XSB2639 : unnamed protein product [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0065
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | cDNA, FLJ92658, highly similar to Homo sapiens poly (ADP-ribose) polymerase family, member 1 (PARP1), mRNA |
| Gene Names | Not available |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| BAG35260 | N/A | N/A | B2R5W3_HUMAN | N/A | N/A | N/A | hsa: |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 1014 aa
Average Mass: 113.086 kDa
Monoisotopic Mass: 113.014 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| zf-PARP 1. | 12 | 90 | 151.0 | 3.5e-42 |
| zf-PARP 2. | 116 | 200 | 161.6 | 2.4e-45 |
| PADR1 1. | 279 | 332 | 128.8 | 1.7e-35 |
| BRCT 1. | 385 | 463 | 47.5 | 5.2e-11 |
| WGR 1. | 548 | 633 | 144.0 | 4.6e-40 |
| --- cleavage 656 --- | ||||
| PARP_reg 1. | 662 | 795 | 284.9 | 1.7e-82 |
| PARP 1. | 797 | 1007 | 424.6 | 1.6e-124 |
3. Sequence Information
Fasta Sequence: XSB2639.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] QDEEAVKKLT656-VNPGTKSKLP
Thr656 
Val
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gln647 | Asp648 | Glu649 | Glu650 | Ala651 | Val652 | Lys653 | Lys654 | Leu655 | Thr656 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Val657 | Asn658 | Pro659 | Gly660 | Thr661 | Lys662 | Ser663 | Lys664 | Leu665 | Pro666 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| HSKNFTKYPKRFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAM |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | ADP-ribose | 124.00 | 18 | PARP1_HUMAN Poly |
| 2 | N/A | 124.00 | 9 | - |
| 3 | Homo sapiens | 124.00 | 8 | poly (ADP-ribose) polymerase family, member 1 |
| 4 | synthetic construct | 124.00 | 1 | poly (ADP-ribose) polymerase family, member 1 |
| 5 | Macaca mulatta | 123.00 | 5 | PREDICTED: poly (ADP-ribose) polymerase family, me |
| 6 | Macaca fascicularis | 123.00 | 1 | unnamed protein product |
| 7 | Bos taurus | 120.00 | 2 | ADP-ribosyltransferase (NAD+) poly (ADP-ribose) po |
| 8 | cattle, Peptide Partial, 607 aa | 120.00 | 1 | NAD+:protein(ADP-ribosyl)-transferase, ADPRT |
| 9 | Mus musculus | 116.00 | 11 | unnamed protein product |
| 10 | mice, Peptide Partial, 606 aa | 115.00 | 1 | NAD+:protein(ADP-ribosyl)-transferase, ADPRT |
| 11 | Rattus norvegicus | 114.00 | 2 | ADP-ribosyltransferase 1 |
| 12 | Gallus gallus | 114.00 | 1 | poly (ADP-ribose) polymerase family, member 1 |
| 13 | chickens, Peptide Partial, 607 aa | 114.00 | 1 | NAD+:protein(ADP-ribosyl)-transferase, ADPRT |
| 14 | Monodelphis domestica | 112.00 | 2 | PREDICTED: similar to poly(ADP-ribose) synthetase |
| 15 | Xenopus laevis | 105.00 | 3 | NAD(+) ADP-ribosyltransferase |
| 16 | Xenopus, Peptide Partial, 607 aa | 105.00 | 1 | NAD+:protein(ADP-ribosyl)-transferase, ADPRT |
| 17 | Tetraodon nigroviridis | 105.00 | 1 | unnamed protein product |
| 18 | Danio rerio | 102.00 | 2 | hypothetical protein LOC560788 |
| 19 | Anopheles gambiae str. PEST | 61.20 | 1 | ENSANGP00000014723 |
| 20 | adp-ribose | 58.20 | 1 | poly |
| 21 | Vitis vinifera | 51.60 | 1 | hypothetical protein |
| 22 | Arabidopsis thaliana | 49.30 | 2 | putative poly (ADP-ribose) polymerase |
| 23 | Caenorhabditis elegans | 48.10 | 2 | AF499444_1 poly ADP-ribose metabolism enzyme-1 |
| 24 | Drosophila melanogaster | 47.80 | 3 | CG40411-PC.3 |
