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XSB2808 : integrin beta 7 [Mus musculus]

[ CaMP Format ]

This entry is computationally expanded from SB0062

* Basic Information

OrganismMus musculus (house mouse)
Protein NamesIntegrin beta-7; Integrin beta-P; M290 IEL antigen; integrin beta 7
Gene NamesItgb7; integrin beta 7
Gene Locus15 61.1 cM; chromosome 15
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_038594 NM_013566 16421 ITB7_MOUSE N/A N/A N/A mmu:16421

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 806 aa

Average Mass: 87.411 kDa

Monoisotopic Mass: 87.355 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Integrin_beta 1. 504761065.70
EGF_2 1. 47851116.20.039
EGF_2 2. 52755917.60.027
EGF_2 3. 56659621.30.0039
EGF_2 4. 60563532.61.6e-06
Integrin_B_tail 1. 64572171.82.5e-18
Integrin_b_cyt 1. 74679187.93.7e-23
--- cleavage 764 (inside Integrin_b_cyt 746..791) ---
--- cleavage 765 (inside Integrin_b_cyt 746..791) ---

3. Sequence Information

Fasta Sequence: XSB2808.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] REYRRFEKEQ764-QQLNWKQDNN

Gln764 Gln

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Arg755Glu756Tyr757Arg758Arg759Phe760Glu761Lys762Glu763Gln764
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gln765Gln766Leu767Asn768Trp769Lys770Gln771Asp772Asn773Asn774

Sequence conservation (by blast)

[Site 2] EYRRFEKEQQ765-QLNWKQDNNP

Gln765 Gln

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu756Tyr757Arg758Arg759Phe760Glu761Lys762Glu763Gln764Gln765
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gln766Leu767Asn768Trp769Lys770Gln771Asp772Asn773Asn774Pro775

Sequence conservation (by blast)

* References

[PubMed ID: 18829455] Lad Y, Jiang P, Ruskamo S, Harburger DS, Ylanne J, Campbell ID, Calderwood DA, Structural basis of the migfilin-filamin interaction and competition with integrin beta tails. J Biol Chem. 2008 Dec 12;283(50):35154-63. Epub 2008 Sep 30.

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