XSB2656 : Merlin
[ CaMP Format ]
This entry is computationally expanded from SB0009
* Basic Information
| Organism | Papio anubis (olive baboon) |
| Protein Names | Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomin |
| Gene Names | NF2 |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| P59750 | N/A | N/A | MERL_PAPAN | N/A | N/A | N/A | N/A |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 595 aa
Average Mass: 69.663 kDa
Monoisotopic Mass: 69.619 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| FERM_N 1. | 26 | 102 | 95.0 | 2.7e-25 |
| FERM_M 1. | 104 | 222 | 141.8 | 2.1e-39 |
| FERM_C 1. | 226 | 315 | 177.6 | 3.5e-50 |
| --- cleavage 298 (inside FERM_C 226..315) --- | ||||
| --- cleavage 294 (inside FERM_C 226..315) --- | ||||
| ERM 1. | 347 | 595 | 367.7 | 2.1e-107 |
3. Sequence Information
Fasta Sequence: XSB2656.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
2 [sites]
Cleavage sites (±10aa)
[Site 1] KLRVNKLILQ298-LCIGNHDLFM
Gln298 
Leu
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Lys289 | Leu290 | Arg291 | Val292 | Asn293 | Lys294 | Leu295 | Ile296 | Leu297 | Gln298 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Leu299 | Cys300 | Ile301 | Gly302 | Asn303 | His304 | Asp305 | Leu306 | Phe307 | Met308 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| KEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREE |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 120.00 | 35 | AF369657_1 neurofibromatosis type 2 isoform I |
| 2 | Canis familiaris | 120.00 | 32 | PREDICTED: similar to neurofibromin 2 isoform 1 is |
| 3 | Mus musculus | 120.00 | 25 | neurofibromatosis 2 |
| 4 | N/A | 120.00 | 24 | 1 |
| 5 | Rattus norvegicus | 120.00 | 8 | PREDICTED: similar to neurofibromatosis 2 |
| 6 | Xenopus tropicalis | 120.00 | 6 | neurofibromin 2 |
| 7 | Gallus gallus | 120.00 | 5 | neurofibromin 2 |
| 8 | Monodelphis domestica | 120.00 | 5 | PREDICTED: hypothetical protein |
| 9 | Macaca mulatta | 120.00 | 5 | PREDICTED: similar to neurofibromin 2 isoform 1 is |
| 10 | Bos taurus | 120.00 | 4 | PREDICTED: similar to merlin isoform 1 |
| 11 | Papio anubis anubis | 120.00 | 1 | MERL_PAPAN Merlin (Moesin-ezrin-radixin-like prote |
| 12 | Xenopus laevis | 119.00 | 6 | neurofibromin 2 (bilateral acoustic neuroma) |
| 13 | Danio rerio | 110.00 | 15 | PREDICTED: hypothetical protein |
| 14 | Tetraodon nigroviridis | 108.00 | 7 | unnamed protein product |
| 15 | Strongylocentrotus purpuratus | 89.70 | 4 | PREDICTED: similar to neurofibromin 2 (bilateral a |
| 16 | Oryctolagus cuniculus | 88.60 | 1 | villin 2 (ezrin) |
| 17 | Pan troglodytes | 86.30 | 4 | PREDICTED: moesin |
| 18 | Sus scrofa | 86.30 | 2 | radixin |
| 19 | Macaca fascicularis | 86.30 | 1 | unnamed protein product |
| 20 | mice, keratinocytes, Balb/MK, Peptide, 583 aa | 86.30 | 1 | RADI_MOUSE Radixin (ESP10) gb |
| 21 | Tribolium castaneum | 85.50 | 6 | PREDICTED: similar to neurofibromatosis 2 |
| 22 | Ciona intestinalis | 85.50 | 1 | ezrin/radixin/moesin (ERM)-like protein |
| 23 | Aplysia californica | 84.70 | 1 | ezrin/radixin/moesin |
| 24 | Caenorhabditis briggsae | 84.30 | 2 | Hypothetical protein CBG12867 |
| 25 | Drosophila melanogaster | 83.60 | 7 | Moesin CG10701-PJ, isoform J |
| 26 | Drosophila pseudoobscura | 83.60 | 2 | GA10507-PA |
| 27 | Molgula tectiformis | 83.60 | 2 | Mt-ezrin/radixin/moesin |
| 28 | Caenorhabditis elegans | 83.20 | 6 | ERM-1Asv |
