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XSB2404 : Chain A, Crystal Structure Of Monomeric Actin Bound To Cytochalasin D

[ CaMP Format ]

This entry is computationally expanded from SB0031

* Basic Information

OrganismDrosophila melanogaster (fruit fly)
Protein NamesActin-5C
Gene NamesCG4027
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
3EKS_A N/A N/A ACT1_DROME N/A N/A N/A dme:Dmel_CG4027

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 375 aa

Average Mass: 41.780 kDa

Monoisotopic Mass: 41.753 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Actin 1. 2375817.58.5e-243
--- cleavage 37 (inside Actin 2..375) ---

3. Sequence Information

Fasta Sequence: XSB2404.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1N58 (Model; -; A=1-376), 2HF3 (X-ray; 180 A; A=3-376), 2HF4 (X-ray; 180 A; A=3-376), 3EKS (X-ray; 180 A; A=2-376), 3EKU (X-ray; 250 A; A=2-376), 3EL2 (X-ray; 250 A; A=2-376)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] RAVFPSIVGR37-PRHQGVMVGM

Arg37 Pro

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Arg28Ala29Val30Phe31Pro32Ser33Ile34Val35Gly36Arg37
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Pro38Arg39His40Gln41Gly42Val43Met44Val45Gly46Met47

Sequence conservation (by blast)

* References

[PubMed ID: 16920713] Rould MA, Wan Q, Joel PB, Lowey S, Trybus KM, Crystal structures of expressed non-polymerizable monomeric actin in the ADP and ATP states. J Biol Chem. 2006 Oct 20;281(42):31909-19. Epub 2006 Aug 18.