logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2647 : neurofibromatosis 2, isoform CRA_a [Rattus norvegicus]

[ CaMP Format ]

This entry is computationally expanded from SB0009

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein Namesneurofibromatosis 2; isoform CRA_a
Gene NamesNf2
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
EDM00242 N/A 25744 N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 368 aa

Average Mass: 43.387 kDa

Monoisotopic Mass: 43.359 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
FERM_N 1. 2610295.02.7e-25
FERM_M 1. 104222137.63.8e-38
FERM_C 1. 226315177.63.5e-50
--- cleavage 298 (inside FERM_C 226..315) ---
--- cleavage 294 (inside FERM_C 226..315) ---

3. Sequence Information

Fasta Sequence: XSB2647.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] KLRVNKLILQ298-LCIGNHDLFM

Gln298 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys289Leu290Arg291Val292Asn293Lys294Leu295Ile296Leu297Gln298
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu299Cys300Ile301Gly302Asn303His304Asp305Leu306Phe307Met308

Sequence conservation (by blast)

[Site 2] FNSSKLRVNK294-LILQLCIGNH

Lys294 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Phe285Asn286Ser287Ser288Lys289Leu290Arg291Val292Asn293Lys294
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu295Ile296Leu297Gln298Leu299Cys300Ile301Gly302Asn303His304

Sequence conservation (by blast)

* References

[PubMed ID: 15632090] Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G, Gene and alternative splicing annotation with AIR. Genome Res. 2005 Jan;15(1):54-66.