| 29 | Apis mellifera | 82.80 | 1 | PREDICTED: similar to Moesin CG10701-PD, isoform D |
| 30 | Spodoptera frugiperda | 82.40 | 1 | A unnamed protein product |
| 31 | Biomphalaria glabrata | 82.40 | 1 | ezrin/radixin/moesin |
| 32 | Aedes aegypti | 82.00 | 4 | moesin/ezrin/radixin |
| 33 | Anopheles gambiae str. PEST | 80.90 | 2 | ENSANGP00000017331 |
| 34 | Taenia saginata | 77.80 | 1 | myosin-like protein |
| 35 | Taenia solium | 77.80 | 1 | H17g protein, tegumental antigen |
| 36 | Echinococcus multilocularis | 77.40 | 1 | tegument protein gb |
| 37 | Echinococcus granulosus | 77.40 | 1 | EG10 |
| 38 | Schistosoma japonicum | 51.60 | 1 | SJCHGC06288 protein |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |
| Canis familiaris | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |
| Mus musculus | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |
| N/A | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |
| Rattus norvegicus | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |
| Xenopus tropicalis | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |
| Gallus gallus | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |
| Monodelphis domestica | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |
| Macaca mulatta | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |
| Bos taurus | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |
| Papio anubis anubis | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |
| Xenopus laevis | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 ||||||||+|||||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 269 KEFTIKPLEKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |
| Danio rerio | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 ||| |||+||+ ||||||||||||||||||#|||||||||||||+ ||||||||| ||||| Sbjct 268 KEFAIKPVDKRADVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRRVDSLEVQQMKTQAREE 327 |
| Tetraodon nigroviridis | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 ||||||||+|| |||||||+|| ||||||#|||||||||||||+ ||||||||||||||| Sbjct 163 KEFTIKPLEKKTKVFKFNSSRLRANKLILQ#LCIGNHDLFMRRRRVDSLEVQQMKAQAREE 222 |
| Strongylocentrotus purpuratus | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |+||||| || | | | |||+||||| #||+|||+|||+||+|||+|||||||||||| Sbjct 279 KKFTIKPTAKKAPNFCFISPKLRMNKLILD#LCVGNHELFMQRRRADSMEVQQMKAQAREE 338 |
| Oryctolagus cuniculus | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |+| |||+||| | | + +||+|| |||#||+|||+|+||||| |++|||||||||||| Sbjct 253 KKFVIKPIDKKAPDFVFYAPRLRINKRILQ#LCMGNHELYMRRRKPDTIEVQQMKAQAREE 312 |
| Pan troglodytes | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |+| |||+||| | | + +||+|| || #||+|||+|+||||| |++|||||||||||| Sbjct 225 KKFVIKPIDKKAPDFVFYAPRLRINKRILA#LCMGNHELYMRRRKPDTIEVQQMKAQAREE 284 |
| Sus scrofa | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |+| |||+||| | | + +||+|| || #||+|||+|+||||| |++|||||||||||| Sbjct 253 KKFVIKPIDKKAPDFVFYAPRLRINKRILA#LCMGNHELYMRRRKPDTIEVQQMKAQAREE 312 |
| Macaca fascicularis | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |+| |||+||| | | + +||+|| || #||+|||+|+||||| |++|||||||||||| Sbjct 253 KKFVIKPIDKKAPDFVFYAPRLRINKRILA#LCMGNHELYMRRRKPDTIEVQQMKAQAREE 312 |
| mice, keratinocytes, Balb/MK, Peptide, 583 aa | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |+| |||+||| | | + +||+|| || #||+|||+|+||||| |++|||||||||||| Sbjct 253 KKFVIKPIDKKAPDFVFYAPRLRINKRILA#LCMGNHELYMRRRKPDTIEVQQMKAQAREE 312 |
