logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2626 : epidermal growth factor receptor, isoform CRA_b [Rattus norvegicus]

[ CaMP Format ]

This entry is computationally expanded from SB0050

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein Namesepidermal growth factor receptor; isoform CRA_b
Gene NamesEgfr
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
EDL97896 N/A 24329 N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 1209 aa

Average Mass: 134.896 kDa

Monoisotopic Mass: 134.809 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Recep_L_domain 1. 57168148.12.6e-41
Furin-like 1. 184338259.48.6e-75
Recep_L_domain 2. 361481140.94e-39
Toxin_16 1. 490529-1.87.2
Fer4 1. 572601-7.46.4
Gram_pos_anchor 1. 636673-1.03.9
Pkinase_Tyr 1. 713969443.33.6e-130
--- cleavage 734 (inside Pkinase_Tyr 713..969) ---
Extensin_2 1. 10661130-8.38.2

3. Sequence Information

Fasta Sequence: XSB2626.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] GTVYKGLWIP734-EGEKVKIPVA

Pro734 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gly725Thr726Val727Tyr728Lys729Gly730Leu731Trp732Ile733Pro734
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu735Gly736Glu737Lys738Val739Lys740Ile741Pro742Val743Ala744

Sequence conservation (by blast)

[Site 2] FFPKEAKPNG1184-IFKGPTAENA

Gly1184 Ile

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Phe1175Phe1176Pro1177Lys1178Glu1179Ala1180Lys1181Pro1182Asn1183Gly1184
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ile1185Phe1186Lys1187Gly1188Pro1189Thr1190Ala1191Glu1192Asn1193Ala1194

Sequence conservation (by blast)

* References

[PubMed ID: 15632090] Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G, Gene and alternative splicing annotation with AIR. Genome Res. 2005 Jan;15(1):54-66.