XSB2629 : epidermal growth factor receptor [Gallus gallus]
[ CaMP Format ]
This entry is computationally expanded from SB0050
* Basic Information
| Organism | Gallus gallus (chicken) |
| Protein Names | Tyrosine-protein kinase transforming protein erbB; 2.7.10.1; epidermal growth factor receptor |
| Gene Names | EGFR; V-ERBB; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) |
| Gene Locus | 2; chromosome 2 |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_990828 | NM_205497 | 396494 | ERBB_ALV | N/A | N/A | N/A | gga:396494 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 1226 aa
Average Mass: 136.472 kDa
Monoisotopic Mass: 136.384 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| TPR_4 1. | 12 | 37 | 5.9 | 8.6 |
| Recep_L_domain 1. | 66 | 178 | 156.3 | 9.4e-44 |
| Furin-like 1. | 194 | 348 | 272.2 | 1.2e-78 |
| Recep_L_domain 2. | 371 | 491 | 151.9 | 1.9e-42 |
| Toxin_30 1. | 561 | 593 | -5.9 | 8.4 |
| GSu_C4xC__C2xCH 1. | 607 | 634 | -13.4 | 4.8 |
| Adeno_E3_CR2 1. | 649 | 689 | -2.4 | 1.6 |
| Pkinase_Tyr 1. | 724 | 980 | 449.5 | 4.9e-132 |
| --- cleavage 745 (inside Pkinase_Tyr 724..980) --- | ||||
| CRT-like 1. | 1041 | 1147 | -77.8 | 3.5 |
3. Sequence Information
Fasta Sequence: XSB2629.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] GTVYKGLWIP745-EGEKVKIPVA
Pro745 
Glu
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gly736 | Thr737 | Val738 | Tyr739 | Lys740 | Gly741 | Leu742 | Trp743 | Ile744 | Pro745 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Glu746 | Gly747 | Glu748 | Lys749 | Val750 | Lys751 | Ile752 | Pro753 | Val754 | Ala755 |
Sequence conservation (by blast)
* References
[PubMed ID: 19006119] Suh HN, Lee YJ, Han HJ, Interleukin-6 promotes 2-deoxyglucose uptake through p44/42 MAPKs activation via Ca2+/PKC and EGF receptor in primary cultured chicken hepatocytes. J Cell Physiol. 2009 Mar;218(3):643-52.