| Tribolium castaneum | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |+| |||+|| | | | |+|+||||| #||+||||||||||| ||+|+||||| |+|| Sbjct 263 KKFIIKPVDKNSPNFVFFSQKVRMNKLILD#LCMGNHDLFMRRRKPDSMELQQMKAAAKEE 322 |
| Ciona intestinalis | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |+| |||+||| | | +||+|| || #||+|||+|+||||| |++|||||||||||| Sbjct 277 KKFVIKPIDKKAPDFVFYVERLRINKRILA#LCMGNHELYMRRRKPDTIEVQQMKAQAREE 336 |
| Aplysia californica | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |+| |||+||| | | + +||+|| || #||+|||+|+||||| |++|||||||||||+ Sbjct 254 KKFIIKPIDKKAPDFVFYAPRLRINKRILA#LCMGNHELYMRRRKPDTIEVQQMKAQARED 313 |
| Caenorhabditis briggsae | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |+| |||+||| | | + +||+|| || #||+|||+|+||||| |++|||||| ||||| Sbjct 249 KKFVIKPIDKKAHDFVFYAPRLRINKRILA#LCMGNHELYMRRRKPDTIEVQQMKQQAREE 308 |
| Drosophila melanogaster | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |+| |||+||| | | + ++|+|| || #||+|||+|+||||| |+++||||||||||| Sbjct 254 KKFIIKPIDKKAPDFMFFAPRVRINKRILA#LCMGNHELYMRRRKPDTIDVQQMKAQAREE 313 |
| Drosophila pseudoobscura | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |+| |||+||| | | + ++|+|| || #||+|||+|+||||| |+++||||||||||| Sbjct 249 KKFIIKPIDKKAPDFMFFAPRVRINKRILA#LCMGNHELYMRRRKPDTIDVQQMKAQAREE 308 |
| Molgula tectiformis | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQARE 327 |+| |||+||| | | +||+|| || #||+|||+|+||||| ||+|||||||||+| Sbjct 253 KKFVIKPIDKKAPDFVFYVERLRINKRILA#LCMGNHELYMRRRKPDSIEVQQMKAQAKE 311 |
| Caenorhabditis elegans | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |+| |||+||| | | + +||+|| || #||+|||+|+||||| |++|||||| ||||+ Sbjct 254 KKFVIKPIDKKAHDFVFYAPRLRINKRILA#LCMGNHELYMRRRKPDTIEVQQMKQQARED 313 |
| Apis mellifera | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |+| |||+||| | | ++++++|| || #||+|||+|+||||| |+++||||||||||| Sbjct 188 KKFIIKPIDKKAPDFVFFATRVKINKRILA#LCMGNHELYMRRRKPDTIDVQQMKAQAREE 247 |
| Spodoptera frugiperda | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 ++| |||+||| | | + ++|||| || #||+|||+|+||||| |+++||||||||||| Sbjct 253 RKFIIKPIDKKAPDFVFFAPRVRVNKRILA#LCMGNHELYMRRRKPDTIDVQQMKAQAREE 312 |
| Biomphalaria glabrata | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAR 326 |+| |||+||| | | + +||+|| || #||+|||+|+||||| |++|||||||||| Sbjct 254 KKFVIKPIDKKAPDFVFYAPRLRINKRILA#LCMGNHELYMRRRKPDTIEVQQMKAQAR 311 |
| Aedes aegypti | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 ++| |||+||| | | + ++|+|| || #||+|||+|+||||| |+++||||||||||| Sbjct 259 RKFIIKPIDKKAPDFVFFAPRVRINKRILA#LCMGNHELYMRRRKPDTIDVQQMKAQAREE 318 |
| Anopheles gambiae str. PEST | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 ++| |||+||| | | + ++|+|| || #||+|||+|+||||| |+++|||||||||+| Sbjct 300 RKFIIKPIDKKAPDFVFFAPRVRINKRILA#LCMGNHELYMRRRKPDTIDVQQMKAQARDE 359 |
| Taenia saginata | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |+| ||| || | | | ++|| || #|| |||+|+|||||+||+|||||| ||+|| Sbjct 255 KKFIIKPADKSAKEFYFLVEKSKINKRILA#LCTGNHELYMRRRKSDSIEVQQMKIQAKEE 314 |
| Taenia solium | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |+| ||| || | | | ++|| || #|| |||+|+|||||+||+|||||| ||+|| Sbjct 248 KKFIIKPADKSAKEFYFLVEKSKINKRILA#LCTGNHELYMRRRKSDSIEVQQMKIQAKEE 307 |
| Echinococcus multilocularis | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |+| ||| || | | | ++|| || #|| |||+|+|||||+||+|||||| ||+|| Sbjct 255 KKFIIKPADKSAKEFFFLVEKSKINKRILA#LCTGNHELYMRRRKSDSIEVQQMKIQAKEE 314 |
