XSB2381 : Sodium- and chloride-dependent glycine transporter 2
[ CaMP Format ]
This entry is computationally expanded from SB0013
* Basic Information
| Organism | Mus musculus (house mouse) |
| Protein Names | GlyT2; GlyT-2; Solute carrier family 6 member 5 |
| Gene Names | Glyt2 |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 799 aa
Average Mass: 87.861 kDa
Monoisotopic Mass: 87.804 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| TT_ORF2a 1. | 34 | 81 | -2.3 | 6.7 |
| --- cleavage 164 --- |
| --- cleavage 156 --- |
| SNF 1. | 193 | 756 | 1018.6 | 2.4e-303 |
3. Sequence Information
Fasta Sequence: XSB2381.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
2 [sites]
Cleavage sites (±10aa)
[Site 1] NMSQSTVVLG164-TDGIASVLPG
Gly164 
Thr
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Asn155 | Met156 | Ser157 | Gln158 | Ser159 | Thr160 | Val161 | Val162 | Leu163 | Gly164 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Thr165 | Asp166 | Gly167 | Ile168 | Ala169 | Ser170 | Val171 | Leu172 | Pro173 | Gly174 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
NVSVGKGTLEHNNTPAVGWVNMSQSTVVLGTDGIASVLPGSVATTTIPEDEQGDENKARG
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Mus musculus |
123.00 |
7 |
PREDICTED: similar to Sodium- and chloride-depende |
| 2 |
Rattus norvegicus |
119.00 |
2 |
solute carrier family 6 (neurotransmitter transpor |
| 3 |
Macaca mulatta |
110.00 |
1 |
PREDICTED: solute carrier family 6 (neurotransmitt |
| 4 |
Bos taurus |
110.00 |
1 |
PREDICTED: similar to glycine transporter GLYT2 is |
| 5 |
Homo sapiens |
108.00 |
6 |
Solute carrier family 6 (neurotransmitter transpor |
| 6 |
N/A |
108.00 |
1 |
S |
| 7 |
Pan troglodytes |
107.00 |
1 |
PREDICTED: solute carrier family 6 (neurotransmitt |
| 8 |
Monodelphis domestica |
98.60 |
1 |
PREDICTED: similar to glycine transporter GLYT2 |
| 9 |
Canis familiaris |
98.20 |
1 |
PREDICTED: similar to Sodium- and chloride-depende |
| 10 |
Gallus gallus |
73.20 |
1 |
PREDICTED: similar to glycine transporter GLYT2 |
| 11 |
Tetraodon nigroviridis |
60.50 |
1 |
unnamed protein product |
Top-ranked sequences
| organism | matching |
|---|
| Mus musculus |
Query 135 NVSVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 135 NVSVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
|
| Rattus norvegicus |
Query 135 NVSVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
|||| |||||||||| ||||||||||||||#||||||||||||||||||||||||||||||
Sbjct 135 NVSVAKGTLEHNNTPPVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
|
| Macaca mulatta |
Query 135 NVSVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
|||||||||| |||||||||||||||||||#|||| ||||||||| ||||||||||||
Sbjct 177 NVSVGKGTLERNNTPAVGWVNMSQSTVVLG#TDGITSVLPGSVATVATQEDEQGDENKARG 236
|
| Bos taurus |
Query 135 NVSVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
|||||||||| |||||||||||||||||||#|||| ||||||||| ||||||||||||
Sbjct 134 NVSVGKGTLERNNTPAVGWVNMSQSTVVLG#TDGITSVLPGSVATAATQEDEQGDENKARG 193
|
| Homo sapiens |
