logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2807 : integrin beta-7 subunit

[ CaMP Format ]

This entry is computationally expanded from SB0062

* Basic Information

OrganismMus musculus (house mouse)
Protein NamesIntegrin beta-7; Integrin beta-P; M290 IEL antigen
Gene NamesItgb7
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
AAA02749 N/A N/A ITB7_MOUSE N/A N/A N/A mmu:16421

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 805 aa

Average Mass: 87.321 kDa

Monoisotopic Mass: 87.265 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Integrin_beta 1. 504751054.40
EGF_2 1. 47751016.20.039
EGF_2 2. 52655814.70.06
EGF_2 3. 56559521.30.0039
EGF_2 4. 60463432.61.6e-06
Integrin_B_tail 1. 64472071.82.5e-18
Integrin_b_cyt 1. 74579087.93.7e-23
--- cleavage 763 (inside Integrin_b_cyt 745..790) ---
--- cleavage 764 (inside Integrin_b_cyt 745..790) ---

3. Sequence Information

Fasta Sequence: XSB2807.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] REYRRFEKEQ763-QQLNWKQDNN

Gln763 Gln

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Arg754Glu755Tyr756Arg757Arg758Phe759Glu760Lys761Glu762Gln763
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gln764Gln765Leu766Asn767Trp768Lys769Gln770Asp771Asn772Asn773

Sequence conservation (by blast)

[Site 2] EYRRFEKEQQ764-QLNWKQDNNP

Gln764 Gln

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu755Tyr756Arg757Arg758Phe759Glu760Lys761Glu762Gln763Gln764
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gln765Leu766Asn767Trp768Lys769Gln770Asp771Asn772Asn773Pro774

Sequence conservation (by blast)

* References

[PubMed ID: 1559978] Yuan Q, Jiang WM, Leung E, Hollander D, Watson JD, Krissansen GW, Molecular cloning of the mouse integrin beta 7 subunit. J Biol Chem. 1992 Apr 15;267(11):7352-8.