| Echinococcus granulosus | Query 269 KEFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQAREE 328 |+| ||| || | | | ++|| || #|| |||+|+|||||+||+|||||| ||+|| Sbjct 255 KKFIIKPADKSAKEFFFLVEKSKINKRILA#LCTGNHELYMRRRKSDSIEVQQMKIQAKEE 314 |
| Schistosoma japonicum | Query 270 EFTIKPLDKKIDVFKFNSSKLRVNKLILQ#LCIGNHDLFMRRRKADSLEVQQMKAQARE 327 +| +||+ +| + ++||| #| +||| |+ ||+ ||+|||||| +|+| Sbjct 254 KFYVKPVGASGEVLTLYTDSTHTSRLILN#LSMGNHKLYAVRRQPDSIEVQQMKVKAKE 311 |
[Site 2] FNSSKLRVNK294-LILQLCIGNH
Lys294 Leu
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Phe285 | Asn286 | Ser287 | Ser288 | Lys289 | Leu290 | Arg291 | Val292 | Asn293 | Lys294 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Leu295 | Ile296 | Leu297 | Gln298 | Leu299 | Cys300 | Ile301 | Gly302 | Asn303 | His304 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| SYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQ |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 121.00 | 35 | neurofibromin 2 isoform 1 |
| 2 | Canis familiaris | 121.00 | 32 | PREDICTED: similar to neurofibromin 2 isoform 1 is |
| 3 | Mus musculus | 121.00 | 25 | neurofibromatosis 2 |
| 4 | N/A | 121.00 | 24 | 1 |
| 5 | Rattus norvegicus | 121.00 | 8 | PREDICTED: similar to neurofibromatosis 2 |
| 6 | Xenopus tropicalis | 121.00 | 6 | neurofibromin 2 |
| 7 | Monodelphis domestica | 121.00 | 5 | PREDICTED: hypothetical protein |
| 8 | Gallus gallus | 121.00 | 5 | neurofibromin 2 |
| 9 | Macaca mulatta | 121.00 | 5 | PREDICTED: similar to neurofibromin 2 isoform 1 is |
| 10 | Bos taurus | 121.00 | 4 | PREDICTED: similar to merlin isoform 1 |
| 11 | Papio anubis anubis | 121.00 | 1 | MERL_PAPAN Merlin (Moesin-ezrin-radixin-like prote |
| 12 | Xenopus laevis | 119.00 | 6 | neurofibromin 2 (bilateral acoustic neuroma) |
| 13 | Danio rerio | 110.00 | 14 | PREDICTED: hypothetical protein |
| 14 | Tetraodon nigroviridis | 109.00 | 7 | unnamed protein product |
| 15 | Strongylocentrotus purpuratus | 87.00 | 4 | PREDICTED: similar to neurofibromin 2 (bilateral a |
| 16 | Oryctolagus cuniculus | 86.70 | 1 | villin 2 (ezrin) |
| 17 | Tribolium castaneum | 84.70 | 6 | PREDICTED: similar to neurofibromatosis 2 |
| 18 | Molgula tectiformis | 84.70 | 2 | Mt-ezrin/radixin/moesin |
| 19 | Pan troglodytes | 84.30 | 4 | PREDICTED: moesin |
| 20 | Sus scrofa | 84.30 | 2 | radixin |
| 21 | Biomphalaria glabrata | 84.30 | 1 | ezrin/radixin/moesin |
| 22 | mice, keratinocytes, Balb/MK, Peptide, 583 aa | 84.30 | 1 | RADI_MOUSE Radixin (ESP10) gb |
| 23 | Macaca fascicularis | 84.30 | 1 | unnamed protein product |
| 24 | Aplysia californica | 84.00 | 1 | ezrin/radixin/moesin |
| 25 | Ciona intestinalis | 83.60 | 1 | ezrin/radixin/moesin (ERM)-like protein |
| 26 | Caenorhabditis elegans | 82.40 | 6 | ERM-1Asv |
| 27 | Caenorhabditis briggsae | 82.40 | 2 | Hypothetical protein CBG12867 |
| 28 | Drosophila melanogaster | 81.30 | 7 | Moesin CG10701-PJ, isoform J |
| 29 | Drosophila pseudoobscura | 81.30 | 2 | GA10507-PA |
| 30 | Spodoptera frugiperda | 80.50 | 1 | A unnamed protein product |
| 31 | Aedes aegypti | 80.10 | 4 | moesin/ezrin/radixin |
| 32 | Anopheles gambiae str. PEST | 80.10 | 2 | ENSANGP00000017331 |
| 33 | Apis mellifera | 79.30 | 1 | PREDICTED: similar to Moesin CG10701-PD, isoform D |
| 34 | Taenia saginata | 76.30 | 1 | myosin-like protein |
| 35 | Taenia solium | 76.30 | 1 | H17g protein, tegumental antigen |
| 36 | Echinococcus multilocularis | 75.90 | 1 | tegument protein gb |
| 37 | Echinococcus granulosus | 75.90 | 1 | EG10 |
