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XSB2648 : neurofibromin 2 (merlin) [Rattus norvegicus]

[ CaMP Format ]

This entry is computationally expanded from SB0009

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein NamesMerlin; Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomin; neurofibromin 2 (merlin); neurofibromatosis 2
Gene NamesNf2; neurofibromin 2 (merlin)
Gene Locus14q21; chromosome 14
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_037325 NM_013193 25744 MERL_RAT N/A N/A N/A rno:25744

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 591 aa

Average Mass: 69.204 kDa

Monoisotopic Mass: 69.160 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
FERM_N 1. 2610295.02.7e-25
FERM_M 1. 104222137.63.8e-38
FERM_C 1. 226315177.63.5e-50
--- cleavage 298 (inside FERM_C 226..315) ---
--- cleavage 294 (inside FERM_C 226..315) ---
ERM 1. 347580290.63.4e-84

3. Sequence Information

Fasta Sequence: XSB2648.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] KLRVNKLILQ298-LCIGNHDLFM

Gln298 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys289Leu290Arg291Val292Asn293Lys294Leu295Ile296Leu297Gln298
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu299Cys300Ile301Gly302Asn303His304Asp305Leu306Phe307Met308

Sequence conservation (by blast)

[Site 2] FNSSKLRVNK294-LILQLCIGNH

Lys294 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Phe285Asn286Ser287Ser288Lys289Leu290Arg291Val292Asn293Lys294
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu295Ile296Leu297Gln298Leu299Cys300Ile301Gly302Asn303His304

Sequence conservation (by blast)

* References

[PubMed ID: 17891137] Tang X, Jang SW, Wang X, Liu Z, Bahr SM, Sun SY, Brat D, Gutmann DH, Ye K, Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation. Nat Cell Biol. 2007 Oct;9(10):1199-207. Epub 2007 Sep 23.

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