Query 135 NVSVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
|||||||||| |||| ||||||||||||||#|||| ||||||||| ||||||||||||
Sbjct 133 NVSVGKGTLERNNTPVVGWVNMSQSTVVLG#TDGITSVLPGSVATVATQEDEQGDENKARG 192
|
| N/A |
Query 135 NVSVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
|||||||||| |||| ||||||||||||||#|||| ||||||||| ||||||||||||
Sbjct 133 NVSVGKGTLERNNTPVVGWVNMSQSTVVLG#TDGITSVLPGSVATVATQEDEQGDENKARG 192
|
| Pan troglodytes |
Query 135 NVSVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
|||||||||| |||| |||||+||||||||#|||| ||||||||| ||||||||||||
Sbjct 133 NVSVGKGTLERNNTPVVGWVNVSQSTVVLG#TDGITSVLPGSVATVATQEDEQGDENKARG 192
|
| Monodelphis domestica |
Query 137 SVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
| |||||| |+| | ||+||||||||||#|||| ||||||| ||+ |||++||||||||
Sbjct 134 SSGKGTLERNSTQAAGWINMSQSTVVLG#TDGITSVLPGSVTTTSTPEDDEGDENKARG 191
|
| Canis familiaris |
Query 137 SVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
|||||||| |+||| |||||||| ||||#|||| ||||||||+ ||||||||||||
Sbjct 242 SVGKGTLERNSTPAGGWVNMSQSAVVLG#TDGITSVLPGSVASAAAQEDEQGDENKARG 299
|
| Gallus gallus |
Query 135 NVSVGKGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
| ++|| ||| || + || +||||||||#||| ||||| | + ||+ ||||||||
Sbjct 191 NAALGKSTLEQNNAKST-WVTLSQSTVVLG#TDGNTSVLPGRVEGVSTDEDDVGDENKARG 249
|
| Tetraodon nigroviridis |
Query 140 KGTLEHNNTPAVGWVNMSQSTVVLG#TDGIASVLPGSVATTTIPEDEQGDENKARG 194
+ | | |||| | |||+|++||#||| || ||+| | ++| ||||||||
Sbjct 54 RATAEQNNTPGT-WTAMSQTTIILG#TDGNTSVQPGTV-TANDDDEEGGDENKARG 106
|
[Site 2] NTPAVGWVNM156-SQSTVVLGTD
Met156 Ser
|
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Asn147 | Thr148 | Pro149 | Ala150 | Val151 | Gly152 | Trp153 | Val154 | Asn155 | Met156 |
|
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Ser157 | Gln158 | Ser159 | Thr160 | Val161 | Val162 | Leu163 | Gly164 | Thr165 | Asp166 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
LRGPEEDANVSVGKGTLEHNNTPAVGWVNMSQSTVVLGTDGIASVLPGSVATTTIPEDEQ
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Mus musculus |
123.00 |
7 |
PREDICTED: similar to Sodium- and chloride-depende |
| 2 |
Rattus norvegicus |
117.00 |
2 |
solute carrier family 6 (neurotransmitter transpor |
| 3 |
Macaca mulatta |
107.00 |
1 |
PREDICTED: solute carrier family 6 (neurotransmitt |
| 4 |
Homo sapiens |
105.00 |
6 |
Solute carrier family 6 (neurotransmitter transpor |
| 5 |
N/A |
105.00 |
1 |
S |
| 6 |
Bos taurus |
103.00 |
1 |
PREDICTED: similar to glycine transporter GLYT2 is |
| 7 |
Pan troglodytes |
103.00 |
1 |
PREDICTED: solute carrier family 6 (neurotransmitt |
| 8 |
Canis familiaris |
94.40 |
1 |
PREDICTED: similar to Sodium- and chloride-depende |
| 9 |
Monodelphis domestica |
84.00 |
1 |
PREDICTED: similar to glycine transporter GLYT2 |
| 10 |
Gallus gallus |
62.80 |
1 |
PREDICTED: similar to glycine transporter GLYT2 |
| 11 |
Tetraodon nigroviridis |
46.60 |
1 |
unnamed protein product |
| 12 |
Danio rerio |
45.80 |
1 |
solute carrier family 6 (neurotransmitter transpor |
Top-ranked sequences