| 38 | Schistosoma japonicum | 53.10 | 1 | SJCHGC06288 protein |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |
| Canis familiaris | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |
| Mus musculus | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |
| N/A | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |
| Rattus norvegicus | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |
| Xenopus tropicalis | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |
| Monodelphis domestica | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |
| Gallus gallus | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |
| Macaca mulatta | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |
| Bos taurus | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |
| Papio anubis anubis | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |
| Xenopus laevis | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 ||||||||||||+|||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 265 SYSDKEFTIKPLEKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |
| Danio rerio | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 ||||||| |||+||+ ||||||||||||||#|||||||||||||||||+ ||||||||| | Sbjct 264 SYSDKEFAIKPVDKRADVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRRVDSLEVQQMKTQ 323 |
| Tetraodon nigroviridis | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 ||||||||||||+|| |||||||+|| ||#|||||||||||||||||+ ||||||||||| Sbjct 159 SYSDKEFTIKPLEKKTKVFKFNSSRLRANK#LILQLCIGNHDLFMRRRRVDSLEVQQMKAQ 218 |
| Strongylocentrotus purpuratus | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |+ ||+||||| || | | | |||+||#||| ||+|||+|||+||+|||+|||||||| Sbjct 275 SFRDKKFTIKPTAKKAPNFCFISPKLRMNK#LILDLCVGNHELFMQRRRADSMEVQQMKAQ 334 |
| Oryctolagus cuniculus | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |++||+| |||+||| | | + +||+||# |||||+|||+|+||||| |++|||||||| Sbjct 249 SFNDKKFVIKPIDKKAPDFVFYAPRLRINK#RILQLCMGNHELYMRRRKPDTIEVQQMKAQ 308 |
| Tribolium castaneum | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKA 323 |+ ||+| |||+|| | | | |+|+||#||| ||+||||||||||| ||+|+||||| Sbjct 259 SFDDKKFIIKPVDKNSPNFVFFSQKVRMNK#LILDLCMGNHDLFMRRRKPDSMELQQMKA 317 |
| Molgula tectiformis | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |++||+| |||+||| | | +||+||# || ||+|||+|+||||| ||+|||||||| Sbjct 249 SFNDKKFVIKPIDKKAPDFVFYVERLRINK#RILALCMGNHELYMRRRKPDSIEVQQMKAQ 308 |
| Pan troglodytes | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |++||+| |||+||| | | + +||+||# || ||+|||+|+||||| |++|||||||| Sbjct 221 SFNDKKFVIKPIDKKAPDFVFYAPRLRINK#RILALCMGNHELYMRRRKPDTIEVQQMKAQ 280 |
| Sus scrofa | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |++||+| |||+||| | | + +||+||# || ||+|||+|+||||| |++|||||||| Sbjct 249 SFNDKKFVIKPIDKKAPDFVFYAPRLRINK#RILALCMGNHELYMRRRKPDTIEVQQMKAQ 308 |
| Biomphalaria glabrata | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |++||+| |||+||| | | + +||+||# || ||+|||+|+||||| |++|||||||| Sbjct 250 SFNDKKFVIKPIDKKAPDFVFYAPRLRINK#RILALCMGNHELYMRRRKPDTIEVQQMKAQ 309 |
| mice, keratinocytes, Balb/MK, Peptide, 583 aa | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |++||+| |||+||| | | + +||+||# || ||+|||+|+||||| |++|||||||| Sbjct 249 SFNDKKFVIKPIDKKAPDFVFYAPRLRINK#RILALCMGNHELYMRRRKPDTIEVQQMKAQ 308 |
| Macaca fascicularis | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |++||+| |||+||| | | + +||+||# || ||+|||+|+||||| |++|||||||| Sbjct 249 SFNDKKFVIKPIDKKAPDFVFYAPRLRINK#RILALCMGNHELYMRRRKPDTIEVQQMKAQ 308 |