| 25 | Drosophila, Peptide Partial, 593 aa | 47.80 | 1 | NAD+:protein(ADP-ribosyl)-transferase, ADPRT |
| 26 | Zea mays | 47.40 | 1 | poly(ADP-ribose) polymerase |
| 27 | Caenorhabditis briggsae | 47.00 | 1 | Hypothetical protein CBG04221 |
| 28 | Oryza sativa (japonica cultivar-group) | 45.80 | 5 | Os07g0413700 |
| 29 | Oryza sativa (indica cultivar-group) | 45.80 | 2 | hypothetical protein OsI_024833 |
| 30 | Trypanosoma brucei TREU927 | 44.70 | 1 | poly(ADP-ribose) polymerase, putative |
| 31 | Trypanosoma brucei brucei | 44.70 | 1 | poly(ADP-ribose) polymerase |
| 32 | Dictyostelium discoideum AX4 | 40.80 | 3 | poly(ADP-ribosyl)transferase |
| 33 | Dictyostelium discoideum | 40.80 | 2 | NAD(+) ADP-ribosyltransferase-1A |
| 34 | Schistosoma japonicum | 38.90 | 1 | SJCHGC03992 protein |
| 35 | Pan troglodytes | 36.20 | 3 | PREDICTED: poly (ADP-ribose) polymerase family, me |
| 36 | Entamoeba histolytica HM-1:IMSS | 35.80 | 1 | poly(ADP-ribose) polymerase |
| 37 | Dictyostelium discoideum, Peptide Partial, 612 aa | 35.00 | 1 | NAD+:protein(ADP-ribosyl)-transferase, ADPRT {EC 2 |
Top-ranked sequences
| organism | matching |
|---|---|
| ADP-ribose | Query 627 HSKNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 ||||||||||+|||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 627 HSKNFTKYPKKFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 |
| N/A | Query 627 HSKNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 ||||||||||+|||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 627 HSKNFTKYPKKFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 |
| Homo sapiens | Query 627 HSKNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 ||||||||||+|||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 627 HSKNFTKYPKKFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 |
| synthetic construct | Query 627 HSKNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 ||||||||||+|||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 627 HSKNFTKYPKKFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 |
| Macaca mulatta | Query 627 HSKNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 ||||||||||+|||||||||||||||||||#||||||||||||||||||+||||||||||| Sbjct 627 HSKNFTKYPKKFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKLIFDVESMKKAM 686 |
| Macaca fascicularis | Query 627 HSKNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 ||||||||||+|||||||||||||||||||#||||||||||||||||||+||||||||||| Sbjct 24 HSKNFTKYPKKFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKLIFDVESMKKAM 83 |
| Bos taurus | Query 627 HSKNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 |||||||+||+|||||||||||||||||||#||||||||||||||+||||||||||||||| Sbjct 629 HSKNFTKHPKKFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQNLIKMIFDVESMKKAM 688 |
| cattle, Peptide Partial, 607 aa | Query 627 HSKNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 |||||||+||+|||||||||||||||||||#||||||||||||||+||||||||||||||| Sbjct 220 HSKNFTKHPKKFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQNLIKMIFDVESMKKAM 279 |
| Mus musculus | Query 627 HSKNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 ||||||||||+|||||||||||||||||||#| ||||||||||||+|+ |||||||||||+ Sbjct 627 HSKNFTKYPKKFYPLEIDYGQDEEAVKKLT#VKPGTKSKLPKPVQELVGMIFDVESMKKAL 686 |
| mice, Peptide Partial, 606 aa | Query 627 HSKNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 ||||||||||+|||||||||||||||||||#| ||||||||||||+|+ |||||+|||||+ Sbjct 219 HSKNFTKYPKKFYPLEIDYGQDEEAVKKLT#VKPGTKSKLPKPVQELVGMIFDVDSMKKAL 278 |
