||#||| |||||||| ||||||||+ ||||
Sbjct 232 LRGPEGDAAASVGKGTLERNSTPAGGWVNM#SQSAVVLGTDGITSVLPGSVASAAAQEDEQ 291
|
| Monodelphis domestica |
Query 127 LRGPE--EDENVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPED 184
||| |+|+ | |||||| |+| | ||+||#|||||||||||| ||||||| ||+ |||
Sbjct 122 LRGASVGEEESGSSGKGTLERNSTQAAGWINM#SQSTVVLGTDGITSVLPGSVTTTSTPED 181
Query 185 EQ 186
++
Sbjct 182 DE 183
|
| Gallus gallus |
Query 127 LRGPEEDENVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDE 185
|+ + | | ++|| ||| || + || +#||||||||||| ||||| | + ||+
Sbjct 183 LQSTDGDANAALGKSTLEQNNAKST-WVTL#SQSTVVLGTDGNTSVLPGRVEGVSTDEDD 240
|
| Tetraodon nigroviridis |
Query 140 KGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 186
+ | | |||| | |#||+|++||||| || ||+| | +||+
Sbjct 54 RATAEQNNTPGT-WTAM#SQTTIILGTDGNTSVQPGTV--TANDDDEE 97
|
| Danio rerio |
Query 135 NVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDE 185
| | + ||||+ | +|#||+|++||||| |||||+| | | |+
Sbjct 110 NQSAVRIAAEHNNSTG-DWTSM#SQTTIILGTDGNTSVLPGTV--TGPPTDD 157
|
* References
[PubMed ID: 15632090] Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G, Gene and alternative splicing annotation with AIR. Genome Res. 2005 Jan;15(1):54-66.
