logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2631 : Chain A, Crystal Structure Of Mutated Egfr Kinase Domain (G719s)

[ CaMP Format ]

This entry is computationally expanded from SB0050

* Basic Information

OrganismHomo sapiens (human)
Protein NamesEpidermal growth factor receptor; 2.7.10.1; Receptor tyrosine-protein kinase ErbB-1
Gene NamesERBB1
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
2EB2_A N/A N/A EGFR_HUMAN N/A N/A N/A hsa:1956

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 334 aa

Average Mass: 37.960 kDa

Monoisotopic Mass: 37.935 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Pkinase_Tyr 1. 24280430.72.4e-126
--- cleavage 45 (inside Pkinase_Tyr 24..280) ---

3. Sequence Information

Fasta Sequence: XSB2631.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1DNQ (Model; -; A=25-336), 1DNR (Model; -; A=337-645), 1IVO (X-ray; 330 A; A/B=25-646), 1M14 (X-ray; 260 A; A=695-1022), 1M17 (X-ray; 260 A; A=695-1022), 1MOX (X-ray; 250 A; A/B=25-525), 1NQL (X-ray; 280 A; A=25-642), 1XKK (X-ray; 240 A; A=695-1022), 1YY9 (X-ray; 260 A; A=25-642), 1Z9I (NMR; -; A=669-721), 2EB2 (X-ray; 250 A; A=695-1022), 2EB3 (X-ray; 284 A; A=695-1022), 2EXP (Model; -; A=311-326), 2EXQ (Model; -; A=27-536), 2GS2 (X-ray; 280 A; A=696-1022), 2GS6 (X-ray; 260 A; A=696-1022), 2GS7 (X-ray; 260 A; A/B=696-1022), 2ITN (X-ray; 247 A; A=696-1019), 2ITO (X-ray; 325 A; A=696-1022), 2ITP (X-ray; 274 A; A=696-1022), 2ITQ (X-ray; 268 A; A=696-1022), 2ITT (X-ray; 273 A; A=696-1022), 2ITU (X-ray; 280 A; A=696-1022), 2ITV (X-ray; 247 A; A=696-1022), 2ITW (X-ray; 288 A; A=696-1022), 2ITX (X-ray; 298 A; A=696-1022), 2ITY (X-ray; 342 A; A=696-1022), 2ITZ (X-ray; 272 A; A=696-1022), 2J5E (X-ray; 310 A; A=696-1022), 2J5F (X-ray; 300 A; A=696-1022), 2J6M (X-ray; 310 A; A=696-1022), 2JIT (X-ray; 310 A; A/B=696-1022), 2JIU (X-ray; 305 A; A/B=695-1022), 2JIV (X-ray; 350 A; A/B=695-1022), 2RF9 (X-ray; 350 A; A/B=696-1022), 2RFD (X-ray; 360 A; A/B=702-1022), 2RFE (X-ray; 290 A; A/B/C/D=702-1022), 2RGP (X-ray; 200 A; A=702-1016), 3B2U (X-ray; 258 A; A/B/E/I/M/P/S/V=335-538), 3B2V (X-ray; 330 A; A=25-642), 3BEL (X-ray; 230 A; A=702-1016), 3BUO (X-ray; 260 A; A/C=1063-1075), 3C09 (X-ray; 320 A; A/D=335-538)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] GTVYKGLWIP45-EGEKVKIPVA

Pro45 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gly36Thr37Val38Tyr39Lys40Gly41Leu42Trp43Ile44Pro45
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu46Gly47Glu48Lys49Val50Lys51Ile52Pro53Val54Ala55

Sequence conservation (by blast)

* References

None.