| Rattus norvegicus | Query 627 HSKNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 ||||||||||+|||||||||||||||||| #| ||||||||||||+|+ |||||||||||+ Sbjct 627 HSKNFTKYPKKFYPLEIDYGQDEEAVKKLA#VKPGTKSKLPKPVQELVGMIFDVESMKKAL 686 |
| Gallus gallus | Query 627 HSKNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 ||||||||||+|||||||||||||||+|||#|+ |||||| ||+||||||||||||||||| Sbjct 624 HSKNFTKYPKKFYPLEIDYGQDEEAVRKLT#VSAGTKSKLAKPIQDLIKMIFDVESMKKAM 683 |
| chickens, Peptide Partial, 607 aa | Query 627 HSKNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 ||||||||||+|||||||||||||||+|||#|+ |||||| ||+||||||||||||||||| Sbjct 220 HSKNFTKYPKKFYPLEIDYGQDEEAVRKLT#VSAGTKSKLAKPIQDLIKMIFDVESMKKAM 279 |
| Monodelphis domestica | Query 627 HSKNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 || |||||||+|||||||||||||||||||#|+ ||||||| |||+||||||||||||||| Sbjct 624 HSTNFTKYPKKFYPLEIDYGQDEEAVKKLT#VSAGTKSKLPIPVQNLIKMIFDVESMKKAM 683 |
| Xenopus laevis | Query 627 HSKNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 || |||||||+||||||||||+|+ ||||+#| |||||| ||||+|||+||||||||||| Sbjct 623 HSPNFTKYPKKFYPLEIDYGQEEDVVKKLS#VGAGTKSKLAKPVQELIKLIFDVESMKKAM 682 |
| Xenopus, Peptide Partial, 607 aa | Query 627 HSKNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 || |||||||+||||||||||+|+ ||||+#| |||||| ||||+|||+||||||||||| Sbjct 219 HSPNFTKYPKKFYPLEIDYGQEEDVVKKLS#VGAGTKSKLAKPVQELIKLIFDVESMKKAM 278 |
| Tetraodon nigroviridis | Query 628 SKNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 | |||||| +|||||||||||||||||||# |||||| ||||+||||||||||||||| Sbjct 370 SSNFTKYPNKFYPLEIDYGQDEEAVKKLT#ATAGTKSKLAKPVQELIKMIFDVESMKKAM 428 |
| Danio rerio | Query 628 SKNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 | |||||| +|||||||||||||||||||# + | ||+| |||||||+|||||||||||| Sbjct 627 SSNFTKYPNKFYPLEIDYGQDEEAVKKLT#QSAGAKSQLEKPVQDLIRMIFDVESMKKAM 685 |
| Anopheles gambiae str. PEST | Query 627 HSKNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 | ++| | |||+|||| | |+| # | | |||| ||||++|+|||++| + | Sbjct 610 HDSVYSKMPGAFYPIEIDYS--ETKTKRLA#ENSGIKSKLAPAVQDLVRMLFDVDAMNRVM 667 |
| adp-ribose | Query 631 FTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 | |+| +||++||| +| | | # | |||| ||||++|+|||++||| | Sbjct 620 FHKHPGAYYPVDIDYNDEE--TKTLA#ENNDIKSKLEPAVQDLVRMLFDVDTMKKVM 673 |
| Vitis vinifera | Query 629 KNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 +|| | | ||+||+|||| +++ || #++ |+| | +|+||+|+||+ + || Sbjct 626 QNFQKQPGRFFPLDIDYGVNKQVSKKNN#LS-NVNSQLAPQVVELMKMLFNVETYRSAM 682 |
| Arabidopsis thaliana | Query 630 NFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 || | | +| ||+|||| +++ || # | | | + +|+||+||||+ + || Sbjct 629 NFQKQPGKFLPLDIDYGVNKQVAKKEP#FQ--TSSNLAPSLIELMKMLFDVETYRSAM 683 |
| Caenorhabditis elegans | Query 627 HSKNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 + |+| | | | +| || + + + #+ ||+|+ ||| |++++ |||||+|| |+ Sbjct 552 YRKHFRKMPGMFSYVETDYSEFAQ-ITDTE#ITPGSKTLLPKSVKEVVMSIFDVENMKSAL 610 |
| Drosophila melanogaster | Query 630 NFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 || | | ||+|| | |++ || # + ||| ||+|||+|||++|| | + Sbjct 614 NFVKRTGRMYPIEIQYDDDQKLVKH--#ESHFFTSKLEISVQNLIKLIFDIDSMNKTL 668 |
