XSB2630 : epidermal growth factor receptor [Sus scrofa]
[ CaMP Format ]
This entry is computationally expanded from SB0050
* Basic Information
| Organism | Sus scrofa (pig) |
| Protein Names | epidermal growth factor receptor; egf receptor |
| Gene Names | EGFR; epidermal growth factor receptor |
| Gene Locus | 9; chromosome 9 |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_999172 | NM_214007 | 397070 | Q8MIL8_PIG | N/A | N/A | N/A | ssc:397070 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 1209 aa
Average Mass: 133.532 kDa
Monoisotopic Mass: 133.445 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Recep_L_domain 1. | 57 | 168 | 142.3 | 1.5e-39 |
| Furin-like 1. | 184 | 338 | 277.6 | 2.7e-80 |
| Recep_L_domain 2. | 361 | 481 | 139.6 | 9.9e-39 |
| Toxin_16 1. | 490 | 529 | 1.8 | 1.8 |
| Laminin_EGF 1. | 570 | 617 | -25.8 | 9.7 |
| PSI_8 1. | 643 | 673 | 2.9 | 8.1 |
| Pkinase_Tyr 1. | 712 | 968 | 443.9 | 2.4e-130 |
| --- cleavage 733 (inside Pkinase_Tyr 712..968) --- | ||||
| Hox9_act 1. | 1073 | 1201 | -99.9 | 7.3 |
3. Sequence Information
Fasta Sequence: XSB2630.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] GTVYKGLWIP733-EGEKVKIPVA
Pro733 
Glu
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gly724 | Thr725 | Val726 | Tyr727 | Lys728 | Gly729 | Leu730 | Trp731 | Ile732 | Pro733 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Glu734 | Gly735 | Glu736 | Lys737 | Val738 | Lys739 | Ile740 | Pro741 | Val742 | Ala743 |
Sequence conservation (by blast)
* References
[PubMed ID: 18424208] Kalbe C, Mau M, Rehfeldt C, Developmental changes and the impact of isoflavones on mRNA expression of IGF-I receptor, EGF receptor and related growth factors in porcine skeletal muscle cell cultures. Growth Horm IGF Res. 2008 Oct;18(5):424-33.