| organism | matching |
|---|
| Mus musculus |
Query 127 LRGPEEDANVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 186
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 127 LRGPEEDANVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 186
|
| Rattus norvegicus |
Query 127 LRGPEEDANVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 186
||||||| |||| |||||||||| ||||||#||||||||||||||||||||||||||||||
Sbjct 127 LRGPEEDENVSVAKGTLEHNNTPPVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 186
|
| Macaca mulatta |
Query 127 LRGPEEDANVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 186
||||| |||||||||||| |||||||||||#|||||||||||| ||||||||| ||||
Sbjct 169 LRGPEGDANVSVGKGTLERNNTPAVGWVNM#SQSTVVLGTDGITSVLPGSVATVATQEDEQ 228
|
| Homo sapiens |
Query 127 LRGPEEDANVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 186
||||| |||||||||||| |||| ||||||#|||||||||||| ||||||||| ||||
Sbjct 125 LRGPEGDANVSVGKGTLERNNTPVVGWVNM#SQSTVVLGTDGITSVLPGSVATVATQEDEQ 184
|
| N/A |
Query 127 LRGPEEDANVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 186
||||| |||||||||||| |||| ||||||#|||||||||||| ||||||||| ||||
Sbjct 125 LRGPEGDANVSVGKGTLERNNTPVVGWVNM#SQSTVVLGTDGITSVLPGSVATVATQEDEQ 184
|
| Bos taurus |
Query 127 LRGPEEDANVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 186
||| | |||||||||||| |||||||||||#|||||||||||| ||||||||| ||||
Sbjct 126 LRGLEGDANVSVGKGTLERNNTPAVGWVNM#SQSTVVLGTDGITSVLPGSVATAATQEDEQ 185
|
| Pan troglodytes |
Query 127 LRGPEEDANVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 186
||||| |||||||||||| |||| |||||+#|||||||||||| ||||||||| ||||
Sbjct 125 LRGPEGDANVSVGKGTLERNNTPVVGWVNV#SQSTVVLGTDGITSVLPGSVATVATQEDEQ 184
|
| Canis familiaris |
Query 127 LRGPEEDANVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 186
||||| || |||||||| |+||| |||||#||| |||||||| ||||||||+ ||||
Sbjct 232 LRGPEGDAAASVGKGTLERNSTPAGGWVNM#SQSAVVLGTDGITSVLPGSVASAAAQEDEQ 291
|
| Monodelphis domestica |
Query 127 LRGPE--EDANVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPED 184
||| |+ + | |||||| |+| | ||+||#|||||||||||| ||||||| ||+ |||
Sbjct 122 LRGASVGEEESGSSGKGTLERNSTQAAGWINM#SQSTVVLGTDGITSVLPGSVTTTSTPED 181
Query 185 EQ 186
++
Sbjct 182 DE 183
|
| Gallus gallus |
Query 127 LRGPEEDANVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDE 185
|+ + ||| ++|| ||| || + || +#||||||||||| ||||| | + ||+
Sbjct 183 LQSTDGDANAALGKSTLEQNNAKST-WVTL#SQSTVVLGTDGNTSVLPGRVEGVSTDEDD 240
|
| Tetraodon nigroviridis |
Query 140 KGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDEQ 186
+ | | |||| | |#||+|++||||| || ||+| | +||+
Sbjct 54 RATAEQNNTPGT-WTAM#SQTTIILGTDGNTSVQPGTV--TANDDDEE 97
|
| Danio rerio |
Query 135 NVSVGKGTLEHNNTPAVGWVNM#SQSTVVLGTDGIASVLPGSVATTTIPEDE 185
| | + ||||+ | +|#||+|++||||| |||||+| | | |+
Sbjct 110 NQSAVRIAAEHNNSTG-DWTSM#SQTTIILGTDGNTSVLPGTV--TGPPTDD 157
|
* References
[PubMed ID: 15081419] Ebihara S, Yamamoto T, Obata K, Yanagawa Y, Gene structure and alternative splicing of the mouse glycine transporter type-2. Biochem Biophys Res Commun. 2004 May 7;317(3):857-64.
