logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2622 : Chain A, Crystal Structure Of The Complex Between The Egfr Kinase Domain And A Mig6 Peptide

[ CaMP Format ]

This entry is computationally expanded from SB0050

* Basic Information

OrganismHomo sapiens (human)
Protein NamesEpidermal growth factor receptor; 2.7.10.1; Receptor tyrosine-protein kinase ErbB-1
Gene NamesERBB1
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
2RFD_A N/A N/A EGFR_HUMAN N/A N/A N/A hsa:1956

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 324 aa

Average Mass: 36.921 kDa

Monoisotopic Mass: 36.897 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Pkinase_Tyr 1. 14270439.26.5e-129
--- cleavage 35 (inside Pkinase_Tyr 14..270) ---

3. Sequence Information

Fasta Sequence: XSB2622.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1DNQ (Model; -; A=25-336), 1DNR (Model; -; A=337-645), 1IVO (X-ray; 330 A; A/B=25-646), 1M14 (X-ray; 260 A; A=695-1022), 1M17 (X-ray; 260 A; A=695-1022), 1MOX (X-ray; 250 A; A/B=25-525), 1NQL (X-ray; 280 A; A=25-642), 1XKK (X-ray; 240 A; A=695-1022), 1YY9 (X-ray; 260 A; A=25-642), 1Z9I (NMR; -; A=669-721), 2EB2 (X-ray; 250 A; A=695-1022), 2EB3 (X-ray; 284 A; A=695-1022), 2EXP (Model; -; A=311-326), 2EXQ (Model; -; A=27-536), 2GS2 (X-ray; 280 A; A=696-1022), 2GS6 (X-ray; 260 A; A=696-1022), 2GS7 (X-ray; 260 A; A/B=696-1022), 2ITN (X-ray; 247 A; A=696-1019), 2ITO (X-ray; 325 A; A=696-1022), 2ITP (X-ray; 274 A; A=696-1022), 2ITQ (X-ray; 268 A; A=696-1022), 2ITT (X-ray; 273 A; A=696-1022), 2ITU (X-ray; 280 A; A=696-1022), 2ITV (X-ray; 247 A; A=696-1022), 2ITW (X-ray; 288 A; A=696-1022), 2ITX (X-ray; 298 A; A=696-1022), 2ITY (X-ray; 342 A; A=696-1022), 2ITZ (X-ray; 272 A; A=696-1022), 2J5E (X-ray; 310 A; A=696-1022), 2J5F (X-ray; 300 A; A=696-1022), 2J6M (X-ray; 310 A; A=696-1022), 2JIT (X-ray; 310 A; A/B=696-1022), 2JIU (X-ray; 305 A; A/B=695-1022), 2JIV (X-ray; 350 A; A/B=695-1022), 2RF9 (X-ray; 350 A; A/B=696-1022), 2RFD (X-ray; 360 A; A/B=702-1022), 2RFE (X-ray; 290 A; A/B/C/D=702-1022), 2RGP (X-ray; 200 A; A=702-1016), 3B2U (X-ray; 258 A; A/B/E/I/M/P/S/V=335-538), 3B2V (X-ray; 330 A; A=25-642), 3BEL (X-ray; 230 A; A=702-1016), 3BUO (X-ray; 260 A; A/C=1063-1075), 3C09 (X-ray; 320 A; A/D=335-538)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] GTVYKGLWIP35-EGEKVKIPVA

Pro35 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gly26Thr27Val28Tyr29Lys30Gly31Leu32Trp33Ile34Pro35
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu36Gly37Glu38Lys39Val40Lys41Ile42Pro43Val44Ala45

Sequence conservation (by blast)

* References

[PubMed ID: 18046415] Zhang X, Pickin KA, Bose R, Jura N, Cole PA, Kuriyan J, Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature. 2007 Nov 29;450(7170):741-4.