| Aplysia californica | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |++||+| |||+||| | | + +||+||# || ||+|||+|+||||| |++|||||||| Sbjct 250 SFNDKKFIIKPIDKKAPDFVFYAPRLRINK#RILALCMGNHELYMRRRKPDTIEVQQMKAQ 309 |
| Ciona intestinalis | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |++||+| |||+||| | | +||+||# || ||+|||+|+||||| |++|||||||| Sbjct 273 SFNDKKFVIKPIDKKAPDFVFYVERLRINK#RILALCMGNHELYMRRRKPDTIEVQQMKAQ 332 |
| Caenorhabditis elegans | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |++||+| |||+||| | | + +||+||# || ||+|||+|+||||| |++|||||| | Sbjct 250 SFNDKKFVIKPIDKKAHDFVFYAPRLRINK#RILALCMGNHELYMRRRKPDTIEVQQMKQQ 309 |
| Caenorhabditis briggsae | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |++||+| |||+||| | | + +||+||# || ||+|||+|+||||| |++|||||| | Sbjct 245 SFNDKKFVIKPIDKKAHDFVFYAPRLRINK#RILALCMGNHELYMRRRKPDTIEVQQMKQQ 304 |
| Drosophila melanogaster | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |+|+|+| |||+||| | | + ++|+||# || ||+|||+|+||||| |+++||||||| Sbjct 250 SFSEKKFIIKPIDKKAPDFMFFAPRVRINK#RILALCMGNHELYMRRRKPDTIDVQQMKAQ 309 |
| Drosophila pseudoobscura | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |+|+|+| |||+||| | | + ++|+||# || ||+|||+|+||||| |+++||||||| Sbjct 245 SFSEKKFIIKPIDKKAPDFMFFAPRVRINK#RILALCMGNHELYMRRRKPDTIDVQQMKAQ 304 |
| Spodoptera frugiperda | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |++|++| |||+||| | | + ++||||# || ||+|||+|+||||| |+++||||||| Sbjct 249 SFNDRKFIIKPIDKKAPDFVFFAPRVRVNK#RILALCMGNHELYMRRRKPDTIDVQQMKAQ 308 |
| Aedes aegypti | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |++|++| |||+||| | | + ++|+||# || ||+|||+|+||||| |+++||||||| Sbjct 255 SFNDRKFIIKPIDKKAPDFVFFAPRVRINK#RILALCMGNHELYMRRRKPDTIDVQQMKAQ 314 |
| Anopheles gambiae str. PEST | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |++|++| |||+||| | | + ++|+||# || ||+|||+|+||||| |+++||||||| Sbjct 296 SFNDRKFIIKPIDKKAPDFVFFAPRVRINK#RILALCMGNHELYMRRRKPDTIDVQQMKAQ 355 |
| Apis mellifera | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |+++|+| |||+||| | | ++++++||# || ||+|||+|+||||| |+++||||||| Sbjct 184 SFNEKKFIIKPIDKKAPDFVFFATRVKINK#RILALCMGNHELYMRRRKPDTIDVQQMKAQ 243 |
| Taenia saginata | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |+ ||+| ||| || | | | ++||# || || |||+|+|||||+||+|||||| | Sbjct 251 SFHDKKFIIKPADKSAKEFYFLVEKSKINK#RILALCTGNHELYMRRRKSDSIEVQQMKIQ 310 |
| Taenia solium | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |+ ||+| ||| || | | | ++||# || || |||+|+|||||+||+|||||| | Sbjct 244 SFHDKKFIIKPADKSAKEFYFLVEKSKINK#RILALCTGNHELYMRRRKSDSIEVQQMKIQ 303 |
| Echinococcus multilocularis | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |+ ||+| ||| || | | | ++||# || || |||+|+|||||+||+|||||| | Sbjct 251 SFHDKKFIIKPADKSAKEFFFLVEKSKINK#RILALCTGNHELYMRRRKSDSIEVQQMKIQ 310 |
| Echinococcus granulosus | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 |+ ||+| ||| || | | | ++||# || || |||+|+|||||+||+|||||| | Sbjct 251 SFHDKKFIIKPADKSAKEFFFLVEKSKINK#RILALCTGNHELYMRRRKSDSIEVQQMKIQ 310 |
| Schistosoma japonicum | Query 265 SYSDKEFTIKPLDKKIDVFKFNSSKLRVNK#LILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324 ||| +| +||+ +| + ++#||| | +||| |+ ||+ ||+|||||| + Sbjct 249 SYSQNKFYVKPVGASGEVLTLYTDSTHTSR#LILNLSMGNHKLYAVRRQPDSIEVQQMKVK 308 |
* References
[PubMed ID: 12925885] Hansson CM, Ali H, Bruder CE, Fransson I, Kluge S, Andersson B, Roe BA, Menzel U, Dumanski JP, Strong conservation of the human NF2 locus based on sequence comparison in five species. Mamm Genome. 2003 Aug;14(8):526-36.