| Drosophila, Peptide Partial, 593 aa | Query 630 NFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 || | | ||+|| | |++ || # + ||| ||+|||+|||++|| | + Sbjct 213 NFVKRTGRMYPIEIQYDDDQKLVKH--#ESHFFTSKLEISVQNLIKLIFDIDSMNKTL 267 |
| Zea mays | Query 630 NFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 || | | |||||++||| ++| |+ #++ || | + +|+||+|+||+ + || Sbjct 588 NFRKQPGRFYPLDVDYGV-KKAPKRKD#ISE-MKSSLAPQLLELMKMLFNVETYRAAM 642 |
| Caenorhabditis briggsae | Query 629 KNFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 |+| | | | +| || + ++ +|+ #+ ||+++ ||+ |++++ |||+|+|| |+ Sbjct 545 KHFRKMPGAFSFVETDYSEFDQ-LKEQD#IIPGSRTLLPRAVKEIVMSIFDIENMKSAL 601 |
| Oryza sativa (japonica cultivar-group) | Query 630 NFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 || | | +||||+|||| + |+ #++ || || + +|+ |+|++|+ + || Sbjct 596 NFQKQPGKFYPLDIDYGV-RQGPKRKD#IDK-MKSSLPPQLLELMNMLFNIETYRAAM 650 |
| Oryza sativa (indica cultivar-group) | Query 630 NFTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 || | | +||||+|||| + |+ #++ || || + +|+ |+|++|+ + || Sbjct 579 NFQKQPGKFYPLDIDYGV-RQGPKRKD#IDK-MKSSLPPQLLELMNMLFNIETYRAAM 633 |
| Trypanosoma brucei TREU927 | Query 631 FTKYPKRFYPLEIDYGQDEE--------AVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESM 682 | | | ++ +|+|||+|++ || # | +||||| ||||+++| ||| Sbjct 190 FKKVPGKYEYMEVDYGEDDDDDAGGEKPGKKKKA#EKPVRESKLPKEVQDLMRLIGCRESM 249 Query 683 KKAM 686 + + Sbjct 250 SQVL 253 |
| Trypanosoma brucei brucei | Query 631 FTKYPKRFYPLEIDYGQDEE--------AVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESM 682 | | | ++ +|+|||+|++ || # | +||||| ||||+++| ||| Sbjct 190 FKKVPGKYEYMEVDYGEDDDDDAGGEKPGKKKKA#EKPVRESKLPKEVQDLMRLIGCRESM 249 Query 683 KKAM 686 + + Sbjct 250 SQVL 253 |
| Dictyostelium discoideum AX4 | Query 631 FTKYPKRFYPLEIDYGQDEEAVKKL-----------T#VNPGT-------KSKLPKPVQDL 672 | | |+++| + +| | ||| + | |# | | ||+ | || Sbjct 541 FKKLPRKYYMISLDDGNDEEEEENLVETVLKRKKSET#TTTSTSQEIEPKKEGLPQRVLDL 600 Query 673 IKMIFDVESMKKAM 686 +|++|| | ||| + Sbjct 601 VKLMFDPEMMKKQL 614 |
| Dictyostelium discoideum | Query 631 FTKYPKRFYPLEIDYGQDEEAVKKL-----------T#VNPGT-------KSKLPKPVQDL 672 | | |+++| + +| | ||| + | |# | | ||+ | || Sbjct 541 FKKLPRKYYMISLDDGNDEEEEENLVETVLKRKKSET#TTTSTSQEIEPKKEGLPQRVLDL 600 Query 673 IKMIFDVESMKKAM 686 +|++|| | ||| + Sbjct 601 VKLMFDPEMMKKQL 614 |
| Schistosoma japonicum | Query 630 NFTKYPKRFYPLEIDYG-QDEEAVKKLT#VNPGTKSKLPKPVQDLIKMIFDVESMKKAM 686 +| |+ ++ +||||| ||| + # ||+|| || |+++| |+++|++ | Sbjct 133 HFIKHKGKYDLVEIDYGVQDENVTIETK#KTEEIKSRLPVAVQVLMQLICDMDNMEQVM 190 |
| Pan troglodytes | Query 629 KNFTKYPKRFYPLEIDYG---QDEEAVKK---LT#VNPGTKSKLPKPVQDLIKMIFDVESM 682 + | | | ++ |++|| |||| || | # +|+| ||+|||+| +|++| Sbjct 192 EKFEKVPGKYDMLQMDYATNTQDEEETKKEESLK#SPLKPESQLDLRVQELIKLICNVQAM 251 Query 683 KKAM 686 ++ | Sbjct 252 EEMM 255 |
| Entamoeba histolytica HM-1:IMSS | Query 631 FTKYPKRFYPLEIDYGQDEEAVKKLT#VNPGTKSKLPKP----------------VQDLIK 674 | | +++ +| |+|| ||| #+| || |+ + | |||| Sbjct 467 FKKVGGKYFMQALDTGKDETERKKL-#INEETKKKMEEKRQQLKEKAKENYLDPRVSDLIK 525 Query 675 MIFDVESMKKAM 686 |||| + || + Sbjct 526 MIFDTDMMKNTL 537 |
| Dictyostelium discoideum, Peptide Partial, 612 aa | Query 630 NFTKYPKRFYPLEIDYGQDEE-----------AVKKLT#VNPGTKSKLPKPVQDLIKMIFD 678 || | ++ +|+|| | + | #| + | + ||+|+|+||| Sbjct 228 NFKKVAGKYDMIELDYSTDSKPKNGASTTATTTTTKKV#VEHKKECSLDERVQELVKLIFD 287 Query 679 VESMKKAM 686 |+ |++ | Sbjct 288 VKMMERTM 295 |
* References
None.